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芹菜素

产品编号 A106675 | CAS号 520-36-5 | Aladdin
Apigenin
分析标准品,≥98%
组合的产品项目
货号 规格 库存 价格 数量
A106675-20mg 分析标准品,≥98% 上海(>10)
北方(预计3-5个工作日)
 
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属性

敏感性 对光敏感
密度 1.5480
熔点 345-350°C
存贮条件 避光,储存温度-20°C

描述

产品介绍 芹菜素属于多酚类黄酮类化合物,以植物黄色素的形式存在于多种植物中,吡啶水溶液呈黄色针晶,无嗅无味。几乎不溶于水,部分溶于热酒精,溶于稀KOH溶液。
别名 芹菜素 ;芹黄素,4',5,7-三羟基黄酮,5,7,4'-三羟基黄酮 ;4',5,7-Trihydroxyflavone 5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on 5,7,4'-Trihydroxyflavone
应用 黄酮类化合物(flavonoid),能捕获细胞周期的G2/M期,抑制细胞扩增。抑制生长,诱发凋亡,用于肿瘤药物。
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标识符号 GHS07 GHS07
信号词 Warning
风险声明 (欧洲) R36/37/38;
安全声明(欧洲) S26;S36;
警示性声明 P261,P305+P351+P338
危害声明 H315,H319,H335
RTECS LK9276000
WGK德国 3
Merck Index 730
参考文献
Horng-Huey HH Ko, Wen-Ling WL Chang, Tzy-Ming TM Lu
Three new ent-kaurane type diterpenes, broussonetones A-C (1-3), were isolated from leaves of Broussonetia papyrifera, together with seven known compounds, and their structures determined by 1D and 2D...Read More
Jing Yuan, Ronald L Johnson, Ruili Huang, Jennifer Wichterman, Hongying Jiang, Karen Hayton, David A Fidock, Thomas E Wellems, James Inglese, Christopher P Austin, Xin-zhuan Su
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...Read More
Feng Li, Suresh Awale, Yasuhiro Tezuka, Hiroyasu Esumi, Shigetoshi Kadota
Three new flavonoids, (2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate (1), (7''R)-8-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]chrysin (2), and (7''R)-8...Read More
Mario M Dell'Agli, Germana V GV Galli, Esther E Dal Cero, Federica F Belluti, Riccardo R Matera, Elisa E Zironi, Giampiero G Pagliuca, Enrica E Bosisio
Plant extracts traditionally used for male impotence (Tribulus terrestris, Ferula hermonis, Epimedium brevicornum, Cinnamomum cassia), and the individual compounds cinnamaldehyde, ferutinin, and icari...Read More
Liang Li, Tao Yi, Christopher Wai-Kei Lam
Solid self-microemulsifying drug delivery systems (SMEDDS) have been used increasingly for improving the bioavailability of hydrophobic drugs. Labrasol? and Transcutol? are used widely as surfactant ...Read More
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....Read More
Eugen J Verspohl, Hajime Fujii, Kohei Homma, Sybille Buchwald-Werner
Gastrointestinal discomfort is frequently observed. The effects of Perilla frutescens extract and Vicenin 2 (a compound in this extract) were assayed in rat ileum with or without stimulation with acet...Read More
Ana A Gomes, Eduarda E Fernandes, Artur M S AM Silva, Clementina M M CM Santos, Diana C G A DC Pinto, José A S JA Cavaleiro, José L F C JL Lima
2-Styrylchromones were tested for their scavenging activity against ROS and RNS. Some of the studied compounds proved to be extremely efficient scavengers of the different ROS and RNS, showing, in som...Read More
Haydar ?elik, Müberra Ko?ar, Emel Arin?
The microsomal NADH-dependent electron transport system consisting of cytochrome b5 reductase and cytochrome b5 participates in a number of physiologically important processes including lipid metaboli...Read More
Dragan D Ami?, Bono B Luci?
The applicability of the newly developed RM1 and PM6 methods implemented in the semiempirical quantum chemistry mopac2009 software package in modeling free radical scavenging activity of flavonoids wa...Read More
Peter L PL Katavic, Kenneth K Lamb, Hernan H Navarro, Thomas E TE Prisinzano
Flavonoids have been recognized as the active ingredients of many medicinal plant extracts due to interactions with proteins via phenolic groups and low toxicity. Here, we report the investigation of ...Read More
Satoru Tamura, Kunichika Yoshihira, Katsuaki Fujiwara, Nobutoshi Murakami
Exploration for inhibitors against expression of IgE receptor (Fc@eRI) on human mast cell, a significant trigger to acute and chronic allergic symptoms, disclosed epigallocatechin gallate (EGCG), epic...Read More
Jenny M JM Pedersen, P?r P Matsson, Christel A S CA Bergstr?m, Ulf U Norinder, Janet J Hoogstraate, Per P Artursson
The chemical space of registered oral drugs was explored for inhibitors of the human multidrug-resistance associated protein 2 (MRP2; ABCC2), using a data set of 191 structurally diverse drugs and dru...Read More
Anne Pick, Henrik Müller, Ralf Mayer, Britta Haenisch, Ilza K Pajeva, Mathias Weigt, Heinz B?nisch, Christa E Müller, Michael Wiese
Flavonoids are an interesting group of natural products ubiquitously present in human diet. Their consumption has been associated with various and differing beneficial health effects. However, several...Read More
Hisashi H Matsuda, Yuichiro Y Kogami, Seikou S Nakamura, Tomomi T Sugiyama, Tsubasa T Ueno, Masayuki M Yoshikawa
To search for a new class of antidiabetic compounds, effects of 44 flavonoids on the adipogenesis of 3T3-L1 cells were examined. Among them, 3,4',7-trimethylkaempferol, tetramethylkaempferol, and...Read More
Marnie L MacDonald, Jane Lamerdin, Stephen Owens, Brigitte H Keon, Graham K Bilter, Zhidi Shang, Zhengping Huang, Helen Yu, Jennifer Dias, Tomoe Minami, Stephen W Michnick, John K Westwick
We present a strategy for identifying off-target effects and hidden phenotypes of drugs by directly probing biochemical pathways that underlie therapeutic or toxic mechanisms in intact, living cells. ...Read More
Manar M MM Salem, Karl A KA Werbovetz
Bioactivity-guided fractionation of the root extract of Psorothamnus arborescens yielded the new isoflavone 5,7,3',4'-tetrahydroxy-2'-(3,3-dimethylallyl)isoflavone (1a) and the new 2-ar...Read More
Gang Chen, Sicong Li, Xinxing Dong, Ying Bai, Ailiang Chen, Shuming Yang, Meiying Fang, Galia Zamaratskaia, Olena Doran
Steroid metabolism is important in various species. The accumulation of androgen metabolite, androstenone, in pig adipose tissue is negatively associated with pork flavor, odour and makes the meat unf...Read More
Yusuke Sekiguchi, Tetsuko Nakaniwa, Takayoshi Kinoshita, Isao Nakanishi, Kazuo Kitaura, Akira Hirasawa, Gozoh Tsujimoto, Toshiji Tada
We determined the 2.35-A crystal structure of a human CK2 catalytic subunit (referred to as CK2@a complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2@a wi...Read More
Kee Dong KD Yoon, Doc Gyun DG Jeong, Yun Ha YH Hwang, Jei Man JM Ryu, Jinwoong J Kim
Three new flavonoid glycosides ( 1- 3), 11-hydroxyhainanolidol ( 4), and a new dibenzylbutyrolactone lignan glycoside ( 5) were isolated from the aerial parts of Cephalotaxus koreana Nakai, along with...Read More
Daniela D Schuster, Lyubomir G LG Nashev, Johannes J Kirchmair, Christian C Laggner, Gerhard G Wolber, Thierry T Langer, Alex A Odermatt
17Beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) plays a pivotal role in the local synthesis of the most potent estrogen estradiol. Its expression is a prognostic marker for the outcome of pat...Read More
Pablo R PR Duchowicz, Martín G MG Vitale, Eduardo A EA Castro, Juan C JC Autino, Gustavo P GP Romanelli, Daniel O DO Bennardi
Experimentally assigned values to binding affinity constants of flavonoid ligands towards the benzodiazepine site of the GABA(A) receptor complex were compiled from several publications, and enabled t...Read More
Nam Hee NH Yoo, Dae Sik DS Jang, Jeong Lim JL Yoo, Yun Mi YM Lee, Young Sook YS Kim, Jung-Hee JH Cho, Jin Sook JS Kim
A novel 2,3-dioxygenated flavanone, erigeroflavanone ( 1), as well as eight known flavonoids and two known gamma-pyranone derivatives, were isolated from an ethyl acetate-soluble extract of the flower...Read More
Azadeh Matin, Navnath Gavande, Moon S Kim, Nancy X Yang, Noeris K Salam, Jane R Hanrahan, Rebecca H Roubin, David E Hibbs
Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARalpha and gamma agonists discovered through a structure-driven design paradigm are described. The 7-hydroxy-benzopyra...Read More
Yosuke Y Nishizaki, Yoichi Y Ishimoto, Yudai Y Hotta, Akifumi A Hosoda, Hiromichi H Yoshikawa, Miki M Akamatsu, Hiroto H Tamura
The effect of 32 flavonoids on androgen (AR) and glucocorticoid receptors (GR) was investigated using an MDA-kb2 human breast cancer cell line to predict potential AR and GR activities. Among them, 5-...Read More
Hyung Jae Jeong, Young Bae Ryu, Su-Jin Park, Jang Hoon Kim, Hyung-Jun Kwon, Jin Hyo Kim, Ki Hun Park, Mun-Chual Rho, Woo Song Lee
Five flavonols (3, 5, and 9-11) were isolated from Rhodiola rosea, and compared with commercially available flavonoids (1, 2, 4, 6-8, and 12-14) to facilitate analysis of their structure-activity rela...Read More
Ga?bor Borbe?ly, Istva?n Szabadkai, Zolta?n Horva?th, Pe?ter Marko?, Zolta?n Varga, No?ra Breza, Ferenc Baska, Tibor Va?ntus, Mo?nika Husza?r, Miklo?s Geiszt, La?szlo? Hunyady, La?szlo? Buday, La?szlo? O?rfi, Gyo?rgy Ke?ri
NOX enzymes are the major contributors in many oxidative damage related diseases. Unfortunately, at present no specific NOX inhibitor is available. Here, we describe the discovery and development of n...Read More
Hitomi Takemura, Toshimasa Itoh, Keiko Yamamoto, Hiroyuki Sakakibara, Kayoko Shimoi
Cytochrome P450 (CYP) 1B1 catalyzes 17@b-estradiol (E"2) to predominantly carcinogenic 4-hydroxy-E"2, whereas CYP1A1 and 1A2 convert E"2 to non-carcinogenic 2-hydroxy-E"2. Hence, s...Read More
Gugan G Kothandan, Changdev G CG Gadhe, Thirumurthy T Madhavan, Cheol Hee CH Choi, Seung Joo SJ Cho
In order to explore the interactions between flavones and P-gp, in silico methodologies such as docking and 3D-QSAR were performed. CoMFA and CoMSIA analyses were done using ligand based and receptor ...Read More
Jean J K Bankeu, Rustamova Khayala, Bruno N Lenta, Didérot T Noungoué, Silvère A Ngouela, Sufyan A Mustafa, Khalid Asaad, Mohammed I Choudhary, Sean T Prigge, Ralphreed Hasanov, Augustin E Nkengfack, Etienne Tsamo, Muhammad S Ali
Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A-C (1-3), together with 16 known compounds. Some of the isolat...Read More
Bernadette M McArdle, Marc R Campitelli, Ronald J Quinn
The relationship between a natural product's biosynthetic enzyme and its therapeutic target is unknown. The concept of protein fold topologies, as a determining factor in recognition, has been de...Read More
Veljko V Veljkovic, Jean-Fran?ois JF Mouscadet, Nevena N Veljkovic, Sanja S Glisic, Zeger Z Debyser
Flavonoid compounds represent an important natural source of antiretrovirals for AIDS therapy due to their significant anti-HIV-1 activity and low toxicity. Here we propose a simple theoretical criter...Read More
Andrei I Khlebnikov, Igor A Schepetkin, Nina G Domina, Liliya N Kirpotina, Mark T Quinn
Quantitative structure-activity relationship (QSAR) models are useful in understanding how chemical structure relates to the biological activity of natural and synthetic chemicals and for design of ne...Read More
Sheldon S Holder, Michael M Lilly, Milton L ML Brown
The PIM-1 protein, the product of the pim-1 oncogene, is a serine/threonine kinase. Dysregulation of the PIM-1 kinase has been implicated in the development of human malignancies including lymphomas, ...Read More
Ai-Lin AL Liu, Hai-Di HD Wang, Simon MingYuen SM Lee, Yi-Tao YT Wang, Guan-Hua GH Du
Flavonoids are polyphenolic compounds that widely exist in plant kingdom, and the structure-activity relationship (SAR) of 25 flavonoids was studied on neuraminidase (NA) activity of influenza virus. ...Read More
S Paoletta, G B Steventon, D Wildeboer, T M Ehrman, P J Hylands, D J Barlow
We're sorry this abstract is currently not available....Read More
Albert Sánchez, Enrique Pedroso, Anna Grandas
Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular ol...Read More
Vesna Rastija, Marica Medi?-Sari?
Quantitative structure activity relationships (QSAR) were obtained describing the antioxidant activity of the main pharmacologically active polyphenols of wine, using molecular properties and descript...Read More
Shingo Arioka, Masahiro Sakagami, Rie Uematsu, Hiroto Yamaguchi, Hiroko Togame, Hiroshi Takemoto, Hiroshi Hinou, Shin-Ichiro Nishimura
The protozoan Trypanosoma cruzi, the causative agent of Chagas' disease, can infect the heart, causing cardiac arrest frequently followed by death. To treat this disease, a potential molecular dr...Read More
Andrew G Mercader, Alicia B Pomilio
We performed a predictive analysis based on Quantitative Structure-Activity Relationships (QSAR) of a very important property of flavonoids which is the inhibition (IC"5"0) of influenza H1N1...Read More
Maja Katalini?, Gordana Rusak, Jelena Doma?inovi? Barovi?, Goran inko, Dubravko Jeli?, Roberto Antolovi?, Zrinka Kovarik
Selected flavonoids: galangin, kaempferol, quercetin, myricetin, fisetin, apigenin, luteolin and rutin, reversibly inhibited human butyrylcholinesterase (BChE, EC 3.1.1.8). Inhibition potency of the f...Read More
Eduardo Borges de Melo, Jo?o Paulo Ataide Martins, Teresa Cristina Marinho Jorge, Marcelo Couto Friozi, Márcia Miguel Castro Ferreira
A quantitative structure-activity relationship (QSAR) study of twenty flavonoid derivatives with antimutagenic activity against 3-nitrofluoranthene (3-NFA) was performed by Partial Least Squares (PLS)...Read More
Vasilis P VP Androutsopoulos, Athanasios A Papakyriakou, Dionisios D Vourloumis, Demetrios A DA Spandidos
CYP1A1 and CYP1B1 are two extrahepatic enzymes that have been implicated in carcinogenesis and cancer progression. Selective inhibition of CYP1A1 and CYP1B1 by dietary constituents, notably the class ...Read More
Shyue-An SA Chan, Luis L Polo-Parada, Lynn T LT Landmesser, Corey C Smith
Neural cell adhesion molecule (NCAM) plays several critical roles in neuron path-finding and intercellular communication during development. In the clinical setting, serum NCAM levels are altered in b...Read More
J Song, L Parker, L Hormozi, M A Tanouye
The Drosophila DNA topoisomerase type I mutant allele, top1JS is an effective general seizure-suppressor mutation, reverting seizure-sensitive phenotypes of several mutant strains in a genetic model o...Read More
Parminder P Kaur, Sanjeev S Shukla, Sanjay S Gupta
Inappropriate activation of phosphatidylinositol 3-kinase-Akt signaling contributes to the development of several human malignancies. Modulation of Akt activity is a strategy that may be valuable in c...Read More
John J Sanseverino, Melanie L ML Eldridge, Alice C AC Layton, James P JP Easter, Jason J Yarbrough, Terry Wayne TW Schultz, Gary S GS Sayler
Saccharomyces cerevisiae bioluminescent bioreporter assays were developed previously to assess a chemical's estrogenic or androgenic disrupting potential. S. cerevisiae BLYES, S. cerevisiae BLYAS...Read More
Jeffrey B Woodruff, David G Drubin, Georjana Barnes
Dynein is a minus-end-directed microtubule motor important for mitotic spindle positioning. In budding yeast, dynein activity is restricted to anaphase when the nucleus enters the bud neck, yet the na...Read More
Yan-Ling Li, Jin-Yu Wang, De-Bin Yang, Mei-Hong Dong, Yan Tong
To prepare the new traditional Chinese medicine preparation--pH-dependent brevisapin colon-specific tablets, and investigate its in vitro release, in order to discuss the feasibility of preparing colo...Read More
Daniel Arango, Kengo Morohashi, Alper Yilmaz, Kouji Kuramochi, Arti Parihar, Bledi Brahimaj, Erich Grotewold, Andrea I Doseff
Flavonoids constitute the largest class of dietary phytochemicals, adding essential health value to our diet, and are emerging as key nutraceuticals. Cellular targets for dietary phytochemicals remain...Read More
L P Li, X D Wu, Z J Chen, S Y Sun, J F Ye, S Zeng, H D Jiang
The aims of the present study were to study the interspecies difference in the pharmacokinetics of luteolin and apigenin occurring in Chrysanthemum morifolium extract (CME) among rats, beagle dogs, mi...Read More
Kaihui Lu, Miaomiao Han, Hui Lin Ting, Zeyu Liu, Dawei Zhang
Adipocyte dysfunction is a major cause of obesity, which is associated strongly with many disorders including psychological and medical morbidities, metabolic abnormalities, and cardiovascular disease...Read More
Alessio Papi, Fulvia Farabegoli, Renato Iori, Marina Orlandi, Gina R De Nicola, Manuela Bagatta, Donato Angelino, Lorenzo Gennari, Paolino Ninfali
Cytotoxic effects of the combination of the food components vitexin-2-O-xyloside (X), raphasatin (4-methylsulphanyl-3-butenyl isothiocyanates; G) and (-)-epigallocatechin-3-gallate (E) were investigat...Read More
Bo Yang, Yu-Lin Zhao, Xia Yang, Xia-Li Liao, Jian Yang, Ji-Hong Zhang, Chuan-Zhu Gao
A series of scutellarin-cyclodextrin conjugates (SCU-CD conjugates), in which scutellarin was covalently bound to one of the primary hydroxyl groups of β-CD, were prepared, and their structures were ...Read More
Sreemanti Das, Jayeeta Das, Asmita Samadder, Naoual Boujedaini, Anisur Rahman Khuda-Bukhsh
We isolated apigenin (5,7,4'-trihydroxy flavone) from ethanolic extract of Lycopodium clavatum (LC) used as a homeopathic mother tincture for treatment of various diseases. We assessed the antica...Read More
Kai-An Chuang, Chien-Hui Lieu, Wei-Jern Tsai, Wen-Hsin Huang, An-Rong Lee, Yuh-Chi Kuo
Aberrant activation of Wnt/β-catenin signaling has been implicated in carcinogenesis. Identification of inhibitors of this pathway may help in cancer therapy. The purpose of this study is to investig...Read More
Jianjun Zhang, Yanting Huang, Dapeng Liu, Yuan Gao, Shuai Qian
The aim of the study was to investigate the potential of nanocrystals to enhance the oral bioavailability of apigenin (AP), a bioactive flavonoid with various pharmacological activities but poor aqueo...Read More
Yuan-Chuen Wang, Kai-Ming Huang
Infection with Helicobacter pylori causes extensive gastric epithelial cell inflammation which may progress to atrophic gastritis, intestinal metaplasia, and even gastric adenocarcinoma. Apigenin (4&#...Read More
R Praveena, K Sadasivam, R Kumaresan, V Deepha, Raman Sivakumar
Rhynchosia capitata (=Glycine capitata) Heyne ex roth, was found to possess polyphenolics including flavonoids, which acts as potential antioxidant. The study of ethanolic extract of roots and leaves ...Read More
Eun Young Kim, Ji Sun Yu, Mihi Yang, An Keun Kim
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is regarded as a promising candidate for anticancer therapy due to its selective toxicity to cancer cells. Nevertheless, because of TRAI...Read More
Griangsak Eumkeb, Somnuk Chukrathok
The purpose of this investigation was to examine the antibacterial and synergistic effect of naturally occurring flavonoids, apigenin, quercetin, naringenin and ceftazidime when use singly and in comb...Read More
Mrinmay Chakrabarti, Naren L Banik, Swapan K Ray
Decrease in expression of the tumor suppressor microRNA-138 (miR-138) correlates well with an increase in telomerase activity in many human cancers. The ability of almost all human cancer cells to gro...Read More
Mario J Simirgiotis, Guillermo Schmeda-Hirschmann, Jorge Bórquez, Edward J Kennelly
The banana passion fruit (Passiflora tripartita Breiter, Passifloraceae) known as "tumbo" is very appreciated in tropical and subtropical countries of South America. Methanolic extracts from...Read More
Paolo Paoli, Paolo Cirri, Anna Caselli, Francesco Ranaldi, Giulia Bruschi, Alice Santi, Guido Camici
Type-2 diabetes is a worldwidely diffuse disease characterized by insulin resistance that arises from alterations of receptor and/or post-receptor events of insulin signalling. Studies performed with ...Read More
Hui H Zou, Kang-Ping KP Xu, Zhen-Xin ZX Zou, Hong-Ping HP Long, Hui H Wang, Fu-Shuang FS Li, Jing J Li, Jun-Wei JW Kuang, Guang G Li, Gui-Shan GS Tan
A new flavonoid, 6-(5-acetyl-2-methoxyphenyl)-apigenin (1), together with nine known compounds (2-10), was isolated from Selaginella uncinata (Desv.) Spring. This is the first report of the spectrosco...Read More
Pavlos Lampropoulos, Maria Lambropoulou, Apostolos Papalois, Neofitos Basios, Maria Manousi, Constantinos Simopoulos, Alexandra K Tsaroucha
The aim of the present study is to evaluate pathologic changes in the pancreatic parenchyma in an experimental model of acute pancreatitis (AP) following bilio-pancreatic duct ligation. An effort was ...Read More
Sheng-Miao SM Cui, Xiu-Fang XF Wei, Jian J Zhang, Zhen-Zhen ZZ Ye, Hua-Wei HW Liao
To establish a HPLC-MS/MS method for the determination of vitexin in rat plasma and its pharmacokinetics....Read More
Qing Ye, Samuel Kantonen, Julian Gomez-Cambronero
Our laboratory has reported earlier that in leukocytes, phospholipase D2 (PLD2) is under control of Janus kinase 3 (JAK3), which mediates chemotaxis. Investigating JAK3 in cancer cells led to an impor...Read More
Sophie S Chen, Randolph Corteling, Lara Stevanato, John Sinden
Metastasis is one of the cancer hallmarks described by Hanahan and Weinberg. Emerging evidence shows that it requires interplays between cancer cells and micro-environmental biofactors. Indoleamine 3,...Read More
Cheng-Hua He, Zhen-Hai Zhang, Shu Wang, Jian-Ping Zhou, Hui-Xia Lv
To establish an in situ single-way intestinal perfusion model, in order to study the intestinal absorption kinetics of AP. The concentration of AP in the perfusate was determined by HLPC. The results ...Read More
Si Hyoung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Seong Jin Lee
Apigenin promotes apoptosis in cancer cells. We studied the effect of apigenin on cell survival and c-Myc expression in FRO anaplastic thyroid carcinoma (ATC) cells. Apigenin caused apoptosis via the ...Read More
Hellen H Meyer, Adrian A Bolarinwa, Guenther G Wolfram, Jakob J Linseisen
Absorption and excretion of apigenin after the ingestion of apiin-rich food, i.e. parsley, was tested....Read More
Sivaprakasam S Balasubramanian, Ling L Zhu, Richard L RL Eckert
Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. In the present study, we examine the mechanism whereby apigenin regulates normal human kerati...Read More
Melissa A MA Vargo, Oliver H OH Voss, Frantisek F Poustka, Arturo J AJ Cardounel, Erich E Grotewold, Andrea I AI Doseff
Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly defined mechanisms. In the present study, the...Read More
Mano M Horinaka, Tatsushi T Yoshida, Takumi T Shiraishi, Susumu S Nakata, Miki M Wakada, Toshiyuki T Sakai
Dietary flavonoid apigenin is expected to have preventive and therapeutic potential against malignant tumors. In this report, we show for the first time that apigenin markedly induces the expression o...Read More
Heshu H Lu, Debbie J DJ Chang, Blandine B Baratte, Laurent L Meijer, Ursula U Schulze-Gahmen
Cyclin-dependent kinases (CDKs) play a central role in cell cycle control, apoptosis, transcription, and neuronal functions. They are important targets for the design of drugs with antimitotic or anti...Read More
Gao-Jun Fan, Young-Hwa Kang, Yong Nam Han, Byung Hoon Han
Two new compounds 6-hydroxy-1,7-diphenyl-4-en-3-heptanone (1) and 6-(2-hydroxy-phenyl)-4-methoxy-2-pyrone (4) along with three known compounds were isolated from the extracts of Alpinia officinarum un...Read More
Anastasia A Karioti, Anastasia A Protopappa, Nikolaos N Megoulas, Helen H Skaltsa
Forty-five secondary metabolites isolated from Marrubium velutinum and Marrubium cylleneum belonging to the classes of flavonoids, phenylethanoid glycosides, phenolic acids and lignan glycosides were ...Read More
Iris L K Wong, Kin-Fai Chan, Brendan A Burkett, Yunzhe Zhao, Yi Chai, Hongzhe Sun, Tak Hang Chan, Larry M C Chow
Drug resistance by overexpression of ATP-binding cassette (ABC) transporters is an impediment in the treatment of leishmaniasis. Flavonoids are known to reverse multidrug resistance (MDR) in Leishmani...Read More
Betty C BC Galarreta, Roxana R Sifuentes, Angela K AK Carrillo, Luis L Sanchez, Maria Del Rosario I Mdel R Amado, Helena H Maruenda
We're sorry this abstract is currently not available....Read More
Takuto Kumano, Stéphane B Richard, Joseph P Noel, Makoto Nishiyama, Tomohisa Kuzuyama
We're sorry this abstract is currently not available....Read More
Simone C B SC Gnoatto, Alexandra A Dassonville-Klimpt, Sophie S Da Nascimento, Philippe P Galéra, Karim K Boumediene, Grace G Gosmann, Pascal P Sonnet, Safa S Moslemi
The inhibitory potency of ursolic acid extracted from Ilex paraguariensis, a plant used in South American population for a tea preparation known as mate, and its derivatives to inhibit aromatase activ...Read More
Masaaki M Ozawa, Tadahiro T Etoh, Masahiko M Hayashi, Kanki K Komiyama, Akio A Kishida, Ayumi A Ohsaki
A new Erythrinan alkaloid (1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan alkaloids (2-7, 9) and an indole alkaloid (8). The structure o...Read More
Young Bae Ryu, Marcus J Curtis-Long, Ji Won Lee, Hyung Won Ryu, Jun Young Kim, Woo Song Lee, Ki Hun Park
The structural characteristics of flavonoids (1-3 and 6-8) from the root of Cudrania tricuspidata required for neuraminidase inhibition were studied and compared with commercially available flavonoids...Read More
Min Hye Yang, Kee Dong Yoon, Young-Won Chin, Ju Hyun Park, Jinwoong Kim
Phytochemical studies of the chloroform soluble fraction of Dioscoreaopposita resulted in the isolation of four new compounds, 3,5-dihydroxy-4-methoxybibenzyl (1), 3,3',5-trihydroxy-2'-metho...Read More
Young Bae Ryu, Marcus J Curtis-Long, Ji Won Lee, Jin Hyo Kim, Jun Young Kim, Kyu Young Kang, Woo Song Lee, Ki Hun Park
Natural polyphenolic compounds generally transpire to show relatively low inhibition against glycosidase including neuraminidase. In addition the inhibition modes of such compounds are rarely competit...Read More
Na N Sha, Shu-Hong SH Guan, Zhi-Qiang ZQ Lu, Guang-Tong GT Chen, Hui-Lian HL Huang, Fu-Bo FB Xie, Qing-Xi QX Yue, Xuan X Liu, De-An DA Guo
A pair of new flavanol racemates (1a and 1b) and a new flavanol racemic mixture (2) were isolated from crude propolis from Henan Province, People's Republic of China. Also obtained were nine know...Read More
Marco Bonesi, Monica R Loizzo, Giancarlo A Statti, Sylvie Michel, Fran?ois Tillequin, Francesco Menichini
A series of chalcones (1-9) and pyrazoles (10-18) was prepared to investigate their potential activity as Angiotensin I-Converting Enzyme (ACE) inhibitors. Their structures were verified by elemental ...Read More
Yagmur Muftuoglu, Gabriela Mustata
The present study utilizes for the first time the structural information of aromatase, an important pharmacological target in anti-breast cancer therapy, to extract the pharmacophoric features importa...Read More
Franco F Chimenti, Rossella R Fioravanti, Adriana A Bolasco, Paola P Chimenti, Daniela D Secci, Francesca F Rossi, Matilde M Yá?ez, Francisco F Orallo, Francesco F Ortuso, Stefano S Alcaro, Roberto R Cirilli, Rosella R Ferretti, M Luisa ML Sanna
A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the ...Read More
Guo-Biao Liu, Jian-Liang Xu, Mei Geng, Rui Xu, Rong-Rong Hui, Jian-Wei Zhao, Qiang Xu, Hong-Xi Xu, Jian-Xin Li
A novel series of diphenolic chromone derivatives were synthesized and their inhibitory activity on nitric oxide (NO) production and cytotoxicity were evaluated using LPS-activated murine macrophages ...Read More
Young Bae Ryu, Hyung Jae Jeong, Jang Hoon Kim, Young Min Kim, Ji-Young Park, Doman Kim, Thi Thanh Hanh Naguyen, Su-Jin Park, Jong Sun Chang, Ki Hun Park
As part of our search for botanical sources of SARS-CoV 3CL^p^r^o inhibitors, we selected Torreya nucifera, which is traditionally used as a medicinal plant in Asia. The ethanol extract of T. nucifera...Read More
Bui Huu Tai, Nguyen Xuan Nhiem, Tran Hong Quang, Nguyen Thi Thanh Ngan, Nguyen Huu Tung, Yohan Kim, Jung-Jin Lee, Chang-Seon Myung, Nguyen Manh Cuong, Young Ho Kim
A new iridoid, named methylscutelloside (1) together with 19 known compounds belonging to the iridoids (2-4), monoterpenoids (5), flavonoids (6-8), triterpenoids (9-14), and phenylethanoids (15-20) we...Read More
Gabriel G Sagrera, Ana A Bertucci, Alvaro A Vazquez, Gustavo G Seoane
The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol and Ullmann condensations. Some of these...Read More
Srinivas S Kantevari, Dinesh D Addla, Pankaj K PK Bagul, Balasubramanian B Sridhar, Sanjay K SK Banerjee
A series of novel 2-butyl-4-chloro-1-methylimidazole embedded aryl and heteroaryl derived chalcones and pyrazoles were synthesized and evaluated for their angiotensin converting enzyme (ACE) inhibitor...Read More
F F Sato, Y Y Matsukawa, K K Matsumoto, H H Nishino, T T Sakai
Flavonoids are pigments of edible plants. We have recently reported that most flavonoids induce G1 arrest in human cancer cells, and that genistein (an isoflavone) specifically inhibits their cell cyc...Read More
Tzong-Der TD Way, Ming-Ching MC Kao, Jen-Kun JK Lin
We have shown that exposure of the HER2/neu-overexpressing breast cancer cells to apigenin resulted in induction of apoptosis by depleting HER2/neu protein and, in turn, suppressing the signaling of t...Read More
Y T Huang, M L Kuo, J Y Liu, S Y Huang, J K Lin
Apigenin, a low-toxic and non-mutagenic plant flavonoid, suppresses 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-mediated tumour promotion of mouse skin. TPA has the ability to activate protein kinase ...Read More
Ronald D RD Snyder, Peter J PJ Gillies
Bioflavonoids are naturally occurring polyphenols with intriguing and varied therapeutic and chemoprotective activities generally ascribed to their antioxidant properties. However, many flavonoids hav...Read More
Jaroslaw Czyz, Uwe Irmer, Claudia Zappe, Matthias Mauz, Dieter F Hülser
We discriminated the role of gap junctional communication and phenotypic constitution of tumour cells in determining their responsiveness to apigenin. Effects of apigenin on intercellular communicatio...Read More
Deniz Tasdemir, Gabriela Lack, Reto Brun, Peter Rüedi, Leonardo Scapozza, Remo Perozzo
After the discovery of a potent natural flavonoid glucoside as a potent inhibitor of FabI, a large flavonoid library was screened against three important enzymes (i.e., FabG, FabZ, and FabI) involved ...Read More