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D-天冬氨酸

产品编号 A105951 | CAS号 1783-96-6 | Aladdin
D-Aspartic acid
98%
组合的产品项目
货号 规格 库存 价格 数量
A105951-100g 98% 上海(预计4-8周)
北方(预计4-8周)
 
A105951-25g 98% 上海(3)
北方(4)
 
A105951-5g 98% 上海(>10)
北方(预计3-5个工作日)
 
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属性

旋光率 -25 ° (C=8, 50% HCl)
密度 1.5140
熔点 300°C

描述

产品介绍 溶于水,不溶于醇和醚。
别名 D-天冬氨酸 ;D-天门冬氨酸;(R)-(−)-Aminosuccinic acid (R)-2-Aminosuccinic acid D-Asparaginic Acid H-D-Asp-OH
应用 合成药品。
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安全声明(欧洲) S24/25
个人防护设备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
WGK德国 1
Merck Index 840
参考文献
Aiko Torikoshi-Hatano, Akira Namera, Hiroaki Shiraishi, Yousuke Arima, Hirokazu Toubou, Jiro Ezaki, Masami Morikawa, Masataka Nagao
In forensic medicine, the personal identification of cadavers is one of the most important tasks. One method of estimating age at death relies on the high correlation between racemization rates in tee...Read More
Alessandra Santillo, Claudia Pinelli, Lavinia Burrone, Gabriella Chieffi Baccari, Maria Maddalena Di Fiore
There is evidence that d-aspartate (d-Asp) modulates sex hormone levels in frog testis by regulating the activity of P450 aromatase (P450 aro), the key enzyme which converts Testosterone (T) in 17?-Es...Read More
Jean-Pierre Mothet, Solomon H Snyder
We're sorry this abstract is currently not available....Read More
Jean-Marie Billard
Far from our initial view of D-amino acids as being limited to invertebrates, they are now considered active molecules at synapses of mammalian central and peripheral nervous systems, capable of modul...Read More
Yuichi Kaji, Tetsuro Oshika, Yutaka Takazawa, Masashi Fukayama, Noriko Fujii
Gelatinous drop-like corneal dystrophy (GDLD), also known as familial subepithelial corneal amyloidosis, is an autosomal recessive disorder that causes progressive corneal opacity due to accumulation ...Read More
Silvia S Holmseth, Yvette Y Dehnes, Yanhua H YH Huang, Virginie V VV Follin-Arbelet, Nina J NJ Grutle, Maria N MN Mylonakou, Celine C Plachez, Yun Y Zhou, David N DN Furness, Dwight E DE Bergles, Knut P KP Lehre, Niels C NC Danbolt
The extracellular levels of excitatory amino acids are kept low by the action of the glutamate transporters. Glutamate/aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) are the most ab...Read More
Jamal J Jamil, Ashley A Wright, Na'cara N Harrison, Edem E Kegey, Arnecia Faye AF Flowers, Namonique Jarell NJ Flyod, Casey C Kotera, Alexandre A Guy, Jean-Marie JM Galano, Thierry T Durand, Ya Fatou YF Njie-Mbye, Sunny E SE Ohia, Catherine A CA Oper
We have evidence that 15-F(2)-isoprostanes (15-F(2)-IsoPs) regulate excitatory neurotransmitter release in ocular tissues. Although 5-F(2)-IsoPs are abundantly produced in mammals, their pharmacologic...Read More
Lavinia L Burrone, Franca F Raucci, Maria Maddalena MM Di Fiore
Previous studies have provided evidence that D-Asp plays a role in steroid-mediated reproductive biology in amphibians, reptiles, birds and mammals. To examine the molecular involvement of D-Asp on st...Read More
George H GH Fisher, Mara M Tsesarskaia
D-Amino acids are stereoisomers or optical isomers of naturally occurring L-amino acids and thus possess the same chemical structure, but may differ in their biological/physiological properties. Until...Read More
Tadatoshi T Kinouchi, Norihiko N Fujii, Noriko N Fujii
The formation and accumulation of D-aspartate residue (D-Asp) in proteins caused by oxidative stress leads to dysfunction and/or denaturation of proteins, and is consequently responsible for aging-rel...Read More
Maria M Summa, Silvia S Di Prisco, Massimo M Grilli, Mario M Marchi, Anna A Pittaluga
α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) autoreceptors exist on glutamate hippocampal terminals. Aimed at investigating whether these autoreceptors traffic constitutively, (S)AMPA-evo...Read More
Ikuhiko I Noji, Akifumi A Oda, Kana K Kobayashi, Ohgi O Takahashi
Unusual amino acid residues such as L-β-aspartyl (Asp), D-α-Asp, and D-β-Asp have been detected in proteins and peptides such as α-crystallin in the lens and β-amyloid in the brain. These residue...Read More
Noriko N Fujii, Yuichi Y Kaji, Norihiko N Fujii
Homochirality is essential for life. L-Amino acids are exclusively used as substrates for the polymerization and formation of peptides and proteins in living systems. However, d-amino acids, which are...Read More
Yuhei Y Mori, Kenzo K Aki, Katsunori K Kuge, Shingo S Tajima, Natsuko N Yamanaka, Yuichi Y Kaji, Naoki N Yamamoto, Ryoji R Nagai, Hanako H Yoshii, Norihiko N Fujii, Masami M Watanabe, Tadatoshi T Kinouchi, Noriko N Fujii
UV-B irradiation is one of the risk factors in age-related diseases. We have reported that biologically uncommon D-β-Asp residues accumulate in proteins from sun-exposed elderly human skin. A previou...Read More
Masahiro Yamanaka, Yurika Miyoshi, Hiroko Ohide, Kenji Hamase, Ryuichi Konno
D-Amino acids are stereoisomers of L-amino acids. They are often called unnatural amino acids, but several D-amino acids have been found in mammalian brains. Among them, D-serine is abundant in the fo...Read More
Nobutoshi Ota, Ting Shi, Jonathan V Sweedler
D-Aspartate (D-Asp) is an endogenous amino acid in the central nervous and reproductive systems of vertebrates and invertebrates. High concentrations of D-Asp are found in distinct anatomical location...Read More
Francesco Errico, Francesco Napolitano, Robert Nisticò, Alessandro Usiello
Free D-aspartate (D-Asp) occurs in substantial amounts in the brain at the embryonic phase and in the first few postnatal days, and strongly decreases in adulthood. Temporal reduction of D-Asp levels ...Read More
Yuanqi Y Tao, Neil R NR Quebbemann, Ryan R RR Julian
The presence of a single D-amino acid in a peptide is very difficult to detect. Mass spectrometry-based approaches rely on differences in fragmentation between all L-amino acid-containing peptides and...Read More
Lavinia Burrone, Alessandra Santillo, Claudia Pinelli, Gabriella Chieffi Baccari, Maria Maddalena Di Fiore
D-Aspartic acid is an endogenous amino acid occurring in the endocrine glands as well as in the nervous system of various animal phyla. Our previous studies have provided evidence that D-aspartate pla...Read More
Edi Erwan, Shozo Tomonaga, Junki Yoshida, Mao Nagasawa, Yumi Ogino, D Michael Denbow, Mitsuhiro Furuse
Intracerebroventricular (i.c.v.) administration of L-aspartate (L-Asp) attenuates stress responses in neonatal chicks, but the mechanism has not been clarified. In the present study, three behavioral ...Read More
Paolo P Bigini, Marco M Milanese, Fabrizio F Gardoni, Annalisa A Longhi, Tiziana T Bonifacino, Sara S Barbera, Elena E Fumagalli, Monica M Di Luca, Tiziana T Mennini, Giambattista G Bonanno
Neuronal ceroid lipofuscinoses (NCLs) are a group of hereditary childhood diseases characterized mainly by lipopigment accumulation and a multisystemic pattern of symptoms including mental retardation...Read More
Francesco F Errico, Alessandra A Bonito-Oliva, Vincenza V Bagetta, Daniela D Vitucci, Rosaria R Romano, Elisa E Zianni, Francesco F Napolitano, Silvia S Marinucci, Monica M Di Luca, Paolo P Calabresi, Gilberto G Fisone, Manolo M Carta, Barbara B Picconi,
In Parkinson's disease (PD) progressive alteration of striatal N-methyl-D-aspartate receptors (NMDARs) signaling has emerged as a considerable factor for the onset of the adverse motor effects of...Read More
Oda, Kobayashi, Takahashi
Molecular dynamics simulations of amyloid @b"1"-"4"2 containing d-aspartic acid residues were performed using several continuous solvent models to investigate the usefulness of sim...Read More
Takehiko T Yokoyama, Masafumi M Amano, Masae M Sekine, Hiroshi H Homma, Masaharu M Tokuda, Minoru M Sato
Immunohistochemical localization (cellular localization) of endogenous D-aspartate in the marine brown alga Sargassum fusiforme was investigated by the use of a specific polyclonal antibody raised aga...Read More
Franca F Raucci, Maria Maddalena MM Di Fiore
We investigated the involvement of D-Aspartic acid (D-Asp) on ovarian and testicular morphology of the green frog, Rana esculenta, and its effect on the testosterone production. The study has been per...Read More
H H Homma
Recent investigations have shown that D-aspartate (D-Asp) plays an important physiological role(s) in the mammalian body. Here, several recent studies of free D-Asp metabolism in mammals, focusing on ...Read More
Olga Boudker, Renae M Ryan, Dinesh Yernool, Keiko Shimamoto, Eric Gouaux
Secondary transporters are integral membrane proteins that catalyse the movement of substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion gradients, thereby p...Read More