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5-氮胞苷

产品编号 A100625 | CAS号 320-67-2 | Aladdin
5-Azacytidine
98%
组合的产品项目
货号 规格 库存 价格 数量
A100625-100mg 98% 上海(6)
北方(>10)
 
A100625-1g 98% 上海(6)
北方(5)
 
A100625-250mg 98% 上海(>10)
北方(6)
 
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属性

密度 2.0800
熔点 228-230°C

描述

产品介绍 溶于甲醇。
别名 5-氮胞苷 ;5-氮杂胞嘧啶核苷;4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one Ladakamycin
应用 一种潜在的生长抑制因子和细胞毒素载体;抑制DNA甲基化转移酶,该酶是一种重要的调控基因表达、基因激活和基因关闭的机关。
该因子引起DNA去甲基化或半去甲基化,允许转录因子结合到DNA上,重新激活肿瘤抑制基因。
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标识符号 GHS07 GHS07, GHS08 GHS08
信号词 Danger
风险声明 (欧洲) 45,46,22
安全声明(欧洲) 53,22,36/37/39,45
警示性声明 P201,P308+P313
危害码(欧洲) T
危害声明 H302,H350
个人防护设备 Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS XZ3017500
WGK德国 3
Merck Index 887
参考文献
R Scott RS Obach, Franco F Lombardo, Nigel J NJ Waters
We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ...Read More
S Ekins, A J Williams, J J Xu
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...Read More
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....Read More
Nigel N Greene, Lilia L Fisk, Russell T RT Naven, Reine R RR Note, Mukesh L ML Patel, Dennis J DJ Pelletier
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...Read More
Samiha Mateen, Komal Raina, Chapla Agarwal, Daniel Chan, Rajesh Agarwal
Aggressive cancers in the epithelial-to-mesenchymal transition (EMT) phase are characterized by loss of cell adhesion, repression of E-cadherin, and increased cell mobility. Non-small cell lung cancer...Read More
Johannes J Kornhuber, Philipp P Tripal, Martin M Reichel, Lothar L Terfloth, Stefan S Bleich, Jens J Wiltfang, Erich E Gulbins
Some organic weak bases induce a detachment from inner lysosomal membranes and subsequent inactivation of acid sphingomyelinase (ASM) and thus work as functional ASM inhibitors. The aim of the present...Read More
Zhichao Liu, Qiang Shi, Don Ding, Reagan Kelly, Hong Fang, Weida Tong
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...Read More
Denis Fourches, Julie C Barnes, Nicola C Day, Paul Bradley, Jane Z Reed, Alexander Tropsha
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...Read More
Chun-Chen Kuo, Chi-Yuan Chu, Jing-Jer Lin, Lee-Chiang Lo
Src homology-2 (SH2) domain-containing phosphatase 2 (SHP2) is known to participate in several different signaling pathways to mediate cell growth, survival, migration, and differentiation. However, d...Read More
Georgia Pennarossa, Sara Maffei, Marino Campagnol, Letizia Tarantini, Fulvio Gandolfi, Tiziana A L Brevini
The differentiated state of mature cells of adult organisms is achieved and maintained through the epigenetic regulation of gene expression, which consists of several mechanisms including DNA methylat...Read More
Rui Zhang, Kyoung Ah Kang, Ki Cheon Kim, Soo-Young Na, Weon Young Chang, Gi Young Kim, Hye Sun Kim, Jin Won Hyun
The intestine-specific transcription factor, caudal type homeobox-1 (CDX1), is a candidate tumor suppressor gene that plays key roles in regulating intestinal epithelial differentiation and proliferat...Read More
Su-Jie Jia, Yong-Quan Lai, Ming Zhao, Ting Gong, Bi-Kui Zhang
Homocysteine (Hcy) could induce apoptosis of endothelial cells (ECs). Dimethylarginine dimethylaminohydrolase 2 (DDAH2) is recognized as a protective factor to improve the endothelial function. Defect...Read More
Emanuela Matteucci, Paola Maroni, Paola Bendinelli, Alessia Locatelli, Maria Alfonsina Desiderio
Here, we report a complex regulation of endothelin-1 (ET-1) axis driven by epigenetic reactions in 1833-bone metastatic cells, emphasizing the importance in skeletal metastasis from breast carcinoma. ...Read More
Hatsune Makino, Masashi Toyoda, Kenji Matsumoto, Hirohisa Saito, Koichiro Nishino, Yoshihiro Fukawatase, Masakazu Machida, Hidenori Akutsu, Taro Uyama, Yoshitaka Miyagawa, Hajime Okita, Nobutaka Kiyokawa, Takashi Fujino, Yuichi Ishikawa, Takuro Nakamura,
POU5F1 (more commonly known as OCT4/3) is one of the stem cell markers, and affects direction of differentiation in embryonic stem cells. To investigate whether cells of mesenchymal origin acquire emb...Read More
Jianting J Long, Brian B Parkin, Peter P Ouillette, Dale D Bixby, Kerby K Shedden, Harry H Erba, Shaomeng S Wang, Sami N SN Malek
The survival of most patients with acute myelogenous leukemia (AML) remains poor, and novel therapeutic approaches are needed to improve outcomes. Given that the fraction of AML with mutated p53 is sm...Read More
Jufang Chang, Bin Zhang, Helen Heath, Niels Galjart, Xinyu Wang, Jeffrey Milbrandt
Cellular metabolism alters patterns of gene expression through a variety of mechanisms, including alterations in histone modifications and transcription factor activity. Nicotinamide adenine dinucleot...Read More
Ming-Xiang Zhang, Cheng Zhang, Ying H Shen, Jian Wang, Xiao-Nan Li, Liang Chen, Yun Zhang, Joseph S Coselli, Xing Li Wang
We have reported previously that the 27nt repeat polymorphism in endothelial nitric-oxide synthase (eNOS) intron 4--a source of 27nt small RNA--inhibits eNOS expression. In the current study, we have ...Read More
Alexandra Duverger, Jennifer Jones, Jori May, Frederic Bibollet-Ruche, Frederic A Wagner, Randall Q Cron, Olaf Kutsch
Recent research has emphasized the notion that human immunodeficiency virus type 1 (HIV-1) latency is controlled by a restrictive histone code at, or DNA methylation of, the integrated viral promoter ...Read More
Arkadiusz Gertych, Kolja A Wawrowsky, Erik Lindsley, Eugene Vishnevsky, Daniel L Farkas, Jian Tajbakhsh
Today's advanced microscopic imaging applies to the preclinical stages of drug discovery that employ high-throughput and high-content three-dimensional (3D) analysis of cells to more efficiently ...Read More
Tao Yan-Fang, Ni Jian, Lu Jun, Wang Na, Xiao Pei-Fang, Zhao Wen-Li, Wu Dong, Pang Li, Wang Jian, Feng Xing, Pan Jian
There is growing evidence supporting a role for microRNAs (miRNA) as targets in aberrant mechanisms of DNA hypermethylation. Epigenetic silencing of tumor suppressor miRNAs, including miR-663, which h...Read More
David P Steensma, Mikkael A Sekeres
We're sorry this abstract is currently not available....Read More
Miriam Schiffgen, Doris H Schmidt, Alexander von Rücker, Stefan C Müller, J?rg Ellinger
The underlying mechanisms of microRNA deregulation in cancer cells include epigenetic modifications, which play a crucial role in carcinogenesis. We demonstrate that numerous microRNAs are induced in ...Read More
Ulrich Germing, Judith Neukirchen
We're sorry this abstract is currently not available....Read More
G Piazzi, M Selgrad, M Garcia, C Ceccarelli, L Fini, P Bianchi, L Laghi, L D'Angelo, P Paterini, P Malfertheiner, P Chieco, C R Boland, F Bazzoli, L Ricciardiello
Background:Aberrant activation of the canonical WNT signaling is a feature of colorectal cancer (CRC). Van-Gogh-like 2 (VANGL2) belongs to the non-canonical WNT pathway whose activation inhibits canon...Read More
Hagop Kantarjian, Wyndham Wilson, Farhad Ravandi, Elihu Estey
We're sorry this abstract is currently not available....Read More
Giorgia Benegiamo, Manlio Vinciguerra, Vito Guarnieri, Grazia Anna Niro, Angelo Andriulli, Valerio Pazienza
Hepatitis delta virus (HDV) is a small, defective RNA virus that can infect only individuals carrying hepatitis B virus. HBV/HDV co-infection results in more severe liver disease than HBV single infec...Read More
Kostantin Kiianitsa, Nancy Maizels
A number of proteins form covalent bonds with DNA as obligatory transient intermediates in normal nuclear transactions. Drugs that trap these complexes have proven to be potent therapeutics in both ca...Read More
M Poplineau, C Doliwa, M Schnekenburger, F Antonicelli, M Diederich, A Trussardi-Régnier, J Dufer
Chromatin texture patterns of tumour cell nuclei can serve as cancer biomarkers, either to define diagnostic classifications or to obtain relevant prognostic information, in a large number of human tu...Read More
Cecile Bally, Sylvain Thépot, Bruno Quesnel, Norbert Vey, Francois Dreyfus, Jehane Fadlallah, Pascal Turlure, Stephane de Botton, Caroline Dartigeas, Benoit de Renzis, Raphael Itzykson, Pierre Fenaux, Lionel Adès
The effect of azacitidine (AZA) in therapy related MDS and AML (t-MDS/AML) is not well established. 54 patients (42 t-MDS and 12 t-AML), 71% of whom had complex karyotype, received AZA for at least on...Read More
Agata Magdalena Wasik, Martin Lord, Xiao Wang, Fang Zong, Patrik Andersson, Eva Kimby, Birger Christensson, Mohsen Karimi, Birgitta Sander
The related transcription factors SOX11, SOX4 and SOX12 (classified as the SOXC family) compete for the same target genes. SOX11 is expressed in most mantle cell lymphomas (MCL) but a small subset is,...Read More
Ramy Rahmé, Emmanuel Benayoun, Cécile Pautas, Catherine Cordonnier, Orianne Wagner-Ballon, Sébastien Maury
We're sorry this abstract is currently not available....Read More
Zili Lv, Yangjun DU, Jianming Wen
To investigate the relationship between Zinc-fingers and homeoboxes 2 (ZHX2) promoter methylation and alpha-fetoprotein (AFP) gene expression, and analyze the mechanism of AFP gene expression.HepG2 ce...Read More
Frank Neumann, Dominic Kaddu-Mulindwa, Thomas Widmann, Klaus-Dieter Preuss, Gerhard Held, Carsten Zwick, Klaus Roemer, Michael Pfreundschuh, Boris Kubuschok
EBV-transformed lymphoblastoid cell lines (LCL) are potent antigen-presenting cells. To investigate their potential use as cancer testis antigen (CTA) vaccines, we studied the expression of 12 cancer ...Read More
Farhad Ravandi, Mona Lisa Alattar, Michael R Grunwald, Michelle A Rudek, Trivikram Rajkhowa, Mary Ann Richie, Sherry Pierce, Naval Daver, Guillermo Garcia-Manero, Stefan Faderl, Aziz Nazha, Marina Konopleva, Gautam Borthakur, Jan Burger, Tapan Kadia, Sara
Patients received 5-azacytidine (AZA) 75 mg/m(2) intravenously daily for 7 days and sorafenib 400 mg orally twice daily continuously; cycles were repeated at ~1-month intervals. Forty-three acute my...Read More
Manuel Luís Orta, José Manuel Calderón-Monta?o, Inmaculada Domínguez, Nuria Pastor, Estefanía Burgos-Morón, Miguel López-Lázaro, Felipe Cortés, Santiago Mateos, Thomas Helleday
5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological diseases and works by being incorporated into DNA and trapping DNMT. ...Read More
Yoko Ito, Raffaella Nativio, Adele Murrell
Choriocarcinomas are embryonal tumours with loss of imprinting and hypermethylation at the insulin-like growth factor 2 (IGF2)-H19 locus. The DNA methyltransferase inhibitor, 5-Aza-2'deoxycytidin...Read More
Albert Hagelgans, Mario Menschikowski, Susanne Fuessel, Brit Nacke, Borros M Arneth, Manfred P Wirth, Gabriele Siegert
Plasminogen activator inhibitor-1 (PAI-1) and urokinase-type plasminogen activator (uPA) play a crucial role in cancer progression. In the present study we examined the regulation of PAI-1 and uPA exp...Read More
Ana Sofia Cerdeira, Augustine Rajakumar, Caroline M Royle, Agnes Lo, Zaheed Husain, Ravi I Thadhani, Vikas P Sukhatme, S Ananth Karumanchi, Hernan D Kopcow
NK cells that populate the decidua are important regulators of normal placentation. In contrast to peripheral blood NK cells, decidual NK (dNK) cells lack cytotoxicity, secrete proangiogenic factors, ...Read More
Guillermo Garcia-Manero, Elias Jabbour, Gautam Borthakur, Stefan Faderl, Zeev Estrov, Hui Yang, Sirisha Maddipoti, Lucy A Godley, Nashat Gabrail, Jesus G Berdeja, Ahmed Nadeem, Laurent Kassalow, Hagop Kantarjian
PURPOSE This open-label, randomized phase II trial assessed efficacy and tolerability of two low-dose regimens of subcutaneous (SC) decitabine in patients with low- or intermediate-1-risk myelodysplas...Read More
Evdoxia Douvali, Menelaos Papoutselis, Theodoros P Vassilakopoulos, Vasileios Papadopoulos, Emmanouil Spanoudakis, Costas Tsatalas, Ioannis Kotsianidis
Myelodysplastic syndrome (MDS) patients with renal impairment (RI) were not assessed in the approval trials of 5-azacytidine, thus the optimal use of 5-azacytidine in such patients is currently undefi...Read More
Martin F Kaiser, David C Johnson, Ping Wu, Brian A Walker, Annamaria Brioli, Fabio Mirabella, Christopher P Wardell, Lorenzo Melchor, Faith E Davies, Gareth J Morgan
Outcome in multiple myeloma is highly variable and a better understanding of the factors that influence disease biology is essential to understand and predict behavior in individual patients. In the p...Read More
Omar Al Ustwani, Laurie A Ford, Sheila J N Sait, Anne Marie W Block, Maurice Barcos, Carlos E Vigil, Elizabeth A Griffiths, James E Thompson, Eunice S Wang, Julian Ambrus, Meir Wetzler
Our objective was to recognize the association of autoimmune diseases (AD) in patients with myelodysplastic syndromes (MDS) and understand how this association could affect prognosis and management of...Read More
Xu Han, Zhi-Jun Tan, Ren-de Guo, Zhao-Jin Li, Yu-Liang Wang
To investigate the effect of demethylating agent 5-aza-2'-deoxycytidine (5-Aza-CdR) on the growth of human pancreatic cancer cell line MiaPaca2 and the expression and methylation of tumor suppres...Read More
L H van der Helm, N J G M Veeger, M van Marwijk Kooy, A Beeker, O de Weerdt, M de Groot, C Alhan, M Hoogendoorn, L Laterveer, A A van de Loosdrecht, J Koedam, E Vellenga, G Huls
The efficacy of azacitidine has been demonstrated in acute myeloid leukemia (AML) patients with 20-30% bone marrow (BM) blasts, but limited data is available on patients with ≥30% blasts. We analyze...Read More
Friederike Braulke, Klaus Jung, Julie Schanz, Katharina G?tze, Catharina Müller-Thomas, Uwe Platzbecker, Ulrich Germing, Tim H Brümmendorf, Gesine Bug, Oliver Ottmann, Aristoteles A N Giagounidis, Michael Stadler, Wolf-Karsten Hofmann, Philippe Schafhause
The gold standard of cytogenetic analysis in myelodysplastic syndromes (MDS) is conventional chromosome banding (CCB) analysis of bone marrow (BM) metaphases. Most aberrations can also be detected by ...Read More
Takashi Sato, Eri Arai, Takashi Kohno, Koji Tsuta, Shun-ichi Watanabe, Kenzo Soejima, Tomoko Betsuyaku, Yae Kanai
The aim of this study was to clarify the significance of DNA methylation alterations at precancerous stages of lung adenocarcinoma. Using single-CpG resolution Infinium array, genome-wide DNA methylat...Read More
Stefanie Libnow, Karen Methling, Martin Hein, Dirk Michalik, Manuela Harms, Kristian Wende, Anke Flemming, Martin K??ckerling, Helmut Reinke, Patrick J Bednarski, Michael Lalk, Peter Langer
We're sorry this abstract is currently not available....Read More
L Broday, Y W Lee, M Costa
The cytosine analog 5-azacytidine (5-AzaC) is a demethylating agent that is also known to induce mutagenesis in mammalian cells. In this study, the mutagenic potential of this drug was tested in the G...Read More
X Qian, L Jin, E Kulig, R V Lloyd
We previously reported loss of expression of p27Kip1 (p27) protein in rat GH3 and mouse GHRH-CL1 pituitary tumor cells compared with normal pituitary (NP). The molecular basis for the loss of expressi...Read More
C Canova, G Chevalier, S Remy, P Brachet, D Wion
In mammalian DNA cytosine methylation occurs specifically at CpG dinucleotide. Although the full array of function of DNA methylation is yet to be elucidated, it is well established that DNA methylati...Read More