|产品介绍||2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.|
|别名||二苯基硼酸2-氨基乙酯;2-氨基乙基二苯硼酸酯;2-氨基乙基联苯基硼酸酯;2-氨基乙酯二苯基硼酸;2-氨基乙基联苯基硼酸酯;二苯基硼酸;(2-Aminoethoxy)diphenylborane;2-Aminoethyl diphenyl borate;Diphenylboric acid 2-aminoethyl ester;2-APB|
|个人防护设备||Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter|
Drosophila melanogaster flies carrying the trp (transient receptor potential) mutation are rapidly blinded by bright light, because of the absence of a Ca2+-permeable ion channel in their photorecepto...Read More
2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.
The effects of a novel membrane-penetrable modulator, 2APB (2-aminoethoxy diphenyl borate), on Ins(1,4,5)P3-induced Ca2+ release were examined. 2APB inhibited Ins(1,4,5)P3-induced Ca2+ release from ra...Read More