,SB-203580,p38 MAPK抑制剂,152121-47-6|SB 203580|SB-203580|SB203580|4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole|Adezmapimod|4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine,SB-203580-阿拉丁试剂

货号 (SKU)	包装规格	是否现货
S131899-5mg	5mg	现货
S131899-25mg	25mg	现货
S131899-100mg	100mg	现货
S131899-500mg	500mg	现货

基本描述

英文别名	152121-47-6\|SB 203580\|SB-203580\|SB203580\|4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole\|Adezmapimod\|4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine\|4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-
规格或纯度	≥98%(HPLC)
英文名称	SB-203580
生化机理	细胞可渗透的p38 MAPK抑制剂。对许多其他激酶具有选择性，但对GAK，CK1，RIP2，c-Raf和GSK3也具有抑制作用。
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	SB203580是一种p38 MAPK抑制剂，在THP-1细胞中IC50为0.3-0.5 μM，对SAPK3(106T)和SAPK4(106T)选择性低10倍，且阻断PKB磷酸化，IC50为3-5 μMMDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.¹⁶ It was used to inhibit MAPK signaling in mouse cortical neurons¹⁷ and human hepatocellular carcinoma cell lines.¹⁸ SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. MDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.¹⁶ It was used to inhibit MAPK signaling in mouse cortical neurons¹⁷ and human hepatocellular carcinoma cell lines.¹⁸

名称和标识符

IUPAC Name	4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
INCHI	InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
InChi Key	CDMGBJANTYXAIV-UHFFFAOYSA-N
Canonical SMILES	CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
Isomeric SMILES	CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
WGK Germany	3
PubChem CID	176155
分子量	377.43

数据库链接

CAS Registry No.	152121-47-6
Wikipedia	SB_203580
PubChem CID	176155
DiscoveRx TREEspot	SB-203580\|
ChEMBL Ligand	CHEMBL10

化学和物理性质

溶解性	Soluble in DMSO (50 mg/ml), aqueous buffers (Sparingly soluble), methanol, acetone, ethanol (~0.2 mg/ml), and 1:9 solution of DMF:PBS(PH 7.2) (~0.5 mg/ml).
密度	1.4
敏感性	对热敏感
折光率	1.71
沸点	615.6° C
熔点	280.73°C

安全和危险性（GHS）

象形图	Corrosive Harmful
信号词	Danger
危险声明	H302: Harmful if swallowed H318: Causes serious eye damage
预防措施声明	P305+P351+P338,P280
WGK Germany	3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

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参考文献

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SB-203580,p38 MAPK抑制剂

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基本描述

名称和标识符

数据库链接

化学和物理性质

安全和危险性（GHS）

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