为了获得访问"阿拉丁铁蛋"实时聊天框的流畅支持体验,建议您使用Chrome浏览器或选择360浏览器极速模式(如何切换极速模式?),感谢您选择我们!

N-甲基甲酰胺

规格或纯度: ≥99%
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
M107591-25g
25g 现货 Stock Image
M107591-100g
100g 现货 Stock Image
M107591-500g
500g 现货 Stock Image
M107591-1kg
1kg 期货 Stock Image
M107591-5kg
5kg 期货 Stock Image

基本描述

英文别名 Methylformamide | Formamide, N-methyl-|Monomethylformamide | N-Formylmethylamine | n-methyl-Formamide | NSC 3051|N-Monomethylformamide | EK 7011 | HCONHCH3 | X 188 | Formamide, methyl- | methylimidoformic acid | NMF | N-Methyl-formimidic acid
规格或纯度 ≥99%
英文名称 N-Methylformamide
运输条件 常规运输
备注 25g卖完停产,不再备货
产品介绍

N-甲基甲酰胺(NMF)是一种甲酰胺衍生物,被广泛用作有机溶剂。NMF分子含有C=O和N-H基团,因此,它可以作为质子供体和受体。它在小鼠中的抗肿瘤活性已被评估。NMF的光外差检测光学Kerr效应(OHD-OKE)光谱评估已被报道。由于NMF具有重要的物理性质,如高介电常数、高溶解度、低电导率和两性性质,因此,它适合用作毛细管电泳研究的分离介质。

N-甲基甲酰胺可用于制备:

• Li2S-P2S5 固体电解质(SE)

• 质子化层状硅酸盐(麦烃硅钠石)的夹层压缩材料

• Li3PS4 固体电解质

N-Methylformamide (NMF), a formamide derivative, is widely employed as an organic solvent. NMF molecule contains C=O and N-H groups, so it can act as a proton donor and acceptor. Its antitumor activities in mice have been assessed. Optical-heterodyne-detected optical Kerr effect (OHD-OKE) spectroscopic evaluation of NMF has been reported. Due to its important physical properties such as high dielectric constant, high solubility, low conductivity and amphiprotic nature, it is suitable for use as a separation medium in capillary electrophoresis studies.

N-Methylformamide may be employed in the preparation of the following:

• Li2S-P2S5 solid electrolytes (SE) 

• interlayer-condensed materials of protonated layered silicate (magadiite) 

• Li3PS4 solid electrolyte


Application

N-Methylformamide is used to prepare methyl isocyanate. It is used as an extraction solvent for aromatic hydrocarbons and acts as a ligand in coordination chemistry. It is employed as a solvent in oil refineries and in aluminum electrolytic capacitors. Further, it is used as a reagent in organic synthesis. In addition to this, it is used as an investigational anticancer drug and an intermediate in the production of some pharmaceutical compounds.

名称和标识符

EC号 204-624-6
IUPAC Name N-methylformamide
INCHI InChI=1S/C2H5NO/c1-3-2-4/h2H,1H3,(H,3,4)
InChi Key ATHHXGZTWNVVOU-UHFFFAOYSA-N
Canonical SMILES CNC=O
Isomeric SMILES CNC=O
WGK Germany 1
RTECS LQ3000000
PubChem CID 31254
分子量 59.07
Beilstein号 1098352
Reaxy-Rn 1098352

化学和物理性质

溶解性 Miscible with water, acetone and ethanol. Immiscible with ether.
密度 1.01
折光率 1.43
闪点(℉) 208 °F
闪点(℃) 98 °C
沸点 183°C
熔点 -5°C(lit.)

安全和危险性(GHS)

象形图
ghs08

Health Hazard

ghs07

Harmful

信号词 Danger
危险声明 H312: Harmful in contact with skin
H303: May be harmful if swallowed
H360: May damage fertility or the unborn child
预防措施声明 P280,P302+P352,P321,P405,P501,P201,P362+P364,P202,P203,P318,P317
WGK Germany 1
RTECS LQ3000000
Reaxy-Rn 1098352
Merck Index 6076
个人防护装备 Eyeshields,Faceshields,full-face respirator (US),Gloves,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter

质检证书(COA)

质检报告(COA)

输入批号以搜索COA:

相关文档

质检报告COA

请输入批号:


产品问答

产品问答

登录提交问题 Hover me 请先登录再提交问题
您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. K Clagett-Carr,G Sarosy,J Plowman,D F Hoth,B Leyland-Jones.  (1988-05-01)  N-methylformamide: cytotoxic, radiosensitizer, or chemosensitizer..  Journal of clinical oncology : official journal of the American Society of Clinical Oncology,  ((5)):  (906-918).  [PMID:3284976]
2. Zhao D, Sonawane ND, Levin MH, Yang B.  (2007)  Comparative transport efficiencies of urea analogues through urea transporter UT-B..  Biochim Biophys Acta,  1768  (7):  (1815-21).  [PMID:17506977]
3. A Gescher,N W Gibson,J A Hickman,S P Langdon,D Ross,G Atassi.  (1982-06-01)  N-methylformamide: antitumour activity and metabolism in mice..  British journal of cancer,  45  ((6)):  (843-850).  [PMID:7201320]
4. H Igisu,M Matsuoka.  (1999-10-30)  [N-methylformamide in urine]..  Nihon rinsho. Japanese journal of clinical medicine,  57 Suppl  ():  (460-462).  [PMID:10543154]
5. J Mráz,J Cimlová,V Stránský,H Nohová,R Kicová,P Simek.  (2005-11-18)  N-Methylcarbamoyl-lysine adduct in globin: a new metabolic product and potential biomarker of N, N-dimethylformamide in humans..  Toxicology letters,  162  ((2-3)):  (211-218).  [PMID:16289959]
6. Abdul Mutlib,Ping Jiang,Jim Atherton,Leslie Obert,Seva Kostrubsky,Steven Madore,Sidney Nelson.  (2006-10-17)  Identification of potential genomic biomarkers of hepatotoxicity caused by reactive metabolites of N-methylformamide: Application of stable isotope labeled compounds in toxicogenomic studies..  Chemical research in toxicology,  19  ((10)):  (1270-1283).  [PMID:17040096]
7. Dar-Bin Shieh,Chia-Chun Chen,Tung-Sheng Shih,Huo-Mu Tai,Yau-Hui Wei,Ho-Yuan Chang.  (2007-01-27)  Mitochondrial DNA alterations in blood of the humans exposed to N,N-dimethylformamide..  Chemico-biological interactions,  165  ((3)):  (211-219).  [PMID:17254560]
8. Johan Sjödahl,Peter Lindberg,Johan Roeraade.  (2007-02-23)  Separation of oligonucleotides in N-methyl-formamide-based polymer matrices by capillary electrophoresis..  Journal of separation science,  30  ((1)):  (104-109).  [PMID:17313148]
9. Jakub Chalupský,Jirí Vondrásek,Vladimír Spirko.  (2008-01-08)  Quasiplanarity of the peptide bond..  The journal of physical chemistry. A,  112  ((4)):  (693-699).  [PMID:18177024]
10. D O Futino,M C B Mendes,W N L Matos,R G Mondadori,C M Lucci.  (2008-11-21)  Glycerol, methyl-formamide and dimethyl-formamide in canine semen cryopreservation..  Reproduction in domestic animals = Zuchthygiene,  45  ((2)):  (214-220).  [PMID:19019075]
11. Edward M Kosower,Gil Markovich,Galina Borz.  (2009-03-31)  N-methylformamide, a hyperplectic model for peptides in thin film infrared spectroscopy on planar AgX..  The journal of physical chemistry. B,  113  ((16)):  (5622-5632).  [PMID:19326884]
12. Jun He,Jing-ping Zhou,Pei Wang.  (2009-04-09)  [High performance liquid chromatography for determination of N-acetyl-S-(N-methylformamide) cysteine in human urine derivative oscillopolarography for determination of urine arsenic]..  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,  27  ((2)):  (103-104).  [PMID:19351480]
13. Diane Fournier,Jalal Hawari,Annamaria Halasz,Sheryl H Streger,Kevin R McClay,Hisako Masuda,Paul B Hatzinger.  (2009-06-23)  Aerobic biodegradation of N-nitrosodimethylamine by the propanotroph Rhodococcus ruber ENV425..  Applied and environmental microbiology,  75  ((15)):  (5088-5093).  [PMID:19542346]
14. Kwame Frimpong,Joseph Wzorek,Claire Lawlor,Katharine Spencer,Thomas Mitzel.  (2009-07-29)  Use of N-methylformamide as a solvent in indium-promoted Barbier reactions en route to enediyne and epoxy diyne formation: comparison of rate and stereoselectivity in C-C bond-forming reactions with water..  The Journal of organic chemistry,  74  ((16)):  (5861-5870).  [PMID:19634900]
15. Jolanta Swiergiel,Jan Jadzyn.  (2009-10-07)  Conductivity dynamics and static dielectric permittivity of highly conducting molecular liquids studied with impedance spectroscopy. Formamides..  The journal of physical chemistry. B,  113  ((43)):  (14225-14228).  [PMID:19803483]
16. Ewa Kamieńska-Piotrowicz,Kamila Dziewulska,Janusz Stangret.  (2010-04-13)  An effective method for studying intermolecular interactions in binary liquids with hydrogen bonds; FTIR spectra and ab initio calculations in the N-methylformamide-methanol system..  The journal of physical chemistry. B,  114  ((17)):  (5810-5818).  [PMID:20380396]
17. Xing-Guo Zhang,Hui-Xiong Dai,Masayuki Wasa,Jin-Quan Yu.  (2012-07-12)  Pd(II)-catalyzed ortho trifluoromethylation of arenes and insights into the coordination mode of acidic amide directing groups..  Journal of the American Chemical Society,  134  ((29)):  (11948-11951).  [PMID:22780303]
18. A Nakazawa,I Nishii.  (2012-07-25)  Amidic and acetonic cryoprotectants improve cryopreservation of volvocine green algae..  Cryo letters,  33  ((3)):  (202-213).  [PMID:22825787]
19. Rachel Crespo-Otero,Artur Mardyukov,Elsa Sanchez-Garcia,Mario Barbatti,Wolfram Sander.  (2012-10-04)  Photochemistry of N-methylformamide: matrix isolation and nonadiabatic dynamics..  Chemphyschem : a European journal of chemical physics and physical chemistry,  14  ((4)):  (827-836).  [PMID:23033207]
20. P Imrat,P Suthanmapinanth,K Saikhun,S Mahasawangkul,E Sostaric,P Sombutputorn,S Jansittiwate,N Thongtip,A Pinyopummin,B Colenbrander,W V Holt,T A E Stout.  (2012-11-22)  Effect of pre-freeze semen quality, extender and cryoprotectant on the post-thaw quality of Asian elephant (Elephas maximus indicus) semen..  Cryobiology,  66  ((1)):  (52-59).  [PMID:23168056]
21. Hideki Igisu,Takafumi Ezaki.  (2005-01-22)  [N-methylformamide in urine]..  Nihon rinsho. Japanese journal of clinical medicine,  62 Suppl 12  ():  (488-490).  [PMID:15658371]
22. Shih-Min Wang,Yao-Ming Chu,Shih-Chun Candice Lung,Tung-Sheng Shih,Yue-Ching Lin,Ho-Yuan Chang.  (2007-09-15)  Combining novel strategy with kinetic approach in the determination of respective respiration and skin exposure to N,N-dimethylformamide vapor..  The Science of the total environment,  388  ((1-3)):  (398-404).  [PMID:17854864]
23. Jeppe S Spicker,Søren Brunak,Klaus S Frederiksen,Henrik Toft.  (2008-01-08)  Integration of clinical chemistry, expression, and metabolite data leads to better toxicological class separation..  Toxicological sciences : an official journal of the Society of Toxicology,  102  ((2)):  (444-454).  [PMID:18178960]
24. Aleksandr B Sahakyan,Aleksan G Shahkhatuni,Astghik A Shahkhatuni,Henry A Panosyan.  (2008-03-28)  Electric field effects on one-bond indirect spin-spin coupling constants and possible biomolecular perspectives..  The journal of physical chemistry. A,  112  ((16)):  (3576-3586).  [PMID:18363392]
25. Merwe Albrecht,Corey A Rice,Martin A Suhm.  (2008-07-31)  Elementary peptide motifs in the gas phase: FTIR aggregation study of formamide, acetamide, N-methylformamide, and N-methylacetamide..  The journal of physical chemistry. A,  112  ((33)):  (7530-7542).  [PMID:18665575]
26. Xichen Li,Wenlan Liu,Kening Sun,Yan Wang,Hongwei Tan,Guangju Chen.  (2008-10-29)  Theoretical exploration of the cooperative effect in NMF-NMF-amino acid residue hydrogen bonding system..  Physical chemistry chemical physics : PCCP,  10  ((36)):  (5607-5615).  [PMID:18956096]
27. Gregory M Fahy.  (2009-06-09)  Cryoprotectant toxicity neutralization..  Cryobiology,  60  ((3 Suppl)):  (S45-S53).  [PMID:19501081]
28. Walther Caminati,Juan Carlos López,Susana Blanco,Santiago Mata,Josè Luis Alonso.  (2010-07-27)  How water links to cis and trans peptidic groups: the rotational spectrum of N-methylformamide-water..  Physical chemistry chemical physics : PCCP,  12  ((35)):  (10230-10234).  [PMID:20657893]
29. M Sałdyka,Z Mielke,K Mierzwicki,S Coussan,P Roubin.  (2011-07-12)  CH stretching vibration of N-methylformamide as a sensitive probe of its complexation: infrared matrix isolation and computational study..  Physical chemistry chemical physics : PCCP,  13  ((31)):  (13992-14002).  [PMID:21743931]
30. João M M Cordeiro,Alan K Soper.  (2013-02-08)  A hybrid neutron diffraction and computer simulation study on the solvation of N-methylformamide in dimethylsulfoxide..  The Journal of chemical physics,  138  ((4)):  (044502-044502).  [PMID:23387600]