|旋光率||-24o±2o, c = 4 in methanol|
|溶解性||Soluble in water (partly), ethanol (5%), and methanol.|
Monoclonal antibodies, induced with a phosphonate diester hapten, catalyzed the coupling of p-nitrophenyl esters of N-acetyl valine, leucine, and phenylalanine with tryptophan amide to form the corres...Read More
Cross-polarization transfer is employed in virtually every solid-state NMR experiment to enhance magnetization of low-gamma spins. Theory and experiment is used to assess the magnitude of the final qu...Read More
On the performance of spin diffusion NMR techniques in oriented solids: prospects for resonance assignments and distance measurements from separated local field experiments.
NMR spin diffusion experiments have the potential to provide both resonance assignment and internuclear distances for protein structure determination in oriented solid-state NMR. In this paper, we com...Read More
Sensitivity enhancement in static solid-state NMR experiments via single- and multiple-quantum dipolar coherences.
We present a new method for enhancing the sensitivity in static solid-state NMR experiments for a gain in signal-to-noise ratio of up to 40%. This sensitivity enhancement is different from the corresp...Read More
Effects of acetyl-DL-leucine in vestibular patients: a clinical study following neurotomy and labyrinthectomy.
For 40 years, the amino acid acetyl-DL-leucine (or isoleucine - Tanganil) has been used in clinical practice to reduce imbalance and autonomic manifestations associated with acute vertigo crises. In a...Read More
Pitch head-and-trunk movements during constant velocity rotation are a provocative vestibular stimulus that produces vertigo and nausea. When exposed to this stimulus repeatedly, motion sickness sympt...Read More
The acquisition and analysis of high resolution one- and two-dimensional solid-state nuclear magnetic resonance (NMR) spectra without chemical shift frequencies are described. Many variations of shift...Read More
Investigation of finite-pulse radiofrequency-driven recoupling methods for measurement of intercarbonyl distances in polycrystalline and membrane-associated HIV fusion peptide samples.
Two finite-pulse radiofrequency-driven recoupling (RFDR) methods were compared and applied to the measurement of 3-6 ? (13)CO-(13)CO distances in polycrystalline and membrane-associated HIV fusion pep...Read More
Maximum Entropy reconstruction is applied to two-dimensional PISEMA spectra of stationary samples of peptide crystals and proteins in magnetically aligned virus particles and membrane bilayers. Improv...Read More
The ribosome is a large RNP complex but its main enzymatic activity, the peptidyl transferase, is a ribozyme. As many RNA enzymes use divalent metal ions in catalysis, one of the hypotheses put forwar...Read More
A "magic sandwich" pulse sequence with reduced offset dependence for high-resolution separated local field spectroscopy.
A pulse sequence for high resolution separated local field spectroscopy based on "magic sandwich" elements is demonstrated on a single crystal sample. Simulations and experimental results sh...Read More
The experimental parameters critical for the implementation of multidimensional solid-state NMR experiments that incorporate heteronuclear spin exchange at the magic angle are discussed. This family o...Read More
[Effects of acetyl-DL-leucine on the recovery of the locomotor equilibrium and spontaneous discharge of lateral vestibular nucleus neurons in unilateral vestibular neurectomized cats].
The effects of acetyl-DL-leucine (AL) treatment (28 mg/kg.day, p.o.) on the vestibular compensation were studied over period of 6 weeks in unilateral vestibular neurectomized cats. This investigation ...Read More
To investigate the function of tRNAs or any other aminoacylable RNAs in vivo, it is important to be able to estimate the amounts and species of aminoacylated RNAs in living cells. We have developed a...Read More
Three-Dimensional Solid-State NMR Experiment That Correlates the Chemical Shift and Dipolar Coupling Frequencies of Two Heteronuclei
We're sorry this abstract is currently not available....Read More
Sensitivity enhanced heteronuclear correlation spectroscopy in multidimensional solid-state NMR of oriented systems via chemical shift coherences.
We present new sensitivity enhanced schemes for heteronuclear correlation spectroscopy (HETCOR) in solid-state NMR of oriented systems. These schemes will enhance the sensitivity of the HETCOR by 40% ...Read More
In vitro effects of acetyl-DL-leucine (tanganil) on central vestibular neurons and vestibulo-ocular networks of the guinea-pig.
For 40 years, the amino acid acetyl-DL-leucine (or isoleucine/Tanganil) has been used in clinical practice to reduce the imbalance and autonomic signs associated with acute vertigo crises. In animal m...Read More
Direct evidence for modified solvent structure within the hydration shell of a hydrophobic amino acid.
Neutron scattering experiments are used to determine scattering profiles for aqueous solutions of hydrophobic and hydrophilic amino acid analogs. Solutions of hydrophobic solutes show a shift in the m...Read More