SB-408124 Hydrochloride

≥98%

CAS编号: 1431697-90-3
分子式: C₁₉H₁₉ClF₂N₄O
分子量: 392.83
PubChem编号: 71576692

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货号 (SKU)	包装规格	是否现货
S648569-5mg	5mg	期货
S648569-10mg	10mg	期货
S648569-50mg	50mg	期货
S648569-100mg	100mg	期货

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GPCR/G Protein (3176) Orexin Receptor (OX Receptor) (38) 神经元信号传导 (3333)

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基本描述

别名	SB-408124 盐酸盐
英文别名	CS-1073 \| N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea hydrochloride \| F84881 \| MS-26581 \| SB-408124 HCl \| SB-408124 Hydrochloride \| AKOS030526528 \| SB-408124 (Hydrochloride) \| 1-(6,8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimeth
规格或纯度	≥98%
英文名称	SB-408124 Hydrochloride
生化机理	SB-408124 Hydrochloride 是一种选择性非肽奥曲肽受体 1（OX1）受体拮抗剂，在全细胞和膜中的 K i s 分别为 57 nM 和 27 nM。SB-408124 Hydrochloride 对 OX2 受体具有 50 倍的选择性。
储存温度	2-8°C储存,干燥
运输条件	冰袋运输
产品介绍	SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor In Vitro Primary neuronal cultures from the hypothalamus of newborn SD rats are incubated with orexin A (1 µM), orexin A (1 µM) together with SB-408124 (100 µM) for 6 h. Orexin A-induced increases in arginine Vasotocin (AVP) mRNA levels (2.7-fold) are attenuated by SB-408124 (1.2-fold). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SB-408124 reduces anxiety after psychotraumatic exposure. Predator induces acute psychotraumatic exposure decrease corticoliberin level in the rat's amygdala. Intranasal administration of SB-408124 restores it closely to normal and has an anxiolytic effect on animal behaviour. Bilateral paraventricular nucleus microinjection of SB-408124 (30 pmol/50 nL per side) results in a greater reduction in mean arterial pressure (MAP) in high-salt intake (-16 mmHg) compared with NS-fed (-4 mmHg) anesthetized Dahl salt-sensitive rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:OX 1 Receptor 57 nM (Ki, in whole cell ) OX 1 Receptor 27 nM (Ki, in cell membrane)

名称和识别符

IUPAC Name	1-(6,8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea;hydrochloride
INCHI	InChI=1S/C19H18F2N4O.ClH/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3;/h4-10H,1-3H3,(H2,22,23,24,26);1H
InChi Key	DIHXPSGMLOETTI-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C2C=C(C=C(C2=N1)F)F)NC(=O)NC3=CC=C(C=C3)N(C)C.Cl
Isomeric SMILES	CC1=CC(=C2C=C(C=C(C2=N1)F)F)NC(=O)NC3=CC=C(C=C3)N(C)C.Cl
关联CAS	1431697-90-3
PubChem CID	71576692
分子量	392.83

化学和物理性质

溶解性	H2O : 1 mg/mL (2.55 mM; ultrasonic and warming and heat to 60°C) DMSO : <1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
分子量	392.800 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	5
可旋转键计数Rotatable Bond Count	3
精确质量Exact Mass	392.122 Da
单同位素质量Monoisotopic Mass	392.122 Da
拓扑极表面积Topological Polar Surface Area	57.300 Å²
重原子数Heavy Atom Count	27
形式电荷Formal Charge	0
复杂度Complexity	484.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	2

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SB-408124 Hydrochloride

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名称和识别符

化学和物理性质

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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