Hydrocotarnine

≥99%

CAS编号: 550-10-7
分子式: C₁₂H₁₅NO₃
分子量: 221.25
EC号: 208-978-2
PubChem编号: 3646

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
H651198-10mg	10mg	期货
H651198-25mg	25mg	期货
H651198-50mg	50mg	期货

查看相关系列

E1/E2/E3 Enzyme (112) Immunology/Inflammation (1945) Interleukin Related (133) Metabolic Enzyme/Protease (4884)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

别名	氢化可他明
英文别名	HYDROCOTARNINE [WHO-DD] \| 4-27-00-06395 (Beilstein Handbook Reference) \| KBio1_001969 \| KBioGR_002283 \| BRN 0017283 \| 1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7,8-tetrahydro-4-methoxy-6-methyl- \| NCGC00016666-01 \| NCGC00016666-03 \| 1,3-DIOXOLO(4,5-g)ISOQUINOLI
规格或纯度	≥99%
英文名称	Hydrocotarnine
生化机理	氢化可他宁是一种 Cbl 抑制剂，可导致炎症体介导的 IL-18 在结肠炎中分泌。氢化可他宁可增加糖酵解代谢中 GLUT1 的表达和细胞葡萄糖摄取量。氢化可他宁是一种提供镇痛作用的制剂。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Hydrocotarnine is a Cbl inhibitor, and results in inflammasome-mediated IL-18 secretion in colitis. Hydrocotarnine increases expression of GLUT1 and cellular glucose uptake in glycolytic metabolism. Hydrocotarnine acts as an agent that provides analgesic effect in cancer research In Vitro Hydrocotarnine is an analgesic agent (CRIN-2), with the patent ID of WO2011160016A2. Hydrocotarnine (10 μM; 1 h) elevates the secretion of IL-1β and IL-18, and (0.1-10 μM; 1 h) increases the global level of tyrosine-phosphorylated proteins in THP-1 cells. Hydrocotarnine (50 μM; 0-100 min) increases the glycolytic capacity and glycolytic reserve capacity in THP-1-derived macrophages. Hydrocotarnine (50 μM; 16 h) inhibits Cbl and increases the total GLUT1 protein in THP-1-derived macrophages. Hydrocotarnine is known to enhance the analgesic effect of opioids, and alleviates cancer pain. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: THP-1 cells Concentration: 0.1, 1, 10 μM Incubation Time: 1 hour Result: Induced p-Pyk2 loss and increased the level of tyrosine-phosphorylated proteins in a dose-dependent manner. In Vivo Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) shows inhibitory effect on Cbl and results in increasing IL-18 levels, indicating that NLRP3 inflammasome activation is enhanced in mice . Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) protects mice from DSS-induced colitis, with low scores of pathological evaluation of inflammation, epithelial defects, and crypt atrophy . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: DSS-induced colitis model in C57BL/6 mice (6-9 weeks old) Dosage: 10 mg/kg Administration: Intraperitoneal injection; once daily; 9 days while 2.5% DSS treatment began on day 1 and ended on day 7 Result: Significantly attenuated the weight loss of DSS-induced colitis mice compared to PBS-treated control mice, indicating that decreasing negative regulation of the NLRP3 inflammasome activation could attenuate colitis in an animal model. Form:Solid IC50& Target:Cbl

AI解读

关联靶点（人）

CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)

点击查看靶蛋白信息： CYP2D6

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)

点击查看靶蛋白信息： CYP1A2

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)

点击查看靶蛋白信息： CYP2C9

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)

点击查看靶蛋白信息： CYP2C19

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)

点击查看靶蛋白信息： CYP3A4

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)

点击查看靶蛋白信息： SLCO1B1

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)

点击查看靶蛋白信息： SLCO1B3

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

EC号	208-978-2
分子类型	小分子
IUPAC Name	4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline
INCHI	InChI=1S/C12H15NO3/c1-13-4-3-8-5-10-12(16-7-15-10)11(14-2)9(8)6-13/h5H,3-4,6-7H2,1-2H3
InChi Key	XXANNZJIZQTCBP-UHFFFAOYSA-N
Canonical SMILES	CN1CCC2=CC3=C(C(=C2C1)OC)OCO3
Isomeric SMILES	CN1CCC2=CC3=C(C(=C2C1)OC)OCO3
关联CAS	550-10-7
PubChem CID	3646
MeSH Entry Terms	hydrocotarnine;hydrocotarnine hydrobromide;hydrocotarnine hydrochloride;hydrocotarnine hydrochloride monohydrate
分子量	221.25

化学和物理性质

溶解性	DMSO : ≥ 100 mg/mL (451.98 mM)
分子量	221.250 g/mol
XLogP3	1.600
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	1
精确质量Exact Mass	221.105 Da
单同位素质量Monoisotopic Mass	221.105 Da
拓扑极表面积Topological Polar Surface Area	30.900 Å²
重原子数Heavy Atom Count	16
形式电荷Formal Charge	0
复杂度Complexity	261.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Hydrocotarnine

库存信息

库存信息

库存信息

基本描述

AI解读

关联靶点（人）

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器