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3-氨基-1,2,4-三唑

¥ 71.28

产品编号 A107202 | CAS号 61-82-5 | Aladdin
3-Amino-1,2,4-triazole
96%
组合的产品项目
货号 规格 库存 价格 数量
A107202-100g 96% 上海(>10)
北方(预计3-5个工作日)
 
A107202-2.5kg 96% 上海(1)
北方(预计3-5个工作日)
 
A107202-25g 96% 上海(>10)
北方(>10)
 
A107202-500g 96% 上海(>10)
北方(预计3-5个工作日)
 
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属性

密度 1.1380
熔点 149-156°C
溶解性 Soluble in water (280 g/l) at 20 °C, methanol, ethanol, chloroform, and ethyl acetate (slightly). Insoluble in ether, and acetone.

描述

产品介绍 3-Amino-1,2,4-triazole is a small molecule irreversible inhibitor of catalase, an enzyme responsible for converting cellular H2O2 into H2O and O2. Impeding the natural clearance of H2O2 from the cell by catalase has proven useful in studies investigating free radical-mediated damage of cardiac tissue in ischemia. 3-Amino-1,2,4-triazole also shows inhibition of imidazoleglycerol-phosphate dehydratase (HIS3) activity, which interrupts the biosynthesis of histidines. When 3-Amino-1,2,4-triazole is diazotized, the resulting 3-Diazo-1,2,4-triazole is shown to react specifically with tryptophan at acidic pH, presenting a method for determining the tryptophan content of proteins.
别名 3-氨基-1,2,4-三氮唑;3-氨基-1,2,4-三氮杂茂;氨基三唑;杀草强;Aminotriazole;Amitrol;3-Amino-1H-1,2,4-triazole
应用 An irreversible catalase inhibitor
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标识符号 GHS08 GHS08, GHS09 GHS09
信号词 Warning
风险声明 (欧洲) R63;R48/22;R51/53
安全声明(欧洲) S13;S36/37;S61
警示性声明 P273,P281
危害码(欧洲) Xn,N
危害声明 H361d,H373,H411
个人防护设备 Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS XZ3850000
WGK德国 2
Merck Index 489
UN代码 3077
参考文献
Bianka Steffens, Alexander Kovalev, Stanislav N Gorb, Margret Sauter
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Abstract Pharmacological ascorbate, via its oxidation, has been proposed as a pro-drug for the delivery of H(2)O(2) to tumors. Pharmacological ascorbate decreases clonogenic survival of pancreatic c...Read More
M C MC DeTraglia, J S JS Brand, A M AM Tometsko
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We report a novel regulatory mechanism by which reactive oxygen species (ROS) regulate fumonisin B1 (FB1)-induced cell death. We found that FB1 induction of light-dependent ROS production promoted the...Read More
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Bacteria were isolated from wastewater containing highly concentrated hydrogen peroxide that had been used to clean the pure water delivery system in a semiconductor plant. One bacterium was selected ...Read More
Leonardo M Cardoso, Eduardo Colombari, Glenn M Toney
The hypothalamic paraventricular nucleus (PVN) is important for maintenance of sympathetic nerve activity (SNA) and cardiovascular function. PVN-mediated increases of SNA often involve the excitatory ...Read More
G Ermondi, G Caron
Molecular Interaction Fields (MIFs) based descriptors can be conveniently used to characterize and compare chromatographic scales. In this study, Quantitative Structure-Retention Relationships (QSRR) ...Read More
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Rayhanur R Jannat, Misugi M Uraji, Mohammad Anowar MA Hossain, Mohammad Muzahidul MM Islam, Yoshimasa Y Nakamura, Izumi C IC Mori, Yoshiyuki Y Murata
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Dou D Dou, Xiaoxu X Zheng, Juan J Liu, Xiaojian X Xu, Liping L Ye, Yuansheng Y Gao
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Yi-Ting YT Tsai, Jah-Yao JY Liu, Chung-Yi CY Lee, Chien-Sung CS Tsai, Ming-Hurng MH Chen, Chien-Chih CC Ou, Wei-Hwa WH Chen, Shih-Hurng SH Loh
Changing intracellular pH (pHi) exerts considerable influence on many cellular functions. Different pHi regulators, such as the Na-H exchanger (NHE), Na/(Equation is included in full-text article.)sym...Read More
Rayhanur R Jannat, Misugi M Uraji, Miho M Morofuji, Mohammad Anowar MA Hossain, Mohammad Muzahidul MM Islam, Yoshimasa Y Nakamura, Izumi C IC Mori, Yoshiyuki Y Murata
We investigated the roles of catalase (CAT) in abscisic acid (ABA)-induced stomatal closure using a cat2 mutant and an inhibitor of CAT, 3-aminotriazole (AT). Constitutive reactive oxygen species (ROS...Read More
Yao Y Xu, Qing Q Gao, Xian-Bing XB Gan, Lei L Chen, Lei L Zhang, Guo-Qing GQ Zhu, Xing-Ya XY Gao
An enhancement of the cardiac sympathetic afferent reflex (CSAR) contributes to sympathetic activation in renovascular hypertension. Angiotensin II in the paraventricular nucleus (PVN) augments the CS...Read More
Hongmei H Pan, Lishi L Zhang
The mechanisms of the effects of amitrole on the thyroglobulin (TG) was investigated in Fischer rat thyroid follicle-5 cell (FRTL-5 cells) and in the medium....Read More
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Cytochrome P-450 metabolites of arachidonic acid, the epoxyeicosatrienoic acids (EETs) and hydrogen peroxide (H(2)O(2)), are important signaling molecules in the kidney. In renal arteries, EETs cause ...Read More
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Reactive oxygen species (ROS), including hydrogen peroxide (H(2)O(2)), are among the important second messengers in abscisic acid (ABA) signaling in guard cells. In this study, to investigate specific...Read More
Y M YM Issa, H B HB Hassib, H E HE Abdelaal, I M IM Kenawi
3-Amino-1,2,4-triazole Schiff bases were reported to contain intramolecular charge-transfer. The enhancing and depressing effects were remarkable as the substituent was changed from electron-donating ...Read More
X Chen, H Han, P Jiang, L Nie, H Bao, P Fan, S Lv, J Feng, Y Li
Inhibition of lycopene cyclization decreased the salt tolerance of the euhalophyte Salicornia europaea L. We isolated a β-lycopene cyclase gene SeLCY from S. europaea and transformed it into Arabidop...Read More
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Thoraya A Farghaly, Magda A Abdallah, Mohamed R Abdel Aziz
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Many studies have investigated the role of oxidative stress on cardiovascular system in the brainstem of spontaneously hypertensive rats (SHR). However, we do not know yet if catalase inhibition influ...Read More
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