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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M299664-1ml |
1ml |
现货  |
|
| 英文别名 | Microcystin-LA|Cyanoginosin LA|Microcystin LA|96180-79-9|MC-LA|Microcystin-leucine-alanine|Toxin BE 4 (Microcystis aeruginosa)|Cyanoginosin-LA|3E7C54U3SY|CHEMBL421377|(5R,8S,11R,12S,15S,18S,19S,22R)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1 |
|---|---|
| 规格或纯度 | 10ug/ml in methanol |
| 英文名称 | Microcystin-LA |
| 生化机理 | 微囊藻毒素 LA 抑制蛋白磷酸酶类型 A 型和蛋白磷酸酶 3 类型的能力强于蛋白磷酸酶 1 类型（效价顺序 PP2A > PP3 > PP1）。诱导中性粒细胞活化趋化因子和胞外活性氧，可能的机制是其肝毒性作用。 |
| 应用 | Microcystin LA 是一种天然毒素，Microcystin LA 通过抑制丝氨酸-苏氨酸蛋白磷酸酶 PP1 (IC50=0.3 nM) 和 PP2A (IC50=0.3 nM) 来发挥其细胞毒性作用。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
产品介绍： 微囊藻毒素是一种单环小分子多肽，由 7 个氨基酸通过肽键连接而成。是一种具有肝毒性和促癌属性的青毒素。鱼腥藻属、 丝囊藻属、 微胞藻属 和 浮丝藻属等几个藻属产生微囊藻毒素。微囊藻毒素有四种同源物，即-LR、-LA、-YR 和-RR。 产品用途： Microcystin LA inhibit PP1 and PP2A quite potently and specifically relative to other known phosphatases, such as PP2B (calcineurin), PP2C, and the tyrosine phosphatases Product introduction: Microcystin is a small, monocyclic peptide, composed of seven amino acids connected via peptide bonds. It is a cyanotoxin with hepatotoxic and tumor promoting properties. Several algal genera like Anabaena, Aphanizomenon, Microcystis and Planktothrix produce microcystin.[2] Microcystin has four congeners namely, -LR, -LA, -YR and -RR. Application： Microcystin LA inhibit PP1 and PP2A quite potently and specifically relative to other known phosphatases, such as PP2B (calcineurin), PP2C, and the tyrosine phosphatases |
| IUPAC Name | (5R,8S,11R,12S,15S,18S,19S,22R)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,15,19-pentamethyl-2-methylidene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarboxylic acid |
|---|---|
| INCHI | InChI=1S/C46H67N7O12/c1-24(2)21-35-44(60)52-38(46(63)64)28(6)40(56)47-29(7)41(57)49-33(18-17-25(3)22-26(4)36(65-11)23-32-15-13-12-14-16-32)27(5)39(55)50-34(45(61)62)19-20-37(54)53(10)31(9)43(59)48-30(8)42(58)51-35/h12-18,22,24,26-30,33-36,38H,9,19-21,23H2,1-8,10-11H3,(H,47,56)(H,48,59)(H,49,57)(H,50,55)(H,51,58)(H,52,60)(H,61,62)(H,63,64)/b18-17+,25-22+/t26-,27-,28-,29-,30+,33-,34+,35-,36-,38+/m0/s1 |
| InChi Key | DIAQQISRBBDJIM-DRSCAGMXSA-N |
| Canonical SMILES | CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)C)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C |
| Isomeric SMILES | C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)C)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C |
| WGK Germany | WGK 3 |
| PubChem CID | 6437382 |
| 分子量 | 910.06 |
| 溶解性 | methanol: 2 mg/mL |
|---|
| 象形图 |
Toxic |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H317: May cause an allergic skin reaction H300+H310+H330: Fatal if swallowed, in contact with skin or if inhaled |
| 预防措施声明 | P305+P351+P338,P280,P301+P310,P310,P302+P352,P304+P340,P330,P262 |
| WGK Germany | WGK 3 |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| RIDADR | UN 2811PIH 6.1 / PGI |
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