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2-氨基苯并咪唑

产品编号 A104845 | CAS号 934-32-7 | Aladdin
2-Aminobenzimidazole
97%
组合的产品项目
货号 规格 库存 价格 数量
A104845-100g 97% 上海(3)
北方(预计3-5个工作日)
 
A104845-25g 97% 上海(>10)
北方(7)
 
A104845-5g 97% 上海(>10)
北方(8)
 
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属性

敏感性 对光敏感
密度 1.3670
熔点 224°C
溶解性 Soluble in water (Slightly).,
存贮条件 密封避光保存

描述

产品介绍 易溶于水、乙醇和丙酮,难溶于乙醚和苯。最小致死量(大鼠,经口)500mg/kg。有刺激性。避光保存
别名 α-氨基间二氮茚; 2-氨基间二氮茚; 1H-苯并咪唑-2-胺; 2-苯并咪唑胺;2-Benzimidazolamine; 1H-Benzimidazol-2-amine; 1H-Benzo[d]imidazol-2-amine
应用 2-Aminobenzimidazole was used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles
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标识符号 GHS07 GHS07
信号词 Warning
风险声明 (欧洲) R22;R36/37/38
安全声明(欧洲) S22;S26;S36/37/39
警示性声明 P261,P280,P305+P351+P338
危害码(欧洲) Xn
危害声明 H302,H315,H317,H319,H335
个人防护设备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves
RTECS DD5775000
WGK德国 3
参考文献
Fabian López-Vallejo, José Luis Medina-Franco, Alicia Hernández-Campos, Sergio Rodríguez-Morales, Lilián Yépez, Roberto Cedillo, Rafael Castillo
CoMFA models that explain the amoebicidal activity of tautomeric benzimidazole derivatives were developed....Read More
Satoshi Ueda, Stephen L Buchwald
We're sorry this abstract is currently not available....Read More
Sai Pradeep Velagapudi, Alexei Pushechnikov, Lucas P Labuda, Jonathan M French, Matthew D Disney
There are many potential RNA drug targets in bacterial, viral, and human transcriptomes. However, there are few small molecules that modulate RNA function. This is due, in part, to a lack of fundament...Read More
E E Molnár, G G Fábián, J J Klem, Z Z Darula, E E Hunyadi-Gulyás, A A Medgyesi, K F KF Medzihradszky, L G LG Puskás
Cellular drug target identification through affinity chromatography is often hindered by the quantity of nonspecific binders, such as cytoskeletal and heat shock proteins. Thus, we prepared a 2-aminob...Read More
S S Sudha, M M Karabacak, M M Kurt, M M Cinar, N N Sundaraganesan
In the present work, we reported a combined experimental and theoretical study on molecular structure, vibrational spectra and HOMO-LUMO analysis of 2-aminobenzimidazole (2-ABD). The FTIR (400-4000 cm...Read More
Fei F Wang, Shangjun S Cai, Qian Q Liao, Chanjuan C Xi
An efficient strategy for the synthesis of a variety of 2-animobenzimidazole derivatives has been developed. The reaction proceeded from o-haloanilines and carbodiimides via copper(I)-catalyzed domino...Read More
Dolors D Jornet, Pavel P Bartovsky, Luis R LR Domingo, Rosa R Tormos, Miguel A MA Miranda
This work has examined the photoreactivity of benzophenone (3), 2-benzoylthiophene (4), 4-methoxybenzophenone (5), 4,4'-dimethoxybenzophenone (6), and 4-carboxybenzophenone (7) with 2-aminobenzim...Read More
Verónica Viudes, Pavel Bartovsky, Luis R Domingo, Rosa Tormos, Miguel A Miranda
Fluorescence spectroscopy, laser flash photolysis (LFP), and density functional theory (DFT) calculations have been performed to understand the photobehavior of 2-aminobenzimidazole (1). The emission ...Read More
Dinty J DJ Musk
We're sorry this abstract is currently not available....Read More
Xiao S XS Liu, Zhang F ZF Tong, Ling L Zhen, Da X da X Huang, Xin X Gao, Chao Y CY Xu
A method using liquid chromatography and a single mix-mode solid-phase extraction cleanup for the simultaneous analysis of thiabendazole [2-(1,3-thiazol-4-yl)-1H-benzoimidazole], carbendazim [(methyl ...Read More
Ranxin Shi, Daniel Re, Eric Dudl, Michael Cuddy, Karl J Okolotowicz, Russell Dahl, Ying Su, Andrew Hurder, Shinichi Kitada, Satyamaheshwar Peddibhotla, Gregory P Roth, Layton H Smith, Thomas J Kipps, Nicholas Cosford, John Cashman, John C Reed
Dysregulation of NF-kappaB activity contributes to many autoimmune and inflammatory diseases. At least nine pathways for NF-kappaB activation have been identified, most of which converge on the Ikappa...Read More
Steven A SA Rogers, Robert W RW Huigens, Christian C Melander
A number of 2-aminobenzimidazole derivatives were synthesized and screened for their ability to inhibit and disperse bacterial biofilms. From these compounds, a lead 2-aminobenzimidazole was identifie...Read More
Timothy T Coon, Wilna J WJ Moree, Binfeng B Li, Jinghua J Yu, Said S Zamani-Kord, Siobhan S Malany, Mark A MA Santos, Lisa M LM Hernandez, Robert E RE Petroski, Aixia A Sun, Jenny J Wen, Sue S Sullivan, Jason J Haelewyn, Michael M Hedrick, Samuel J SJ Hoa
The benzimidazole core of the selective non-brain-penetrating H"1-antihistamine mizolastine was used to identify a series of brain-penetrating H"1-antihistamines for the potential treatment ...Read More
Minoru Moriya, Hiroyuki Kishino, Shunji Sakuraba, Toshihiro Sakamoto, Takuya Suga, Hidekazu Takahashi, Takao Suzuki, Masahiko Ito, Junko Ito, Ryuichi Moriya, Norihiro Takenaga, Hisashi Iwaasa, Akane Ishihara, Akio Kanatani, Takehiro Fukami
A series of 2-aminobenzimidazole-based MCH1R antagonists was identified by core replacement of the aminoquinoline lead 1. Subsequent modification of the 2- and 5-positions led to improvement in potenc...Read More
Kazuya K Kikuchi, Renate B RB Hannak, Mao-Jun MJ Guo, Anthony J AJ Kirby, Donald D Hilvert
We're sorry this abstract is currently not available....Read More
Claudio C Gnaccarini, Sascha S Peter, Ute U Scheffer, Stefan S Vonhoff, Sven S Klussmann, Michael W MW G?bel
RNA cleaving tris(2-aminobenzimidazoles) have been attached to DNA oligonucleotides via disulfide or amide bonds. The resulting conjugates are effective organocatalytic nucleases showing substrate and...Read More
Mirko Rivara, Valentina Zuliani, Giuseppe Cocconcelli, Giovanni Morini, Mara Comini, Silvia Rivara, Marco Mor, Fabrizio Bordi, Elisabetta Barocelli, Vigilio Ballabeni, Simona Bertoni, Pier Vincenzo Plazzi
A novel series of non-imidazole H(3)-receptor antagonists was developed, by chemical modification of a potent lead H(3)-antagonist composed by an imidazole ring connected through an alkyl spacer to a ...Read More
Reto Frei, Anthony S Breitbach, Helen E Blackwell
We're sorry this abstract is currently not available....Read More
Ricardo G Correa, Pasha M Khan, Nadav Askari, Dayong Zhai, Motti Gerlic, Brock Brown, Gavin Magnuson, Roberto Spreafico, Salvatore Albani, Eduard Sergienko, Paul W Diaz, Gregory P Roth, John C Reed
NLR family proteins play important roles in innate immune response. NOD1 (NLRC1) activates various signaling pathways including NF-κB in response to bacterial ligands. Hereditary polymorphisms in the...Read More
Silvia E Angelova, Milena I Spassova, Vera V Deneva, Marin I Rogojerov, Liudmil M Antonov
An investigation of 2-aminobenzimidazole was carried out by calculations at HF, MP2, and DFT levels of theory and also by UV and IR spectroscopy. The quantum chemical calculations predict a full shift...Read More
Robert W Huigens, Samuel Reyes, Catherine S Reed, Cynthia Bunders, Steven A Rogers, Andrew T Steinhauer, Christian Melander
Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These ac...Read More
Gunther Zischinsky, Roland Stragies, Marco Schaudt, Jochen R Pfeifer, Christoph Gibson, Elsa Locardi, Dirk Scharn, Uwe Richter, Holger Kalkhof, Klaus Dinkel, Karsten Schnatbaum
Efforts to find new bradykinin B(1) receptor antagonists identified 2-aminobenzimidazole as a novel core. Subsequent transformation into five-membered diaminoheterocycle derivatives and their synthesi...Read More
Min Zhong, Minna Bui, Wang Shen, Subramanian Baskaran, Darin A Allen, Robert A Elling, W Michael Flanagan, Amy D Fung, Emily J Hanan, Shannon O Harris, Stacey A Heumann, Ute Hoch, Sheryl N Ivy, Jeffrey W Jacobs, Stuart Lam, Heman Lee, Robert S McDowell, J
This Letter describes the discovery and key structure-activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors. 2-Aminobenzimidazole serves as a bioisostere ...Read More
Ho Yin Lo, J?rg Bentzien, Roman W Fleck, Steven S Pullen, Hnin Hnin Khine, Joseph R Woska, Stanley Z Kugler, Mohammed A Kashem, Hidenori Takahashi
The design and syntheses of a series of trans-stilbene-like ITK antagonists were described....Read More
Ahmad A Shaabani, Elham E Farhangi, Abbas A Rahmati
Tetraheterocyclic benzimidazo[1,2-a]quinazolin-4(1H)-one and tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-one were synthesized in relatively high yields by the condensation reaction of an aldehyde...Read More
Xuan X Guida, Han H Jianhua, Li L Xiaomin
Eight compounds were synthesized as described below: the potassium salt of 2-aminobenzimidazole was first prepared by reaction with powdered potassium hydroxide in acetone at room temperature, and the...Read More
Chidochangu P Mpamhanga, Daniel Spinks, Lindsay B Tulloch, Emma J Shanks, David A Robinson, Iain T Collie, Alan H Fairlamb, Paul G Wyatt, Julie A Frearson, William N Hunter, Ian H Gilbert, Ruth Brenk
The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual screening campaign for fragments inhibiting PTR1 was carried out. Two ...Read More