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3-氨基丙烷磺酸

¥ 107.40

产品编号 A107500 | CAS号 3687-18-1 | Aladdin
3-Amino-1-propanesulfonic acid
97%
组合的产品项目
货号 规格 库存 价格 数量
A107500-1g 97% 上海(>10)
北方(4)
 
A107500-25g 97% 上海(预计3-5个工作日)
北方(预计3-5个工作日)
 
A107500-5g 97% 上海(预计3-5个工作日)
北方(预计3-5个工作日)
 
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属性

密度 1.3870
熔点 293°C

描述

别名 3-氨基-1-丙磺酸,高牛磺酸;3 APS Homotaurine
应用 重要的 GABA-mimetic 药物成分,可引起类似于 γ-氨基丁酸 (GABA) 诱导的神经反应。
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标识符号 GHS07 GHS07
信号词 Warning
风险声明 (欧洲) 36/37/38
安全声明(欧洲) 26,36
警示性声明 P261,P305+P351+P338
危害码(欧洲) Xi
危害声明 H315,H319,H335
个人防护设备 dust mask type N95 (US),Eyeshields,Gloves
WGK德国 1
参考文献
R Nageswara RN Rao, Pawan K PK Maurya, Dhananjay D DD Shinde, Sara S Khalid
Alzheimer disease (AD) is characterized pathologically by extracellular amyloid deposits composed of amyloid @b (A@b) protein. A simple and rapid method using HPLC with fluorescence detector was devel...Read More
Paul M PM Mayer, Eric E Martineau
The gas-phase binding of small molecules to the Amyloid β-40 peptide generated by electrospray ionization has been explored with collision-induced dissociation mass spectrometry and kinetic rate theo...Read More
R Nageswara Rao, Pawan K Maurya, Dhananjay D Shinde, Sachin B Agwane
A simple and reliable method was developed for determining blood concentrations of tramiprosate using reversed-phase HPLC with evaporative light scattering detection. The optimum evaporator and nebuli...Read More
Yoshitsugu Y Shitaka, Yasuyuki Y Mitani, Akira A Nagakura, Akira A Miyake, Nobuya N Matsuoka
We're sorry this abstract is currently not available....Read More
Eric Martineau, Janna M de Guzman, Lioudmila Rodionova, Xianqi Kong, Paul M Mayer, Ahmed M Aman
This paper describes an efficient and reproducible screening method for identifying low molecular weight compounds that bind to amyloid @b peptides (A@b) peptides using electrospray ionization mass sp...Read More
M T Swanoski
We're sorry this abstract is currently not available....Read More
Jutta Mayer, Alasdair M Cook
Homotaurine (3-aminopropanesulfonate), a natural product and an analogue of GABA (4-aminobutyrate), was found to be a sole source of nitrogen for Cupriavidus necator (Ralstonia eutropha) H16, whose ge...Read More
D Saumier, P S Aisen, S Gauthier, B Vellas, S H Ferris, A Duong, J Suhy, J Oh, W Lau, D Garceau, D Haine, J Sampalis
We're sorry this abstract is currently not available....Read More
Jutta J Mayer, Karin K Denger, Katrin K Kaspar, Klaus K Hollemeyer, Theo H M TH Smits, Thomas T Huhn, Alasdair M AM Cook
Homotaurine (3-aminopropanesulfonate), free or derivatized, is in widespread pharmaceutical and laboratory use. Studies with enrichment cultures indicated that the compound is degradable as a sole sou...Read More
Ismael Santa-María, Felix Hernández, Francisco J Moreno, Jesús Avila
Taurine is an abundant aminoacid present in brain. Its concentration is decreased in the brain of Alzheimer's disease (AD) patients. The chemical structure of taurine is similar to 3-amino-1-prop...Read More
P S Aisen, D Saumier, R Briand, J Laurin, F Gervais, P Tremblay, D Garceau
BACKGROUND: As a potential disease-modifying treatment for Alzheimer disease (AD), 3-amino-1-propanesulfonic acid (3APS) is a compound that binds to amyloid beta (Abeta), a toxic protein known to aggr...Read More
Tamsin M Wright
Current treatment options for patients with Alzheimer's disease are limited to providing symptomatic relief, with no effects on the underlying pathophysiology. However, a greater understanding of...Read More
Xiao-Dong XD Hu, Yu-Xing YX Ge, Neng-Wei NW Hu, Hong-Mei HM Zhang, Li-Jun LJ Zhou, Tong T Zhang, Wen-Ming WM Li, Yi-Fan YF Han, Xian-Guo XG Liu
The benzodiazepine diazepam impairs memory and long-term potentiation (LTP) in the hippocampus. Here, we investigate the effect of diazepam on LTP of C-fiber evoked field potentials in spinal dorsal h...Read More
Laurence Desrues, Hélène Castel, Maria M Malagon, Hubert Vaudry, Marie-Christine Tonon
In frog melanotrope cells, @c-aminobutyric acid (GABA) induces a biphasic effect, i.e. a transient stimulation followed by a more sustained inhibition of @a-MSH release, and both phases of the GABA ef...Read More
M Foster Olive, Michelle A Nannini, Christine J Ou, Heather N Koenig, Clyde W Hodge
The purpose of the present study was to determine the acute effects of the anticraving compound acamprosate (calcium acetylhomotaurinate) and the closely related compound homotaurine on ethanol intake...Read More
M I Serrano, J S Serrano, I Asadi, A Fernández, M C Serrano-Martino
In previous articles, antinociceptive activity for homotaurine has been demonstrated to be mediated by opioid, GABAergic and cholinergic mechanisms. GABAB-agonists affect K+-channels and it is known t...Read More
J Y Wu, H Jin, J V Schloss, M D Faiman, N S Ningaraj, T Foos, W Chen
Acamprosate (AC), N-acetyl-homotaurine, has recently been introduced for treating alcohol craving and reducing relapses in weaned alcoholics. AC may exert its action through the taurine system rather ...Read More
D D Saumier, A A Duong, D D Haine, D D Garceau, J J Sampalis
Tramiprosate (homotaurine, ALZHEMEDTM) was recently investigated for its efficacy, safety and disease-modification effects in a Phase III clinical study in mild to moderate Alzheimer's disease (A...Read More
S Gauthier, P S Aisen, S H Ferris, D Saumier, A Duong, D Haine, D Garceau, J Suhy, J Oh, W Lau, J Sampalis
The efficacy, safety and disease-modification of tramiprosate (homotaurine)were investigated in a recently completed large-scale Phase III clinical study in patients with mild to moderate Alzheimer�...Read More
Irena I Melnikova
We're sorry this abstract is currently not available....Read More
Steven M SM Greenberg, Jonathan J Rosand, Alexander T AT Schneider, L L Creed Pettigrew, Samuel E SE Gandy, Barry B Rovner, Brian-Fred BF Fitzsimmons, Eric E EE Smith, M M Edip Gurol, Kristin K Schwab, Julie J Laurin, Denis D Garceau
No treatments have been identified to lower the risk of intracerebral hemorrhage due to cerebral amyloid angiopathy (CAA). A potential approach to prevention is the use of agents that interfere with t...Read More
Francine Gervais, Julie Paquette, Céline Morissette, Pascale Krzywkowski, Mathilde Yu, Mounia Azzi, Diane Lacombe, Xianqi Kong, Ahmed Aman, Julie Laurin, Walter A Szarek, Patrick Tremblay
Amyloid @b-peptide (A@b) is a major constituent of senile plaques in Alzheimer's disease (AD). Neurotoxicity results from the conformational transition of A@b from random-coil to @b-sheet and its...Read More
N M NM van Gelder, R J RJ Bowers
Epilepsy, trauma and other circumstances leading to hyperexcitable conditions in the CNS tend neurochemically to be associated with excessive stimulated release of glutamic acid and/or a failure of GA...Read More
Fanling Meng, Daniel P Raleigh
Islet amyloid polypeptide (IAPP; also known as amylin) is responsible for islet amyloid formation in type 2 diabetes, and IAPP-induced toxicity is believed to contribute to the loss of β-cell mass as...Read More