产品编号 A105216 | CAS号 578-95-0 | 阿拉丁
货号 规格 库存 价格 数量
A105216-100g 98% 上海(3)
A105216-1g 98% 上海(>10)
A105216-25g 98% 上海(5)
A105216-5g 98% 上海(>10)


密度 1.2300
熔点 361-362°C
溶解性 Soluble in DMF: 50 mg/ml Does not mix with water.


产品介绍 Acridone is useful in various pharmacological activities. Acridone acetic acid is one of the most important derivatives of acridone and is known as neovir, an antiviral drug. Some of acridone's derivatives may be potentially used as antimalarial drugs.
别名 吖啶酮;氮蒽酮;9-吖啶酮;9,10-Dihydro-9-oxoacridin;9-Acridone;Acridone
应用 A scaffold for the antiviral agent acridone acetic acid.
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安全声明(欧洲) 22,24/25
个人防护设备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS AR6976000
WGK德国 3
Pang-Chi Huang, Kanniyappan Parthasarathy, Chien-Hong Cheng
A good move: A copper-catalyzed intramolecular oxidative C?H functionalization of 2-aminobenzophenone affords two regioisomeric acridones. The reaction involves an unusual pseudo-1,2-migration of R(2)...Read More
Hiroaki H Ozaki, Yasuhisa Y Hagiwara, Hiromi H Asakura, Masayasu M Kuwahara
An acridone-labeled DNA aptamer was synthesized to produce an aptamer probe. This aptamer probe could detect a specific molecule based on conformational changes upon binding of the specific molecules ...Read More
Chunmei Gao, Yuyang Jiang, Chunyan Tan, Xuyu Zu, Huachen Liu, Derong Cao
A novel series of 10-benzyl-9(10H)-acridinones were synthesized and evaluated as potent antileukemic activities. Structure-activity relationships are also studied....Read More
Aleksandar Putic, Lambert Stecher, Helge Prinz, Klaus Müller
A series of N-unsubstituted hydroxy-10H-acridin-9-ones were synthesized and evaluated for inhibitory action against HaCaT keratinocyte growth, in order to explore their potential as antipsoriatic agen...Read More
Aleksandar Putic, Lambert Stecher, Helge Prinz, Klaus Müller
A series of 10-substituted hydroxy-10H-acridin-9-ones were synthesized and studied as potential antipsoriatic agents. The antiproliferative activity of the novel derivatives, which can be considered a...Read More
Frederik B FB Pruijn, Joanna R JR Sturman, H D Sarath HD Liyanage, Kevin O KO Hicks, Michael P MP Hay, William R WR Wilson
The extravascular diffusion of antitumor agents is a key determinant of their therapeutic activity, but the relationships between physicochemical properties of drugs and their extravascular transport ...Read More
He-Bin Tang, Yu-Sang Li, Kanako Miyano, Yoshihiro Nakata
Cathepsins, also known as lysosomal cysteine peptidases, are members of the papain-like peptidase family, involved in different physiological processes. In addition, cathepsins are implicated in many ...Read More
Alessandra A Di Veroli, Enzo E Goretti, Miriam Le?n ML Paumen, Michiel H S MH Kraak, Wim W Admiraal
The aim of the present study was to improve the cause-effect relationship between toxicant exposure and chironomid mouthpart deformities, by linking induction of mouthpart deformities to contaminated ...Read More
Jacob M Goldberg, Lee C Speight, Mark W Fegley, E James Petersson
Fluorescent probe pairs that can be selectively excited in the presence of Trp and Tyr are of great utility in studying conformational changes in proteins. However, the size of these probe pairs can r...Read More
Maizatul Akmal MA Yahayu, Mawardi M Rahmani, Najihah Mohd NM Hashim, Muhammad Aizat Mohd MA Amin, Gwendoline Cheng Lian GC Ee, Mohd Aspollah MA Sukari, Abdah A Akim
Extraction and chromatographic separation of the extracts of dried stem barks of Glycosmis macrantha lead to isolation of two new acridone alkaloids, macranthanine and 7-hydroxynoracronycine, and a kn...Read More
Magdalena Kukowska-Kaszuba, Krystyna Dzierzbicka, Marcin Serocki, Andrzej Skladanowski
New tuftsin/retro-tuftsin conjugates were designed and synthesized using a classical fluorenylmethoxycarbonyl (Fmoc) solid phase procedure. All the peptide conjugates were divided into three series: 1...Read More
Florian Astelbauer, Andreas Obwaller, Adriane Raninger, Brigitte Brem, Harald Greger, Michael Duchêne, Walther Wernsdorfer, Julia Walochnik
Visceral and cutaneous leishmaniases are an important public health problem in endemic geographic regions in 88 countries worldwide, with around 12 million infected people. Treatment options are limit...Read More
Jatinder Kaur, Palwinder Singh
Acridones carrying an appropriate substituent at N-10 showed significant fluorescence changes on interacting with ATP in HEPES buffer at pH 7.2. The selectivity and sufficient binding of these probes ...Read More
Richele P RP Severino, Rafael V C RV Guido, Emerson F EF Marques, Dieter D Br?mme, M Fátima das G F MF da Silva, Jo?o B JB Fernandes, Adriano D AD Andricopulo, Paulo C PC Vieira
Cathepsin V is a lysosomal cysteine peptidase highly expressed in thymus, testis and corneal epithelium. Eleven acridone alkaloids were isolated from Swinglea glutinosa (Bl.) Merr. (Rutaceae), with ei...Read More
Emmanuel Ngeufa EN Happi, Alain Fran?ois AF Waffo, Jean Duplex JD Wansi, Bonaventure Tchaleu BT Ngadjui, Norbert N Sewald
Two new O-prenylated acridone alkaloids, balsacridone A (1) and B (2), together with eighteen known compounds were isolated from the methanol extract from the stems of Balsamocitrus paniculata, a Came...Read More
O O Arnaud, A A Boumendjel, A A Gèze, M M Honorat, E L EL Matera, J J Guitton, W D WD Stein, S E SE Bates, P P Falson, C C Dumontet, A A Di Pietro, L L Payen
The breast cancer resistance protein ABCG2 confers cellular resistance to irinotecan (CPT-11) and its active metabolite SN-38. We utilised ABCG2-expressing xenografts as a model to evaluate the abilit...Read More
Olivier O Mathieu, Olivier O Dereure, Dominique D Hillaire-Buys
Carbamazepine (CBZ) is a useful anticonvulsive drug associated with rare severe adverse drug reactions. The physio-pathological mechanisms of these reactions are unknown although evidence of immunolog...Read More
Vishal P Zambre, Prashant R Murumkar, Rajani Giridhar, Mange Ram Yadav
G-quadruplex structures of DNA represent a potentially useful target for anticancer drugs. Telomerase enzyme, involved in immortalization of cancer cells is inhibited by stabilization of G-quadruplex ...Read More
Markus Bacher, Günter Brader, Harald Greger, Otmar Hofer
Phytochemical analysis of different organs of the rutaceaeous plant Severinia buxifolia led to the isolation of a new limonoid, a new acridone alkaloid, and a new flavone. Structure elucidation and si...Read More
Francisco Cuenca, Michael JB Moore, Karin Johnson, Bérangère Guyen, Anne De Cian, Stephen Neidle
A series of 4,5-di-substituted acridones have been designed and synthesized. Several compounds show high affinity for telomeric G-quadruplex DNA in classical and competition FRET assays, together with...Read More
Palwinder P Singh, Jatinder J Kaur, Bhawna B Yadav, Sneha Sudha SS Komath
In order to search for MDR modulators, rationally designed acridone derivatives were investigated for their effect on influx or efflux of Rhodamine6G (R6G) in CAI4 cells. Results of these investigatio...Read More
Giuseppe G Manfroni, Jan J Paeshuyse, Serena S Massari, Samantha S Zanoli, Barbara B Gatto, Giovanni G Maga, Oriana O Tabarrini, Violetta V Cecchetti, Arnaldo A Fravolini, Johan J Neyts
We report the synthesis and structure-activity relationship (SAR) of a large series of acridones and acridone-fragment derivatives designed on the basis of the selective antihepatitis C virus (HCV) ac...Read More
Atul Bhardwaj, Jatinder Kaur, Sai Kiran Sharma, Zhangjian Huang, Frank Wuest, Edward E Knaus
The observation that the cyclooxygenase-2 (COX-2) isozyme is over-expressed in multiple types of cancer, relative to that in adjacent non-cancerous tissue, prompted this investigation to prepare a gro...Read More
Naoto N Takahashi, Subehan, Shigetoshi S Kadota, Yasuhiro Y Tezuka
Fourteen acridone alkaloids isolated from Lunasia amara Blanco were tested for their mechanism-based inhibition on human liver microsomal dextromethorphan O-demethylation activity, a prototype marker ...Read More
Arnon A Chukaew, Chanita C Ponglimanont, Chatchanok C Karalai, Supinya S Tewtrakul
Cycloatalaphylline-A (1), N-methylcycloatalaphylline-A (2) and N-methyl-buxifoliadine-E (3), along with eight known acridone alkaloids and two known coumarins were isolated from the root of Atalantia ...Read More
Chinmay C Pal, Milan Kumar MK Kundu, Uday U Bandyopadhyay, Susanta S Adhikari
Heme is an important prosthetic molecule for various hemoproteins and serves important function in living aerobic organisms. But degradation of hemoprotein, for example, hemoglobin during different pa...Read More