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6-氨基己酸

产品编号 A103971 | CAS号 60-32-2 | Aladdin
6-Aminocaproic acid
99%
组合的产品项目
货号 规格 库存 价格 数量
A103971-100g 99% 上海(>10)
北方(预计3-5个工作日)
 
A103971-2.5kg 99% 上海(1)
北方(预计3-5个工作日)
 
A103971-25g 99% 上海(9)
北方(>10)
 
A103971-500g 99% 上海(6)
北方(预计3-5个工作日)
 
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属性

密度 1.0420
熔点 204-209°C
溶解性 Soluble in water (50 mg/ml), ethanol (≥1 mg/ml), methanol (sparingly soluble), ether, and DMSO (≥6 mg/ml).
存贮条件 密封干燥保存。

描述

产品介绍 ε-Amino-n-caproic Acid (EACA) is an antifibrinolytic agent shown to enhance the activation of urinary-type and tissue-type plasminogen, while inhibiting plasminogen activation induced by streptokinase through a kringle-dependent mechanism. Believed to act as a lysine analog that competitively inhibits basic carboxypeptidases, and promotes the rapid dissociation of plasmin by inhibiting activation of plasminogen by streptokinase. Incorporation of EACA into short polypeptide fragments with hydrophobic amino acids yielded cytotoxic compounds against MCF-7 breast cells and fibroblast cells. These factors make EACA a potentially useful compound for research in areas such as: oncology, immunology, and in the general elucidation of biochemical pathways.
别名 6-氨基己酸 ;氨基己酸,氨己酸,抗血纤溶酸,ε氨基已酸,6-氨基正己酸; EACA;ε-Aminocaproic acid 6-Aminohexanoic acid EACA Hemocaprol
生化机理 EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo-xy-peptidase, plasmin, and plasminogen activator.

赖氨酸类似物。促进纤溶酶快速解离,从而抑制纤溶酶原?的活化以及后续的纤维蛋白溶解。据报告,EACA 可抑制纤溶酶原结合至活化的血小板。早期报告表明,EACA 可抑制补体系统第一组分的活化。结合并灭活羧肽酶 B。
应用 EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
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标识符号 GHS07 GHS07
信号词 Warning
风险声明 (欧洲) R36/37/38
安全声明(欧洲) S26;S37/39
警示性声明 P261,P305+P351+P338
危害码(欧洲) Xi
危害声明 H315,H319,H335
个人防护设备 dust mask type N95 (US), Eyeshields, Gloves
WGK德国 2
参考文献
R Scott RS Obach, Franco F Lombardo, Nigel J NJ Waters
We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ...Read More
S Ekins, A J Williams, J J Xu
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...Read More
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Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....Read More
Nigel N Greene, Lilia L Fisk, Russell T RT Naven, Reine R RR Note, Mukesh L ML Patel, Dennis J DJ Pelletier
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...Read More
Iris I Thondorf, Valerie V Voigt, Sarah S Sch?fer, Sabine S Gebauer, Katja K Zebisch, Linda L Laug, Matthias M Brandsch
The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...Read More
Patrick Meybohm, Eva Herrmann, Julia Nierhoff, Kai Zacharowski
To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of ...Read More
Ching-Yi Chen, Tae Hee Kim, Wen-Chung Wu, Chi-Ming Huang, Hua Wei, Christopher W Mount, Yanqing Tian, Sei-Hum Jang, Suzie H Pun, Alex K-Y Jen
Polymeric micelles are promising carriers for anti-cancer agents due to their small size, ease of assembly, and versatility for functionalization. A current challenge in the use of polymeric micelles ...Read More
Zhichao Liu, Qiang Shi, Don Ding, Reagan Kelly, Hong Fang, Weida Tong
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...Read More
Denis Fourches, Julie C Barnes, Nicola C Day, Paul Bradley, Jane Z Reed, Alexander Tropsha
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...Read More
Tulsidas G Shrivastav, Shail K Chaube, Kiran P Kariya, Pramod K V Prasad, Dinesh Kumar
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The oxidative phosphorylation (OXPHOS) system consists of five multimeric complexes embedded in the mitochondrial inner membrane. They work in concert to drive the aerobic synthesis of ATP. Mitochondr...Read More
Klaus K Albertshofer, Andrew M AM Siwkowski, Edward V EV Wancewicz, Christine C CC Esau, Tanya T Watanabe, Kenji C KC Nishihara, Garth A GA Kinberger, Leila L Malik, Anne B AB Eldrup, Muthiah M Manoharan, Richard S RS Geary, Brett P BP Monia, Eric E EE Sw
Improving cellular uptake and biodistribution remains one of the major obstacles for a successful and broad application of peptide nucleic acids (PNAs) as antisense therapeutics. Recently, we reported...Read More
Silke S Hack, Babette B W?rlein, Georg G H?fner, J?rg J Pabel, Klaus T KT Wanner
A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been s...Read More
M M Heimrich, M M B?nsch, H H Nickl, T J TJ Simat
Cyclic oligomers are the major substances migrating from polyamide (PA) food contact materials. However, no commercial standards are available for the quantification of these substances. For the first...Read More
Chengfei Lu, Susmita Das, Paul K S Magut, Min Li, Bilal El-Zahab, Isiah M Warner
We report on the synthesis and characterization of a PEGylated IR786 GUMBOS (Group of Uniform Materials Based on Organic Salts). The synthesis of this material was accomplished using a three step prot...Read More
Krystyna Midura-Nowaczek, Maciej Purwin, Agnieszka Markowska, Danuta Drozdowska, Magdalena Bruzgo
Effects of eight short peptides containing lysine and epsilon-aminocaproic acid (EACA) on prolongation of the clot lysis time, as well as hemolytic and antibacterial activities were investigated. Inte...Read More
P A Stricker, A F Zuppa, J E Fiadjoe, L G Maxwell, E M Sussman, E Y Pruitt, T K Goebel, M R Gastonguay, J A Taylor, S P Bartlett, M S Schreiner
/st> Understanding the clinical pharmacology of the antifibrinolytic epsilon-aminocaproic acid (EACA) is necessary for rational drug administration in children. The aim of this study is to determin...Read More
Ai Kia Yip, Katsuhiko Iwasaki, Chaitanya Ursekar, Hiroaki Machiyama, Mayur Saxena, Huiling Chen, Ichiro Harada, Keng-Hwee Chiam, Yasuhiro Sawada
Cells sense the rigidity of their substrate; however, little is known about the physical variables that determine their response to this rigidity. Here, we report traction stress measurements carried ...Read More
K Martin, R Gertler, M MacGuill, N P Mayr, A Hapfelmeier, J H?rer, M Vogt, P Tassani, G Wiesner
Once aprotinin was no longer available for clinical use, ε-aminocaproic acid (EACA) and tranexamic acid became the only two options for antifibrinolytic therapy. We compared aprotinin and EACA with r...Read More
Irene Lecker, Dian-Shi Wang, Alexander D Romaschin, Mark Peterson, C David Mazer, Beverley A Orser
Antifibrinolytic drugs are widely used to reduce blood loss during surgery. One serious adverse effect of these drugs is convulsive seizures; however, the mechanisms underlying such seizures remain po...Read More
Seung Yon Han, Si Hyung Yang, Insoo Yoon, Myung Gull Lee, Young Hee Choi
Anti-ulcer drugs are frequently used in patients with acute renal failure (ARF). Zinc acexamate is ionized to zinc and ε-acetamidocaproic acid and free EACA exerts a potent therapeutic effect in trea...Read More
Marten N MN Basta, Paul A PA Stricker, Jesse A JA Taylor
A systematic review aimed to evaluate the efficacy and safety of aprotinin, epsilon-aminocaproic acid (EACA), and tranexamic acid (TXA) in reducing perioperative blood loss, risk for transfusion, and ...Read More
Liliana M Marín, M Cristina Iazbik, Sara Zaldivar-Lopez, Julien Guillaumin, Mary A McLoughlin, C Guillermo Couto
To evaluate the effects of epsilon aminocaproic acid (EACA) on the prevalence of postoperative bleeding in retired racing Greyhounds (RRG), and to assess its effects on selected thrombelastography (TE...Read More
Daniel J DJ Fletcher
We're sorry this abstract is currently not available....Read More
Jenny J Ross, Rustam Al-Shahi RA Salman
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Ian Roberts, Haleema Shakur, Katherine Ker, Tim Coats, Tim Coats
Uncontrolled bleeding is an important cause of death in trauma victims. Antifibrinolytic treatment has been shown to reduce blood loss following surgery and may also be effective in reducing blood los...Read More
J M Balaguer, C Yu, J G Byrne, S K Ball, M R Petracek, N J Brown, M Pretorius
Bradykinin increases during cardiopulmonary bypass (CPB) and stimulates the release of nitric oxide, inflammatory cytokines, and tissue-type plasminogen activator (t-PA), acting through its B2 recepto...Read More
Liliana M LM Marín, M Cristina MC Iazbik, Sara S Zaldivar-Lopez, Linda K LK Lord, Nicole N Stingle, Paulo P Vilar, Ana A Lara-Garcia, Francisco F Alvarez, Kenji K Hosoya, Laura L Nelson, Antonio A Pozzi, Edward E Cooper, Mary A MA McLoughlin, Rebecca R Ba
To determine the frequency of delayed postoperative bleeding in retired racing Greyhounds with appendicular bone tumors undergoing limb amputations. To identify if administration of epsilon-aminocapro...Read More
Illa I Ramakanth, Archita A Patnaik
A two-component gel resulting from the amphiphilic cationic surfactant cetylpyridinium chloride (CPC) in the presence of a structure-forming bola-amphiphilic additive 6-aminocaproic acid (6-ACA) was r...Read More
Jing J Huang, Limin L Zhang, Huiru H Tang
The molecular dynamics of metabolites is structure dependent and vitally important for the interactive functions in their potential applications as natural materials. To understand the relationship be...Read More
Harold V Cohen, Raphael Figueroa, Samuel Y P Quek, Ali M Abbas
We're sorry this abstract is currently not available....Read More
Hisataka Taguchi, Makoto Wakamatsu, Kenji Aso, Shin Ono, Takashi Shin, Takashi Akamatsu
We synthesized N-(4-nitrophenyl)-6-aminohexanamide (AHpNA) and used it as a substrate in a kinetic study of 6-aminohexanoate-hydrolase (NylB), a nylon oligomer-hydrolyzing enzyme. NylBs derived from A...Read More
C S CS Kim, C H CH Lee, J W JW Chung, C D CD Kim
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E M Van Hoeyveld, E A Stevens
The effect of epsilon-aminocaproic acid (EACA) on the degradation of an aqueous Lolium perenne extract was studied by intracutaneous tests and by RAST inhibition. Extracts for skin testing stored at 4...Read More
C C Krishnamurti, S J SJ Vukelja, B M BM Alving
The lysine analogues epsilon-aminocaproic acid (EACA) and trans-4-amino-methyl cyclohexane carboxylic acid (AMCA) are used to prevent excessive bleeding in patients with coagulopathies, such as hemoph...Read More
B Adelman, A Rizk, E Hanners
In this report we used a fluorescent flow cytometry-based assay to examine plasminogen binding to platelets in plasma. Our data indicate that platelets activated in platelet-rich plasma (PRP) by adeno...Read More
N A Soter, K F Austen, I Gigli
The influence of EACA on C1 in whole human serum and on C1 and C (see article) as isolated molecules was assessed hemolytically. There was selective inhibition of C1 without effect on the levels of C4...Read More
J P JP Dessaint, S P SP Katz, B H BH Waksman
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