| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M334622-5mg |
5mg |
期货  |
|
| 英文别名 | 2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one |
|---|---|
| 规格或纯度 | ≥97% |
| 英文名称 | MK-2 Inhibitor III |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
MK-2抑制剂III是可渗透细胞的吡咯并吡啶基化合物，可作为有效的，选择性的和ATP结合位点的MK-2 / MAPKAP-K2抑制剂（IC | 50 | = 8.5、81和210 nM对抗MAPKAPK -2（MK-2），PRAK（MK-5）和3pK（MK-3）），而对其他8种常用激酶的活性却低得多或没有。在U937细胞中显示抑制LPS诱导的TNF-α的产生（IC | 50 | = 4.4μM）。 MK-2 Inhibitor III is a cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC|50|= 8.5, 81, and 210 nM agaisnt MAPKAPK-2 (MK-2), PRAK(MK-5), and 3pK(MK-3), respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC|50|= 4.4 μM). |
| IC50 | MAPKAPK-2 : IC₅₀= 8.5 nM; PRAK: IC₅₀= 81 nM; 3pK: IC₅₀= 210 nM; LPS-induced TNF-α production: IC₅₀= 4.4 μM (U937 cells) |
|---|
| IUPAC Name | 2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one;hydrate |
|---|---|
| INCHI | InChI=1S/C21H16N4O.H2O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15;/h1-5,7,9-12,25H,6,8H2,(H,23,26);1H2 |
| InChi Key | NIKCVKMHGQQSRN-UHFFFAOYSA-N |
| Canonical SMILES | C1CNC(=O)C2=C1NC(=C2)C3=CC(=NC=C3)C4=CC5=CC=CC=C5N=C4.O |
| Isomeric SMILES | C1CNC(=O)C2=C1NC(=C2)C3=CC(=NC=C3)C4=CC5=CC=CC=C5N=C4.O |
| PubChem CID | 25163932 |
| 分子量 | 358.39 |
| 溶解性 | Soluble in DMSO (50 mg/ml). |
|---|---|
| 折光率 | n20D1.70 (Predicted) |
| 沸点 | 784.9° C at 760 mmHg (Predicted) |
| 分子量 | 358.400 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 358.143 Da |
| 单同位素质量Monoisotopic Mass | 358.143 Da |
| 拓扑极表面积Topological Polar Surface Area | 71.700 Ų |
| 重原子数Heavy Atom Count | 27 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 526.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
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