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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| I329467-1mg |
1mg |
现货  |
|
| 英文别名 | Indolmycin|21200-24-8|Indolemycin|(-)-indolmycin|tak-083|PA 155 A|PA-155-A|ZMC93U2C8P|CHEBI:79394|PA-155A|(1R,5S)-(-)-5-(1-Indol-3-ylethyl)-2-(methylamino)-2-oxazolin-4-one|5-(1-Indol-3-ylethyl)-2-(methylamino)-2-oxazolin-4-one|(5S)-5-[(1R)-1-(1H-indol-3- |
|---|---|
| 规格或纯度 | 95% |
| 英文名称 | Indolmycin |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
吲哚霉素是一种天然细菌，可对抗幽门螺杆菌和幽门螺杆菌。该化合物是灰链霉菌的次级代谢产物，具有抑制细菌色氨酸-tRNA合成酶的能力。 Indolmycin is a naturally occurring antibiotic that acts against|Staphylococci|and|Helicobacter pylori.|The compound is a secondary metabolite of|Streptomyces griseus|with the ability to inhibit bacterial tryptophanyl-tRNA synthetase. |
| pKa值 | pKa: 0.96 (Predicted) |
|---|
| IUPAC Name | (5S)-5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-methylimino-1,3-oxazolidin-4-one |
|---|---|
| INCHI | InChI=1S/C14H15N3O2/c1-8(12-13(18)17-14(15-2)19-12)10-7-16-11-6-4-3-5-9(10)11/h3-8,12,16H,1-2H3,(H,15,17,18)/t8-,12+/m1/s1 |
| InChi Key | GNTVWGDQPXCYBV-PELKAZGASA-N |
| Canonical SMILES | CC(C1C(=O)NC(=NC)O1)C2=CNC3=CC=CC=C32 |
| Isomeric SMILES | C[C@@H]([C@H]1C(=O)NC(=NC)O1)C2=CNC3=CC=CC=C32 |
| PubChem CID | 135417159 |
| 分子量 | 257.29 |
| PubChem CID | 135417159 |
|---|---|
| CAS Registry No. | 21200-24-8 |
| ChEBI | CHEBI:79394 |
| ChEMBL Ligand | CHEMBL417852 |
| RCSB PDB Ligand | 5BX |
| Antibiotic DB | 1319 |
| 溶解性 | Soluble in ethanol, methanol, DMSO, DMF, and water (poor). |
|---|---|
| 密度 | 1.36 g/cm3(Predicted) |
| 折光率 | n20D1.67 (Predicted) |
| 沸点 | 420.75° C at 760 mmHg (Predicted) |
| 熔点 | 186.82° C (Predicted) |
输入批号以搜索COA:
| 1. Hurdle JG, O'Neill AJ, Chopra I. (2004) Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections.. J Antimicrob Chemother, 54 (2): (549-52). [PMID:15243028] |
| 2. Chadha N, Silakari O. (2017) Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.. Eur J Med Chem, 134 (13): (159-184). [PMID:28412530] |
| 3. Pasaje CF, Cheung V, Kennedy K, Lim EE, Baell JB, Griffin MD, Ralph SA. (2016) Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum.. Sci Rep, 6 (13): (27531). [PMID:27277538] |
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