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吡咯烷二硫代甲酸铵盐

产品编号 A106037 | CAS号 5108-96-3 | Aladdin
Ammonium pyrrolidinedithiocarbamate
99%
组合的产品项目
货号 规格 库存 价格 数量
A106037-100g 99% 上海(4)
北方(预计3-5个工作日)
 
A106037-1g 99% 上海(>10)
北方(7)
 
A106037-25g 99% 上海(1)
北方(预计3-5个工作日)
 
A106037-5g 99% 上海(>10)
北方(预计3-5个工作日)
 
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属性

敏感性 对空气和热敏感
密度 1.2640
熔点 149-152°C
溶解性 Soluble in water (50 mg/ml), ethanol, chloroform, and DMSO (100 mM).
存贮条件 储存温度2-8°C,充氩保存

描述

产品介绍 有氨气味。有吸湿性。在空气中不稳定,宜保存在氨气流中。溶于水,微溶于乙醇。有刺激性。
别名 四亚甲基二硫代氨基甲酸铵;1-吡咯烷二硫代羧酸铵盐;吡咯烷二硫代氨基甲酸铵;APDC; PDC;PDTC;;Ammonium 1-pyrrolidinedithiocarbamate; APDC; PDC; PDTC; Pyrrolidinedithiocarbamate, ammonium derivative; Ammonium tetramethylenedithiocarbamate; Ammonium 1-Pyrrolidinecarbodithioate; 1-Pyrrolidinecarbodithioic Acid Ammonium Salt; Ammonium Pyrrolidine-N-dithiocarbamate; Pyrrolidine-N-dithiocarbamic Acid Ammonium Salt;
生化机理 Pyrrolidinedithiocarbamic acid (PDTC) ammonium salt is a potent inhibitor of NF κB (Nuclear Factor κB). Experiments show that micromolar amounts of this compound suppress IL-1β and completely inhibit the increase of nitric oxide synthase mRNA in response to IL-1β. Further studies suggest that PDTC ammonium salt also displays metal-ion chelating and antioxidant characteristics.
应用 原子吸收分析用试剂。发射光谱测定三价铬。多种金属络合剂。测尿中痕量铅。微量测定镉、钴、铋和钼。从酸性溶液中沉淀砷、铋、镉、钴、铜、铁、锰、镍、铅、锑、锡、钒、锌。
依托抑制NOS mRNA的翻译,从而防止一氧化氮合成酶(nitric oxide synthetase)的诱导;诱导大鼠血管平滑肌细胞凋亡和抑制白血病HL- 60细胞凋亡。99%规格适用于此类研究。
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标识符号 GHS07 GHS07
信号词 Warning
风险声明 (欧洲) R22;R36/37/38
安全声明(欧洲) S26;S37/39
警示性声明 P261,P305+P351+P338
危害码(欧洲) Xn
危害声明 H315,H319,H335
个人防护设备 dust mask type N95 (US),Eyeshields,Gloves
WGK德国 3
参考文献
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Calcineurin (protein phosphatase 2B) (CN) comprises a family of serine/threonine phosphatases that play a pivotal role in signal transduction cascades in a variety of cells, including neutrophils. Ang...Read More
Yasuhiro Horita, Takemasa Takii, Ryuji Kuroishi, Taku Chiba, Kenji Ogawa, Laurent Kremer, Yasuo Sato, Yoosa Lee, Tomohiro Hasegawa, Kikuo Onozaki
The present study was undertaken to optimize the anti-tubercular activity of 2-acetamido-2-deoxy-@b-d-glucopyranosyl N,N-dimethyldithiocarbamate (OCT313, Glc-NAc-DMDC), a lead compound previously repo...Read More
Jian Guo Cui, Yuan Yuan Li, Yuhai Zhao, Surjyadipta Bhattacharjee, Walter J Lukiw
Specific microRNAs (miRNAs), small non-coding RNAs that support homeostatic gene expression, are significantly altered in abundance in human neurological disorders. In monocytes, increased expression ...Read More
Weirong Wang, Qinqin Lin, Rong Lin, Jiye Zhang, Feng Ren, Jianfeng Zhang, Meixi Ji, Yanxiang Li
The ligand-activated transcription factor peroxisome proliferator-activated receptor-α (PPARα) participates in the regulation of cellular inflammation. More recent studies indicated that sirtuin1 (S...Read More
Ye Wang, Fei Suo, Ju Liu, Hesheng Hu, Mei Xue, Wenjuan Cheng, Yongli Xuan, Suhua Yan
Cardiac sympathetic hyperinnervation after myocardial infarction (MI) is associated with a high incidence of lethal arrhythmia. However, the mechanisms of nerve sprouting induced by MI are unclear. In...Read More
Xiu Dong, Jian-Chun Li, Yuan-Yuan Jiang, Ming-Yu Xia, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejima
Previous study proved that norcantharidin (NCTD) could exert its anticancer activity in a variety of malignant cell lines, including human cervical carcinoma HeLa cells. In this study, we found that N...Read More
Serhat D?ker, Lokman Uzun, Adil Denizli
A miniaturized solid phase extraction procedure has been developed for ultra-trace determination of inorganic arsenic species. Arsenic(III) as pyrrolidinedithiocarbamate complex was selectively adsorb...Read More
Hong Feng, Chounghun Kang, Jonathan R Dickman, Ryan Koenig, Iwalola Awoyinka, Yong Zhang, Li Li Ji
Interaction of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) with other cellular signalling pathways plays an important role in training-induced mitochondrial adaptations. Th...Read More
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LL37, originally found in the innate immune system, is a robust antimicrobial peptide. LL37 exhibits multiple bio-functions in various cell types, such as migration, cytokine production, apoptosis, an...Read More
Chun-Fa CF Huang, Shing-Hwa SH Liu, Shoei-Yn SY Lin-Shiau
Exposure to mercury can lead to several injuries in mammals, including immune system dysfunction, and pyrrolidine dithiocarbamate (PDTC), as a metal chelator and antioxidant, has been indicated to inc...Read More
A S Dos Passos, T S Néri, M V Maciel, I L da Silva Rom?o, V A Lemos
A pre-concentration procedure with solid-phase extraction was developed for the determination of arsenic (As) in chicken feed using hydride generation atomic absorption spectrometry (HG-AAS). The proc...Read More
Hongli Li, Hao Xu, Baogui Sun
Matrix metalloproteinases (MMPs) are critical to vascular smooth muscle cell migration in vivo. The dysregulation of MMPs is involved in the pathogenesis of abnormal arterial r...Read More
Andreas A Dacho, Christine C Hanusch, Stefan S Lyutenski, Andreas A Dietz
Immune and inflammatory responses and the regulation of cellular events seem to be major factors in ischemia-reperfusion (I/R) injury. The inhibition of nuclear transcription factor κB (NF-κB) by py...Read More
Xinghua X Guo, Yunfeng Y Pan, Chuyin C Xiao, Yuqiong Y Wu, Daozhang D Cai, Jieruo J Gu
After the onset of rheumatoid arthritis (RA), fibroblast-like synoviocytes (RA-FLS) which are specialized types of fibroblasts, become tumor-like, keeping their ability to increase proliferation and i...Read More
Sibel Tunali ST Akar, Derya D Arslan, Tugba T Alp
The biosorption properties of APDC modified S. albus were tested in batch and column conditions. Effective experimental parameters such as pH, biosorbent dosage, contact time, temperature, initial lea...Read More
Rijun R Gui, Xueqin X An, Hongjuan H Su, Weiguo W Shen, Zhiyun Z Chen, Xiaoyong X Wang
A near-infrared-emitting CdTe/CdS core/shell quantum dots (QDs)-based photoluminescence (PL) sensor was designed and applied for highly selective and sensitive detection of Cd(2+). This sensor was bas...Read More
Zhe Zhao, Gaozhong Huang, Beiyun Wang, Yuan Zhong
Matrix metalloproteinase-9 (MMP-9) has been found at significantly increased activity and also contributes to blood-brain barrier degradation in diabetes. Activation of NF-κB pathway is associated wi...Read More
C Raspé, K H?cherl, S Rath, C Sauvant, M Bucher
Fractalkine is a unique member of the CX3C chemokine family by unfolding its potential through the chemokine (C-X3-C motif) receptor 1 (CX3CR1) with dual function acting both as an adhesion molecule a...Read More
Chang-Hee Kang, Rajapaksha Gendara Prasad Tharanga Jayasooriya, Matharage Gayani Dilshara, Yung Hyun Choi, Yong-Kee Jeong, Nam Deuk Kim, Gi-Young Kim
Since the anti-inflammatory effect of caffeine is unclear in microglial cells, we performed whether caffeine attenuates the expression of pro-inflammatory mediators in lipopolysaccharide (LPS)-stimula...Read More
Weiwei Wang, Ming Zheng
To elucidate the functions of nuclear factor kappa B (NF-κB) in mucin hypersecretion in allergic rhinitis (AR), we examined the in vivo effects of an NF-κB inhibitor, ammonium pyrrolidine dithiocarb...Read More
Judith J Sylvester, Mohammed M El Mabrouk, Rasheed R Ahmad, Ataf A Chaudry, Muhammad M Zafarullah
We investigated the unknown molecular mechanisms of Interleukin-1 (IL-1β)-induced cartilage aggrecan degeneration by aggrecanase (ADAMTS-A Disintegrin And Metalloproteinase with ThromboSpondin motifs...Read More
Venugopal Reddy Venna, Gillian Weston, Sharon E Benashski, Sami Tarabishy, Fudong Liu, Jun Li, Lisa H Conti, Louise D McCullough
Social isolation (SI) is increasingly recognized as a risk factor for stroke. Individuals with lack of social support systems have an increased incidence of stroke, poorer recovery, and greater functi...Read More
Anna E Montegudo, Mary A Palilonis, Cathy C Moore, Toan Huynh, Iain H McKillop, Susan L Evans
Hemorrhagic shock is a life threatening condition characterized by diminishing organ function. The aim of this study was to determine whether an effective pyrrolidine dithiocarbamate (PDTC) treatment ...Read More
J S JS Kim, K D KD Kim, H S HS Na, S Y SY Jeong, H R HR Park, S S Kim, J J Chung
Streptococcus mutans, a major etiological agent of dental caries, frequently causes systemic disease, such as subacute bacterial endocarditis, if it enters the bloodstream. In this study, the producti...Read More
Qiaozhuan Q Li, Ming M Li, Ya-Lan YL Wang, Nilufer Jasmine Selimah NJ Fauzee, Yi Y Yang, Juan J Pan, Lian L Yang, Alexander A Lazar
To investigate the role and mechanism of PARG inhibition of metastatic behavior in colonic carcinoma cells....Read More
Min Qiu, Yu Chen, Lin Cheng, Ying Chu, Hong-Yong Song, Zhi-Wei Wu
Pyrrolidine dithiocarbamate (PDTC) is widely used as an antioxidant or an NF-κB inhibitor. It has been reported to inhibit the replication of human rhinoviruses, poliovirus, coxsackievirus, and influ...Read More
M P MP Sherman, E E EE Aeberhard, V Z VZ Wong, J M JM Griscavage, L J LJ Ignarro
Since nuclear factor kappa B (NF-kappa B) is activated during many inflammatory conditions, we assessed its role in expression of the L-arginine-nitric oxide pathway by rat alveolar macrophages. Pyrro...Read More