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L-α-氨基己二酸

产品编号 A100535 | CAS号 1118-90-7 | Aladdin
L-α-Aminoadipic acid
98%
组合的产品项目
货号 规格 库存 价格 数量
A100535-1g 98% 上海(5)
北方(2)
 
A100535-5g 98% 上海(预计4-8周)
北方(预计4-8周)
 
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属性

旋光率 25 ° (C=5, 6mol/L HCl)
密度 1.3330
熔点 203-205°C
溶解性 Soluble in 1N HCl (50 mg/ml), and water (slightly).

描述

产品介绍 L-α-Aminoadipic acid, a gliotoxic analogue of glutamate, has been shown to competitively inhibit the transport protein of D-[3H]-aspartate. Experiments have reported that this compound also causes a reduction in ischemic glutamate release in murine hippocampal slices in vitro. Additional research suggests that L-α-Aminoadipic acid inhibits astrocyte culture Kynurenic acid synthesis which demonstrates the ability to modulate neuronal degeneration. L-α-Aminoadipic acid is a inhibitor of GluR and Gl Syn.
别名 L-2-氨基己二酸;(S)-2-氨基己二酸;Aad;L-2-Aminoadipic acid;(S)-2-Aminohexanedioic acid;L-Homoglutamic acid;H-2-Aad-OH;Aad
应用 An inhibitor of ischemic glutamate release
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安全声明(欧洲) S22;S24/25;
个人防护设备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
WGK德国 3
参考文献
G J McBean
1. The effect of the gliotoxic analogue of glutamate, alpha aminoadipate, on the high affinity transport of D-[3H]-aspartate into a crude striatal P2 preparation, and on the activity of two enzymes of...Read More
M J MJ Tsai, Y F YF Chang, R R Schwarcz, N N Brookes
The mechanism of the selective gliotoxicity of L-alpha-aminoadipate (L-alpha AA) is thought to involve its entry into glia as a substrate for glutamate transporters or, alternatively, its ability to i...Read More
V Alvarez-Maubecin, F Garcia-Hernandez, J T Williams, E J Van Bockstaele
Neuronal-glial interactions play an important role in information processing in the CNS. Previous studies have indicated that electrotonic coupling between locus ceruleus (LC) neurons is involved in s...Read More
David J DJ Fox, Jill J Reckless, Sibylle M SM Wilbert, Ian I Greig, Stuart S Warren, David J DJ Grainger
3-(acylamino)glutarimides, a class of broad spectrum chemokine inhibitors, are rapidly hydrolyzed in serum, despite being stable in aqueous solution. Synthesis and high-performance liquid chromatograp...Read More
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....Read More