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7-氨基头孢霉烷酸

产品编号 A101213 | CAS号 957-68-6 | 阿拉丁
7-Aminocephalosporanic acid
98%
组合的产品项目
货号 规格 库存 价格 数量
A101213-1g 98% 上海(>10)
北方(预计3-5个工作日)
 
A101213-25g 98% 上海(1)
北方(预计3-5个工作日)
 
A101213-5g 98% 上海(4)
北方(4)
 
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属性

密度 1.6000
熔点 >300°C
存贮条件 储存温度2-8°C

描述

别名 7-氨基头孢霉烷酸;7-ACA
应用 医药中间体。是许多半合成头孢菌素的起始原料。各种半合成头孢菌素的工业生产,是由发酵制得头孢菌素C。再用化学裂解获得母核7-ACA,然后进行化学改造的途径制取的。
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标识符号 GHS08 GHS08
信号词 Danger
风险声明 (欧洲) 42/43
安全声明(欧洲) 22,36/37
警示性声明 P261,P280,P342+P311
危害码(欧洲) Xn
危害声明 H317,H334
个人防护设备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves
WGK德国 3
Merck Index 434
参考文献
Caterina Boniello, Torsten Mayr, Juan M Bolivar, Bernd Nidetzky
Industrial-scale biocatalytic synthesis of fine chemicals occurs preferentially as continuous processes employing immobilized enzymes on insoluble porous carriers. Diffusional effects in these systems...Read More
D Lupa?cu, Cristina Tuchilu?, Maria Sutu, Alexandra Neagu, Lenu?a Profire
Many studies show that flavonoids have a numerous biological properties, antimicrobial effects included. It is also known that rutin is able to increase the antibacterial activity of other compounds.S...Read More
Emily Golden, Rachel Paterson, Wan Jun Tie, Anandhi Anandan, Gavin Flematti, Gianluca Molla, Elena Rosini, Loredano Pollegioni, Alice Vrielink
The crystal structure of the wild-type form of glutaryl-7-ACA (7-aminocephalosporanic acid) acylase from Pseudomonas N176 and a double mutant of the protein (H57βS/H70βS) that displays enhanced cata...Read More
Loredano Pollegioni, Elena Rosini, Gianluca Molla
Cephalosporins currently constitute the most widely prescribed class of antibiotics and are used to treat diseases caused by both Gram-positive and Gram-negative bacteria. Cephalosporins contain a 7-a...Read More
V A VA Redo, E K EK Novikova, M A MA él'darov
Effective recombinant strains Pichia pastoris that produce functionally active hybrid of Trigonopsis variabilis D-aminoacids bond with chitin-connecting domain of chitinase A1 of Bacillus circulans (D...Read More
Hideyuki Suzuki, Chiaki Yamada, Kyoko Kijima, Sayaka Ishihara, Kei Wada, Keiichi Fukuyama, Hidehiko Kumagai
Semisynthetic cephalosporins, the best-selling antibiotics worldwide, are derived from 7-aminocephalosporanic acid (7-ACA). Currently, in the pharmaceutical industrie, 7-ACA is mainly produced from ce...Read More
Yan Y Liu, Guihua G Gong, Chunbao C Zhu, Baoquan B Zhu, Youjia Y Hu
7-Amino cephalosporanic acid (7-ACA), which is currently obtained by chemical deacylation from cephalosporin C (CPC), is a major intermediate for industrial production of β-lactam antibiotics. 7-ACA ...Read More
Kin-Sing Wong, Wing-Ping Fong, Paul Wai-Kei Tsang
The industrial importance of Trigonopsis variabilisd-amino acid oxidase (TvDAAO) is represented by its biocatalytic oxidative deamination of cephalosporin C (CPC) to yield glutaryl-7-aminocephalospora...Read More
Jin Bai, Jian-fang Zou, Shao-qiu Sun
We're sorry this abstract is currently not available....Read More
Irene I Martínez-Martínez, Silvia S Montoro-García, José Daniel JD Lozada-Ramírez, Alvaro A Sánchez-Ferrer, Francisco F García-Carmona
A bromothymol blue-based colorimetric assay has been devised to screen for acetyl xylan esterase or cephalosporin C (CPC) deacetylase activities using 7-amino cephalosporanic acid (7-ACA), CPC, or ace...Read More
V K Nigam, S Kundu, P Ghosh
Entrapped cells of P. diminuta were used for the production of 7-aminocephalosporanic acid (7-ACA), a key intermediate required for the production of most of the clinically used cephalosporin derivati...Read More
Huabao H Zheng, Tongbo T Zhu, Jun J Chen, Yuhua Y Zhao, Weihong W Jiang, Guoping G Zhao, Sheng S Yang, Yunliu Y Yang
The main drawback in the industrial production of 7-aminocephalosporanic acid is the accumulation of intermediate (AKA-7-ACA) and destruction of substrate (cephalosporin C) catalyzed by catalase and @...Read More
Iskandar Dib, Anita Slavica, Waander Riethorst, Bernd Nidetzky
Trigonopsis variabilis D-amino acid oxidase (TvDAO) is a long-known flavoenzyme whose most important biocatalytic application is currently the industrial production of 7-amino-cephalosporanic acid (7-...Read More
Michael S MS Barber, Ulrich U Giesecke, Arno A Reichert, Wolfgang W Minas
Cephalosporins are chemically closely related to penicillins both work by inhibiting the cell wall synthesis of bacteria. The first generation cephalosporins entered the market in 1964. Second and thi...Read More
Hui H Luo, Qiang Q Li, Huimin H Yu, Zhongyao Z Shen
Two fusion proteins of D-amino acid oxidase (DAAO) and glutaryl-7-aminocephalosporanic acid acylase (GLA) were designed to simplify the bioconversion process of cephalosporin C to 7-aminocephalosporan...Read More
Hae-Sim HS Park, Ki-Up KU Kim, Young-Mok YM Lee, Jeong-Hee JH Choi, June-Hyuk JH Lee, Sung-Woo SW Park, An-Soo AS Jang, Choon-Sik CS Park
We're sorry this abstract is currently not available....Read More
Ying Wang, Huimin Yu, Jing Zhang, Hui Luo, Zhongyao Shen
The phenomenon of CPC decomposition occurs in Escherichia coli JM105/pMKC-sCPCacy during the one-step enzymatic conversion of cephalosporin C (CPC) into 7-aminocephalosporanic acid (7-ACA) by CPC acyl...Read More
Zaixing Z Li, Xuguang X Ren, Jiane J Zuo, Yanfang Y Liu, Erhong E Duan, Jingliang J Yang, Ping P Chen, Yongjun Y Wang
7-Aminocephalosporanic acid wastewater usually contains high concentrations of ammonium (NH??-N), which is known to inhibit nitrification during biological treatment processes. Chemical precipitation ...Read More
Julia M?rk, Max Andre, Martin Karner, Christian W Huck
NIR spectroscopy was applied to develop a fast and reliable quality control system for a pharmaceutical substance to support information obtained through PAT surveillance of its manufacturing process....Read More
Kumar K Gaurav, Kanika K Kundu, Subir S Kundu
The development of beta-lactam antibiotics has been a continuous battle of the design of new compounds to withstand inactivation by the ever-increasing diversity of beta-lactamases. Semisynthetic ceph...Read More
Kristóf Kóczián, Zoltán Szakács, József K?k?si, Béla Noszál
Acid-base chemistry of 6-aminopenicillanic acid (6-APA) and 7-aminocephalosporanic acid (7-ACA), the fundamental units of the two classical antibiotic families is characterised at the macroscopic and ...Read More
V K VK Nigam, S S Kundu, P P Ghosh
7-Aminocephalosporanic acid (7-ACA), the starting material for the production of a number of clinically used semisynthetic cephalosporins, is produced by deacylation of cephalosporin-C. The production...Read More
Akio A Takimoto, Tomoaki T Takakura, Hiroyoshi H Tani, Shigeo S Yagi, Kenji K Mitsushima
Bacillus subtilis SHS0133 cephalosporin-C deacetylase (CAH) overexpressed in Escherichia coli was immobilized on an anion-exchange resin, KA-890, using glutaraldehyde. The activity yield of immobilize...Read More