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阿曲汀

产品编号 A102064 | CAS号 55079-83-9 | Aladdin
Acitretin
98%
组合的产品项目
货号 规格 库存 价格 数量
A102064-100mg 98% 上海(预计3-5个工作日)
北方(预计3-5个工作日)
 
A102064-25mg 98% 上海(>10)
北方(预计3-5个工作日)
 
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属性

密度 1.0510

描述

别名 阿维A酸,9-(4-甲氧基-2,3,6-三甲基苯基)-3,7-二甲基-2,4,6,8-壬四烯酸; 芳香维A酸;9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
生化机理 合成类视黄醇,是一种依曲替酯(etretinate)的代谢物。优先结合到细胞视黄酸结合的蛋白质(CRABPs)上。
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标识符号 GHS07 GHS07, GHS08 GHS08, GHS09 GHS09
信号词 Danger
风险声明 (欧洲) 61,36/38,50/53
安全声明(欧洲) 53,26,45,60,61
警示性声明 P201,P273,P305+P351+P338,P308+P313,P501
危害码(欧洲) T,N
危害声明 H315,H319,H360,H410
个人防护设备 Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
WGK德国 3
UN代码 3077
参考文献
Byong Hoon Yoo, Sunshine Daddario Axlund, Peter Kabos, Brian G Reid, Jerome Schaack, Carol A Sartorius, Daniel V LaBarbera
Breast cancers expressing hormone receptors for estrogen (ER) and progesterone (PR) represent ~70% of all cases and are treated with both ER-targeted and chemotherapies, with near 40% becoming resista...Read More
Justin Cheeley, Rachel E Sahn, Laura K Delong, Sareeta R Parker
Bexarotene is the only Food and Drug Administration-approved retinoid for the treatment of cutaneous T-cell lymphoma (CTCL) and is associated with a relatively high frequency of adverse effects. Acitr...Read More
Y P Tian, L Yao, P Malla, Y Song, S S Li
Giant condyloma acuminatum, or Buschke-L?wenstein tumour, is a unique variant of anogenital warts. It is characterized by locally aggressive behaviour but rarely metastasizes. Many treatment strategie...Read More
Rachael R Anforth, Tatiana Cristina Moraes Pinto TC Blumetti, Azura A Mohd Affandi, Pablo P Fernandez-Penas
We're sorry this abstract is currently not available....Read More
P P Mavrogianni, E E Fallidas, E E Nicolaidou, K K Villias, I I Stefanaki, A A Katsambas, T T Lira, P P Apostolopoulos, I I Androne, G G Rouvas, P P Tsibouris, G G Alexandrakis
Giant condyloma acuminatum (GCA), or Buschke-L?wenstein tumour (BLT), is a rare large tumour of the anogenital area. It is caused by human papillomavirus genotypes 6 and 11, and it is characterized by...Read More
Gino A Vena, Nicoletta Cassano
Alcohol has long been suspected to be a triggering and precipitating factor of psoriasis. Alcohol misuse is common in patients with moderate-to-severe psoriasis and appears to impair treatment outcome...Read More
Sanjeev Srinivas SS Kumar, Stephen S Lee
A 51-year-old man presented with a 12-year history of an expanding, irritable rash on his buttocks, groin and scrotum. He gradually developed erythematous, annular plaques with ridged borders and depr...Read More
Rajiv I Nijhawan, Achiamah Osei-Tutu, Jeremy M Hugh
Increased cases of acquired epidermodysplasia verruciformis (EDV) have been reported in patients with human immunodeficiency virus (HIV). With regard to management, there are no randomized controlled ...Read More
Filomena S G Silva, Mariana P C Ribeiro, Maria S Santos, Petronila Rocha-Pereira, Alice Santos-Silva, José B A Custódio
Acitretin is a synthetic retinoid used for severe extensive psoriasis and it has been shown to be an effective and a safe therapeutic drug for other diseases including cancer when used in combination ...Read More
M M Tang, Z Spanou, H Tang, F Schibler, N Pelivani, N Yawalkar
Generalized pustular psoriasis (GPP) is a severe inflammatory disease characterized by recurrent eruptions of sterile pustules on erythematous skin. Although tumor necrosis factor (TNF) antagonists ma...Read More
Ming-Lian Yu, Yue Yang, Cong-Min Wang, Meng-Meng Zhang, Miao-Chun Bai, Yue-Ling Guo
The present study aimed to evaluate the potential risk of drug-drug interactions associated with acitretin which is a drug for therapy of psoriasis approved by the Food and Drug Administration (FDA). ...Read More
F Tippmann, J Hundt, A Schneider, K Endres, F Fahrenholz
Late-onset Alzheimer's disease is often connected with nutritional misbalance, such as enhanced cholesterol intake, deficiency in polyunsaturated fatty acids, or hypovitaminosis. The alpha-secret...Read More
Xiu-Ying Lin, Chun-Di He, Ting Xiao, Xin Jin, Jiang Chen, Ya-Kun Wang, Mei Liu, Kai-Bo Wang, Yi Jiang, Hua-Chen Wei, Hong-Duo Chen
Skin cancers are by far the most common human malignancies. Retinoids have shown promising preventive and therapeutic effects against a variety of human malignancies. The aim of this study was to inve...Read More
David D Holthoewer, Kristina K Endres, Florian F Schuck, Christoph C Hiemke, Ulrich U Schmitt, Falk F Fahrenholz
ADAM10 (a disintegrin and metalloproteinase 10) has been demonstrated to act as the main physiological α-secretase. Enzymatic activity of the α-secretase on the one hand prevents the formation of to...Read More
Justin D Lutz, Vaishali Dixit, Catherine K Yeung, Leslie J Dickmann, Alex Zelter, Jayne E Thatcher, Wendel L Nelson, Nina Isoherranen
Retinoic acid (RA) is a critical signaling molecule that performs multiple functions required to maintain cellular viability. It is also used in the treatment of some cancers. Enzymes in the CYP26 fam...Read More
F S G Silva, H Oliveira, A Moreiras, J C Fernandes, E Bronze-da-Rocha, A Figueiredo, J B A Custódio, P Rocha-Pereira, A Santos-Silva
Acitretin is currently used alone or combined with PUVA (psoralen + UVA) or with narrow-band ultraviolet B (NBUVB), to treat moderate and severe psoriasis. However, little is known about the potential...Read More
P Bilan, A Levy, C Sin, A Marchal, M-L Sigal, E Mahé
Erythrokeratodermia variabilis (EKV) is a rare genodermatosis associated with keratinisation disorders. Mutations are found in genes encoding connexin 31 and 30.3 mapped to chromosome 1 p34-35. We rep...Read More
F Ricceri, L Pescitelli, L Tripo, A Bassi, F Prignano
Nail psoriasis is common in adult psoriatic patients. Although several new drugs have recently been introduced for the treatment of skin psoriasis, treatment of nail psoriasis still remains a challeng...Read More
John J Digiovanna, Theodora Mauro, Leonard M Milstone, Matthias Schmuth, Jorge R Toro
The term retinoid includes both natural and synthetic derivatives of vitamin A. Retinoid-containing treatments have been used since ~1550BC by the early Egyptians. Treatment of ichthyosiform disorde...Read More
Roberta Gualtierotti, Gabriele De Marco, Antonio Marchesoni
We're sorry this abstract is currently not available....Read More
Hsien-Yi Chiu, Tsen-Fang Tsai
We're sorry this abstract is currently not available....Read More
Peter J Green, Sylvia Pasternak
Hypertrophic lupus is an uncommon clinical variant of chronic cutaneous lupus that remains a challenge to treat. A 45-year-old female day-care worker with long-standing lupus presented with hypertroph...Read More
Nevena Skroza, Ilaria Proietti, Nicoletta Bernardini, Francesca Nicolucci, Ersilia Tolino, Giorgio La Viola, Diego Orsini, Sara Zuber, Concetta Potenza
We're sorry this abstract is currently not available....Read More
Sandra Philipp, Dagmar Wilsmann-Theis, Ansgar Weyergraf, Sebastian Rotterdam, Yvonne Frambach, Sascha Gerdes, Rotraut M?ssner
Monotherapy with TNF-α inhibitors does not always produce a sufficient response in psoriasis patients. Combinations of TNF-α antagonists such as adalimumab with systemic antipsoriatic therapies such...Read More
Howa Yeung, Joy Wan, Abby S Van Voorhees, Kristina Callis Duffin, Gerald G Krueger, Robert E Kalb, Jamie D Weisman, Brian R Sperber, Bruce A Brod, Stephen M Schleicher, Bruce F Bebo, Daniel B Shin, Andrea B Troxel, Joel M Gelfand
Despite widespread dissatisfaction and low treatment persistence in moderate to severe psoriasis, patients' reasons behind treatment discontinuation remain poorly understood.We sought to characte...Read More
Emiliano Antiga, Walter Volpi, Elisa Cardilicchia, Laura Maggi, Lucia Filì, Cinzia Manuelli, Paola Parronchi, Paolo Fabbri, Marzia Caproni
To evaluate circulating and lesional CD4(+) and CD8(+) cells belonging to Th1, Th2, and Th17 patterns as well as IL-10(+) cells before and after a 12-week lasting course with etanercept or acitretin i...Read More
Kate K Newland, Gillian G Marshman
Post-irradiation morphoea is a rare but under-recognised complication of radiotherapy treatment for breast cancer. Management of this condition is difficult, and many cases are recalcitrant to therapy...Read More
H S Füessl, P Stiefelhagen
We're sorry this abstract is currently not available....Read More
Lindsay LaPresto, Lee Cranmer, Lynne Morrison, Christof P Erickson, Clara Curiel-Lewandrowski
We're sorry this abstract is currently not available....Read More
Vincenzo Bettoli, Stefania Zauli, Anna Virgili
Introduction: The chemoprevention refers to the use of various types of chemical agents for preventing carcinogenic progression. Systemic retinoids are the most studied chemopreventive agents due to t...Read More