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规格或纯度: ≥98%

CAS编号: 863513-91-1
分子式: C₂₄H₂₇FN₂O
分子量: 378.48
PubChem编号: 11848225

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货号 (SKU)	包装规格	是否现货	价格	数量
C126216-5mg	5mg	期货
C126216-10mg	10mg	期货
C126216-50mg	50mg	期货

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NOP receptor Agonist δ receptor Agonist κ receptor Agonist μ receptor Agonist

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基本描述

英文别名	Cebranopadol\|863513-91-1\|GRT6005\|GRT-6005\|GRT 6005\|863513-93-3\|Cebranopadol ((1alpha,4alpha)stereoisomer)\|Cebranopadol(GRT-6005)\|7GDW9S3GN3\|863513-91-1 (free base)\|(1r,4r)-6'-Fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4
规格或纯度	≥98%
英文名称	Cebranopadol
生化机理	Description: IC50 Value: N/A Cebranopadol and GRT 6006 are novel first-in-class compounds with unique pharmacological and pharmacokinetic profiles that may enhance their effect in certain pain conditions. The unique mode of action of these compounds builds on the ORL-1 receptor and, supported by the established mu opioid receptor, is particularly suitable for the treatment of moderate to severe chronic pain [1]. in vitro: N/A in vivo: N/A Clinical trial: Cebranopadol has successfully completed initial proof-of-concept studies in nociceptive and neuropathic pain with further Phase II studies planned prior to initiation of Phase III studies.
储存温度	-20°C储存
运输条件	超低温冰袋运输

名称和标识符

IUPAC Name	6-fluoro-N,N-dimethyl-1'-phenylspiro[4,9-dihydro-3H-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine
INCHI	InChI=1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3
InChi Key	CSMVOZKEWSOFER-UHFFFAOYSA-N
Canonical SMILES	CN(C)C1(CCC2(CC1)C3=C(CCO2)C4=C(N3)C=CC(=C4)F)C5=CC=CC=C5
Isomeric SMILES	CN(C)C1(CCC2(CC1)C3=C(CCO2)C4=C(N3)C=CC(=C4)F)C5=CC=CC=C5
PubChem CID	11848225
分子量	378.48

数据库链接

PubChem CID	11848225
ChEMBL Ligand	CHEMBL2364605
CAS Registry No.	863513-91-1
Wikipedia	Cebranopadol
GPCRdb Ligand	cebranopadol

化学和物理性质

溶解性	DMSO

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参考文献

1. Linz K, Christoph T, Tzschentke TM, Koch T, Schiene K, Gautrois M, Schröder W, Kögel BY, Beier H, Englberger W et al.. (2014) Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist.. J Pharmacol Exp Ther, 349 (3): (535-48). [PMID:24713140]
2. Schunk S, Linz K, Hinze C, Frormann S, Oberbörsch S, Sundermann B, Zemolka S, Englberger W, Germann T, Christoph T et al.. (2014) Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol.. ACS Med Chem Lett, 5 (8): (857-62). [PMID:25147603]
3. Lambert DG, Bird MF, Rowbotham DJ. (2015) Cebranopadol: a first in-class example of a nociceptin/orphanin FQ receptor and opioid receptor agonist.. Br J Anaesth, 114 (3): (364-6). [PMID:25248647]
4. Sałat K, Jakubowska A, Kulig K. (2015) Cebranopadol : a first-in-class potent analgesic agent with agonistic activity at nociceptin/orphanin FQ and opioid receptors.. Expert Opin Investig Drugs, 24 (6): (837-44). [PMID:25865744]
5. Bird MF, Lambert DG. (2015) Simultaneous targeting of multiple opioid receptor types.. Curr Opin Support Palliat Care, 9 (2): (98-102). [PMID:25872121]

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