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雄烯二酮

产品编号 A101164 | CAS号 63-05-8 | Aladdin
4-Androstene-3,17-dione
99%
组合的产品项目
货号 规格 库存 价格 数量
A101164-100mg 99% 上海(>10)
北方(预计3-5个工作日)
 
A101164-1g 99% 上海(8)
北方(预计3-5个工作日)
 
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属性

密度 1.1100
熔点 170-173°C

描述

别名 雄烯二酮 ;4-AD,4-雄烯二酮;Androstenedione 10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]ph 10,13-Dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
备注 仅用于分析实验室研究使用
应用 睾酮和带有雄激素活性代谢产物的前体,可能会增加前列腺癌(prostate cancer)或胰腺癌(pancreatic cancer)的风险。
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安全声明(欧洲) S22;S24/25;
WGK德国 3
参考文献
Markus A MA Lill, Fabienne F Winiger, Angelo A Vedani, Beat B Ernst
We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...Read More
Jing Yuan, Ronald L Johnson, Ruili Huang, Jennifer Wichterman, Hongying Jiang, Karen Hayton, David A Fidock, Thomas E Wellems, James Inglese, Christopher P Austin, Xin-zhuan Su
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...Read More
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....Read More
Leslie Harris O'Hanlon
We're sorry this abstract is currently not available....Read More
Ewa ?ucja Gregoraszczuk, Agnieszka Rak-Mardy?a
Evidence from both clinical and animal studies suggests that exposure to excess androgens results in cyst formation. The present in vitro study assessed the effects of supraphysiological concentration...Read More
Dalei Zhang, Bei Yang, Weiying Zou, Xiaying Lu, Mingdi Xiong, Lei Wu, Jinglei Wang, Junhong Gao, Sifan Xu, Ting Zou
Bone marrow stem cells (BMSCs) have the capacity to differentiate into mature cell types of multiple tissues. Thus, they represent an alternative source for organ-specific cell replacement therapy in ...Read More
M Galdiero, P Vitale, C Simeoli, L Afeltra, D Melis, C Alviggi, F Cariati, F Lo Calzo, C Di Somma, A Colao, R Pivonello
Deficiency of 17β-hydroxysteroid dehydrogenase type 3 (17βHSD3), an enzyme converting androstenedione (A) to testosterone (T), is a rare cause of autosomal recessive 46,XY disorder of sexual develop...Read More
Takeo Kosaka, Akira Miyajima, Hirohiko Nagata, Takahiro Maeda, Eiji Kikuchi, Mototsugu Oya
Physiologically relevant steroid 5α-reductase (SRD5A) activity that is essential for dihydrotestosterone (DHT) biosynthesis in human castration-resistant prostate cancer (CRPC) has not been fully cha...Read More
Joanna M Oswiecimska, Agnieszka Ksiazek, Katarzyna Sygulla, Magdalena Pys-Spychala, Grzegorz R Roczniak, Wojciech Roczniak, Malgorzata Stojewska, Katarzyna Ziora
Excessive hyperandrogenism, though proper hydrocortisone supplementation is a frequent clinical problem in girls with congenital adrenal hyperplasia (CAH). This may result from autonomic regulation of...Read More
Xiao-Yan Zhang, Yong Peng, Zhong-Rui Su, Qi-He Chen, Hui Ruan, Guo-Qing He
Biotransformation of phytosterol (PS) by a newly isolated mutant Mycobacterium neoaurum ZJUVN-08 to produce androstenedione has been investigated in this paper. The parameters of the biotransformation...Read More
Olivia A Petritz, David Sanchez-Migallon Guzman, Joanne Paul-Murphy, Kellie Fecteau, Asl? Mete, Philip H Kass, Michelle G Hawkins
Objective-To evaluate the effects of 4.7-mg deslorelin acetate implants on egg production and plasma concentrations of 17β-estradiol and androstenedione in Japanese quail (Coturnix coturnix japonica)...Read More
Marc W van der Kamp, Robin Chaudret, Adrian J Mulholland
Ketosteroid isomerase (Δ(5)-3-keto steroid isomerase or steroid Δ-isomerase) is a highly efficient enzyme at the centre of current debates on enzyme catalysis. We have modelled the reaction mechanis...Read More
Ercan Yilmaz, Onder Celik, Nilufer Celik, Yavuz Simsek, Ebru Celik, Engin Yildirim
In the current study, we aimed to investigate whether serum orexin-A (OXA) levels are different in polycystic ovary syndrome (PCOS) subjects.Thirty-six women with PCOS and 40 healthy, age and body mas...Read More
Sophie Rettenbacher, Rie Henriksen, Ton G Groothuids, Michael Lepschy
Glucocorticoids affect reproductive hormone production in many species. In chickens, elevated plasma corticosterone down-regulates testosterone and progesterone concentrations in plasma, but also in e...Read More
Denise Fernandes, Giorgio Dimastrogiovanni, Mercedes Blázquez, Cinta Porte
This study investigates the metabolism and mode of action of galaxolide (HHCB) in the European sea bass -Dicentrarchus labrax- following a single intraperitoneal injection of 50?mg HHCB/kg body weight...Read More
Chun-Chi Wang, Shu-Fang Cheng, Hui-Ling Cheng, Yen-Ling Chen
This study describes an on-line stacking CE approach by sweeping with whole capillary sample filling for analyzing five anabolic androgenic steroids in urine samples. The five anabolic steroids for de...Read More
S Arai, Y Shibata, Y Nakamura, B Kashiwagi, T Uei, Y Tomaru, Y Miyashiro, S Honma, K Hashimoto, Y Sekine, K Ito, H Sasano, K Suzuki
Intratumoural steroidogenesis may play a significant role in the progression of prostate cancer (PC) in the context of long-term ablation of circulating testosterone (T). To clarify the mechanism acco...Read More
Damjana Cvelbar, Vanja Zist, Katja Kobal, Du?an Zigon, Marija Zakelj-Mavri?
In the last couple of decades fungal infections have become a significant clinical problem. A major interest into fungal steroid action has been provoked since research has proven that steroid hormone...Read More
Floriane Guibert, Sophie Lumineau, Kurt Kotrschal, Erich M?stl, Marie-Annick Richard-Yris, Cécilia Houdelier
The prenatal environment is a source of phenotypic variability influencing the animal's characteristics. Prenatal stress affects not only the development of offspring, but also that of the follow...Read More
S N Schauer, D Guillaume, C Decourt, E D Watson, C Briant, F X Donadeu
There is evidence in several species that high circulating LH concentrations can interfere with normal follicle development and ovulation. In the mare, high LH levels after induction of luteolysis wit...Read More
Annette Mouritsen, Casper P Hagen, Kaspar S?rensen, Lise Aksglaede, Mikkel G Mieritz, Katharina M Main, Kristian Almstrup, Ewa Rajpert-De Meyts, Anders Juul
Longer androgen receptor gene CAG trinucleotide repeats, AR (CAG)n, have been associated with reduced sensitivity of the androgen receptor (AR) in vitro as well as in humans. Furthermore, short AR (CA...Read More
Juilee Rege, Yasuhiro Nakamura, Fumitoshi Satoh, Ryo Morimoto, Michael R Kennedy, Lawrence C Layman, Seijiro Honma, Hironobu Sasano, William E Rainey
Context: A broad analysis of adrenal gland-derived 19-carbon (C19) steroids has not been reported. This is the first study that uses liquid chromatography-tandem mass spectrometry to quantify 9 C19 st...Read More
M Y Roth, J J S Nya-Ngatchou, K Lin, S T Page, B D Anawalt, A M Matsumoto, B T Marck, W J Bremner, J K Amory
The concentration of intratesticular testosterone (IT-T) required for human spermatogenesis is unknown because spermatogenesis can persist despite the markedly reduced IT-T concentrations observed wit...Read More
Hidetaka Tasaki, Hisataka Iwata, Daichi Sato, Yasunori Monji, Takehito Kuwayama
Antrum formation and estradiol (E2) secretion occur during early folliculogenesis. The objective was to determine the role of E2 in antrum formation of oocyte-granulosa cell complexes (OGCs) derived f...Read More
C Kamrath, M F Hartmann, S Wudy
During the last year, alternative androgen synthesis pathways have been discovered in humans. This review article highlights these new concepts of androgen synthesis.We performed a selec-tive literatu...Read More
Wenqing Zhang, Minglong Shao, Zhiming Rao, Meijuan Xu, Xian Zhang, Taowei Yang, Hui Li, Zhenghong Xu
The enzyme 3-ketosteroid-Δ(1)-dehydrogenase (KSDD), involved in steroid metabolism, catalyzes the transformation of 4-androstene-3,17-dione (AD) to androst-1,4-diene-3,17-dione (ADD) specifically. It...Read More
Ivan Rubio-Gayosso, Israel Ramirez-Sanchez, Israel Ita-Islas, Pilar Ortiz-Vilchis, Gabriela Gutierrez-Salmean, Alejandra Meaney, Icela Palma, Ivonne Olivares, Ruben Garcia, Eduardo Meaney, Guillermo Ceballos
The role of testosterone in cardiovascular (CV) homeostasis is in controversy, and the exact effects of testosterone on the cardiovascular system remain poorly understood. Testosterone is metabolized ...Read More
V Vaggopoulos, E Trakakis, P Panagopoulos, G Basios, I Salloum, C Christodoulaki, C Chrelias
Since 2003, when the American Society for Reproductive Medicine (ASRM) and European Society of Human Reproduction and Embryology (ESHRE) sponsored consensus established criteria for polycystic ovarian...Read More
T S?eborg, H Frederiksen, P Fruekilde, T H Johannsen, A Juul, A M Andersson
Diagnosis and management of infants and children with sex steroid disorders require fast and simultaneous assessment of several sex steroid metabolites in serum at low concentrations and on small samp...Read More
K K Farker, H H Schweer, R R Vollandt, N N Nassr, U U Nagel, H W HW Seyberth, A A Hoffmann, M M Oettel
The purpose of the present work was to study the prostaglandin excretion in young nonpregnant ovulatory women during the menstrual cycle on the one hand and in postmenopausal women on the other hand a...Read More
H M Liebich, C Di Stefano, A Wixforth, H R Schmid
It is known that some modified, especially methylated, nucleosides originating from RNA degradation are excreted in abnormal levels in the urine of patients with malignant tumours and they have been p...Read More
R S RS Riikonen
Infants with cryptogenic infantile spasms seem to differ from those with symptomatic spasms in having a higher cerebrospinal fluid corticotropin content, different levels of corticotropin release afte...Read More
S Zarrilli, L Paesano, V Mirone, L Finelli, M De Rosa
268 patients (age 16-47 years) affected with idiopathic varicocele, submitted to surgery, have been studied. Semen analysis, pampiniphorm plexus doppler examination and testosterone, estradiol, D4 and...Read More
G Atkinson, D J Campbell, M L Cawood, R E Oakey
Little is known of the hormone environment of the developing early human embryo. We have therefore measured selected steroids in the intrauterine fluids of early pregnancy....Read More
M E Reichman, J T Judd, C Longcope, A Schatzkin, B A Clevidence, P P Nair, W S Campbell, P R Taylor
Most epidemiologic studies of the relationship between alcohol consumption and breast cancer risk over the past decade have shown that persons who consume a moderate amount of alcohol are at 40%-100% ...Read More
A T Kicman, S B Coutts, D A Cowan, D J Handelsman, C J Howe, S Burring, F C Wu
The ratio of urinary testosterone (T) to epitestosterone (EpiT) is used to detect T abuse in sport. Also, plasma or urinary concentrations of EpiT have been measured to assess testicular steroidogenes...Read More
C C Chavis, L L Fraissinet, P P Chanez, E E Thomas, J J Bousquet
We're sorry this abstract is currently not available....Read More
Willem A van Vloten, Christian W van Haselen, Esther J van Zuuren, Christoph Gerlinger, Renate Heithecker
A new oral contraceptive has been developed that contains a unique progestogen, drospirenone (DRSP), and that has both antiandrogenic and antimineralocorticoid activity. Our objective was to compare t...Read More
Kyung Mee Kim, Byung Hwa Jung, Dong-Seok Lho, Woung Youn Chung, Ki-Jung Paeng, Bong Chul Chung
To explore the possible involvement of a relationship between steroids and polyunsaturated fatty acids (PUFAs) in thyroid cancer, we studied the concentration levels of 21 endogenous urinary androgens...Read More
R H RH Straub, C C Weidler, B B Demmel, M M Herrmann, F F Kees, M M Schmidt, J J Sch?lmerich, J J Schedel
In rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), patients demonstrate low levels of adrenal hormones....Read More
Trine T Jensen, Mette M Klarlund, Michael M Hansen, Karl Erik KE Jensen, Henrik H Skj?dt, Lars L Hyldstrup,
To assess the applicability of serum concentrations of markers of synovial inflammation, cartilage, and bone metabolism in relation to conventional markers of disease activity, bone mineral density (B...Read More
Ravi R Jasuja, Pandurangan P Ramaraj, Ricky Phong RP Mac, Atam B AB Singh, Thomas W TW Storer, Jorge J Artaza, Aria A Miller, Rajan R Singh, Wayne E WE Taylor, Martin L ML Lee, Tina T Davidson, Indrani I Sinha-Hikim, Nestor N Gonzalez-Cadavid, Shalender S
Previous studies of Delta 4-androstene-3,17-dione (4-androstenedione) administration in men have not demonstrated sustained increments in testosterone levels, fat-free mass (FFM), and muscle strength,...Read More
S Zarrilli, G Lombardi, L Paesano, C Di Somma, A Colao, V Mirone, M De Rosa
Seven patients (aged 25-38 years) were admitted because of mono- or bilateral gynaecomastia. Plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, testosterone, 17-...Read More
R A RA Rajaratnam, H H Gylling, T A TA Miettinen
Squalene, found in earlier studies in human atherosclerotic plaques, was measured in the serum of postmenopausal women with coronary artery disease (CAD) (n = 25) and randomly chosen age-matched healt...Read More
R Heikkil?¤, K Aho, M Heli??vaara, M Hakama, J Marniemi, A Reunanen, P Knekt
BACKGROUND: It has been hypothesized that high androgen levels are determinants of prostate carcinoma. METHODS: Serum concentrations of testosterone, sex hormone-binding globulin (SHBG), and androsten...Read More
Bulent O BO Yildiz, Keslie S KS Woods, Frank F Stanczyk, Al A Bartolucci, Ricardo R Azziz
Adrenocortical secretion is up-regulated in women with polycystic ovary syndrome (PCOS), and absolute adrenal androgen (AA) excess is evident in approximately 25% of these patients. We hypothesized th...Read More
T Mune, H Morita, K Yasuda, M Murayama, N Yamakita, K Miura
The regulation of 19-hydroxyandrostenedione secretion has been suggested to be under the control of both the ACTH-adrenal axis and renin-angiotensin system. We undertook the present study to evaluate ...Read More
D S DS King, R L RL Sharp, M D MD Vukovich, G A GA Brown, T A TA Reifenrath, N L NL Uhl, K A KA Parsons
Androstenedione, a precursor to testosterone, is marketed to increase blood testosterone concentrations as a natural alternative to anabolic steroid use. However, whether androstenedione actually incr...Read More
Aitziber A Azurmendi, Francisco F Braza, Aizpea A Sorozabal, Ainhoa A García, Paloma P Braza, María R MR Carreras, José M JM Mu?oz, Jaione J Cardas, José R JR Sánchez-Martín
This study explores the potential relationship between a series of cognitive abilities and testosterone, dehydroepiandrosterone (DHEA), androstenedione, and body mass index (BMI) measurements in 5-yea...Read More
Catherine C Schairer, Deirdre D Hill, Susan R SR Sturgeon, Thomas T Fears, Carolyn C Mies, Regina G RG Ziegler, Robert N RN Hoover, Mark E ME Sherman
We sought to determine whether serum concentrations of estrogens, androgens, and sex hormone binding globulin in postmenopausal women were related to the presence of mammary hyperplasia, an establishe...Read More
P S Feldman, K Kovacs, E Horvath, G L Adelson
A 51-year-old man had a malignant Leydig cell tumor of the testis with elevation of serum estrone and androstenedione as well as urine chorionic gonadotropin. The fine structural features of the neopl...Read More
A A Johansson, A A Henriksson, B O BO Olofsson, T T Olsson
To evaluate circulating adrenal steroid hormones, cortisol diurnal rhythm and the negative feedback function of the cortisol axis in patients with dystrophia myotonica (DyM), a disease where metabolic...Read More
M M Egloff, N N Savouré, J J Tardivel-Lacombe, C C Massart, M M Nicol, H H Degrelle
The influence of human serum albumin and sex hormone binding globulin (SHBG) on the enzymic conversion of androstenedione to testosterone in human erythrocytes was investigated in vitro. Total plasma ...Read More
S S Schwarz, P P Pohl
We measured in simultaneously withdrawn cerebrospinal fluid (CSF) and serum samples from 56 endocrinologically grossly normal patients the concentrations of several lipophilic unconjugated steroids [i...Read More
O O Laitinen, E E Seppal?, M M Nissil?, H H Vapaatalo
No significant differences were found in plasma concentrations and urinary excretion of prostaglandin E2 (PGE2), 6-keto-prostaglandin-F1 alpha (6-keto-PGF1 alpha) and thromboxane B2 (TxB2), between rh...Read More
R R Schlaghecke, H K HK Kley, H L HL Krüskemper
A radioimmunoassay (RIA) method is described for the determination of 4-androstene-3, 11, 17-trione (11-oxo-androstenedione) in human plasma. 4-androstene-3, 11, 17-trione 3-(0-carboxymethyl) oxime-bo...Read More
G D Berkovitz, A Guerami, T R Brown, P C MacDonald, C J Migeon
We evaluated a family in which gynecomastia occurred in five males in two generations. In each affected subject, gynecomastia and male sexual maturation began at an early age. The ratio of the concent...Read More
C L?ser, U R F?lsch, C Paprotny, W Creutzfeldt
We investigated the total, free, and acetylated polyamine concentrations in pancreatic tissue, serum, and urine of 20 patients with pancreatic cancer, 30 healthy volunteers, and 40 patients with nonma...Read More
T T Sakai, K K Yamamoto, H H Yokota, K K Hakozaki-Usui, F F Hino, I I Kato
We devised a kit for use with automated analyzers, for assay of urinary free L-fucose by means of a newly isolated L-fucose dehydrogenase (EC 1.1.1.122), and we measured L-fucose in healthy subjects, ...Read More
Nan-Hee NH Jeong, Eun-Seop ES Song, Jong-Min JM Lee, Kwang-Beom KB Lee, Mi-Kyung MK Kim, Young-Mi YM Yun, Jae-Kwan JK Lee, Sung-Kyong SK Son, Jung-Pil JP Lee, Jae-Hoon JH Kim, Soo-Young SY Hur, Yong-Il YI Kwon
To examine the relation between the plasma concentration of antioxidant micronutrients and endometrial cancer risk in Korean women....Read More
Rachele R Berria, Amalia A Gastaldelli, Scott S Lucidi, Renata R Belfort, Eleanna E De Filippis, Caraan C Easton, Robert R Brytzki, Kenneth K Cusi, Lois L Jovanovic, Ralph R DeFronzo
Thiazolidinediones have gained widespread use for the treatment of type 2 diabetes mellitus and other insulin resistance states, including polycystic ovary syndrome (PCOS). In thiazolidinedione-treate...Read More
Gustav G Ahlin, Johan J Karlsson, Jenny M JM Pedersen, Lena L Gustavsson, Rolf R Larsson, P?r P Matsson, Ulf U Norinder, Christel A S CA Bergstr?m, Per P Artursson
The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In t...Read More
Artem A Cherkasov, Fuqiang F Ban, Osvaldo O Santos-Filho, Nels N Thorsteinson, Magid M Fallahi, Geoffrey L GL Hammond
A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data s...Read More
I J IJ Chopra, F F Santini, R E RE Hurd, G N GN Chua Teco
A highly sensitive, specific, and reproducible RIA has been developed to measure T4 sulfate (T4S) in ethanol extracts of serum. rT3 sulfate (rT3S) cross-reacted 7.1%, and T3S cross-reacted 0.59% in th...Read More
Chiang EP, Smith DE, Selhub J, Dallal G, Wang YC, Roubenoff R
Previously we observed strong and consistent associations between vitamin B6 status and several indicators of inflammation in patients with rheumatoid arthritis. Clinical indicators, including the dis...Read More
L L Viinikka, O O Ylikorkala
We're sorry this abstract is currently not available....Read More
Maurizio M Cutolo, Alberto A Sulli, Silvia S Capellino, Barbara B Villaggio, Paola P Montagna, Carmen C Pizzorni, Sabrina S Paolino, Bruno B Seriolo, Lamberto L Felli, Rainer H RH Straub
Whenever serum estrogen concentrations are normal in rheumatoid arthritis (RA) patients, lower androgen concentrations (i.e., testosterone, androstenedione, and dehydroepiandrosterone sulfate [DHEAS])...Read More
Patrick Bydal, Van Luu-The, Fernand Labrie, Donald Poirier
Androgens are well known to play a predominant role in prostate cancer and other androgen-dependent diseases. To decrease the level of androgen testosterone in the prostate, we are interested in devel...Read More
S S Thomson, A M AM Wallace, B B Cook
We developed a radioimmunoassay with a gamma-emitting radioligand to measure androstenedione in human serum and in dried blood-spot samples from newborns. Antisera were raised in rabbits against andro...Read More
Béatrice B Tchédam Ngatcha, Van V Luu-The, Fernand F Labrie, Donald D Poirier
Type 3 17beta-hydroxysteroid dehydrogenase (17beta-HSD) is involved in the biosynthesis of androgen testosterone. To produce potent inhibitors of this key steroidogenic enzyme, we prepared a series of...Read More
Margarida M D S MM Cepa, Elisiário J EJ Tavares da Silva, Georgina G Correia-da-Silva, Fernanda M F FM Roleira, Natércia A A NA Teixeira
Inhibition of aromatase is an efficient approach for the prevention and treatment of breast cancer. New A,D-ring modified steroid analogues of formestane and testolactone were designed and synthesized...Read More