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6-甲氧基吲哚

规格或纯度: >98.0%(GC)
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货号 (SKU) 包装规格 是否现货 价格 数量
M123429-250mg
250mg 现货 Stock Image
M123429-1g
1g 现货 Stock Image
M123429-5g
5g 现货 Stock Image
M123429-10g
10g 期货 Stock Image
M123429-25g
25g 现货 Stock Image
M123429-100g
100g 现货 Stock Image
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五元杂环化合物 吡咯类

基本描述

别名 6-甲氧基吲哚
英文别名 NSC 92517 | 6-Methoxy indole | ethyl-o-toluate | MLS000689267 | STK893352 | 4-Bromo Phthalic anhydride | 6-Methoxy-1H-indole | chloroxoquinoline | 1H-Indol-6-yl methyl ether | HMS2718O18 | NCGC00245927-01 | FT-0621193 | 6-Methoxyindole | AQ-776/40228276 |
规格或纯度 >98.0%(GC)
英文名称 6-Methoxyindole
生化机理 6-Methoxyindole inhibits the chlorinating activity of myeloperoxidase and inhibits the generation of hypochlorous acid released by activated leukocytes.
储存温度 避光,充氩
运输条件 常规运输
产品介绍

Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators.and for synthesis of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors.and for preparation of diindolyloxyindoles as anticancer agents.

Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators.and for synthesis of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors.and for preparation of diindolyloxyindoles as anticancer agents.

名称和标识符

EC号 221-689-6
IUPAC Name 6-methoxy-1H-indole
INCHI InChI=1S/C9H9NO/c1-11-8-3-2-7-4-5-10-9(7)6-8/h2-6,10H,1H3
InChi Key QJRWYBIKLXNYLF-UHFFFAOYSA-N
Canonical SMILES COC1=CC2=C(C=C1)C=CN2
Isomeric SMILES COC1=CC2=C(C=C1)C=CN2
WGK Germany 3
PubChem CID 76659
分子量 147.17
Beilstein号 116483
Reaxy-Rn 116483

化学和物理性质

敏感性 对光敏感,对空气敏感
沸点 105°C/0.2mm
熔点 90-94°C

安全和危险性(GHS)

象形图
ghs07

Harmful

信号词 Warning
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
预防措施声明 P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319
WGK Germany 3
Reaxy-Rn 116483
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

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参考文献

1. Dolusić E, Larrieu P, Moineaux L, Stroobant V, Pilotte L, Colau D, Pochet L, Van den Eynde B, Masereel B, Wouters J et al..  (2011)  Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators..  J Med Chem,  54  (15):  (5320-34).  [PMID:21726069]
2. R F Chen.  (1968-06-01)  Fluorescence of protonated excited-state forms of 5-hydroxytryptamine (serotonin) and related indoles..  Proceedings of the National Academy of Sciences of the United States of America,  60  ((2)):  (598-605).  [PMID:5303878]
3. Eugene L Piatnitski Chekler,Reeti Katoch-Rouse,Alexander S Kiselyov,Dan Sherman,Xiaohu Ouyang,Ki Kim,Ying Wang,Yaron R Hadari,Jacqueline F Doody.  (2008-07-22)  Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors..  Bioorganic & medicinal chemistry letters,  18  ((15)):  (4344-4347).  [PMID:18640036]
4. Barry G Shearer, Hari S Patel, Andrew N Billin, James M Way, Deborah A Winegar, Millard H Lambert, Robert X Xu, Lisa M Leesnitzer, Raymond V Merrihew, Stephane Huet, Timothy M Willson,.  (2008-08-30)  Discovery of a novel class of PPARdelta partial agonists..  Bioorganic & medicinal chemistry letters,  18  ((18)):  ( 5018-5022 ).  [PMID:18722772]
5. Yu-Shan Wu,Mohane Selvaraj Coumar,Jang-Yang Chang,Hsu-Yi Sun,Fu-Ming Kuo,Ching-Chuan Kuo,Ying-Jun Chen,Chi-Yen Chang,Chia-Ling Hsiao,Jing-Ping Liou,Ching-Ping Chen,Hsien-Tsung Yao,Yi-Kun Chiang,Uan-Kang Tan,Chiung-Tong Chen,Chang-Ying Chu,Su-Ying Wu,Teng-Kuang Yeh,Chin-Yu Lin,Hsing-Pang Hsieh.  (2009-07-10)  Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach..  Journal of medicinal chemistry,  52  ((15)):  (4941-4945).  [PMID:19586033]
6. Ahmed Kamal,Y V V Srikanth,M Naseer A Khan,Thokhir Basha Shaik,Md Ashraf.  (2010-08-03)  Synthesis of 3,3-diindolyl oxyindoles efficiently catalysed by FeCl3 and their in vitro evaluation for anticancer activity..  Bioorganic & medicinal chemistry letters,  20  ((17)):  (5229-5231).  [PMID:20673629]
7. Thomas Heine, Kathryn Tucker, Nonye Okonkwo, Berhanegebriel Assefa, Catleen Conrad, Anika Scholtissek, Michael Schlömann, George Gassner, Dirk Tischler,.  (2016-11-11)  Engineering Styrene Monooxygenase for Biocatalysis: Reductase-Epoxidase Fusion Proteins..  Applied biochemistry and biotechnology,  181  ((4)):  ( 1590-1610 ).  [PMID:27830466]
8. V F Ximenes,I M M Paino,O M M de Faria-Oliveira,L M da Fonseca,I L Brunetti.  (2005-11-01)  Indole ring oxidation by activated leukocytes prevents the production of hypochlorous acid..  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,  38  ((11)):  (1575-1583).  [PMID:16258625]
9. Matthias Herdemann,Isabelle Heit,Frank-Uwe Bosch,Gianluca Quintini,Claudia Scheipers,Alexander Weber.  (2010-10-23)  Identification of potent ITK inhibitors through focused compound library design including structural information..  Bioorganic & medicinal chemistry letters,  20  ((23)):  (6998-7003).  [PMID:20965724]