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乙酰氧肟酸

产品编号 A106239 | CAS号 546-88-3 | Aladdin
Acetohydroxamic acid
98%
组合的产品项目
货号 规格 库存 价格 数量
A106239-1g 98% 上海(3)
北方(预计3-5个工作日)
 
A106239-25g 98% 上海(2)
北方(2)
 
A106239-5g 98% 上海(4)
北方(预计3-5个工作日)
 
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属性

敏感性 易吸潮,对光敏感
密度 1.1550
熔点 86-90°C
存贮条件 极易潮解,密封避光保存。

描述

产品介绍 几乎无臭;味微苦;遇光变色;易吸潮;易溶于水、无水乙醇;水溶液呈调酸性反应。
别名 乙酰氧肟酸 ;醋羟胺酸, N-羟基乙酰胺,乙酰异羟肟酸 ;N-Hydroxyacetamide
应用 牧业上用于提高饲料蛋白质转化率 。
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标识符号 GHS08 GHS08
信号词 Danger
风险声明 (欧洲) R61;
安全声明(欧洲) S45;S53;
警示性声明 P201,P308+P313
危害码(欧洲) T
危害声明 H360
个人防护设备 Eyeshields,Gloves,type P2 (EN 143) respirator cartridges
RTECS AK8157000
WGK德国 3
Merck Index 63
参考文献
Jennifer A Jacobsen, Jessica L Fullagar, Melissa T Miller, Seth M Cohen
Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...Read More
Francisco J Prado-Prado, Xerardo García-Mera, Humberto González-Díaz
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one pa...Read More
Danuta D Gillner, Nicola N Armoush, Richard C RC Holz, Daniel P DP Becker
The dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) is a critical bacterial enzyme for the construction of the bacterial cell wall. A screen biased toward compounds containing zin...Read More
Sandeep S Kumar, Arvind M AM Kayastha
Soybean urease has been investigated extensively to reveal the presence of histidine residue (s) in the active site and their potential role in the catalysis. The spectrophotometric studies using diet...Read More
Claudia C Temperini, Alessio A Innocenti, Andrea A Scozzafava, Claudiu T CT Supuran
We're sorry this abstract is currently not available....Read More
Denis Fourches, Julie C Barnes, Nicola C Day, Paul Bradley, Jane Z Reed, Alexander Tropsha
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...Read More
Hillary E HE Hoffman, Jana J Jirásková, Petr P Cígler, Miloslav M Sanda, Jan J Schraml, Jan J Konvalinka
Mammalian serine racemase (SR) is a pyridoxal-5'-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter D-serine, which activates N-methyl-D-aspartate (NMDA) re...Read More
Filip F Jaros, Tomás T Straka, Zdenka Z Dobesová, Mária M Pintérová, Karel K Chalupsky, Jaroslav J Kunes, Gustav G Entlicher, Josef J Zicha
Several non-aromatic substituted oxime derivatives (formamidoxime, acetaldoxime, acetone oxime, acetohydroxamic acid, formaldoxime) function as vasorelaxant NO donors when added to precontracted aorti...Read More
Yuval Samuni, Uri Samuni, Sara Goldstein
Reduction of cyclic stable nitroxides (RNO) by HNO to the respective hydroxylamines (RNO-H) has been demonstrated using EPR spectrometry. HNO shows low reactivity toward piperidine, pyrrolidine and ni...Read More
Rashmi Sharma, Wesley R Harris
Serum transferrin is the protein that transports ferric ion through the bloodstream and is thus a potential target for iron chelation therapy. However, the release of iron from transferrin to low-mole...Read More
Deepak D Pandey, Rajendra R Singh, Duni D Chand
Acyltransferase activity of amidase from Bacillus sp. APB-6 was enhanced (24 U) by multiple feedings of N-methylacetamide (70 mM) into the production medium. Hyperinduced whole resting cells of Bacill...Read More
Yang Y Liu, Liang L Yang, S?ren S Molin
The efflux pump inhibitor phenyl-arginine-beta-naphthylamide (PAbetaN) was paired with iron chelators 2,2'-dipyridyl, acetohydroxamic acid, and EDTA to assess synergistic activities against Pseud...Read More
Paruvathanahalli Siddalingam Rajinikanth, Brahmeshwar Mishra
The objective of this study was to develop a novel floating in situ gel system for sustained drug delivery of acetohydroxamic acid (FIGA) for eradication of Helicobacter pylori (H. pylori). The FIGA w...Read More
Parauvathanahalli Siddalingam PS Rajinikanth, Brahmeshwar B Mishra
Gellan based floating beads of acetohydroxamic acid (AHA) were prepared by the ionotropic gellation method to achieve controlled and sustained drug release for treatment of Helicobacter pylori infecti...Read More
Ivano I Bertini, Vito V Calderone, Marco M Fragai, Andrea A Giachetti, Mauro M Loconte, Claudio C Luchinat, Massimiliano M Maletta, Cristina C Nativi, Kwon Joo KJ Yeo
By solving high-resolution crystal structures of a large number (14 in this case) of adducts of matrix metalloproteinase 12 (MMP12) with strong, nanomolar, inhibitors all derived from a single ligand ...Read More
Faith E FE Jacobsen, Jana A JA Lewis, Seth M SM Cohen
In an effort to identify promising non-hydroxamate inhibitors of matrix metalloproteinases (MMPs) several new zinc-binding groups (ZBGs) based on pyridine-derived or aza-macrocycle chelators have been...Read More
Mohamed M Takhi, C C Murugan, M M Munikumar, K M KM Bhaskarreddy, Gurpreet G Singh, K K Sreenivas, M M Sitaramkumar, N N Selvakumar, J J Das, Sanjay S Trehan, Javed J Iqbal
The synthesis of oxazolidinones possessing N-hydroxyacetamidine group on piperazine scaffold and their in vitro antibacterial activity profile are disclosed herein....Read More
Katarzyna K Rudzka, Atta M AM Arif, Lisa M LM Berreau
Mononuclear Ni(II), Co(II), and Zn(II) complexes of the bppppa (N,N-bis[(6-phenyl-2-pyridyl)methyl]-N-[(6-pivaloylamido-2-pyridyl)methyl]amine) ligand have been synthesized and characterized by X-ray ...Read More
Magdalena Sałdyka, Zofia Mielke
Dimerization of the keto tautomer of acetohydroxamic acid has been studied using FTIR matrix isolation spectroscopy and DFT(B3LYP)/6-31+G(d,p) calculations. Analysis of CH"3CONHOH/Ar matrix spect...Read More
Katarzyna K Rudzka, Magdalena M MM Makowska-Grzyska, Ewa E Szajna, Atta M AM Arif, Lisa M LM Berreau
Treatment of a new chelate ligand having both amide- and phenyl-appended pyridyl moieties with Ni(ClO4).6H2O and acetohydroxamic acid in methanol solution results in the production of a novel pseudo-o...Read More
Om Prakash, Lata Sheo Bachan Upadhyay
Urease from the seeds of watermelon (Citrullus vulgaris) was purified to apparent homogeneity, using two acetone fractionation steps, heat treatment at 48 degrees C and gel filtration through Sephadex...Read More
Howard A Fink, Timothy J Wilt, Keith E Eidman, Pranav S Garimella, Roderick MacDonald, Indulis R Rutks, Michelle Brasure, Robert L Kane, Jeannine Ouellette, Manoj Monga
Optimum management to prevent recurrent kidney stones is uncertain.To evaluate the benefits and harms of interventions to prevent recurrent kidney stones.MEDLINE, Cochrane, and other databases through...Read More
Amram Samuni, Sara Goldstein
The pharmacological effects of hydroxamate derivatives have been attributed not only to metal chelation or enzyme inhibition but also to their ability to serve as nitroxyl (HNO/NO(-)) and nitric oxide...Read More
Valentina V Borsi, Vito V Calderone, Marco M Fragai, Claudio C Luchinat, Niko N Sarti
For several drug leads obtained by tethering weak binding ligands, the dissociation constant is smaller than the product of those of the individual fragments by a factor named the linking coefficient,...Read More
Peter P Tkac, Martin M Precek, Alena A Paulenova
The reduction of Pu(IV) in the presence of acetohydroxamic acid (HAHA) was monitored by vis-NIR spectroscopy. All experiments were performed under low HAHA/Pu(IV) ratios, where only the Pu(IV)-monoace...Read More
Barbara Krajewska, Wies?awa Zaborska
Of the active-site binding inhibitors of urease studied, PPD, AHA, boric acid and fluoride, only PPD was able to thoroughly and effectively protect the active site flap cysteine from further modificat...Read More
David C Edwards, Satish C B Myneni
X-ray absorption spectroscopy (XAS) is widely used to explore the coordination environments and structures of metal complexes in aqueous solutions and disordered phases. Although soft-XAS studies on g...Read More
Ivano Bertini, Vito Calderone, Marta Cosenza, Marco Fragai, Yong-Min Lee, Claudio Luchinat, Stefano Mangani, Beatrice Terni, Paola Turano
The structures of the catalytic domain of matrix metalloproteinase 12 in the presence of acetohydroxamic acid and N-isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid have been solved by x-ray...Read More
Hui Ming HM Ge, Bo B Huang, Shu Hua SH Tan, Da Hua da H Shi, Yong Chun YC Song, Ren Xiang RX Tan
Hopeanolin (1), an unusual resveratral trimer with an ortho-quinone nucleus, was isolated and characterized from the stem bark of Hopea exalata. Also obtained were six known stibenoids, shoreaphenol (...Read More
David J DJ Witter, Sandro S Belvedere, Liqiang L Chen, J Paul JP Secrist, Ralph T RT Mosley, Thomas A TA Miller
Benzo[b]thienyl hydroxamic acids were identified via a targeted screen of small molecule hydroxamic acids. Various substitutions were explored in the benzo[b]thiophene C5- and C6-positions which lead ...Read More
Phieng P Siliphaivanh, Paul P Harrington, David J DJ Witter, Karin K Otte, Paul P Tempest, Sam S Kattar, Astrid M AM Kral, Judith C JC Fleming, Sujal V SV Deshmukh, Andreas A Harsch, Paul J PJ Secrist, Thomas A TA Miller
2-(4-{[(2-Aminophenyl)amino]carbonyl}phenyl)-N,N'-diphenylmalonamide containing excellent HDAC and cellular proliferation inhibitory activities was identified as a novel benzamide-derived HDAC in...Read More
Zhu-Ping Xiao, Da-Hua Shi, Huan-Qiu Li, Li-Na Zhang, Chen Xu, Hai-Liang Zhu
A series of polyphenols were synthesized and evaluated for inhibitory activity against Helicobacter pylori urease. Compounds 15 and 17 were the potent inhibitors with IC"5"0=0.03 and 0.14mM,...Read More
Stamatia Vassiliou, Agnieszka Grabowiecka, Paulina Kosikowska, Athanasios Yiotakis, Pawe? Kafarski, ?ukasz Berlicki
A new group of organophosphorus inhibitors of urease, P-methyl phosphinic acids was discovered by using the structure based inhibitor design approach. Several derivatives of the lead compound, aminome...Read More
Wen-Jun Mao, Peng-Cheng Lv, Lei Shi, Huan-Qiu Li, Hai-Liang Zhu
Fourteen metronidazole derivatives (compounds 3a-f and 4b-h) have been synthesized by coupling of metronidazole and salicylic acid derivatives. All of them are reported for the first time. Their chemi...Read More
Huan-Qiu HQ Li, Zhu-Ping ZP Xiao, Yin-Luo, Tao T Yan, Peng-Cheng PC Lv, Hai-Liang HL Zhu
Twenty amines and oximes from deoxybenzoins were prepared and evaluated for their inhibitory activity against Helicobacter pylori urease. Among these compounds, high inhibitory activities were observe...Read More
Stamatia S Vassiliou, Paulina P Kosikowska, Agnieszka A Grabowiecka, Athanasios A Yiotakis, Pawe? P Kafarski, Lukasz L Berlicki
Urease inhibitors can be considered as a tool to control the damaging effect of ureolytic bacteria infections in humans which occur commonly in the developed countries. Computer-aided optimization of ...Read More
Zhu-Ping Xiao, Tao-Wu Ma, Wei-Chang Fu, Xiao-Chun Peng, Ai-Hua Zhang, Hai-Liang Zhu
Some pyrogallol and catechol derivatives were synthesized, and their urease inhibitory activity was evaluated by using acetohydroxamic acid (AHA), a well known Helicobacter pylori urease inhibitor, as...Read More