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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| R329613-250μg |
250μg |
期货  |
|
| 英文别名 | Reveromycin C|144860-69-5|(2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-2-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dienyl]-3-(3-carboxypropanoyloxy)-9-methyl-3-(3-methylbutyl)-1,7-dioxaspiro[5.5]undecan-8-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid|Butanedioic |
|---|---|
| 规格或纯度 | >95% |
| 英文名称 | Reveromycin C |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Reveromycin C是与Reveromycins A，B和D一起从链霉菌汤中分离得到的天然产物抗生素。据描述，Reveromycin C在Balb / MK细胞中可抑制表皮生长因子（EGF）的促有丝分裂活性，效力与Reveromycin A和D（IC | 50 | = 0.7〜1.1μg/ ml）相当。Reveromycins抑制EGF功能与抗增殖作用有关。 Reveromycin C is a natural product antibiotic isolated from|Streptomyces|culture broths along with Reveromycins A , B , and D . Reveromycin C is described to inhibit mitogenic activity in response to epidermal growth factor (EGF) with potency comparable to Reveromycins A and D (IC|50|= 0.7~1.1 μg/ml) in Balb/MK cells. Inhibition of EGF function by Reveromycins is correlated to an antiproliferative effect. |
| IUPAC Name | (2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-2-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dienyl]-3-(3-carboxypropanoyloxy)-9-methyl-3-(3-methylbutyl)-1,7-dioxaspiro[5.5]undecan-8-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid |
|---|---|
| INCHI | InChI=1S/C37H54O11/c1-24(2)17-19-36(48-35(45)16-15-33(41)42)21-22-37(47-31(36)13-9-26(4)23-34(43)44)20-18-28(6)30(46-37)12-8-25(3)7-11-29(38)27(5)10-14-32(39)40/h7-11,13-14,23-24,27-31,38H,12,15-22H2,1-6H3,(H,39,40)(H,41,42)(H,43,44)/b11-7+,13-9+,14-10+,25-8+,26-23+/t27-,28-,29-,30+,31-,36+,37-/m0/s1 |
| InChi Key | NDQHXHWOEDTFCC-UHWSPUDNSA-N |
| Canonical SMILES | CC1CCC2(CCC(C(O2)C=CC(=CC(=O)O)C)(CCC(C)C)OC(=O)CCC(=O)O)OC1CC=C(C)C=CC(C(C)C=CC(=O)O)O |
| Isomeric SMILES | C[C@H]1CC[C@]2(CC[C@@]([C@@H](O2)/C=C/C(=C/C(=O)O)/C)(CCC(C)C)OC(=O)CCC(=O)O)O[C@@H]1C/C=C(\C)/C=C/[C@@H]([C@@H](C)/C=C/C(=O)O)O |
| PubChem CID | 52914812 |
| 分子量 | 674.8 |
| 溶解性 | Soluble in methanol, ethanol, water (poor), DMF, and DMSO. |
|---|---|
| 密度 | 1.21 g/cm3(Predicted) |
| 折光率 | n20D1.56 (Predicted) |
| 沸点 | 851.31° C at 760 mmHg (Predicted) |
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