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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D348369-5mg |
5mg |
期货  |
|
| 英文别名 | N,O-Didesmethylvenlafaxine|135308-74-6|4-[1-(1-hydroxycyclohexyl)-2-(methylamino)ethyl]phenol|rac N,O-Didesmethyl Venlafaxine|D,L N,O-Didesmethyl Venlafaxine|UNII-DYW3W9739Y|D,L N,O-DIDESMETHYLVENLAFAXINE|N,O-Didesvenlafaxine|DYW3W9739Y|WY 46689|4-(1-(1-H |
|---|---|
| 英文名称 | D,L N,O-Didesmethyl Venlafaxine |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
D，L，N，O-去甲基文拉法新是文拉法新的代谢产物。文拉法辛是苯乙胺的衍生物，据报道可通过阻止神经胺如5-羟色胺（5-羟色胺； 5-HT）和去甲肾上腺素（去甲肾上腺素）的突触前再摄取来促进中枢神经系统内的神经传递。还报道了Velanfaxine是多巴胺再摄取的弱抑制剂。|体外研究表明，Venlafaxine对毒蕈碱，组胺能或α-1肾上腺素受体没有明显的活性。据报道，文拉法辛的代谢是通过细胞色素P450（CYP）酶CYP2D6发生的，产生O-去甲基文拉法辛。CYP3A4产生较少的代谢产物N-去甲基文拉法辛。 D,L N,O-Didesmethyl Venlafaxine is a metabolite of Venlafaxine . Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake.|In vitro|studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or α-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4. |
| IUPAC Name | 4-[1-(1-hydroxycyclohexyl)-2-(methylamino)ethyl]phenol |
|---|---|
| INCHI | InChI=1S/C15H23NO2/c1-16-11-14(12-5-7-13(17)8-6-12)15(18)9-3-2-4-10-15/h5-8,14,16-18H,2-4,9-11H2,1H3 |
| InChi Key | MMSWXJSQCAEDLK-UHFFFAOYSA-N |
| Canonical SMILES | CNCC(C1=CC=C(C=C1)O)C2(CCCCC2)O |
| Isomeric SMILES | CNCC(C1=CC=C(C=C1)O)C2(CCCCC2)O |
| PubChem CID | 3451347 |
| 分子量 | 249.35 |
| 溶解性 | Soluble in Dimethyl Sulfoxide, Ethyl Acetate, and Methanol |
|---|---|
| 熔点 | 174-175°C (lit.) |
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