| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P408162-1ml |
1ml |
现货  |
|
| 英文别名 | Phloridzin | 1-Propanone, 1-[2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Phlorizin |
| 生化机理 | Phlorizin（Phloridzin）是一种二氢查尔酮，存在于梨（Pyrus communis）、苹果、樱桃和其他果树的树皮中。Phlorizin 是一种非选择性 SGLT 抑制剂，对 hSGLT1 和 hSGLT2 的 Ki 分别为 300 nM 和 39 nM。Phlorizin 还是一种 Na+/K+-ATPase 抑制剂。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 含主要促进剂超家族结构域 4B 的抑制剂;SGLT6 的抑制剂;SMIT 的抑制剂 |
| 产品介绍 |
Phloridzin is a dihydrochalcone found in all parts of the apple tree, except the mature fruit, and acts as an inhibitor of SGLT-1 and SGLT-2.An SGLT-1 and SGLT-2 inhibitor found in apple trees Information Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a non-selectiveSGLTinhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also aNa+/ Phlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a competitive inhibitor of SGLT1 and SGLT2; this reduces renal glucose transport, lowering the amount of glucose in the blood. Phlorizin\'s principal pharmacological action is to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters located in the proximal renal tubule and mucosa of the small intestine which benefits the treatment of diabetes, obesity, and stress hyperglycemia. In vivo
cell lines：ST88-14, STS26T, and MPNST724 Concentrations： Incubation Time： Powder Purity:≥98% |
| Ki Data | hSGLT2, Ki: 39 nM |
|---|
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | OCC1OC(OC2=C(C(=O)CCC3=CC=C(O)C=C3)C(=CC(=C2)O)O)C(O)C(O)C1O |
| 分子量 | 436.41 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 30 mg/mL (199.77 mM); Ethanol: -1 mg/mL |
|---|
| 1. Zhang Guorong, Wang Qin, Tao Wanyin, Jiang Wei, Elinav Eran, Wang Yucai, Zhu Shu. (2022) Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. Nature Biomedical Engineering, 6 (7): (867-881). [PMID:35798834] [10.1038/s41551-022-00903-4] |
| 2. Fang Li, Yachao Xi, Jianming Jiang, Hao Peng, Bing Li, Jianbo He, Jiangnan Shu, Hua Cui. (2022) O-Fluorobenzoic Acid-Mediated Construction of Porous Graphitic Carbon Nitride with Nitrogen Defects for Multicolor Electrochemiluminescence Imaging Sensing. ANALYTICAL CHEMISTRY, 94 (26): (9306–9315). [PMID:35738019] [10.1021/acs.analchem.2c00702] |
| 3. Zhang Haipin, Song Huijia, Tian Xuemeng, Wang Yue, Hao Yi, Wang Wenting, Gao Ruixia, Yang Wan, Ke YuShen, Tang Yuhai. (2021) Magnetic imprinted nanoparticles with synergistic tailoring of covalent and non-covalent interactions for purification and detection of procyanidin B2. MICROCHIMICA ACTA, 188 (1): (1-12). [PMID:33403455] [10.1007/s00604-020-04693-x] |
| 4. Qingquan Zeng, Mengru Bai, Cui Li, Shuanghui Lu, Zhiyuan Ma, Yunchun Zhao, Hui Zhou, Huidi Jiang, Dongli Sun, Caihong Zheng. (2019) Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, [PMID:31160284] [10.1128/AAC.00199-19] |
| 5. Min Zhang, Ying Peng, Mengyue Wang, Beibei Gao, Lijuan Zhao, Xiaobo Li. (2019) The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers. JOURNAL OF ETHNOPHARMACOLOGY, 228 (164). [PMID:30223050] [10.1016/j.jep.2018.09.022] |
| 6. Yue Yuan, Rong Zhou, Dongliang Li, Cheng Luo, Guoyou Li. (2017) Simultaneous quantitative assessment of nine glycosides in tobacco by liquid chromatography–tandem mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 41 (5): (1009-1016). [PMID:29178289] [10.1002/jssc.201700880] |
| 7. Tong Wang, Hai-Long Wu, Li-Xia Xie, Li Zhu, Zhi Liu, Xiao-Dong Sun, Rong Xiao, Ru-Qin Yu. (2017) Fast and simultaneous determination of 12 polyphenols in apple peel and pulp by using chemometrics-assisted high-performance liquid chromatography with diode array detection. JOURNAL OF SEPARATION SCIENCE, 40 (8): (1651-1659). [PMID:28217915] [10.1002/jssc.201601293] |
| 1. Zhang Guorong, Wang Qin, Tao Wanyin, Jiang Wei, Elinav Eran, Wang Yucai, Zhu Shu. (2022) Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. Nature Biomedical Engineering, 6 (7): (867-881). [PMID:35798834] [10.1038/s41551-022-00903-4] |
| 2. Fang Li, Yachao Xi, Jianming Jiang, Hao Peng, Bing Li, Jianbo He, Jiangnan Shu, Hua Cui. (2022) O-Fluorobenzoic Acid-Mediated Construction of Porous Graphitic Carbon Nitride with Nitrogen Defects for Multicolor Electrochemiluminescence Imaging Sensing. ANALYTICAL CHEMISTRY, 94 (26): (9306–9315). [PMID:35738019] [10.1021/acs.analchem.2c00702] |
| 3. Zhang Haipin, Song Huijia, Tian Xuemeng, Wang Yue, Hao Yi, Wang Wenting, Gao Ruixia, Yang Wan, Ke YuShen, Tang Yuhai. (2021) Magnetic imprinted nanoparticles with synergistic tailoring of covalent and non-covalent interactions for purification and detection of procyanidin B2. MICROCHIMICA ACTA, 188 (1): (1-12). [PMID:33403455] [10.1007/s00604-020-04693-x] |
| 4. Qingquan Zeng, Mengru Bai, Cui Li, Shuanghui Lu, Zhiyuan Ma, Yunchun Zhao, Hui Zhou, Huidi Jiang, Dongli Sun, Caihong Zheng. (2019) Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, [PMID:31160284] [10.1128/AAC.00199-19] |
| 5. Min Zhang, Ying Peng, Mengyue Wang, Beibei Gao, Lijuan Zhao, Xiaobo Li. (2019) The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers. JOURNAL OF ETHNOPHARMACOLOGY, 228 (164). [PMID:30223050] [10.1016/j.jep.2018.09.022] |
| 6. Yue Yuan, Rong Zhou, Dongliang Li, Cheng Luo, Guoyou Li. (2017) Simultaneous quantitative assessment of nine glycosides in tobacco by liquid chromatography–tandem mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 41 (5): (1009-1016). [PMID:29178289] [10.1002/jssc.201700880] |
| 7. Tong Wang, Hai-Long Wu, Li-Xia Xie, Li Zhu, Zhi Liu, Xiao-Dong Sun, Rong Xiao, Ru-Qin Yu. (2017) Fast and simultaneous determination of 12 polyphenols in apple peel and pulp by using chemometrics-assisted high-performance liquid chromatography with diode array detection. JOURNAL OF SEPARATION SCIENCE, 40 (8): (1651-1659). [PMID:28217915] [10.1002/jssc.201601293] |
首页
400-620-6333
