基本描述

产品名称	尿激酶
英文别名	079X63S3DU \| CAMBENDAZOLE [MART.] \| Cambendazole 100 microg/mL in Acetonitrile \| MFCD00864552 \| QZWHWHNCPFEXLL-UHFFFAOYSA-N \| Camdan (TN) \| NOE [French] \| Equiben \| J-690273 \| SMR003475014 \| DTXSID0046852 \| isopropyl N-(2-thiazol-4-yl-1H-benzimidazol-5-yl
规格或纯度	EnzymoPure™, ≥85%, Potency ≥50000IU/mg，specific activeiy 120000IU/mg
生化机理	尿胰蛋白酶抑制剂通过 MEK/ERK/c-Jun 依赖性信号通路抑制尿激酶的表达和侵袭性
产品介绍	为人尿或肾细胞的蛋白水解酶。天然底物是纤溶酶原。对湿敏感。溶于水。干粉在4℃较稳定，水溶液在4℃的稳定期为3天。主要活性成分是尿激酶的低分子量形式，由 2,000 道尔顿的 A 链和 30,400 道尔顿的 B 链通过巯基键连接而成。产品应用：人肾细胞产生的尿激酶已被用作消化混合物的成分，用于三维纤维蛋白培养。也用于纤溶酶原激活试验。生理学机理：尿激酶可促进肾肿瘤细胞的增殖。尿激酶是一种蛋白酶，能裂解纤溶酶原形成纤溶酶。与细胞表面受体 (uPAR) 结合，在组织重塑过程中调节细胞粘附和迁移，并激活细胞内信号通路。尿激酶由三个结构域组成：与表皮生长因子同源的氨基末端结构域通过中央圈形区结构域连接到羧基端的蛋白酶结构域。 Physical form Lyophilized from 1 mL of 50 mM Tris-HCl, pH 7.4 with 100 mM NaCl, 0.1% PEG 6000, and 200 mM mannitol Physical properties High molecular weight form migrating at 54 kDa by SDS-PAGE under non-reducing conditions Urokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains: the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus.

AI解读

关联靶点（人）

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)

点击查看靶蛋白信息： TDP1

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 活性数据)

点击查看靶蛋白信息： GMNN

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Mus musculus (284745 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Luciferin 4-monooxygenase (66902 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 活性数据)

点击查看靶蛋白信息： Rorc

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

产品规格参数

浓度	Potency ≥50000IU/mg，specific activeiy 120000IU/mg
储存温度	-20°C储存,充氩
运输条件	超低温冰袋运输
CAS编号和信息	9039-53-6
分子类型	小分子

安全和危险性（GHS）

象形图	GHS08
信号词	Warning
危险声明	H361: 怀疑破坏生育力或未出生的孩子
预防措施声明	P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。
WGK Germany	3
RTECS	OB8900000

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到13个结果

批号(Lot Number)	证书类型	日期	货号
D2522324	分析证书	25-03-26	U108373
D2522335	分析证书	25-03-26	U108373
D2522348	分析证书	25-03-26	U108373
D2522429	分析证书	25-03-26	U108373
C23081299	分析证书	24-12-20	U108373
C23081293	分析证书	24-12-20	U108373
C23081291	分析证书	24-12-20	U108373
G2404241	分析证书	24-06-11	U108373
G2404252	分析证书	24-06-11	U108373
C2428054	分析证书	24-04-01	U108373
C2226230	分析证书	23-12-22	U108373
C2226247	分析证书	23-12-22	U108373
K2016052	分析证书	22-09-14	U108373

显示更多⌵

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?

1. Zhechang Chen, Caijie Yuan, Yaxin Ye, Bitao Lu, Enling Hu, Fei Lu, Kun Yu, Ruiqi Xie, Guangqian Lan. (2024) Dual-targeting fucoidan-based microvesicle for arterial thrombolysis and re-occlusion inhibition. CARBOHYDRATE POLYMERS, 328 (121703). [PMID:38220339] [10.1016/j.carbpol.2023.121703]
2. Song Jianwen, Kang Xiaoying, Wang Lu, Ding Dan, Kong Deling, Li Wen, Qi Ji. (2023) Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles. Nature Communications, 14 (1): (1-19). [PMID:37898604] [10.1038/s41467-023-42691-8]
3. Weiwei Zhang, Yuguo Deng, Jinhao Zhao, Tao Zhang, Xiang Zhang, Wenping Song, Lin Wang, Tianlong Li. (2023) Amoeba-Inspired Magnetic Venom Microrobots. Small, 19 (23): (2207360). [PMID:36869412] [10.1002/smll.202207360]
4. Mei Jian feng, Cai Shao fen, Yi Yu, Wang Xu dong, Ying Guo qing. (2023) Study of the fibrinolytic activity of serrapeptase and its in vitro thrombolytic effects. Brazilian Journal of Pharmaceutical Sciences, 58 (e201004). [10.1590/s2175-97902022e201004]
5. Songzhi Xie, Shang Li, Wenxiong Cao, Chuanfei Mo, Zhanlin Zhang, Kun Huang, Xiaohong Li. (2022) Bacteria-Templated and Dual Enzyme-Powered Microcapsule Motors To Promote Thrombus Penetration and Thrombolytic Efficacy. ACS Applied Materials & Interfaces, 14 (33): (37553–37565). [PMID:35948498] [10.1021/acsami.2c11213]
6. Dongya Wang, Qianqian Zhao, Jingcan Qin, Yuanyuan Guo, Chuan Zhang, Yuehua Li. (2022) Urokinase loaded black phosphorus nanosheets for sequential thrombolysis and reactive oxygen species scavenging in ischemic stroke treatment. Biomaterials Science, 10 (16): (4656-4666). [PMID:35801526] [10.1039/D2BM00746K]
7. Songzhi Xie, Chuanfei Mo, Wenxiong Cao, Shuang Xie, Shang Li, Zhanlin Zhang, Xiaohong Li. (2022) Bacteria-propelled microtubular motors for efficient penetration and targeting delivery of thrombolytic agents. Acta Biomaterialia, 142 (49). [PMID:35158079] [10.1016/j.actbio.2022.02.008]

参考文献

1. Zhechang Chen, Caijie Yuan, Yaxin Ye, Bitao Lu, Enling Hu, Fei Lu, Kun Yu, Ruiqi Xie, Guangqian Lan. (2024) Dual-targeting fucoidan-based microvesicle for arterial thrombolysis and re-occlusion inhibition. CARBOHYDRATE POLYMERS, 328 (121703). [PMID:38220339] [10.1016/j.carbpol.2023.121703]
2. Song Jianwen, Kang Xiaoying, Wang Lu, Ding Dan, Kong Deling, Li Wen, Qi Ji. (2023) Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles. Nature Communications, 14 (1): (1-19). [PMID:37898604] [10.1038/s41467-023-42691-8]
3. Weiwei Zhang, Yuguo Deng, Jinhao Zhao, Tao Zhang, Xiang Zhang, Wenping Song, Lin Wang, Tianlong Li. (2023) Amoeba-Inspired Magnetic Venom Microrobots. Small, 19 (23): (2207360). [PMID:36869412] [10.1002/smll.202207360]
4. Mei Jian feng, Cai Shao fen, Yi Yu, Wang Xu dong, Ying Guo qing. (2023) Study of the fibrinolytic activity of serrapeptase and its in vitro thrombolytic effects. Brazilian Journal of Pharmaceutical Sciences, 58 (e201004). [10.1590/s2175-97902022e201004]
5. Songzhi Xie, Shang Li, Wenxiong Cao, Chuanfei Mo, Zhanlin Zhang, Kun Huang, Xiaohong Li. (2022) Bacteria-Templated and Dual Enzyme-Powered Microcapsule Motors To Promote Thrombus Penetration and Thrombolytic Efficacy. ACS Applied Materials & Interfaces, 14 (33): (37553–37565). [PMID:35948498] [10.1021/acsami.2c11213]
6. Dongya Wang, Qianqian Zhao, Jingcan Qin, Yuanyuan Guo, Chuan Zhang, Yuehua Li. (2022) Urokinase loaded black phosphorus nanosheets for sequential thrombolysis and reactive oxygen species scavenging in ischemic stroke treatment. Biomaterials Science, 10 (16): (4656-4666). [PMID:35801526] [10.1039/D2BM00746K]
7. Songzhi Xie, Chuanfei Mo, Wenxiong Cao, Shuang Xie, Shang Li, Zhanlin Zhang, Xiaohong Li. (2022) Bacteria-propelled microtubular motors for efficient penetration and targeting delivery of thrombolytic agents. Acta Biomaterialia, 142 (49). [PMID:35158079] [10.1016/j.actbio.2022.02.008]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

=

浓度

x

体积

x

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

x

体积 1 (V1)

=

浓度 2 (C2)

x

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

=

质量（小瓶）

÷

所需的复溶浓度

货号 (SKU)	包装规格	是否现货
U108373-5mg	5mg	现货
U108373-10mg	10mg	现货
U108373-50mg	50mg	现货

尿激酶

库存信息

库存信息

库存信息

基本描述

AI解读

关联靶点（人）

关联靶点（其它种属）

作用机制

产品规格参数

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

显示更多⌵

相关文档

此产品的引用文献

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

相关技术文章