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丫啶橙 半氯化锌盐

产品编号 A100495 | CAS号 10127-02-3 | Aladdin
Acridine Orange hemi(zinc chloride) salt
电泳级
组合的产品项目
货号 规格 库存 价格 数量
A100495-100g 电泳级 上海(预计4-8周)
北方(预计4-8周)
 
A100495-25g 电泳级 上海(8)
北方(5)
 
A100495-5g 电泳级 上海(>10)
北方(>10)
 
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属性

敏感性 易吸潮
密度 2.5400
溶解性 Soluble in water (1 mg/ml).

描述

产品介绍 溶于水、乙醇。溶液为橙黄色带绿色荧光。pH值为8.4~10.4则无荧光。能镶嵌于两个相邻的碱基对之间,使部分双螺旋DNA松开,该两个碱基对的距离拉大一倍。这样的DNA复制过程中,会使DNA链增加或缺失一个碱基,造成移码突变。Colour Index Number 46005
别名 碱性橙 14;3,6-双(二甲基氨基)吖啶氯化锌盐酸盐;3,6-Bis(dimethylamino)acridine hydrochloride zinc chloride double salt;3,6-Bis(dimethylamino)acridinium chloride hemi(zinc chloride salt);Basic Orange 14
应用 用作荧光指示剂,肿瘤细胞及细菌、核酸染色剂及移码突变的诱变剂。
吖啶橙是一种荧光色素,吖啶橙激发滤光片波长488nm。阻断滤光片波长515nm。吖啶橙与细胞中DNA和RNA结合量存在差别,可发出不同颜色的荧光(即着色特异性),这是由于DNA是个高度聚合物,吸收荧光物质的位置较少,发绿色荧光,而RNA聚合度低,能和荧光物质结合的位置多,故发红色荧光。
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风险声明 (欧洲) R20/21/22;
安全声明(欧洲) S36/37;S45;
个人防护设备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
WGK德国 3
参考文献
G G GG Carmichael, G K GK McMaster
We're sorry this abstract is currently not available....Read More
J G JG Bruno, S A SA Sincock, P J PJ Stopa
The acridine dyes acridine orange (AO) and coriphosphine O (CPO) and ethidium bromide (EtBr) were used to stain bacterial digests after electrophoresis in native and denaturing (SDS) polyacrylamide ge...Read More
Z Z Darzynkiewicz, S S Bruno, G G Del Bino, W W Gorczyca, M A MA Hotz, P P Lassota, F F Traganos
The present review describes several methods to characterize and differentiate between two different mechanisms of cell death, apoptosis and necrosis. Most of these methods were applied to studies of ...Read More
H H Baisch, H H Bollmann, S S Bornkessel
Early indicators of apoptosis in mammalian cells are membrane potential breakdown (loss) in mitochondria (MPLM), chromatin condensation, DNA degradation, and phosphatidylserine exposure (PSE) on the o...Read More
F Durrieu, M A Belaud-Rotureau, F Lacombe, P Dumain, J Reiffers, M R Boisseau, P Bernard, F Belloc
Some forms of chemoresistance in leukemia may start from failure of tumour cells to successfully undergo apoptosis and Bcl-2 may play a role in this defect. Therefore, we evaluated the Bcl-2 content a...Read More
B Mdzewski, Z Tomaszewska, B Romer, R Rokicka, J Krawczyński, A Kendziorek, D Derulska
The distribution of the fluorescent euchrysine-binding grains in the peripheral and bonmarrow stem cells was estimated in 28 cases of different types of acute leukemia verified according to Lòffler&#...Read More
J A JA Steffen, B B Mdzewski, E E Kling, K K Swierkowska, Z Z Tomaszewska
The patterns of supravital staining with euchrysine, a fluorescent dye thought to bind preferentially to membranes of lysosomes and other structures involved in endocytosis, were evaluated sequentiall...Read More
A B AB Borisov, A G AG Bulychev, P P PP Rumiantsev
Using supravital fluorescent staining of lysosomes with Euchrysine 3R, the morphology of these organelles was studied in L cells examined from cultures being at different growth phases in the course o...Read More
A D AD Wolfe, R G RG Allison, F E FE Hahn
We're sorry this abstract is currently not available....Read More
J F JF Golden, S S SS West, H M HM Shingleton, T M TM M?rad, C K CK Echols
A system for screening cervical cytological preparations is described which employs the Leitz Texture Analyzer System (E. Leitz, Rockleigh, N. J.) quantitative staining with acridine orange, and a flu...Read More