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  • D-天冬氨酸, 兴奋性氨基酸转运体 1；兴奋性氨基酸转运体 2；兴奋性氨基酸转运体 3；兴奋性氨基酸转运体 4；兴奋性氨基酸转运体 5；GluN1 的激动剂；GluN2A 的激动剂；GluN2B 的激动剂；GluN2C 的激动剂；GluN2D 的激动剂

D-天冬氨酸, 兴奋性氨基酸转运体 1；兴奋性氨基酸转运体 2；兴奋性氨基酸转运体 3；兴奋性氨基酸转运体 4；兴奋性氨基酸转运体 5；GluN1 的激动剂；GluN2A 的激动剂；GluN2B 的激动剂；GluN2C 的激动剂；GluN2D 的激动剂

NMDA激动剂
12篇引用文献
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货号 (SKU) 包装规格 是否现货 价格 数量
A105951-25g
 25g 现货 Stock Image
A105951-100g
 100g 现货 Stock Image
A105951-250g
 250g 现货 Stock Image
A105951-500g
 500g 现货 Stock Image
A105951-2.5kg
 2.5kg 期货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
Excitatory amino acid transporter 1 (6) Excitatory amino acid transporter 2 (6) Excitatory amino acid transporter 3 (5) Excitatory amino acid transporter 4 (5) Excitatory amino acid transporter 5 (5) 神经元信号传导 (3330) 离子型谷氨酸受体 (239) 膜转运器/离子通道 (1833)
main product photo

基本描述

别名 坏血酸,D-天门冬氨酸 | (R)-(-)-氨基琥珀酸, (R)-2-氨基琥珀酸
英文别名 2,2'-methanediylbis(1H-benzimidazole) | 6-benzyloxy-1H-indole | C4H7NO4 | delta-aspartate | SR-01000597731 | C00402 | 7-Benzyloxy-1H-indole | BP-12717 | EN300-67412 | NCGC00024498-01 | Q27076990 | D-Aminosuccinic acid | MFCD0046411
规格或纯度 Moligand™, ≥98%
英文名称 D-Aspartic acid
生化机理 具有与L-异构体相似活性的内源NMDA受体激动剂。也是EAA吸收系统的不可代谢的底物。调节松果体中褪黑激素的合成。
运输条件 常规运输
作用类型 激动剂
作用机制 兴奋性氨基酸转运体 1；兴奋性氨基酸转运体 2；兴奋性氨基酸转运体 3；兴奋性氨基酸转运体 4；兴奋性氨基酸转运体 5；GluN1 的激动剂；GluN2A 的激动剂；GluN2B 的激动剂；GluN2C 的激动剂；GluN2D 的激动剂
产品介绍

溶于水，不溶于醇和醚。 合成药品。

AI解读

关联靶点（人）

SLC1A1 Tchem 兴奋性氨基酸转运体3(Excitatory amino acid transporter 3) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
SLC1A7 Tchem 兴奋性氨基酸转运体5(Excitatory amino acid transporter 5) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
SLC1A3 Tchem 兴奋性氨基酸转运体1(Excitatory amino acid transporter 1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
SLC1A6 Tchem 兴奋性氨基酸转运体4(Excitatory amino acid transporter 4) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
SLC1A2 Tchem 兴奋性氨基酸转运体2(Excitatory amino acid transporter 2) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GRIN1 Tclin 谷氨酸受体离子型，NMDA 1(Glutamate receptor ionotropic, NMDA 1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GRIN2A Tclin 谷氨酸受体离子型，NMDA 2A(Glutamate receptor ionotropic, NMDA 2A) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GRIN2B Tclin 谷氨酸受体离子型，NMDA 2B(Glutamate receptor ionotropic, NMDA 2B) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GRIN2C Tclin 谷氨酸受体离子型，NMDA 2C(Glutamate receptor ionotropic, NMDA 2C) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GRIN2D Tclin 谷氨酸受体离子型，NMDA 2D(Glutamate receptor ionotropic, NMDA 2D) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRM6 Tchem Metabotropic glutamate receptor 6 (361 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRM1 Tchem Metabotropic glutamate receptor 1 (2309 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC1A3 Tchem Excitatory amino acid transporter 1 (586 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Grm2 Metabotropic glutamate receptor 2 (1326 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Glutamate transporter homolog (3 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488186215
EC号 217-234-6
分子类型 小分子
IUPAC Name (2R)-2-aminobutanedioic acid
INCHI InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
InChi Key CKLJMWTZIZZHCS-UWTATZPHSA-N
Canonical SMILES C(C(C(=O)O)N)C(=O)O
Isomeric SMILES C([C@H](C(=O)O)N)C(=O)O
WGK Germany 1
RTECS CI9097500
关联CAS 1783-96-6,27881-01-2
PubChem CID 83887
MeSH Entry Terms 3-hydroxy-N-(2-methyl-1-oxo-2-propenyl)-;D Aspartate;D Aspartic Acid;D-Aspartate;D-Aspartic Acid
分子量 133.10
Beilstein号 1723529
Reaxy-Rn 1723529

化学和物理性质

溶解性 Slightly soluble in water, Soluble in 1N ammonium hydroxide (100 mg/ml), and dilute HCl. Insoluble in ether, and alcohol.
密度 1.514
比旋光度 -24.0 to -26.0 deg(C=8, HCl(1+1))
熔点 300°C
分子量 133.100 g/mol
XLogP3 -2.800
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 3
精确质量Exact Mass 133.038 Da
单同位素质量Monoisotopic Mass 133.038 Da
拓扑极表面积Topological Polar Surface Area 101.000 Ų
重原子数Heavy Atom Count 9
形式电荷Formal Charge 0
复杂度Complexity 133.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 1
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P403+P233: 存放在通风良好的地方。保持容器密闭。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany 1
RTECS CI9097500
Reaxy-Rn 1723529
Merck Index 840
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

技术规格说明书

Specific Rotation [a]20/D(c=8 in 6N HCl) -26--24（°）
Purity(NonaqueousTitration) 97.5-102.5（%）
Appearance（A105951) White to Off-White Powder
Proton NMR spectrum Conforms to Structure
Solubility in 1N NH4OH，Colorless to Faint Yellow,Clear to Hazy,100mg/ml pass

 技术规格说明书

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找到14个结果

批号(Lot Number) 证书类型 日期 货号
D2511035 分析证书 25-04-17 A105951
D2409159 分析证书 24-03-20 A105951
D2409160 分析证书 24-03-20 A105951
K1918152 分析证书 23-09-05 A105951
B2324077 分析证书 22-07-04 A105951
B2511010 分析证书 22-07-04 A105951
H2308230 分析证书 22-07-04 A105951
H2412489 分析证书 22-07-04 A105951
I2224076 分析证书 22-07-04 A105951
I2224077 分析证书 22-07-04 A105951
I2224078 分析证书 22-07-04 A105951
I2224079 分析证书 22-07-04 A105951
K2329235 分析证书 22-07-04 A105951
D2511033 分析证书 21-08-09 A105951

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此产品的引用文献

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1. Wei Jia, Xin Wang.  (2023)  3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner.  FOOD CHEMISTRY,  427  (136729).  [PMID:37385056] [10.1016/j.foodchem.2023.136729]
2. Yonglei Han, Chao Zhou, Shuchen Weng, Guicheng Yu, Fang Lin, Hanlin Hu, Yongfei Wang, Haoran Lin.  (2022)  Natural Product Additive with Multifunctional Groups Enhancing the Efficiency and Stability of Perovskite Solar Cells.  Solar RRL,  7  (4): (2200998).  [10.1002/solr.202200998]
3. Haoyuan Li, Hongxiang Zhu, Zongyan Quan, Zhiping Chen, Lei Wang, Hui He.  (2023)  Tailoring of a bionic bifunctional cellulose nanocrystal-based gold nanocluster probe for the detection of intracellular pathological biomarkers.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  224  (1079).  [PMID:36309238] [10.1016/j.ijbiomac.2022.10.192]
4. Shuli Liu, Xiaoling Wu, Jun Xiong, Xin Yuan, Min-Hua Zong, Wen-Yong Lou.  (2022)  Aspartic acid based metal–organic frameworks with dual function of NADH peroxidase and glycerol dehydrogenase-mimicking activities.  Materials Chemistry Frontiers,  6  (22): (3391-3401).  [10.1039/D2QM00770C]
5. Arabi Maryam, Ostovan Abbas, Wang Yunqing, Mei Rongchao, Fu Longwen, Li Jinhua, Wang Xiaoyan, Chen Lingxin.  (2022)  Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination.  Nature Communications,  13  (1): (1-14).  [PMID:36180485] [10.1038/s41467-022-33448-w]
6. Shutong Yang, Liancheng Gu, Fangling Wu, Xinhua Dai, Fuxing Xu, Qiaoyu Li, Xiang Fang, Shaoning Yu, Chuan-Fan Ding.  (2022)  The chirality determination of amino acids by forming complexes with cyclodextrins and metal ions using ion mobility spectrometry, and a DFT calculation.  TALANTA,  243  (123363).  [PMID:35272154] [10.1016/j.talanta.2022.123363]
7. Lamei Yang, Feng Luo, Weili Wei.  (2021)  Simultaneous determination of the concentration and enantiomeric excess of amino acids with a coumarin-derived achiral probe.  Analytical Methods,  13  (16): (1905-1910).  [PMID:33913945] [10.1039/D1AY00271F]
8. Wen Luo, Huaxiao Liu, Xuan Liu, Lixiao Liu, Wenbo Zhao.  (2021)  Biocompatibility nanoprobe of MXene N-Ti3C2 quantum dot/Fe3+ for detection and fluorescence imaging of glutathione in living cells.  COLLOIDS AND SURFACES B-BIOINTERFACES,  201  (111631).  [PMID:33639506] [10.1016/j.colsurfb.2021.111631]
9. Yang Dan, Mei Shiliang, Wen Zhuoqi, Wei Xian, Cui Zhongjie, Yang Bobo, Wei Chang, Qiu Yi, Li Min, Li Hui, Zhang Wanlu, Xie Fengxian, Wang Le, Guo Ruiqian.  (2020)  Dual-emission of silicon nanoparticles encapsulated lanthanide-based metal-organic frameworks for ratiometric fluorescence detection of bacterial spores.  MICROCHIMICA ACTA,  187  (12): (1-9).  [PMID:33206253] [10.1007/s00604-020-04643-7]
10. Yanyang Zhu, Minxin Cui, Jiajun Ma, Qijin Zhang.  (2020)  Fluorescence detection of d-aspartic acid based on thiol-ene cross-linked molecularly imprinted optical fiber probe.  SENSORS AND ACTUATORS B-CHEMICAL,  305  (127323).  [10.1016/j.snb.2019.127323]
11. Yanni Miao, Qi Liu, Wei Wang, Li Liu, Li Wang.  (2017)  Enantioseparation of amino acids by micellar capillary electrophoresis using binary chiral selectors and determination of D-glutamic acid and D-aspartic acid in rice wine.  JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,  [10.1080/10826076.2017.1364263]
12. Chao Ding, Hanjun Sun, Jinsong Ren, Xiaogang Qu.  (2017)  Immobilization of enzyme on chiral polyelectrolyte surface.  ANALYTICA CHIMICA ACTA,  952  (88).  [PMID:28010846] [10.1016/j.aca.2016.11.047]

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