BML 283,Ca 2+螯合剂

选择性Ca 2+螯合剂。BAPTA的类似物。

规格或纯度: 95%

CAS编号: 126150-97-8
分子式: C₃₄H₄₀N₂O₁₈
分子量: 764.68
Beilstein号: 7458530
MDL号: MFCD00036696
PubChem编号: 2293

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货号 (SKU)	包装规格	是否现货	价格	数量
B115502-25mg	25mg	现货
B115502-100mg	100mg	现货

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细胞信号转导和神经科学

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基本描述

别名	1,2-双(2-氨基苯氧基)乙烷-N,N,N`,N`-四乙酸四乙酸甲酯\|胞内钙荧光探针BAPTA-AM\|1,2-双(2-氨基苯氧基)乙烷-N,N,N',N'-四乙酸四(乙酸基甲基)酯\|1,2-双(2-氨基苯氧基)-乙烷-N,N,N,N'-四乙酸
英文别名	BAPTA-AM\|126150-97-8\|BAPTA/AM\|acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate\|BAPTA/AM(BAPTA-AM)\|(acetyloxy)methyl 2-({2-[(acetyloxy)methoxy]-2-oxoethyl}[2-(2-{2-[bis
规格或纯度	95%
英文名称	BAPTA-AM
生化机理	细胞内Ca2+储存选择性螯合剂。选择性Ca 2+螯合剂。BAPTA的细胞渗透性类似物。用于操纵细胞内游离Ca 2+水平。显示出不同的生物活性。块hK v 1.5，K v 11.1（hERG）和hK v 1.3通道（K i值为1.23、1.30和1.45
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. For more information on AM esters please visit our AM esters FAQ page . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
产品介绍	BAPTA/AM [1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)] is a non-fluorescent, membrane-permeable form of BAPTA. Whereas the BAPTA, Free acid is not cell permeable and is only useful for manipulating extracellular Ca2+ levels, BAPTA/AM can be used with a wide variety of cells, where it is hydrolyzed by cytosolic esterases and trapped intracellularly. Experiments have shown that BAPTA/AM abolishes vitamin D3-induced increase in intracellular Ca2+, and may induce inactivation of protein kinase C. Has also been shown to inhibit thapsigargin-induced apoptosis in rat thymocytes. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. BAPTA-AM抑制自由基介导的毒性，增强非神经细胞中细胞凋亡，保护神经细胞免受缺血性损伤。它调节离子通道，阻止神经Ca2+-激活K+通道电流。BAPTA-AM维持细胞内Ca2+动态平衡。 A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores. · 降低剪切后半胱氨酸蛋白酶-3升高水平 · 阻止细胞死亡，抑制ROS（活性氧化簇）产物，抑制半胱氨酸蛋白酶-8活性。 · 排除细胞内Ca2+ ([Ca2+]i) 浓度变化对癫痫诱导影响 · 消除6-羟多巴胺(6-OHDA)诱导的[Ca2+]i增量水平 BAPTA/AM [1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)] is a non-fluorescent, membrane-permeable form of BAPTA. Whereas the BAPTA, Free acid is not cell permeable and is only useful for manipulating extracellular Ca2+ levels, BAPTA/AM can be used with a wide variety of cells, where it is hydrolyzed by cytosolic esterases and trapped intracellularly. Experiments have shown that BAPTA/AM abolishes vitamin D3-induced increase in intracellular Ca2+, and may induce inactivation of protein kinase C. Has also been shown to inhibit thapsigargin-induced apoptosis in rat thymocytes. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores.

名称和标识符

IUPAC Name	acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
INCHI	InChI=1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
InChi Key	YJIYWYAMZFVECX-UHFFFAOYSA-N
Canonical SMILES	CC(=O)OCOC(=O)CN(CC(=O)OCOC(=O)C)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C
Isomeric SMILES	CC(=O)OCOC(=O)CN(CC(=O)OCOC(=O)C)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C
WGK Germany	3
PubChem CID	2293
分子量	764.68
Beilstein号	7458530

化学和物理性质

溶解性	DMSO: 20 mg/mL;insoluble in water & Ethanol
密度	1.35
敏感性	对热敏感
熔点	98 °C

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319
WGK Germany	3
个人防护装备	dust mask type N95 (US)， Eyeshields， Gloves

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参考文献

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BML 283,Ca 2+螯合剂

库存信息

库存信息

基本描述

名称和标识符

化学和物理性质

安全和危险性（GHS）

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