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铁螯合剂，Dp44mT

基于细胞可渗透的二-2-吡啶基硫代半碳酮（DpT）的三齿配体
规格或纯度: ≥95%
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货号 (SKU) 包装规格 是否现货 价格 数量
I339506-25mg
 25mg 现货 Stock Image
I339506-100mg
 100mg 现货 Stock Image
I339506-500mg
 500mg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
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基本描述

英文别名 Dp44mT|152095-12-0|Iron Chelator, Dp44mT|3-(Dipyridin-2-ylmethylideneamino)-1,1-dimethylthiourea|2-(Di(pyridin-2-yl)methylene)-N,N-dimethylhydrazinecarbothioamide|CHEMBL385064|2,N-dimethylsemicarbazone|Iron Chelator|Hydrazinecarbothioamide, 2-(di-2-pyridi
规格或纯度 ≥95%
英文名称 Iron Chelator, Dp44mT
生化机理 Dp44mT (di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone) influences lysosome integrity through copper binding. It induces reactive oxygen species (ROS) generation by redox cycling of iron complex. Dp44mT exhibits anti cancer action by attenuating Ndrg-1 (N-myc downstream regulated 1), a metastasis suppressor protein. It also alters the cyclin family of proteins (A, B, D1, D2,D3 and cyclin-dependent kinase 2) known for cell-cycle regulation. Dp44mT is known to promote apoptosis in neuroepithelioma, melanoma and breast cancer. Dp44mT is an iron chelator that works as a selective anticancer agent. As other iron chelators it can serve as a therapeutic adjunct to doxorubicin treatment. Additionally Dm44mT possess DNA-damaging activity. It appears that that activity is mediated by top2a inhibition.
储存温度 避光,-20°C储存
运输条件 超低温冰袋运输
产品介绍

铁螯合剂Dp44mT是一种基于细胞可渗透的二-2-吡啶基硫代半碳酸盐（DpT）的三齿配体，在肿瘤细胞中表现出强效和选择性的抗增殖特性，对正常细胞的影响最小。铁螯合剂Dp44mT可以阻止M109肺癌在小鼠中的侵袭性生长，并且已被证明可以有效地动员细胞中的铁，并产生导致凋亡的ROS。

Product Describtion:

Iron Chelator, Dp44mT is a cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand that displays potent and selective antiproliferative properties in neoplastic cells and minimally affects normal cells. Iron Chelator, Dp44mT prevents aggressive growth of M109 lung carcinoma in mice and has been shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.


Product Application：

Dp44mT may be used in cell signaling studies

产品属性

pKa值 pKa: 10.18 (Predicted), pKa: 1.95 (Predicted)
IC50 HL-60 : IC₅₀= 10 nM (human); HCT-116: IC₅₀= 2 nM (human); antiproliferative properties in SK-N-MC cells: IC₅₀= ≤ 0.06 μM; antiproliferative properties in SK-Mel-28 cells: IC₅₀= ≤ 0.06 μM; antiproliferative properties in MCF-7 cells: IC₅₀= ≤ 0.06 μM; antip

名称和标识符

IUPAC Name 3-(dipyridin-2-ylmethylideneamino)-1,1-dimethylthiourea
INCHI InChI=1S/C14H15N5S/c1-19(2)14(20)18-17-13(11-7-3-5-9-15-11)12-8-4-6-10-16-12/h3-10H,1-2H3,(H,18,20)
InChi Key XOBIGRNRXCAMJQ-UHFFFAOYSA-N
Canonical SMILES CN(C)C(=S)NN=C(C1=CC=CC=N1)C2=CC=CC=N2
Isomeric SMILES CN(C)C(=S)NN=C(C1=CC=CC=N1)C2=CC=CC=N2
WGK Germany 3
PubChem CID 10334137
分子量 285.37

化学和物理性质

溶解性 ≥62.5 mg/mL in DMSO; insoluble in H2O; ≥22.95 mg/mL in EtOH
密度 1.20 g/cm3(Predicted)
敏感性 对光敏感
折光率 n20D1.64 (Predicted)
沸点 438.37° C at 760 mmHg (Predicted)
熔点 165.90° C (Predicted)

安全和危险性（GHS）

象形图
ghs06

Toxic
信号词 Danger
危险声明 H301: Toxic if swallowed
预防措施声明 P321,P405,P501,P264,P270,P330,P301+P316
WGK Germany 3

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