| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A649539-5mg |
5mg |
期货  |
| |
| A649539-10mg |
10mg |
期货 |
|
| 别名 | ADRA1D 受体拮抗剂 1 |
|---|---|
| 规格或纯度 | ≥98% |
| 英文名称 | ADRA1D receptor antagonist 1 |
| 生化机理 | ADRA1D 受体拮抗剂 1 是一种强效、具有选择性和口服活性的 α 1D 肾上腺素受体拮抗剂，其 K i 为 1.6 nM。 |
| 储存温度 | 2-8°C储存,避光,干燥 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
ADRA1D receptor antagonist 1 is a potent, selective and orally active α 1D adrenoceptor antagonist, with a K i of 1.6 nM In Vitro ADRA1D receptor antagonist 1 shows low hERG inhibition. ADRA1D receptor antagonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ADRA1D receptor antagonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat with bladder outlet obstruction (BOO) Dosage: 4.4 µg/kg Administration: Intravenous injection Result: Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO. Form:Solid IC50& Target:Ki: 1.6 nM (α 1D adrenoceptor) |
| Canonical SMILES | O=C(C1=CC(Cl)=CN([C@@H](C2=CC=CC(C#N)=C2)C)C1=N)N.[H]Cl |
|---|---|
| 分子量 | 337.20 |
| 溶解性 | DMSO : 100 mg/mL (296.56 mM; Need ultrasonic) |
|---|
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