|溶解性||Soluble in water (50 mg/ml), ethanol (≥1 mg/ml), methanol (sparingly soluble), ether, and DMSO (≥6 mg/ml).|
|产品介绍||ε-Amino-n-caproic Acid (EACA) is an antifibrinolytic agent shown to enhance the activation of urinary-type and tissue-type plasminogen, while inhibiting plasminogen activation induced by streptokinase through a kringle-dependent mechanism. Believed to act as a lysine analog that competitively inhibits basic carboxypeptidases, and promotes the rapid dissociation of plasmin by inhibiting activation of plasminogen by streptokinase. Incorporation of EACA into short polypeptide fragments with hydrophobic amino acids yielded cytotoxic compounds against MCF-7 breast cells and fibroblast cells. These factors make EACA a potentially useful compound for research in areas such as: oncology, immunology, and in the general elucidation of biochemical pathways.|
|别名||6-氨基己酸 ;氨基己酸,氨己酸,抗血纤溶酸,ε氨基已酸,6-氨基正己酸; EACA;ε-Aminocaproic acid 6-Aminohexanoic acid EACA Hemocaprol|
EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo-xy-peptidase, plasmin, and plasminogen activator.
赖氨酸类似物。促进纤溶酶快速解离，从而抑制纤溶酶原?的活化以及后续的纤维蛋白溶解。据报告，EACA 可抑制纤溶酶原结合至活化的血小板。早期报告表明，EACA 可抑制补体系统第一组分的活化。结合并灭活羧肽酶 B。
|应用||EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.|
|个人防护设备||dust mask type N95 (US), Eyeshields, Gloves|