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肿瘤学
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萜烯七脂酸

萜烯七脂酸

高效，选择性，不可逆的GAPDH抑制剂。选择性竞争性DNA聚合酶抑制剂。

规格或纯度: ≥95%

CAS编号: 74310-84-2
分子式: C₁₅H₂₀O₅
分子量: 280.32
PubChem编号: 10016502

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货号 (SKU)	包装规格	是否现货	价格	数量
H275171-1mg	1mg	现货
H275171-250μg	250μg	现货

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基本描述

别名	(5aS,6R,9S,9aS)-1-氧-6-丙-2-基螺[3,5a,6,7,8,9a-六氢-2-苯并xepine-9,2'-环氧乙烷]-4-羧酸\|(+)-萜烯七脂酸
规格或纯度	≥95%
英文名称	Heptelidic acid (Koningic acid)
生化机理	高效，选择性，不可逆的GAPDH抑制剂。选择性竞争性DNA聚合酶抑制剂。抗生素剂。有效抑制糖酵解途径中的ATP生成。
储存温度	-20°C储存,干燥
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	product description： Antibiotic . Potent selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH . Anticancer compound . Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation . Antimalarial . Apoptosis inhibitor. DNA fragmentation and caspase-3 activation inhibitor . Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols . Reduces lactate secretion and causes reductions in overall protein synthesis and production of IFN-α and TNF. application： Heptalidic acid is a sesquiterpene lactone and found to inhibit etoposide-induced apoptosis in human leukemia U937 cells. In addition, it also inhibit mammalian DNA polymerases and terminal deoxynucleotidyl transferase. product description： Antibiotic . Potent selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH . Anticancer compound . Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation . Antimalarial . Apoptosis inhibitor. DNA fragmentation and caspase-3 activation inhibitor . Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols . Reduces lactate secretion and causes reductions in overall protein synthesis and production of IFN-α and TNF. application： Heptalidic acid is a sesquiterpene lactone and found to inhibit etoposide-induced apoptosis in human leukemia U937 cells. In addition, it also inhibit mammalian DNA polymerases and terminal deoxynucleotidyl transferase.

名称和标识符

IUPAC Name	1-oxo-6-propan-2-ylspiro[3,5a,6,7,8,9a-hexahydro-2-benzoxepine-9,2'-oxirane]-4-carboxylic acid
INCHI	InChI=1S/C15H20O5/c1-8(2)10-3-4-15(7-20-15)12-11(10)5-9(13(16)17)6-19-14(12)18/h5,8,10-12H,3-4,6-7H2,1-2H3,(H,16,17)
InChi Key	JESMSCGUTIEROV-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1CCC2(CO2)C3C1C=C(COC3=O)C(=O)O
Isomeric SMILES	CC(C)C1CCC2(CO2)C3C1C=C(COC3=O)C(=O)O
关联CAS	57710-57-3
PubChem CID	10016502
分子量	280.32

化学和物理性质

溶解性	Soluble in DMSO (10 mg/ml), ethanol (1 mg/ml), methanol (1 mg/ml) or water (1 mg/ml).

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参考文献

1. Jimenez-Duran G et al.. (2022) Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages.. Front Immunol, 13 (): (918551). [PMID:36248901]
2. Wu Q et al.. (2022) Long non-coding RNA HOTTIP induces inflammation in asthma by promoting EFNA3 transcription by CCCTC-binding factor.. Am J Transl Res, 14 (12): (8903-8917). [PMID:36628218]
3. Gaude E et al.. (2018) NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.. Mol Cell, 69 (4): (581-593.e7). [PMID:29452638]
4. Kondo H et al.. (2021) Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms.. Cell Rep, 34 (7): (108750). [PMID:33596424]

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