¥ 127.00

产品编号 A103534 | CAS号 50-81-7 | 阿拉丁
Ascorbic acid
99.99% metals basis
货号 规格 库存 价格 数量
A103534-100g 99.99% metals basis 上海(>10)
A103534-500g 99.99% metals basis 上海(10)


敏感性 对光线敏感
旋光率 21 ° (C=10, H2O)
密度 1.7000
熔点 190-192°C
存贮条件 充氩保存


产品介绍 在空气中遇光渐变黄,水溶液呈酸性反应,在空气中易氧化变质。溶于水、醇,不溶于苯、氯仿及乙醚.
别名 L-抗坏血酸;维他命C;维生素C;丙种维生素;2,3,4,5,6-五羟基-2-己烯酸-4-内酯;L-(+)-抗坏血酸维生素C;Vitamin C; L-Ascorbic acid; L-Xyloascorbic acid; 3-Oxo-L-gulofura-nolactone(enol form); L-Threoascorbic acid; Antiscorbutic factor;
生化机理 It protects cells against the damaging effects of radiation and oxygen radicals,increases the rate of mineralization in osteoblasts,reduces Na+/Ca2+ exchange in cultured astrocytes,modulates cyclic nucleotide levels in B and T cells inhibits apoptosis in cultured rat ovarian follicles.
应用 测定砷、铁、磷及碘的基准试剂,色谱分析试剂,抗氧剂,掩蔽剂,还原剂
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安全声明(欧洲) S24/25
个人防护设备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS CI7650000
WGK德国 1
Merck Index 830
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ortho-Dihydroxyisoflavone derivatives isolated from aged Doenjang (1-3) are reported....Read More
Jun-Seong Park, Dong Hyun Kim, Jae Kyoung Lee, Jin Young Lee, Duck Hee Kim, Han Kon Kim, Hak-Ju Lee, Ho Cheol Kim
Natural o-dihydroxyisoflavone (ODI) derivatives with variable hydroxyl substituent at the aromatic ring of isoflavone and three known isoflavones were isolated from five-year-old Korean fermented soyb...Read More
Judit Bartalis, Fathi T Halaweish
The aim of this study was to evaluate cucurbitacins (Cucs) liver protective activity in vitro and conduct QSAR studies against lipophilicity and ab initio descriptors. Nine Cucs were isolated from Cuc...Read More
Sungbum S Kim, Youngmin Y Kim, Younggyu Y Kong, Hyojung H Kim, Jahyo J Kang
A new hybrid derived from retinol was designed to improve the stability and anti-oxidant activity of retinol and also to add whitening properties besides its usual anti-aging properties. A variety of ...Read More
Munirah M Sha'ban, Soon Hee SH Kim, Ruszymah Bh RB Idrus, Gilson G Khang
Synthetic- and naturally derived- biodegradable polymers have been widely used to construct scaffolds for cartilage tissue engineering. Poly(lactic-co-glycolic acid) (PLGA) are bioresorbable and bioco...Read More
Seung Hwan Kim, Ch Naveen Kumar, Hyoung Ja Kim, Dong Han Kim, Jungsook Cho, Changbae Jin, Yong Sup Lee
Due to high reactivity, reactive oxygen species can attack biological molecules leading to cell or tissue injury. In this study, glucose moiety was attached at the C-7 position of quercetin 3-O-methyl...Read More
Kui Zeng, Karin Emmons Thompson, Charles R Yates, Duane D Miller
Quinic acid (QA) esters found in hot water extracts of Uncaria tomentosa (a.k.a. cat's claw) exert anti-inflammatory activity through mechanisms involving inhibition of the pro-inflammatory trans...Read More
Karen Pauwelyn, Philip Roelandt, Tineke Notelaers, Pau Sancho-Bru, Johan Fevery, Catherine M Verfaillie
Mouse embryonic stem cells (mESC) have been used to study lineage specification in vitro, including towards a hepatocyte-like fate, and such investigations guided lineage differentiation protocols for...Read More
Jonathan Ferrand, Philippe Lehours, Annie Schmid-Alliana, Francis Mégraud, Christine Varon
The role of bone marrow-derived mesenchymal stem cells (MSC) in the physiology of the gastrointestinal tract epithelium is currently not well established. These cells can be recruited in response to i...Read More
Kanagasabai Kanagalakshmi, Mariappan Premanathan, Ragunathan Priyanka, Balasubramanian Hemalatha, Arumugasamy Vanangamudi
A convenient, fast and high yielding method for the preparation of 7-methoxyisoflavanone and 2,3-diarylchromanones has been developed by the condensation of benzyl-2-hydroxy-4-alkoxyphenylketone with ...Read More
Bakr F Abdel-Wahab, Ghada EA Awad, Farid A Badria
In the present work, 1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethanone 1 was prepared and used as a precursor for the synthesis of new thiazole, arylidiene and coumarin derivatives. The antimicrobial, an...Read More
Seif-Eldin N SE Ayyad, Mohamed S MS Makki, Nazeeha S NS Al-Kayal, Salim A SA Basaif, Kalid O KO El-Foty, Abdullah M AM Asiri, Walied M WM Alarif, Farid A FA Badria
Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, Amijiol-7, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopach...Read More
M L Alves da Silva, A Martins, A R Costa-Pinto, P Costa, S Faria, M Gomes, R L Reis, N M Neves
Mesenchymal stem cells (MSCs) have been recognized for their ability to differentiate into cells of different tissues such as bone, cartilage, or adipose tissue, and therefore are of great interest fo...Read More
Michelle M Korda, Jia J Hua, Nick J NJ Little, Nima N Heidari, Gordon W GW Blunn
Revision total hip replacement has a failure rate of up to 25%. Part of the reason for this high failure is the lack of bone stock. In this study, we investigated whether mesenchymal stromal cells (MS...Read More
Lean-Teik Ng, Horng-Huey Ko, Tzy-Ming Lu
Deoxybenzoins (DOBs) are one-pot synthetic precursors of isoflavones with feature analogous to those beneficial polyphenols such as resveratrol (stilbene) and phloretin (dihydrochalcone). In this stud...Read More
Qinghao Q Jin, Xiang Hua XH Han, Seong Su SS Hong, Chul C Lee, Sanggil S Choe, Dongho D Lee, Youngsoo Y Kim, Jin Tae JT Hong, Mi Kyeong MK Lee, Bang Yeon BY Hwang
Two new oligostilbenes, caragasinins A (5) and B (10), and eight known compounds, kobophenol A (1), (+)-α-viniferin (2), (+)-ampelopsin F (3), pallidol (4), (+)-isoampelopsin F (6), miyabenol C (7), ...Read More
Takashi T Yoshida, Ryuji R Inoue, Takashi T Morii, Nobuaki N Takahashi, Shinichiro S Yamamoto, Yuji Y Hara, Makoto M Tominaga, Shunichi S Shimizu, Yoji Y Sato, Yasuo Y Mori
Transient receptor potential (TRP) proteins form plasma-membrane cation channels that act as sensors for diverse cellular stimuli. Here, we report a novel activation mechanism mediated by cysteine S-n...Read More
N Garamszegi, S P Garamszegi, P Samavarchi-Tehrani, E Walford, M M Schneiderbauer, J L Wrana, S P Scully
Matrix remodeling, degradation, inflammation and invasion liberate peptide fragments that can subsequently interact with cells in an attachment-independent manner. Such 'soluble' matrix comp...Read More
Abdullah Ozer, Richard K Bruick
We're sorry this abstract is currently not available....Read More
Brice B Nadal, Sophie A-L SA Thetiot-Laurent, Serge S Pin, Jean-Philippe JP Renault, Damien D Cressier, Ghassoub G Rima, Antoine A Le Roux, Stéphane S Meunier, Alain A Wagner, Claude C Lion, Thierry T Le Gall
The synthesis of three types of pulvinic acid analogues, using a diversity-oriented strategy starting from a single compound, dimethyl l-tartrate, is described. Lacey-Dieckmann condensation, alcohol d...Read More
Elizabeth M O EM Yeboah, Runner R T RR Majinda, Anders A Kadziola, Alfred A Muller
Three new dihydro-beta-agarofuran polyesters, 1alpha,9beta-difuranoyloxy-2-oxodihydro-beta-agarofuran (1), 1alpha,9beta-difuranoyloxy-2-oxo-3-enedihydro-beta-agarofuran (2), and 1alpha,9beta-difuranoy...Read More
Katherine R Leaver, Haydn N Allbutt, Nathan J Creber, Michael Kassiou, Jasmine M Henderson
Much recent work is investigating the role of oxidative stress and inflammatory mechanisms in the aetiology of neurodegeneration in Parkinson's disease. The present study evaluated whether the gr...Read More
Antonio Dell'Anno, Cinzia Corinaldesi, Mirko Magagnini, Roberto Danovaro
Viruses are the most abundant and dynamic biological entities in the world's ecosystems. Marine sediments, the largest biome in the world, have the potential to represent an optimal environment f...Read More
Eslam Nouri-Nigjeh, Hjalmar P Permentier, Rainer Bischoff, Andries P Bruins
The study of oxidative drug metabolism by Cytochrome P450s (P450) is important in the earlier stages of drug development. For this purpose, automated analytical techniques are needed for fast and accu...Read More
A S Thakor, H G Richter, A D Kane, C Dunster, F J Kelly, L Poston, D A Giussani
Episodes of hypoxia in utero present a potentially serious challenge to the fetus, but are counteracted by defence responses including marked redistribution of blood flow from peripheral circulations ...Read More
Jenna E JE Fong, Damien D Le Nihouannen, Svetlana V SV Komarova
During breast cancer metastasis to bone, tumor cells home to bone marrow, likely targeting the stem cell niche, and stimulate osteoclasts, which mediate osteolysis required for tumor expansion. Althou...Read More
Damien Le Nihouannen, Jake E Barralet, Jenna E Fong, Svetlana V Komarova
Ascorbic acid (AA) plays a key role in bone formation. However controversy remains about the effect of AA on cells responsible for bone destruction, osteoclasts. We investigated the effect of AA on os...Read More
Eric H Chudler, Ying Lu
The basal ganglia are involved not only with motor processes such as posture, pre-movement planning and movement initiation, but also with the processing and modulation of nociceptive somatosensory in...Read More
N Yamamoto, J-J Soghomonian
Striatal projection neurons use GABA as their neurotransmitter and express the rate-limiting synthesizing enzyme glutamic acid decarboxylase (GAD) and the vesicular GABA transporter vGAT. The chronic ...Read More
Louise C Parr-Brownlie, Stacey L Poloskey, Debra A Bergstrom, Judith R Walters
Parkinson's disease is associated with increased oscillatory firing patterns in basal ganglia output, which are thought to disrupt thalamocortical activity. However, it is unclear how specific th...Read More
P Tyagi, D Postetter, D L Saragnese, C L Randall, M A Mirski, D H Gracias
Spatially resolved electrochemical recording of neurochemicals is difficult due to the challenges associated with producing nanometer-scale patternable and integrated sensors. We describe the lithogra...Read More
Xiao-Qing Zhang, Su-Chun Zhang
Directed differentiation of human embryonic stem cells (hESCs) to a functional cell type, including neurons, is the foundation for application of hESCs. We describe here a reproducible, chemically def...Read More
Hichame Id Boufker, Laurence Lagneaux, Mehdi Najar, Martine Piccart, Ghanem Ghanem, Jean-Jacques Body, Fabrice Journé
The proto-oncogene Src is an important non-receptor protein tyrosine kinase involved in signaling pathways that control cell adhesion, growth, migration and differentiation. It negatively regulates os...Read More
Jonathan E Kohler, Jeff Mathew, Kaniza Tai, Amy L Blass, Edward Kelly, David I Soybel
Caspase-3, a pro-apoptotic enzyme, represents a class of proteins in which the active site contains reduced thiol (S-H) groups and is modulated by heavy metal cations, such as Zn(2+). We explored the ...Read More
Colin A CA Lowery, Kathleen M KM McKenzie, Longwu L Qi, Michael M MM Meijler, Kim D KD Janda
Quorum sensing activity was investigated in the bacterium Vibrio harveyi using a series of both natural and nonnatural analogs of DPD, the penultimate precursor to autoinducer AI-2. The progression of...Read More
Chao C Ma, Wei W Wang, Yun-Yun YY Chen, Rui-Ning RN Liu, Ru-Feng RF Wang, Li-Jun LJ Du
Bioactivity-guided fractionation of an ethanol extract of the aerial parts of Dioscorea opposita afforded a new compound, 6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione (1), and four known compounds, c...Read More
Xiang-Hai XH Cai, Xiao-Dong XD Luo, Jun J Zhou, Xiao-Jiang XJ Hao
Five new quinone derivatives, (R)-7-hydroxy-alpha-dunnione (1), (R)-8-hydroxy-alpha-dunnione (2), (R)-7,8-dihydroxy-alpha-dunnione (3), (R)-7-methoxy-6,8-dihydroxy-alpha-dunnione (4), and 1,7-dihydrox...Read More
Kayo K Akiyama, Hiroe H Kikuzaki, Takako T Aoki, Akiko A Okuda, Nordin H NH Lajis, Nobuji N Nakatani
Four new terpenoids and a diarylheptanoid were isolated together with 16 known compounds from rhizomes of Zingiber ottensii. The structures of the new compounds were determined to be 1,10,10-trimethyl...Read More
Young-Whan Choi, Satoshi Takamatsu, Shabana I Khan, Pullela V Srinivas, Daneel Ferreira, Jianping Zhao, Ikhlas A Khan
Phytochemical investigation of the fruits of Schisandra chinensis led to the isolation of 13 lignans including schisandrene (13), a new lignan based on a dibenzocyclooctadiene backbone with an exocycl...Read More
Ya-Ching Shen, Chia-Ching Liaw, Yuan-Bin Cheng, Atallah F Ahmed, Mei-Chou Lai, Shorong-Shii Liou, Tian-Shung Wu, Yao-Haur Kuo, Yu-Chi Lin
Four new C18 dibenzocyclooctadiene lignans, kadsuphilins A (1) and B (3), 6-epi-gomisin (2), and 1-demethylkadsuphilin A (4), along with eight known related metabolites, were isolated from an EtOAc fr...Read More
Vidavalur V Siddaiah, Muchchintala M Maheswara, Chunduri C Venkata Rao, Somepalli S Venkateswarlu, Gottumukkala V GV Subbaraju
Intricatin (2) has been revised into 3 and antioxidant activity results are reported....Read More
Chan Woo CW Lee, Eun-Mi EM Son, Han Sung HS Kim, Pan P Xu, Tuyagerel T Batmunkh, Burm-Jong BJ Lee, Kyung Ah KA Koo
The synthesis of the potent melanin formation inhibitors (1-3) is reported....Read More
Antonio Fiorentino, Brigida D'Abrosca, Severina Pacifico, Giuseppe Cefarelli, Piera Uzzo, Pietro Monaco
Two new dibenzoxazepinones have been isolated from the leaves of Carex distachya, an herbaceous plant growing in the Mediterranean area. The structures have been elucidated on the basis of their spect...Read More
Basavaraj Girennavar, G K Jayaprakasha, Y Jadegoud, G A Nagana Gowda, Bhimanagouda S Patil
Bergaptol and geranylcoumarin were isolated from grapefruit and characterized using MS and NMR studies. Both the compounds were tested for their radical scavenging property using ABTS and DPPH methods...Read More
Khurshid I KI Molvi, Kamala K KK Vasu, Swapnil G SG Yerande, Vasudevan V Sudarsanam, Navedul N Haque
A series of new tetrasubstituted thiophenes (4a-4i, 5a-5i and 6a-6f) have been synthesized as novel anti-inflammatory agents and were evaluated for their anti-inflammatory activity in carrageenin-indu...Read More
Ya-Ching YC Shen, Yuan-Bin YB Cheng, Ting-Wei TW Lan, Chia-Ching CC Liaw, Shorong-Shii SS Liou, Yao-Haur YH Kuo, Ashraf Taha AT Khalil
Eight new oxygenated lignans, kadsuphilols A-H (1-8), were isolated from the leaves and stems of Kadsura philippinensis. Four of the isolated lignans (1-4) possess the normal C18-dibenzocyclooctadiene...Read More
Wen-Liang WL Wang, Zhen-Yu ZY Lu, Hong-Wen HW Tao, Tian-Jiao TJ Zhu, Yu-Chun YC Fang, Qian-Qun QQ Gu, Wei-Ming WM Zhu
Twelve new compounds, variecolorins A-L ( 1- 12), together with eleven known analogues ( 13- 23) were isolated from the broth of a halotolerant fungus, Aspergillus variecolor. The structures of compou...Read More
Clara C Cena, Konstantin K Chegaev, Silvia S Balbo, Loretta L Lazzarato, Barbara B Rolando, Marta M Giorgis, Elisabetta E Marini, Roberta R Fruttero, Alberto A Gasco
A new class of products in which NO-donor moieties are linked to either the 3-OH or 2-OH group of ascorbic acid was synthesized. Their physico-chemical properties, antioxidant and vasodilator activiti...Read More
Tomohiro T Itoh, Kenji K Ohguchi, Munekazu M Iinuma, Yoshinori Y Nozawa, Yukihiro Y Akao
Polymethoxy flavones (PMFs) are present in fruit tissues of Citrus species. It has been reported that flavonoids isolated from several Citrus have been shown to suppress the degranulation as inferred ...Read More
P Torres, P Galleguillos, E Lissi, C López-Alarcón
The ORAC methodology using pyrogallol red as probe has been employed to estimate the antioxidant capacity and simultaneously, the concentration of ascorbic acid in human blood plasma and human urine....Read More
Fabrice Bailly, Clémence Queffélec, Gladys Mbemba, Jean-Fran?ois Mouscadet, Nicole Pommery, Jean Pommery, Jean-Pierre Hénichart, Philippe Cotelle
A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 inte...Read More
Zhimei Z Zhong, Ronge R Xing, Song S Liu, Lin L Wang, Shengbao S Cai, Pengcheng P Li
Chitosan (CS) with two different molecular weights was modified by reacting with 4-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride or 2-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride to give new 2-...Read More
Axel A Teichert, Jürgen J Schmidt, Andrea A Porzel, Norbert N Arnold, Ludger L Wessjohann
Chemical analysis of the fruiting bodies of the agaricoid fungus Cortinarius subtortus yielded three new natural products, two quinoline and one isocarbostyryl alkaloid. The structures of compounds 1-...Read More
Yalin Wu, Denong Wang
The structure of an antiradical arabinoglucogalactan ( 1) from Panax notoginseng roots was determined. This polymeric carbohydrate was obtained through successive phosphate buffer (pH 7.0) extraction ...Read More
Li L Chen, Yuchun Y Fang, Tianjiao T Zhu, Qianqun Q Gu, Weiming W Zhu
Nine new gentisyl alcohol derivatives, namely, the trimeric terrestrol A (8), dimeric terrestrols B-H (1-7), and a monomeric derivative (12), together with four known analogues (9-11, 13) were isolate...Read More
Yan Chen, Xiaoyi Wei, Haihui Xie, Hongzhu Deng
Two 2-phenylbenzofurans, lespedezavirgatol (1) and lespedezavirgatal (2), and a coumestan, lespedezacoumestan (3), were isolated from the aerial parts of Lespedeza virgata, together with nine known fl...Read More
Lei Xiang Yang, Ke Xin Huang, Hai Bo Li, Jing Xu Gong, Feng Wang, Yu Bing Feng, Qiao Feng Tao, Yi Hang Wu, Xiao Kun Li, Xiu Mei Wu, Su Zeng, Shawn Spencer, Yu Zhao, Jia Qu
A series of C7-O- and C20-O-amidated 2,3-dehydrosilybin (DHS) derivatives ((+/-)-1a-f and (+/-)-2), as well as a set of alkenylated DHS analogues ((+/-)-4a-f), were designed and de novo synthesized. A...Read More
Ho-Il Choi, Heung-Jae Kim, Jong-Il Park, Eun-Ho Shin, Dong-Won Kim, Soung-Soo Kim
Collagen is critical for skin strength and elasticity, and its degradation leads to wrinkles that accompany aging. Based emphasis on the aesthetics, we tried to make a new compound that can highly sti...Read More
Feng F Shi, Chunmei C Li, Ming M Xia, Kangjie K Miao, Yanxia Y Zhao, Shujiang S Tu, Weifa W Zheng, Ge G Zhang, Ning N Ma
The green chemoselective synthesis of thiazolo[3,2-a]pyridine derivatives was achieved in water via microwave-assisted three-component reactions of malononitrile, aromatic aldehydes and 2-mercaptoacet...Read More
Rohan A Davis, Gregory A Fechner, Melissa Sykes, Agatha Garavelas, David M Pass, Anthony R Carroll, Rama Addepalli, Vicky M Avery, John NA Hooper, Ronald J Quinn
Bioassay-guided fractionation of the organic extract from the marine sponge Acanthella costata resulted in the isolation of the known natural product, (-)-dibromophakellin (1). Using a fluorescence im...Read More
Jingxu Gong, Kexin Huang, Feng Wang, Leixiang Yang, Yubing Feng, Haibo Li, Xiaokun Li, Su Zeng, Xiumei Wu, Joachim St?ckigt, Yu Zhao, Jia Qu
An unusual class of 5,6,7-trioxygenated dihydroflavonols (3a-e and 4a-j) were designed and prepared. Their antioxidative properties were assessed by examining their capacities in several in vitro mode...Read More
Thoraya A TA Farghaly, Mohamed M MM Abdalla
2-Dimethylaminomethylene-1-benzosuberone 1 was coupled with diazotized aniline derivatives to afford a series of the hitherto unreported 2-arylazo-1-benzosuberones 3a-i. The tautomeric structure and t...Read More
P Manojkumar, T K Ravi, S Gopalakrishnan
A series of novel 1-(4-methylcoumarinyl-7-oxyacetyl)-3,5-dimethyl-4(arylazo)pyrazoles and 1-(4-methylcoumarinyl-7-oxyacetyl)-3-methyl-4-(substituted phenyl) hydrazono-2-pyrazolin-5-ones were synthesis...Read More
A B A AB El-Gazzar, M M MM Youssef, A M S AM Youssef, A A AA Abu-Hashem, F A FA Badria
The 5,10-dihydro-2-thioxo-pyrimido[4,5-b]quinolines (2a-c) and its oxidized form 3 were prepared and used as key intermediates for the synthesis of thiazolo[3',2':1,2]pyrimido[4,5-b]-quinoli...Read More
Abd El-Galil E Ael-G Amr, Korany A KA Ali, Mohamed M MM Abdalla
The terpenoidal oxaliplatin derivatives (6) and (12) were newly synthesized using 2@b,3@a-dihydroxy-11-oxo-18@b-olean-12-ene-30-oic acid (1) and 2@a,2@b-dihydroxy-18@b-ursan-12-ene-28-oic acid (7) as ...Read More
Wenliang Wang, Yi Wang, Hongwen Tao, Xiaoping Peng, Peipei Liu, Weiming Zhu
In order to search for structurally novel and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment c...Read More
Balaram Ghosh, Tamara Antonio, Juan Zhen, Prashant Kharkar, Maarten E A Reith, Aloke K Dutta
Here we report structure-activity relationship study of a novel hybrid series of compounds where structural alteration of aromatic hydrophobic moieties connected to the piperazine ring and bioisosteri...Read More
Subhash S Padhye, Aamir A Ahmad, Nikhil N Oswal, Prasad P Dandawate, Rukhsana A RA Rub, Jyoti J Deshpande, K Venkateswara KV Swamy, Fazlul H FH Sarkar
Chalcones are involved in the synthesis of flavonoids and are themselves known to exhibit multiple pharmacological properties. However, compared to other structurally similar phytochemicals like garci...Read More
Clementina MM Santos, Marisa Freitas, Daniela Ribeiro, Ana Gomes, Artur MS Silva, José AS Cavaleiro, Eduarda Fernandes
Xanthones are a class of oxygen-containing heterocyclic compounds widely distributed in nature. The natural derivatives can present different substitutions in the xanthone core that include hydroxyl, ...Read More
Sayed M Riyadh, Thoraya A Farghaly, Magda A Abdallah, Mohamed M Abdalla, Mohamed R Abd El-Aziz
Three series of novel pyrazole derivatives 2b-d, 4a-d and 6a-d were synthesized via two step procedure that utilizes hydrazonoyl chlorides 1a-d and enaminones 3a-d and 5a-d, respectively as starting m...Read More
Nilgün Karali, Ozlen Güzel, Nurten Ozsoy, Süheyla Ozbey, Aydin Salman
3H-Spiro[1,3-benzothiazole-2,3'-indol]-2'(1'H)-ones 3a-c and 4a-e were synthesized from treating the 5-substituted 1H-indole-2,3-diones with 2-aminothiophenol in ethanol. The structures...Read More
M Veera Narayana Reddy, A Bala krishna, C Suresh Reddy
Synthesis of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxaphos-phinines] (3a-j) were accomplished via two step process. It involves the prior preparation of monochloride interme...Read More
H Vijay Kumar, Nagaraja Naik
A series of 5H-dibenz[b,f]azepine containing different aminophenols and substituted aminophenols were synthesized. 3-chloro-1-(5H-dibenz[b,f]azepine-5yl)propan-1-one (2) was obtained by N-acylation of...Read More
V Koteswara Rao, A Janardhan Rao, S Subba Reddy, C Naga Raju, P Visweswara Rao, S K Ghosh
A series of novel phosphorylated derivatives of galanthamine 6-11 and 12-17 were synthesized in two step process with high yields. In the first step galanthamine 1 was reacted with bis (2-chloroethyl)...Read More
V Padmavathi, S Nagi Reddy, G Dinneswara Reddy, A Padmaja
A new class of oxadiazoles is prepared by treating aminosulfonylacetic acids with different carboxylic acid hydrazides. Interconversion of oxadiazoles to thiadiazoles is carried out with thiourea. The...Read More
Thoraya A Farghaly, Naglaa A Abdel Hafez, Eman A Ragab, Hanem M Awad, Mohamed M Abdalla
Reaction of benzosuberone 1 with dimethylformamide-dimethylacetal (DMF-DMA) gives 2-dimethylamino-methylenebenozosuberone 2 which in turn reacts with heterocyclic amines to furnish new heterocyclic ri...Read More
Tzung-Han Chou, Hsiou-Yu Ding, Rong-Jyh Lin, Jing-Yao Liang, Chia-Hua Liang
Antioxidant and antimelanogenesis activities of protocatechuic acid (1) from Origanum vulgare (oregano) were investigated. The antioxidative capacity of 1 was confirmed from its free-radical-scavengin...Read More
Yeong Jae YJ Yoo, Dong Hyuk DH Nam, Seo Yun SY Jung, Jae Wan JW Jang, Hyoung Ja HJ Kim, Changbae C Jin, Ae Nim AN Pae, Yong Sup YS Lee
The excessive calpain activation causes serious cellular damage or even cell death in neurological disorders such as stroke and Alzheimer's disease. Oxidative stress has also been implicated in t...Read More
Ebraheem E Abdu Musad, Riyaz R Mohamed, Bahjat Ali BA Saeed, Bannikuppe S BS Vishwanath, K M Lokanatha KM Rai
Two series of five membered heterocyclic bis(1,3,4-oxadiazole) derivatives 2(a-h) and 3,5-bis(substituted)pyrazoles, isoxazoles 3(a,b,d-i), 4(a-c) were synthesized via oxidative cyclization of some di...Read More
Ashok Kumar, Pratibha Sharma, Prerna Kumari, Bhagwan Lal Kalal
A series of 2-(chloromethyl)-3-(4-methyl-6-oxo-5-[(E)-phenyldiazenyl]-2-thioxo-5,6-dihydropyrimidine-1(2H)-yl)quinazoline-4(3H)-ones 9a-j was synthesized by treating 2-(chloroacetyl)amino benzoic acid...Read More
Koneni V KV Sashidhara, Manoj M Kumar, Ram K RK Modukuri, Anuj A Srivastava, Anju A Puri
The synthesis of a series of benzocoumarin keto-enamine schiff bases is reported. The novel compounds were evaluated for their antihyperlipidemic activity in the hyperlipidemic hamster model. The comp...Read More
Kiran Sapkota, Eunmiri Roh, Eunyoung Lee, Eun-Mi Ha, Jae-Ho Yang, Eung-Seok Lee, Youngjoo Kwon, Youngsoo Kim, Younghwa Na
In order to develop potent skin whitening agents, we have synthesized 17 hydroxyphenyl benzyl ether compounds and tested their melanin synthesis inhibitory activity, DPPH free radical scavenging activ...Read More
Mi Kyoung Kim, Wooseong Jeong, Jihoon Kang, Youhoon Chong
For a compound to be a radical-trapping antioxidant, the antioxidant-derived radical must be sufficiently inert to molecular oxygen as this would generate harmful chain-propagating peroxyl radicals. C...Read More
SA Manohara Reddy, Jayesh Mudgal, Punit Bansal, SG Vasanthraju, KK Srinivasan, C Mallikarjuna Rao, N Gopalan Kutty
A series of 19 heterocyclic homoprostanoids were synthesized from easily available oleic and ricinoleic acids and evaluated for their possible antioxidant, anti-inflammatory and anti-hyperlipidaemic a...Read More
Javed Sheikh, Ali Parvez, Harjeet Juneja, Vishwas Ingle, Zahid Chohan, Moulay Youssoufi, Taibi Ben Hadda
This research communication is toward the investigation of the antibacterial, antifungal and antioxidant activities of the synthesized compounds 1-(4'-O-@b-d-glucopyranosyloxy-2'-hydroxyphen...Read More
Sang Hoon Kim, Young Hoon Lee, Seo Yun Jung, Hyoung Ja Kim, Changbae Jin, Yong Sup Lee
The overactivation of @m-calpain can cause serious cell damage in several diseases. Furthermore, cell death in a number of neurodegenerative disorders is linked to the overproduction of reactive oxyge...Read More
A Balakrishna, M Veera Narayana Reddy, P Visweswara Rao, M Anil Kumar, B Siva Kumar, SK Nayak, C Suresh Reddy
A new series of tetraphenyl bisphosphonates have been elegantly synthesized by one-pot method and were characterized by elemental analysis, FTIR, ^1H, ^1^3C, ^3^1P NMR, mass spectra and evaluated for ...Read More
A A Padmaja, C C Rajasekhar, A A Muralikrishna, V V Padmavathi
A new class of oxazolyl/thiazolylsulfonylmethyl pyrazoles (10-13) and isoxazoles (14, 15) were prepared from the synthetically vulnerable intermediate E-styrylsulfonylacetic acid methyl ester (1) and ...Read More
T T Indumathi, V S VS Jamal Ahamed, Surk-Sik SS Moon, Frank R FR Fronczek, K J KJ Rajendra Prasad
The newly synthesized pyrido[2,3-a]carbazoles were prepared in good yields by multicomponent reactions under L-proline as promoter and structurally characterized. Few compounds showed significant acti...Read More
Feng F Shi, Xiao-Ning XN Zeng, Xu-Dong XD Cao, Shu S Zhang, Bo B Jiang, Wei-Fa WF Zheng, Shu-Jiang SJ Tu
This study has achieved the design and diversity-oriented synthesis of novel 1,4-thiazepine derivatives embedded with carbazole, pyrazole or isoxazole motif via microwave-assisted multicomponent react...Read More
Polyethylene wear debris induces progressive osteolysis by increasing bone degradation and suppressing bone formation. Polyethylene particles inhibit the function of mature osteoblasts, but whether po...Read More
Ningling N Wang, Ping P Zhang, Xuejiang X Guo, Zuomin Z Zhou, Jiahao J Sha
The formation of ovarian follicles and subsequent development after birth are critical processes for female reproduction, and inappropriate coordination of these processes contributes to ovarian patho...Read More
Laurel S LS Rodgers, Daniel C DC Schnurr, Derrick D Broka, Todd D TD Camenisch
In vitro cultures of cardiomyocytes have proven to be a useful tool for toxicological, pharmacological, and developmental studies, as well as for the study of the cellular and molecular mechanisms res...Read More
Chengyang Huang, Yang Xiang, Yanru Wang, Xia Li, Longyong Xu, Ziqi Zhu, Ting Zhang, Qingqing Zhu, Kejing Zhang, Naihe Jing, Charlie Degui Chen
Dimethylations of histone H3 lysine 9 and lysine 27 are important epigenetic marks associated with transcription repression. Here, we identified KIAA1718 (KDM7A) as a novel histone demethylase specifi...Read More
Ziqi Zhu, Yanru Wang, Xia Li, Yiqin Wang, Longyong Xu, Xiang Wang, Tianliang Sun, Xiaobin Dong, Lulu Chen, Hailei Mao, Yi Yu, Jinsong Li, Jingsong Li, Pin Adele Chen, Charlie Degui Chen
Dimethylation of histone H3 lysine 9 (H3K9me2) is an important epigenetic mark associated with transcription repression. Here, we identified PHF8, a JmjC-domain-containing protein, as a histone demeth...Read More
Hanqing H Lin, Yiqin Y Wang, Yanru Y Wang, Feng F Tian, Pu P Pu, Yi Y Yu, Hailei H Mao, Ying Y Yang, Ping P Wang, Lulu L Hu, Yan Y Lin, Yi Y Liu, Yanhui Y Xu, Charlie Degui CD Chen
H3K9me2 and H3K27me2 are important epigenetic marks associated with transcription repression, while H3K4me3 is associated with transcription activation. It has been shown that active and repressive hi...Read More
Tiago L TL Duarte, Joseph J Lunec
Vitamin C (or ascorbic acid) is regarded as the most important water-soluble antioxidant in human plasma and mammalian cells which have mechanisms to recycle and accumulate it against a concentration ...Read More