¥ 117.00

产品编号 A107207 | CAS号 3544-24-9 | 阿拉丁
货号 规格 库存 价格 数量
A107207-100g 98% 上海(预计3-7周)
A107207-1g 98% 上海(>10)
A107207-25g 98% 上海(4)
A107207-5g 98% 上海(6)


敏感性 对光线敏感
密度 1.2330
熔点 115-116°C
存贮条件 充氩气储存


别名 间氨基苯甲酰胺;3-AB;3-ABA

INO-1001 a novel potent PARP inhibitor with an IC50 of 3 nM.

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标识符号 GHS07 GHS07
信号词 Warning
风险声明 (欧洲) 36/37/38
安全声明(欧洲) 26,36
警示性声明 P261,P305+P351+P338
危害码(欧洲) Xi
危害声明 H302,H315,H319,H335
个人防护设备 dust mask type N95 (US),Eyeshields,Gloves
RTECS CU8992000
WGK德国 3
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....Read More
Kamelia M Amin, Manal M Anwar, Yasmin M Syam, Mohammed Khedr, Mohsen M Kamel, Emad M M Kassem
Molecular docking simulation study was carried out to design a novel series of spiro [(2H, 3H)quinazoline-2,1'-cyclohexan]-4(1H)-one derivatives as a new class of effective PARP-1 inhibitors. Spi...Read More
M R MR Purnell, W J WJ Whish
In a search for new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, it was found that various benzamides substituted in the 3-position were the most inhibitory compounds found to date. T...Read More
B B Heller, Z Q ZQ Wang, E F EF Wagner, J J Radons, A A Bürkle, K K Fehsel, V V Burkart, H H Kolb
Activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is an early response of cells exposed to DNA-damaging compounds such as nitric oxide (NO) or reactive oxygen intermediates (ROI). Ex...Read More
C C Nosseri, S S Coppola, L L Ghibelli
U937 human myeloid leukemia cells respond to mild treatment with hydrogen peroxide and hyperthermia by undergoing apoptosis, an active mode of cell suicide. Higher concentrations of hydrogen peroxide,...Read More
M L ML Kuo, Y P YP Chau, J H JH Wang, S G SG Shiah
Previous studies have shown that chemically generated nitric oxide (NO) can induce human leukemia HL-60 cells to undergo monocytic differentiation. We show here that exposure of HL-60 cells to chemica...Read More
Xibao Liu, Ana Cotrim, Leyla Teos, Changyu Zheng, William Swaim, James Mitchell, Yasuo Mori, Indu Ambudkar
Xerostomia as a result of salivary gland damage is a permanent and debilitating side effect of radiotherapy for head and neck cancers. Effective treatments for protecting, or restoring, salivary gland...Read More
Wen Ji WJ Li, YuBing Y Peng, Juan J Zhou, Bao B Li, Hao H Wang, Jun J Zhang, Zhong Z Wang
Endothelial dysfunction-induced abnormalities of the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the corpus cavernosum are thought to be the main factors involved in t...Read More
Maria I MI Behrens, Monica M Silva, Felipe F Salech, Daniela P DP Ponce, Daniela D Merino, Mariana M Sinning, Chengjie C Xiong, Catherine M CM Roe, Andrew F G AF Quest
A paucity of cancer in individuals with Alzheimer's disease (AD) and low rates of AD in cancer survivors has been reported in epidemiological studies. Deregulation in opposite directions of biolo...Read More
Li-qun LQ Zhang, Guo-xian GX Qi, Da-ming DM Jiang, Wen W Tian, Ji-li JL Zou
The overactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is considered a final common effector in ischemia/reperfusion (I/R) injury. The aim of the current study was to examine the ...Read More
Chunyan C Wang, Biju B George, Shali S Chen, Biao B Feng, Xiaokun X Li, Subrata S Chakrabarti
Mammalian excision repair cross-complementing 1 (ERCC1) and ERCC4 (a.k.a xeroderma pigmentosum complementation group F) are nucleotide excision repair enzymes, which excise the 5' end of damaged ...Read More
Qin-Hao Chen, Xiao-Mei Liao, Shao-Hui Wang
The study aimed to investigate the effect of inhibition of poly(ADP-ribose) polymerase-1 (PARP-1) activity on tau phosphorylation in HEK293/tau441 cells and its mechanism. HEK293/tau441 cells were tre...Read More
Masataka M Tsuda, Masakazu M Tanaka, Masatoshi M Mushiake, Jun J Takahashi, Koji K Tanaka, Joji J Watase, Jun-Ichi J Fujisawa, Masanao M Miwa
Centrosome amplification (also known as centrosome overduplication) is common in cancer cells and can be induced by DNA damaging agents. However, the mechanism and significance of centrosome amplifica...Read More
Dan Huang, Yan Wang, Lin Wang, Fengxiao Zhang, Shan Deng, Rui Wang, Yun Zhang, Kai Huang
Transforming growth factor type-β (TGF-β)/Smad pathway plays an essential role in vascular fibrosis. Reactive oxygen species (ROS) generation also mediates TGF-β signaling-induced vascular fibrosis...Read More
Shuai Wang, Huibo Wang, Ben C Davis, Jiyong Liang, Rutao Cui, Sai-Juan Chen, Zhi-Xiang Xu
Poly(ADP-ribose) polymerase-1 (PARP1) inhibitors are emerging as an important class of drugs for treating BRCA-deficient cancers. Recent discoveries have shown that PARP1 inhibitors may treat other ca...Read More
M Tomasetti, M Amati, L Nocchi, F Saccucci, E Strafella, S Staffolani, L M Tarquini, D Carbonari, R Alleva, B Borghi, J Neuzil, M Bracci, L Santarelli
Asbestos is known to induce malignant mesothelioma (MM) and other asbestos-related diseases. It is directly genotoxic by inducing DNA strand breaks and cytotoxic by promoting apoptosis in lung target ...Read More
Nabil Aziz, Rakesh K Sharma, Reda Mahfouz, Rajesh Jha, Ashok Agarwal
Apoptosis was induced in immature and mature sperm in the presence or absence of poly (ADP-ribose) polymerase (PARP) inhibitor. The association of cleaved (cPARP) with sperm morphology was examined us...Read More
Pharmacological inhibition of DNA repair pathways has been emerging as an effective tool for cancer treatment. Poly(ADP-ribose) polymerase (PARP) is involved in DNA repair and transcriptional regulati...Read More
Aurelio A Romero-Castro, Ismael I León-Rivera, Laura Citlalli LC Avila-Rojas, Gabriel G Navarrete-Vázquez, Alejandro A Nieto-Rodríguez
In this study we report the synthesis and preliminary evaluation of a series of six 2-aryl-5(6)-nitro-1H-benzimidazole derivatives (1-6) as potential anticancer agents. Cytotoxicity was evaluated agai...Read More
Nataliya Makogon, Tatyana Voznesenskaya, Capital Te Cyrillicatyana Bryzgina, Vera Sukhina, Nataliya Grushka
The activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) may play an important role in numerous pathological conditions. The aim of the present study was to clarify the role of PARP in ...Read More
Petra Lakatos, Eva Szabó, Csaba Heged?s, Gy?rgy Haskó, Pál Gergely, Péter Bai, László Virág
Poly(ADP-ribosyl)ation (PARylation) is a NAD(+)-dependent protein modification carried out by PARP [poly(ADP-ribose) polymerase] enzymes. Here we set out to investigate whether PARylation regulates UV...Read More
Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Nona Abolhassani, Hiroko Nomaru, Kunihiko Sakumi, Hidetaka Yamada, Yusaku Nakabeppu
8-Oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species, is associated with carcinogenesis and neurodegeneration. Although the mechanism by which 8-oxoG causes carcinogenesis is w...Read More
Souichi Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Chiyoko Nukuzuma, Tsutomu Takegami
The incidence of progressive multifocal leukoencephalopathy (PML) has increased due to the AIDS pandemic, hematological malignancies, and immunosuppressive therapies. Recently, the number of cases of ...Read More
Shao-Hui Wang, Xiao-Mei Liao, Dan Liu, Juan Hu, Yang-Yang Yin, Jian-Zhi Wang, Ling-Qiang Zhu
Nerve growth factor (NGF) is a critical secreted protein that plays an important role in development, survival, and function of the mammalian nervous system. Previously reports suggest that endogenous...Read More
Jia J Yu, Wenhong W Deng, Weixing W Wang, Youming Y Ding, Hao H Jin, Chen C Chen, Xiaoyan X Chen, Xingcheng X Xiong, Sheng S Xu
The aim of our present study was to investigate the efficacy of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibition in the development of acute kidney injury in an experimental model of se...Read More
Sheng-Chun Chiu, Sung-Ying Huang, Yu-Chieh Tsai, Shee-Ping Chen, Cheng-Yoong Pang, Chih-Feng Lien, Yu-Jou Lin, Kun-Ta Yang
Episodic cessation of airflow during sleep in patients with sleep apnea syndrome results in intermittent hypoxia (IH). Our aim was to investigate the effects of IH on cerebellar granule cells and to i...Read More
Masakazu M Ishii, Ryouta R Iizuka, Yuji Y Kiuchi, Yasuo Y Mori, Shunichi S Shimizu
Migraine is one of the risk factor for ischemic stroke. The purpose of this study was to examine the effect of lomerizine, a prophylactic drug for migraine, on H(2)O(2)-induced cell death of hippocamp...Read More
Askin Hekimoglu, Zehra Kurcer, Faruk Aral, Fusun Baba, Ahmet Atessahin, Fatih Sakin
The therapeutic effects of poly(adenosine diphosphate-ribose) polymerase inhibition by 3-aminobenzamide (3-AB) were investigated in testicular ischemia-reperfusion (I/R) injury, using sperm analysis a...Read More
Ryan C Dregalla, Junqing Zhou, Rupa R Idate, Christine L R Battaglia, Howard L Liber, Susan M Bailey
Intrigued by the dynamics of the seemingly contradictory yet integrated cellular responses to the requisites of preserving telomere integrity while also efficiently repairing damaged DNA, we investiga...Read More
Edina Bakondi, Betul Catalgol, Istvan Bak, Tobias Jung, Perinur Bozaykut, Mehmet Bayramicli, Nesrin Kartal Ozer, Tilman Grune
Changes in protein turnover are among the dominant metabolic changes during aging. Of special importance is the maintenance of nuclear protein homeostasis to ensure a coordinated cellular metabolism. ...Read More
Prakash G PG Jagtap, Erkan E Baloglu, Garry J GJ Southan, Jon G JG Mabley, Hongshan H Li, Jing J Zhou, John J van Duzer, Andrew L AL Salzman, Csaba C Szabó
Novel indeno[1,2-c]isoquinolinone derivatives were synthesized and evaluated as inhibitors of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1). These potent nonmutagenic PARP-1 inhibitors pos...Read More
Wen-Ting Zhang, Jin-Lan Ruan, Peng-Fei Wu, Feng-Chao Jiang, Li-Na Zhang, Wei Fang, Xiang-Long Chen, Yue Wang, Bao-Shuai Cao, Gang-Ying Chen, Yi-Jing Zhu, Jun Gu, Jian-Guo Chen
A series of novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors were designed within 2-aminothiazole analogues (4-10) based on a constructed three-dimensional pharmacophore model. After synthesis,...Read More
Dana V Ferraris
We're sorry this abstract is currently not available....Read More
Caterina Torrisi, Monica Bisbocci, Raffaele Ingenito, Jesus M Ontoria, Michael Rowley, Carsten Schultz-Fademrecht, Carlo Toniatti, Philip Jones
A novel hexahydrobenzonaphthyridinone PARP-1 pharmacophore is reported, subsequent SAR exploration around this scaffold led to selective PARP-1 inhibitors with low nanomolar enzyme potency, displaying...Read More
Shridhar S SS Kulkarni, Satyakam S Singh, Janki R JR Shah, Woon-Kai WK Low, Tanaji T TT Talele
We have demonstrated that quinazolin-4(3H)-one, a nicotinamide (NI) mimic with PARP-1 inhibitory activity in the high micromolar range (IC(50)?=?5.75?μM) could be transformed into highly active deriv...Read More