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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| F408346-1ml |
1ml |
期货  |
|
| 英文别名 | Fatostatin A;4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Fatostatin (125B11) HBr |
| 生化机理 | Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2. |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Information Fatostatin (125B11) HBr Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP) . It impairs the activation of SREBP-1 and SREBP-2. Fatostatin inhibits the insulin-induced adipogenesis of 3T3-L1 cells and the serum-independent growth of human androgen-independent prostate cancer (DU145) cells. Fatostatin blocks the activation of SREBPs in cells in tissue culture. Fatostatin suppresses cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. Fatostatin also reduced in vitro invasion and migration in both cell lines. Further, fatostatin causes G2/M cell cycle arrest and induces apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP. In vivo Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake. Fatostatin significantly inhibits subcutaneous C4-2B tumor growth and markedly decreases serum PSA level compared to the control group. cell lines： Concentrations：20 μM Incubation Time：20 h Powder Purity:≥99% |
| Canonical SMILES | Br.CCCC1=CC(=CC=N1)C2=NC(=CS2)C3=CC=C(C)C=C3 |
|---|---|
| 分子量 | 375.33 |
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