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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| V100992-10mg |
10mg |
现货  |
|
| 英文别名 | Vinblastine sulfate|143-67-9|Vinblastine 5|VLB monosulfate|Velban (TN)|Vinblastine sulphate|Vincaleukoblastine sulfate|Exal (TN)|Vincaleukoblastine sulfate salt|Vincaleukoblastine sulfate (1:1) (salt)|Belvan, VLB|NSC49842|CHEBI:9984|Vincaleucoblastine sul |
|---|---|
| 规格或纯度 | 分析标准品,≥97%(HPLC) |
| 英文名称 | Vinblastine sulfate salt |
| 生化机理 |
Description: IC50 Value: VIN showed EC50 values of 15 μg/ml, against P815 mastocytoma cells in-vitro[1]. Also supresses nAChR activity with IC50 of 8.9 μM. Vinblastine can inhibit the formation of microtubule, it also inhibit nAChR. It is a anticancer drμg. More and more drμg combination was investigated in clinical status. in vitro: At vinblastine concentrations of 0.5 uM and 2 uM, considerable inhibition of metabolic degradation of vinblastine was observed by competitive inhibitors of CYP3A4 (up to 60% inhibition), 2D6 (30%) and 2E1 (24%), while only a minor effect was observed for 2C9 (14%) and inhibitors of 1A2, 2C8 had no inhibitory effect on vinblastine metabolism. Vinblastine (0.5 and 2 uM) inhibited the metabolic capacity of CYP2C9 (up to 56%), 2C8 (36%), 2D6 (22%) and 3A4-mediated nifedipine oxidation (99%), while 3A4-mediated testosterone 6-beta-hydroxylation (max. 16%) as well as 1A2 and 2E1 remained unaffected[3]. in vivo: In combined intraperitoneal injection with vinblastine (200 micrograms kg-1) into P388/ADR-bearing mice, NA-382 in a suspension form (10 mg kg-1) prolonged the life-span of the mice near to that of P388/S-bearing mice treated with vinblastine alone, but verapamil even at the maximum tolerated dosage (30 mg kg-1) barely affected the in-vivo antitumour effect of vinblastine[2]. Clinical trial: Combination Chemotherapy With or Without Interleukin-2 and Interferon Alfa in Treating Patients With Metastatic Melanoma . Phase 3 Clinical .Potent microtubule dynamics inhibitor. Inhibits tubulin addition (K i = 0.18 μM). Suppresses mitotic spindle formation. Induces apoptosis. Vincristine analog. Potent antiproliferative effects (IC 50 = 1 nM). Antitumor effects in vivo. |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
水溶性:＞=1 g/100 mL at 24.5℃ |
| EC号 | 205-606-0 |
|---|---|
| IUPAC Name | methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid |
| INCHI | InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1 |
| InChi Key | KDQAABAKXDWYSZ-JKDPCDLQSA-N |
| Canonical SMILES | CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O |
| Isomeric SMILES | CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O |
| WGK Germany | 1 |
| PubChem CID | 241902 |
| UN Number | 2811 |
| Packing Group | I |
| 分子量 | 909.05 |
| Beilstein号 | 3659812 |
| 密度 | 1.37 |
|---|---|
| 熔点 | 267°C |
| 象形图 |
Corrosive 
Harmful |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H315: Causes skin irritation H335: May cause respiratory irritation H302: Harmful if swallowed H318: Causes serious eye damage |
| 预防措施声明 | P261,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P305+P354+P338,P317,P332+P317,P319 |
| WGK Germany | 1 |
| Class | 6.1 |
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