3-[3-(胆酰胺丙基)二甲基铵]-1-丙磺酸内盐(CHAPS)

两性离子洗涤剂

8篇引用文献

≥98%

CAS编号: 75621-03-3
分子式: C₃₂H₅₈N₂O₇S
分子量: 614.88
MDL号: MFCD00012116
PubChem编号: 107670
PubChem SID: 504756625

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货号 (SKU)	包装规格	是否现货
C105622-1g	1g	现货
C105622-5g	5g	现货
C105622-25g	25g	现货
C105622-100g	100g	现货

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两性离子表面活性剂 (2) 离子洗涤剂 (2) 类固醇类 (126) 胆烷类 (3) 表面活性剂 (34) 铵盐类 (185)

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基本描述

别名	3-[(3-胆酰胺丙基)二甲基-氨]-1-丙烷磺酸盐 \| 3-((3-胆汁氨丙基)二甲基胺)-1-丙磺酸 \| 3-[(3-胆酰胺丙基)二甲氨基]丙磺酸内盐
英文别名	1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, hydroxide, inner salt \| A865651 \| QBP25342AG \| 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulphonate \| CS-0926 \| 3-((3-Cho
规格或纯度	≥98%
英文名称	CHAPS
生化机理	CHAPS是两性离子非变性去污剂，用于溶解膜蛋白。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
产品介绍	CHAPS 是一种用于膜生物化学的非变性两性离子洗涤剂。可用于溶解膜蛋白以及打断蛋白-蛋白相互作用。CHAPS 具有低胶束分子量 (6,150) 和高临界胶束浓度 (6-10mM)，因此可通过透析从样品中除去。它也适合在等电聚焦和二维电泳中用于溶解蛋白质。CHAPS 常用于非变性（无尿素）等电聚焦，已发现它对某些亚细胞制备物和植物蛋白能够得出优异的分辨率。通常将介于 2-4% (w/v) 间的浓度用于等电聚焦凝胶。 CHAPS is a non-denaturing, zwitterionic detergent derived from cholic acid. CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM. A non-denaturing, zwitterionic detergent for membrane proteins Application： Buffer; zwitterionic nondenaturing detergent for solubilizing membrane proteins CHAPS is used in the laboratory to dissolve biological macromolecules such as proteins. It acts as a non-denaturing solvent used in purification of membrane proteins. It is also useful in conjunction with nonionic detergents like Triton X-100. Further, it is used as a non-denaturing zwitterionic detergent for membrane biochemistry.

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作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504756625
分子类型	小分子
IUPAC Name	3-[dimethyl-[3-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propyl]azaniumyl]propane-1-sulfonate
INCHI	InChI=1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22+,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1
InChi Key	UMCMPZBLKLEWAF-BCTGSCMUSA-N
Canonical SMILES	CC(CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
Isomeric SMILES	C[C@H](CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C
WGK Germany	3
PubChem CID	107670
分子量	614.88

化学和物理性质

溶解性	Slightly soluble in water
密度	1.01
敏感性	对湿度敏感
熔点	156-158℃
分子量	614.900 g/mol
XLogP3	2.900
氢键供体数Hydrogen Bond Donor Count	4
氢键受体数Hydrogen Bond Acceptor Count	7
可旋转键计数Rotatable Bond Count	11
精确质量Exact Mass	614.396 Da
单同位素质量Monoisotopic Mass	614.396 Da
拓扑极表面积Topological Polar Surface Area	155.000 Å²
重原子数Heavy Atom Count	42
形式电荷Formal Charge	0
复杂度Complexity	1030.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	11
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	Warning
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3

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批号(Lot Number)	证书类型	日期	货号
D2503506	分析证书	25-03-27	C105622
D2503270	分析证书	25-03-27	C105622
A2503976	分析证书	24-12-18	C105622
A2503978	分析证书	24-12-18	C105622
A2503986	分析证书	24-12-18	C105622
K2419577	分析证书	24-11-07	C105622
K2419578	分析证书	24-11-07	C105622
K2419582	分析证书	24-11-07	C105622
J2431330	分析证书	24-10-18	C105622
J2431336	分析证书	24-10-18	C105622
I2414438	分析证书	24-09-05	C105622
F2428261	分析证书	24-06-21	C105622
F2428260	分析证书	24-06-21	C105622
E2428208	分析证书	24-05-16	C105622
E2428181	分析证书	24-05-16	C105622
E2414113	分析证书	24-04-30	C105622
E2414065	分析证书	24-04-30	C105622
C2413208	分析证书	24-02-29	C105622
C2413209	分析证书	24-02-29	C105622
C2415009	分析证书	24-02-29	C105622
A2426171	分析证书	24-01-17	C105622
A2426150	分析证书	24-01-17	C105622
A2426148	分析证书	24-01-17	C105622
A2426147	分析证书	24-01-17	C105622
A2426146	分析证书	24-01-17	C105622
L2308192	分析证书	23-11-28	C105622
L2308193	分析证书	23-11-28	C105622
L2308245	分析证书	23-11-28	C105622
A2404269	分析证书	23-11-01	C105622
A2423165	分析证书	23-11-01	C105622
K2320095	分析证书	23-11-01	C105622
K2320078	分析证书	23-11-01	C105622
K2320072	分析证书	23-11-01	C105622
I2311763	分析证书	23-07-17	C105622
I2311288	分析证书	23-07-17	C105622
I2311287	分析证书	23-07-17	C105622
I2311286	分析证书	23-07-17	C105622
G23261004	分析证书	23-07-14	C105622
G2326995	分析证书	23-07-14	C105622
J2326154	分析证书	23-07-14	C105622
G2315516	分析证书	23-07-03	C105622
G2315518	分析证书	23-07-03	C105622
G2315521	分析证书	23-07-03	C105622
E2305699	分析证书	23-04-17	C105622
B23021216	分析证书	23-01-10	C105622
B2302816	分析证书	23-01-10	C105622
B2302829	分析证书	23-01-10	C105622
B2302832	分析证书	23-01-10	C105622
L2228012	分析证书	22-12-20	C105622
L2210449	分析证书	22-12-01	C105622
L2210459	分析证书	22-12-01	C105622
L2213240	分析证书	22-12-01	C105622
L2213258	分析证书	22-12-01	C105622
L2210339	分析证书	22-12-01	C105622
G2222472	分析证书	22-06-17	C105622
G2222444	分析证书	22-06-17	C105622
G2222451	分析证书	22-06-17	C105622
G2222473	分析证书	22-06-17	C105622
G2222452	分析证书	22-06-17	C105622
E2206031	分析证书	22-03-23	C105622
F2205316	分析证书	22-03-23	C105622
E2206042	分析证书	22-03-23	C105622
E2206043	分析证书	22-03-23	C105622
B2212182	分析证书	22-01-18	C105622
B2212181	分析证书	22-01-18	C105622
C2204023	分析证书	22-01-18	C105622
C2204007	分析证书	22-01-18	C105622
B2212180	分析证书	22-01-18	C105622

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1. Li Guanglei, Chen Yao, Liu Fei, Bi Wenhua, Wang Chenxin, Lu Danfeng, Wen Dan. (2023) Portable visual and electrochemical detection of hydrogen peroxide release from living cells based on dual-functional Pt-Ni hydrogels. Microsystems & Nanoengineering, 9 (1): (1-10). [PMID:38033990] [10.1038/s41378-023-00623-y]
2. Xu Daokun, Huang Haolun, Liu Zhen, Wang Yumei, Liu Qinan, Jiang Xing, Yang Jun, Ling Rui. (2023) Comprehensive characterization and detection of nut allergens in bakery foods using Q–TOF mass spectrometry and bioinformatics. Food Quality and Safety, (1): [PMID:11741838] [10.1093/fqsafe/fyad061]
3. Jie Zhao, Shuaiqian Wang, Diandian Jiang, Yan Lu, Yu Chen, Yong Tang, Jie Tang, Zhenju Jiang, Hongbin Lin, Wei Dong. (2023) Unravelling the interaction between α-SOH and myofibrillar protein based on spectroscopy and molecular dynamics simulation. Food Chemistry-X, 20 (100986). [PMID:38144868] [10.1016/j.fochx.2023.100986]
4. Zhe Chen, Yunxia Wang. (2023) A label- and enzyme-free fluorescence assay based on thioflavin T–induced G-quadruplexes for the detection of telomerase activity. JOURNAL OF CHEMICAL RESEARCH, [10.1177/17475198221139085]
5. Pengfei Dong, Longyi Zhu, Jing Huang, Jujie Ren, Jianping Lei. (2019) Electrocatalysis of cerium metal-organic frameworks for ratiometric electrochemical detection of telomerase activity. BIOSENSORS & BIOELECTRONICS, 138 (111313). [PMID:31108380] [10.1016/j.bios.2019.05.018]
6. Min Zhang, Chong-sheng Peng, Xiao-bo Li. (2017) Human intestine and liver microsomal metabolic differences between C19-diester and monoester diterpenoid alkaloids from the roots of Aconitum carmichaelii Debx.. TOXICOLOGY IN VITRO, 45 (318). [PMID:28919359] [10.1016/j.tiv.2017.09.011]
7. Feifei Gong, Huaxin Yang, Wen Sun, Junzi Cao, Wanhui Liu. (2016) Development and validation of a micellar electrokinetic capillary chromatography method for the determination of goserelin and related substances. ELECTROPHORESIS, 37 (4): (623-629). [PMID:26635325] [10.1002/elps.201500328]
8. Yang Li,Ying Peng,Mengyue Wang,Pengfei Tu,Xiaobo Li. (2017-08-05) Human Gastrointestinal Metabolism of the Cistanches Herba Water Extract in Vitro: Elucidation of the Metabolic Profile Based on Comprehensive Metabolite Identification in Gastric Juice, Intestinal Juice, Human Intestinal Bacteria, and Intestinal Microsomes.. Journal of agricultural and food chemistry, 65 ((34)): (7447-7456). [PMID:28771352]

参考文献

1. Li Guanglei, Chen Yao, Liu Fei, Bi Wenhua, Wang Chenxin, Lu Danfeng, Wen Dan. (2023) Portable visual and electrochemical detection of hydrogen peroxide release from living cells based on dual-functional Pt-Ni hydrogels. Microsystems & Nanoengineering, 9 (1): (1-10). [PMID:38033990] [10.1038/s41378-023-00623-y]
2. Xu Daokun, Huang Haolun, Liu Zhen, Wang Yumei, Liu Qinan, Jiang Xing, Yang Jun, Ling Rui. (2023) Comprehensive characterization and detection of nut allergens in bakery foods using Q–TOF mass spectrometry and bioinformatics. Food Quality and Safety, (1): [PMID:11741838] [10.1093/fqsafe/fyad061]
3. Jie Zhao, Shuaiqian Wang, Diandian Jiang, Yan Lu, Yu Chen, Yong Tang, Jie Tang, Zhenju Jiang, Hongbin Lin, Wei Dong. (2023) Unravelling the interaction between α-SOH and myofibrillar protein based on spectroscopy and molecular dynamics simulation. Food Chemistry-X, 20 (100986). [PMID:38144868] [10.1016/j.fochx.2023.100986]
4. Zhe Chen, Yunxia Wang. (2023) A label- and enzyme-free fluorescence assay based on thioflavin T–induced G-quadruplexes for the detection of telomerase activity. JOURNAL OF CHEMICAL RESEARCH, [10.1177/17475198221139085]
5. Pengfei Dong, Longyi Zhu, Jing Huang, Jujie Ren, Jianping Lei. (2019) Electrocatalysis of cerium metal-organic frameworks for ratiometric electrochemical detection of telomerase activity. BIOSENSORS & BIOELECTRONICS, 138 (111313). [PMID:31108380] [10.1016/j.bios.2019.05.018]
6. Min Zhang, Chong-sheng Peng, Xiao-bo Li. (2017) Human intestine and liver microsomal metabolic differences between C19-diester and monoester diterpenoid alkaloids from the roots of Aconitum carmichaelii Debx.. TOXICOLOGY IN VITRO, 45 (318). [PMID:28919359] [10.1016/j.tiv.2017.09.011]
7. Feifei Gong, Huaxin Yang, Wen Sun, Junzi Cao, Wanhui Liu. (2016) Development and validation of a micellar electrokinetic capillary chromatography method for the determination of goserelin and related substances. ELECTROPHORESIS, 37 (4): (623-629). [PMID:26635325] [10.1002/elps.201500328]
8. Yang Li,Ying Peng,Mengyue Wang,Pengfei Tu,Xiaobo Li. (2017-08-05) Human Gastrointestinal Metabolism of the Cistanches Herba Water Extract in Vitro: Elucidation of the Metabolic Profile Based on Comprehensive Metabolite Identification in Gastric Juice, Intestinal Juice, Human Intestinal Bacteria, and Intestinal Microsomes.. Journal of agricultural and food chemistry, 65 ((34)): (7447-7456). [PMID:28771352]

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3-[3-(胆酰胺丙基)二甲基铵]-1-丙磺酸内盐(CHAPS)

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