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氨基蝶呤

¥ 956.80

产品编号 A107171 | CAS号 54-62-6 | Aladdin
Aminopterin
98%
组合的产品项目
货号 规格 库存 价格 数量
A107171-10mg 98% 上海(预计4-8周)
北方(预计4-8周)
 
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属性

密度 1.5880
熔点 185-204°C
存贮条件 -20℃保存

描述

产品介绍 易溶于稀碱、酸或碱金属的碳酸盐溶液,微溶于稀盐酸,几乎不溶于水、乙醇、氯仿、乙醚。
别名 氨基蝶呤 ;白血宁,癌得宁,4-氨基叶酸 ;4-Amino-PGA 4-Aminofolic acid 4-Aminopteroyl-L-glutamic acid
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标识符号 GHS06 GHS06, GHS08 GHS08
信号词 Danger
风险声明 (欧洲) 61,28
安全声明(欧洲) 53,28,36/37,45
警示性声明 P201,P264,P301+P310,P308+P313
危害码(欧洲) T+
危害声明 H300,H360
个人防护设备 Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS MA1050000
WGK德国 3
UN代码 2811
参考文献
Jing Yuan, Ronald L Johnson, Ruili Huang, Jennifer Wichterman, Hongying Jiang, Karen Hayton, David A Fidock, Thomas E Wellems, James Inglese, Christopher P Austin, Xin-zhuan Su
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...Read More
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....Read More
Naomi L NL Kruhlak, Sydney S SS Choi, Joseph F JF Contrera, James L JL Weaver, James M JM Willard, Kenneth L KL Hastings, Lawrence F LF Sancilio
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifes...Read More
Joseph R Bertino, Martin Lubin, Nadine Johnson-Farley, Wing C Chan, Lauri Goodell, Sharathkumar Bhagavathi
The majority of peripheral T-cell lymphomas were found to lack methylthioadenosine phosphorylase, an enzyme that is essential for the salvage of adenine from methylthioadenosine, a product of polyamin...Read More
Christoph Fiehn
High expression of folate receptors is characteristic for the effector cell population of synovial macrophages in synovial inflammation. A new drug conjugate, EC0746, targets the folate inhibitor amin...Read More
Christopher G CG Azzoli, Jyoti D JD Patel, Lee M LM Krug, Vincent V Miller, Leonard L James, Mark G MG Kris, Michelle M Ginsberg, Sara S Subzwari, Leslie L Tyson, Megan M Dunne, Jennifer J May, Martha M Huntington, Michael M Saunders, F M FM Sirotnak
Pralatrexate is an antifolate designed for preferential tumor cell uptake and accumulation and received accelerated Food and Drug Administration approval in relapsed/refractory peripheral T-cell lymph...Read More
Sabina A SA Antoniu
This is the annual perspective paper on the discontinued drugs in the field of pulmonary disease allergy, rheumatology, and dermatology. It is part of series of papers discussing drugs dropped from cl...Read More
Edward C EC Keystone, Valery S VS Shirinsky, Lee S LS Simon, Simon S Pedder, L Arthur LA Hewitt,
To investigate the potential efficacy, safety, and tolerability of daily use of CH-1504 in patients with active rheumatoid arthritis (RA). US National Institutes of Health database no. NCT00658047....Read More
Ken Dornfeld
Aim: Thymidine deprivation is a common cancer treatment. This study examines the role of replication arrest and uracil DNA repair in response to thymidine deprivation.Strains of S. cerevisiae deficien...Read More
Junpei Teramachi, Akiko Kukita, Pengfei Qu, Naohisa Wada, Yin-Ji Li, Seiji Nakamura, Toshio Kukita
To search cell surface molecules involved in the regulation of osteoclastogenesis, especially in fusion process, it is one powerful approach to obtain monoclonal antibodies bearing ability to block fo...Read More
Charlie Schmidt
We're sorry this abstract is currently not available....Read More
Christopher K CK Mathews
We're sorry this abstract is currently not available....Read More
Shouxin S Zhou, Chao C Tian, Chao C Li, Ying Y Guo, Xiaowei X Wang, Junyi J Liu, Zhili Z Zhang
An efficient method for the construction of the tetrahydrofolate skeleton is described. Starting from pterin analogues and aromatic amines, 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives and the he...Read More
Karen Kelly, Christopher G Azzoli, Petr Zatloukal, István Albert, Peter Y Z Jiang, David Bodkin, José Rodrigues Pereira, Erzsébet Juhász, Nicholas O Iannotti, Garry Weems, Tony Koutsoukos, Jyoti D Patel
Pralatrexate, a folate analogue targeting dihydrofolate reductase, has antitumor activity in non-small-cell lung cancer (NSCLC). This randomized phase 2b trial was designed to further evaluate pralatr...Read More
Sara C SC Hyoun, Sarah G SG Obi?an, Anthony R AR Scialli
Methotrexate and aminopterin are folic acid antagonists that inhibit dihydrofolate reductase, resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis. Methotrexate has been ...Read More
Steven M SM Horwitz, Youn H YH Kim, Francine F Foss, Jasmine M JM Zain, Patricia L PL Myskowski, Mary Jo MJ Lechowicz, David C DC Fisher, Andrei R AR Shustov, Nancy L NL Bartlett, Maria L ML Delioukina, Tony T Koutsoukos, Michael E ME Saunders, Owen A OA
Systemic treatment for cutaneous T-cell lymphoma (CTCL) involves the use of less aggressive, well-tolerated therapies. Pralatrexate is a novel antifolate with high affinity for reduced folate carrier-...Read More
Francine M Foss
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of T-cell neoplasms. Most patients with PTCL have a poor outcome with conventional therapies and are not cured without stem-cell transplan...Read More
Francine F Foss
We're sorry this abstract is currently not available....Read More
Yingjuan Lu, Torian W Stinnette, Elaine Westrick, Patrick J Klein, Mark A Gehrke, Vicky A Cross, Iontcho R Vlahov, Philip S Low, Christopher P Leamon
Folate receptor (FR)-expressing macrophages have been shown to accumulate at sites of inflammation, where they promote development of inflammatory symptoms. To target such a macrophage population, we ...Read More
Jacek J Bigda, Patrycja Kosza?ka
In this report we describe Wac?aw Szybalski's fundamental contribution to gene therapy and immunotherapy. His 1962 PNAS paper (Szybalska and Szybalski, 1962) documented the first successful gene ...Read More
Aleem Gangjee, Yibin Zeng, John J McGuire, Roy L Kisliuk
We report, for the first time, the biological activities of four-carbon-atom bridged classical antifolates on dihydrofolate reductase (DHFR), thymidylate synthase (TS), and folylpolyglutamate syntheta...Read More
Aleem Gangjee, Xin Lin, Roy L Kisliuk, John J McGuire
Two novel classical antifolates N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid 3 and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]p...Read More
K K Roy, B B Tolner, J H JH Chiao, F M FM Sirotnak
The apparent Km, but not Vmax, for influx of methotrexate (MTX) mediated through the plasma membrane of S180 cells by the one-carbon, reduced folate transporter as well as the KD for binding to the tr...Read More
B G Rumberger, J R Barrueco, F M Sirotnak
Folylpolyglutamyl synthetase (FPGS), partially purified from murine L1210 leukemia and Sarcoma 180 cells and the proliferative fraction of luminal epithelium from mouse small intestine (the site of li...Read More
L H Matherly, M K Voss, L A Anderson, D W Fry, I D Goldman
The polyglutamylation of aminopterin and methotrexate (N10-methylaminopterin) was compared in the Ehrlich ascites tumor in vitro. Three poly-gamma-glutamyl conjugates of methotrexate and aminopterin w...Read More
Alexei Shimanovsky, Constantin A Dasanu
Introduction: Pralatrexate is a novel antifolate agent that belongs to the class of 10-deazaaminopterins. Its clinical efficacy as a single agent in relapsed or refractory peripheral T-cell lymphom...Read More
Terri Parker, Lisa Barbarotta, Francine Foss
Pralatrexate is a folate analogue metabolic inhibitor manufactured by Allos Therapeutics, Inc., a wholly-owned subsidiary of Spectrum Pharmaceuticals, Inc. In both preclinical and clinical studies, pr...Read More
William W Abramovits, Marcial M Oquendo, Patricia P Granowski, Aditya A Gupta, Jennifer J Cather
T-cell lymphoma accounts for 10% to 15% of all cases of non-Hodgkin lymphoma in the United States (approximately 5000 to 6000 cases a year). Peripheral T-cell lymphoma (PTCL) comprises a subgroup of r...Read More
Domenico D Ribatti
Acute lymphoblastic leukemia (ALL) is the most common malignancy affecting children accounting for approximately 30% of childhood cancers, which was uniformly fatal before the advent of effective chem...Read More
Francine Foss, Steven M Horwitz, Bertrand Coiffier, Nancy Bartlett, Leslie Popplewell, Barbara Pro, Lauren C Pinter-Brown, Andrei Shustov, Richard R Furman, Corinne Haioun, Tony Koutsoukos, Owen A O'Connor
Transformed mycosis fungoides (tMF) is an aggressive disease with a median survival of 12-24 months. In this retrospective analysis of 12 patients with tMF, treatment with pralatrexate resulted in an ...Read More
Ana Rita AR Costa, Maria Elisa ME Rodrigues, Mariana M Henriques, David D Melton, Philip P Cunnah, Rosário R Oliveira, Joana J Azeredo
Biopharmaceutical production of complex recombinant protein therapeutics currently relies on mammalian cells. The development of high-yielding stable cell lines requires processes of transfection, sel...Read More
Hatem A HA Azim, Ahmad A Awada
To discuss the clinical development of new formulations of old cytotoxic agents and highlight the value of adopting this strategy....Read More
John Hui, Eugene Przespo, Anjana Elefante
The pharmacology, pharmacokinetics, clinical trials, adverse effects, dosage, and economic considerations of pralatrexate (PDX) are reviewed.Peripheral T-cell lymphoma (PTCL) comprises approximately 1...Read More