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Ala-Gln

产品编号 A107409 | CAS号 39537-23-0 | Aladdin
Ala-Gln
98%
组合的产品项目
货号 规格 库存 价格 数量
A107409-100g 98% 上海(5)
北方(预计3-5个工作日)
 
A107409-25g 98% 上海(>10)
北方(3)
 
A107409-5g 98% 上海(>10)
北方(8)
 
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属性

旋光率 10 ° (C=5, H2O)
密度 1.3050
熔点 215°C
溶解性 Soluble in water (50 mg/ml).
存贮条件 室温储存

描述

产品介绍 无臭;有引湿性。本品在水中易溶,在甲醇中几乎不溶或不溶;在冰醋酸中略溶。
别名 L-丙氨酰-L-谷氨酸盐;丙氨酰-L-谷氨酰胺;力肽; 丙氨酰谷氨酰胺;丙谷二肽;H-Ala-Gln-OH; L-Alanyl-L-glutamine; Glutamine-S;
生化机理 Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals. Alanyl-glutamine also acts as an antioxidant (peroxide) and anti-apoptosis (LPS-induced) factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro.
应用 在哺乳动物细胞培养基中可以作谷氨酸盐的替代物,加热灭菌过程中稳定。
L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine (Ala-Gln) and Gylcyl-L-glutamine (Gly-Gln) are used in cell culture as alternative delivery forms of stabilized L-glutamine. The primary advantage of using L-alanylglutamine in place of L-glutamine is that it reduces the level of ammonia generated during cell culture
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参考文献
Tony E Haynes, Peng Li, Xilong Li, Kazuhiro Shimotori, Hiroyuki Sato, Nick E Flynn, Junjun Wang, Darrell A Knabe, Guoyao Wu
This study tested the hypothesis that L-glutamine (Gln) or L-alanyl-L-glutamine (Ala-Gln) prevents oxidant- or endotoxin-induced death of neonatal enterocytes. Enterocytes of neonatal pigs rapidly hyd...Read More
Vinicius Fernandes Cruzat, Julio Tirapegui
We investigated the effect of supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine, both in the free form, on the plasma and tissue concent...Read More
Vinicius Fernandes Cruzat, Marcelo Macedo Rogero, Julio Tirapegui
In this study, we investigated the effect of the supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine on plasma levels markers of muscle da...Read More
A A Bartolazzi, M M Mottolese, A A Vocaturo, G G Vocaturo, A A Bigotti, M M Prat, G G Atlante, P G PG Natali
We're sorry this abstract is currently not available....Read More
E Roth, G Ollenschlager, G Hamilton, A Simmel, K Langer, W Fekl, R Jakesz
The instability of the amino acid glutamine prompted us to investigate substitute compounds appropriate for culture conditions. The effect of two glutamine-containing dipeptides, alanylglutamine (Ala-...Read More
Brigitte Kircher, Günther Eibl, Barbara Enrich, Karla L?tzer, Manfred Herold, Dietger Niederwieser
The amino acid glutamine plays an important role in the immune system by providing energy and precursors for biosynthetic processes. For lack of stability it could not so far be generally supplied in ...Read More
John D Biggers, Lynda K McGinnis, J A Lawitts
A comparison of the effects of replacing L -glutamine with either glycyl-L-glutamine or alanyl-L-glutamine in a KSOM-type medium on the development of mouse preimplantation embryos in vitro has been m...Read More
H H Brandhorst, Y Y Duan, M M Iken, R G RG Bretzel, D D Brandhorst
Background: Pig islets are characterized by significant fragility, preventing successful islet culture prior to xenotransplantation. To improve outcome after culture, we compared the effects of glutam...Read More
D E DE Johns, K A KA Athanasiou
The temporomandibular joint (TMJ) is extremely important for activities like eating and talking, which can become painful and difficult for patients with TMJ dysfunction. Tissue engineering is a poten...Read More