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甲基丙胺

规格或纯度: 98%
有货

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
M126637-25mg
 25mg 现货 Stock Image
M126637-100mg
 100mg 现货 Stock Image
M126637-250mg
 250mg 现货 Stock Image
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有机砌块 苯环化合物 苯胺类
main product photo

基本描述

别名 N,N,3-三甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[d]咪唑]-2'-基)苯胺
英文别名 DTXSID80332275 | AS-3282 | MFCD25976766 | N,N,3-trimethyl-4-[5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzimidazol-2'-yl]aniline | N,N,3-trimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline | A908344 | Benzenamine,
规格或纯度 98%
英文名称 Methylproamine
生化机理

Description:
IC50 Value: N/A
Methylproamine is a DNA-binding radioprotector which, on the basis of published pulse radiolysis studies, acts by repair of transient radiation-induced oxidative species on DNA.
in vitro: The extent of radioprotection at the clonogenic survival endpoint increased with methylproamine concentration up to a maximum dose modification factor (DMF) of 2.0 at 10 μM. At least 0.1 fmole/nucleus of methylproamine is required to achieve a substantial level of radioprotection (DMF of 1.3) with maximum protection (DMF of 2.0) achieved at 0.23 fmole/nucleus. The γH2AX focus yield per cell nucleus 45 min after irradiation decreased with drμg concentration with a DMF of 2.5 at 10 μM [1]. Methylproamine-treated cells had fewer γH2AX foci after IR compared to untreated cells. Also, the presence ofmethylproamine decreased the amount of lower molecular weight DNA entering the gel as shown by the pulsed field gel electrophoresis assay [2]. Experiments with V79 cells have shown that methylproamine is approximately 100-fold more potent than the classical aminothiol radioprotector WR1065. The crystal structures of methylproamine and proamine complexes with the dodecamer d(CGCGAATTCGCG)(2) confirm that the new analogues also are minor groove binders [3].
in vivo: N/A
Clinical trial: N/A
 

储存温度 -20°C储存
运输条件 超低温冰袋运输

名称和标识符

IUPAC Name N,N,3-trimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline
INCHI InChI=1S/C28H31N7/c1-18-15-20(33(2)3)6-8-22(18)28-30-23-9-5-19(16-25(23)32-28)27-29-24-10-7-21(17-26(24)31-27)35-13-11-34(4)12-14-35/h5-10,15-17H,11-14H2,1-4H3,(H,29,31)(H,30,32)
InChi Key ADKLMOJIJGHCCD-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=CC(=C1)N(C)C)C2=NC3=C(N2)C=C(C=C3)C4=NC5=C(N4)C=C(C=C5)N6CCN(CC6)C
Isomeric SMILES CC1=C(C=CC(=C1)N(C)C)C2=NC3=C(N2)C=C(C=C3)C4=NC5=C(N4)C=C(C=C5)N6CCN(CC6)C
PubChem CID 448201
分子量 465.59

化学和物理性质

溶解性 25°C: DMSO

质检证书(COA)

质检报告(COA)

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