1-(叔丁氧羰基)哌嗪

规格或纯度: 98%

CAS编号: 57260-71-6
分子式: C₉H₁₈N₂O₂
分子量: 186.25
Beilstein号: 879985
EC号: MFCD00075265
MDL号: MFCD00075265
PubChem编号: 143452

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货号 (SKU)	包装规格	是否现货
B106917-1g	1g	现货
B106917-5g	5g	现货
B106917-25g	25g	现货
B106917-100g	100g	现货
B106917-500g	500g	现货

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哌嗪类杂环砌块

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基本描述

别名	1-Boc-哌嗪 \| 哌嗪-1-甲酸叔丁酯 \| 哌嗪-1-甲酸叔丁酯
英文别名	1 -t-butoxycarbonyl piperazine \| 1-[1,1-dimethylethoxycarbonyl]piperazine \| 1-boc piperazine \| n-tert-butyloxycarbonylpiperazine \| N-tert-butyloxycarbonyl-piperazine \| tert-butyl-1-piperazinecarboxylate \| tertbutyl-1-piperazinecarboxylate \| 1-(t-butoxycar
规格或纯度	98%
英文名称	1-Boc-piperazine
应用	· （m·-苯氧基）苯基取代哌嗪衍生物系列的制备 · 通过活性阳离子开环聚合合成α,β-聚（2-噁唑啉）脂聚合物期间的终止步骤。 · 单取代哌嗪的制备，例如吲唑脱氧核糖核酸回旋酶抑制剂的合成
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
产品介绍	1-Boc-哌嗪与各种芳基卤化物发生 Buchwald-Hartwig 胺化反应，形成相应的的胺衍生物。它可用于合成许多生物活性分子的单取代哌嗪中间体和含有哌嗪的原料药，如曲唑酮。 1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported.1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides.1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine 1-Boc-piperazine was used in Buchwald-Hartwig coupling reaction

名称和标识符

EC号	MFCD00075265
IUPAC Name	tert-butyl piperazine-1-carboxylate
INCHI	InChI=1S/C9H18N2O2/c1-9(2,3)13-8(12)11-6-4-10-5-7-11/h10H,4-7H2,1-3H3
InChi Key	CWXPZXBSDSIRCS-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)OC(=O)N1CCNCC1
Isomeric SMILES	CC(C)(C)OC(=O)N1CCNCC1
WGK Germany	3
关联CAS	143238-38-4
PubChem CID	143452
分子量	186.25
Beilstein号	879985
Reaxy-Rn	879985

化学和物理性质

溶解性	Soluble in ethyl acetate, methanol and water.
密度	1.03
敏感性	对空气敏感;易吸湿; 对热敏感
闪点(℉)	235.4 °F
闪点(℃)	113 °C
熔点	43-47°C

安全和危险性（GHS）

象形图	Harmful
信号词	Danger
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P301+P330+P331,P304+P340,P363,P403+P233,P362+P364,P264+P265,P305+P354+P338,P337+P317,P332+P317,P302+P361+P354,P316,P319
WGK Germany	3
Reaxy-Rn	879985
个人防护装备	dust mask type N95 (US),Eyeshields,Gloves

象形图

Harmful

信号词

Danger

危险声明

H315: Causes skin irritation
H319: Causes serious eye irritation

预防措施声明

P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P301+P330+P331,P304+P340,P363,P403+P233,P362+P364,P264+P265,P305+P354+P338,P337+P317,P332+P317,P302+P361+P354,P316,P319

WGK Germany

Reaxy-Rn

879985

个人防护装备

dust mask type N95 (US),Eyeshields,Gloves

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参考文献

1. Florencio Zaragoza,Henrik Stephensen,Sanne M Knudsen,Lone Pridal,Birgitte S Wulff,Karin Rimvall. (2004-05-14) 1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists.. Journal of medicinal chemistry, 47 ((11)): (2833-2838). [PMID:15139761]
2. Ravi Varala,Sreelatha Nuvula,Srinivas R Adapa. (2006-10-10) Molecular iodine-catalyzed facile procedure for N-Boc protection of amines.. The Journal of organic chemistry, 71 ((21)): (8283-8286). [PMID:17025327]
3. Dengfeng Dou,Guijia He,Sivakoteswara Rao Mandadapu,Sridhar Aravapalli,Yunjeong Kim,Kyeong-Ok Chang,William C Groutas. (2011-11-29) Inhibition of noroviruses by piperazine derivatives.. Bioorganic & medicinal chemistry letters, 22 ((1)): (377-379). [PMID:22119464]
4. Akihiko Tanitame,Yoshihiro Oyamada,Keiko Ofuji,Yoko Kyoya,Kenji Suzuki,Hideaki Ito,Motoji Kawasaki,Kazuo Nagai,Masaaki Wachi,Jun-ichi Yamagishi. (2004-05-06) Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity.. Bioorganic & medicinal chemistry letters, 14 ((11)): (2857-2862). [PMID:15125947]
5. Nisar Ullah. (2013-03-16) Synthesis and dual D2 and 5-HT1A receptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones.. Journal of enzyme inhibition and medicinal chemistry, 29 ((2)): (281-291). [PMID:23488743]

1-(叔丁氧羰基)哌嗪

库存信息

库存信息

库存信息

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库存信息

基本描述

名称和标识符

化学和物理性质

安全和危险性（GHS）

质检证书(COA)

质检报告(COA)

相关文档

质检报告COA

产品问答

产品问答

参考文献