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壬二酸

产品编号 A108440 | CAS号 123-99-9 | Aladdin
Azelaic acid
technical, ~85% (GC)
组合的产品项目
货号 规格 库存 价格 数量
A108440-1kg technical, ~85% (GC) 上海(预计4-8周)
北方(预计4-8周)
 
A108440-2.5kg technical, ~85% (GC) 上海(预计4-8周)
北方(预计4-8周)
 
A108440-250g technical, ~85% (GC) 上海(>10)
北方(预计3-5个工作日)
 
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属性

敏感性 对湿度敏感
折光率 1.4303
密度 0.8210
熔点 109-111°C
沸点 286°C
溶解性 Soluble in water (2.4 mg/ml at 20 °C), ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.
存贮条件 密封保存。

描述

产品介绍 在360℃以上蒸馏时部分形成酸酐。易溶于沸水和乙醇,溶于有机溶剂,微溶于苯。有刺激性。
别名 杜鹃花酸;1,7-壬二酸;庚烷-1,7-二羟酸;王二酸;1,7-庚二甲酸;;Nonanedioic acid; 1,7-heptanedicarboxylic acid;
应用 有机合成。
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安全声明(欧洲) S24/25
个人防护设备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS CM1980000
WGK德国 1
闪点(摄氏) 210 °C
参考文献
Robyn S Fallen, Melinda Gooderham
Rosacea is a common chronic skin disorder that has significant impact on the self-esteem and quality of life of affected individuals. Currently understood as an inflammatory condition that occurs in t...Read More
A Parodi, F Drago, S Paolino, E Cozzani, R Gallo
A range of treatment options are available in rosacea, which include several topical (mainly metronidazole, azelaic acid, other antibiotics, sulfur, retinoids) and oral drugs (mainly tetracyclines, me...Read More
Jennie B JB Nally, Diane S DS Berson
Therapeutic options for rosacea include topical agents, oral therapies, laser and light treatments, and surgical procedures. Topical therapies play a critical role in the treatment of patients with pa...Read More
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....Read More
G G Hoffmann, S S Aramaki, E E Blum-Hoffmann, W L WL Nyhan, L L Sweetman
This new method for qualitative and quantitative determination of organic acids, aldehydes, and ketones in biological samples is effective for use with urine, plasma, and amniotic fluid, and it requir...Read More
Alan R Shalita, Ronald Falcon, Alan Olansky, Patricia Iannotta, Arash Akhavan, Doris Day, Anthony Janiga, Prashant Singri, John E Kallal
Inflammatory acne, particularly in post-adolescent women, is increasing in incidence. The most effective therapeutic modality for treatment of this type of acne has been the administration of oral tet...Read More
Stefania Briganti, Enrica Flori, Arianna Mastrofrancesco, Daniela Kovacs, Emanuela Camera, Matteo Ludovici, Giorgia Cardinali, Mauro Picardo
Azelaic acid (AzA) has been used for the treatment for inflammatory skin diseases, such as acne and rosacea. Interestingly, an improvement in skin texture has been observed after long-time treatment w...Read More
Maria Zoeller, Nadja Stingl, Markus Krischke, Agnes Fekete, Frank Waller, Susanne Berger, Martin J Mueller
Lipid peroxidation (LPO) is induced by a variety of abiotic and biotic stresses. Although LPO is involved in diverse signaling processes, little is known about the oxidation mechanisms and major lipid...Read More
Hongling H Wang, Hao H Chen, Chang'an C Geng, Xuemei X Zhang, Yunbao Y Ma, Zhiyong Z Jiang, Jijun J Chen
To study the chemical constituents of Halenia elliptica....Read More
Neal D ND Bhatia, James Q JQ Del Rosso
The pathophysiology of papulopustular rosacea (PPR) is primarily characterized by inflammation associated with several factors such as abnormal innate immune response, neurovascular dysregulation, str...Read More
Merve Aytekin, R Neslihan Gursoy, Semra Ide, Elif H Soylu, Sueda Hekimoglu
Purpose: The aim of this study is to prepare and characterize azelaic acid (AzA) containing liquid crystal (LC) drug delivery systems for topical use. Methods: Two ternary phase diagrams, containing...Read More
Pei-Wen PW Hsieh, Saleh A SA Al-Suwayeh, Chia-Lang CL Fang, Chwan-Fwu CF Lin, Chun-Che CC Chen, Jia-You JY Fang
A co-drug of hydroquinone (HQ) and azelaic acid (AA), bis(4-hydroxyphenyl)nonanedioate (BHN), was synthesized and investigated as a topical prodrug with the aim of improving the dermal delivery of the...Read More
Maria Vinaixa, Miguel Angel Rodriguez, Sara Samino, Marta Díaz, Antoni Beltran, Roger Mallol, Cinta Bladé, Lourdes Iba?ez, Xavier Correig, Oscar Yanes
Polycystic ovary syndrome (PCOS) is a variable disorder characterized by a broad spectrum of anomalies, including hyperandrogenemia, insulin resistance, dyslipidemia, body adiposity, low-grade inflamm...Read More
Susan S Farshi
Melasma is an irregular brown or grayish-brown symmetric facial hypermelanosis, often affecting women, especially those living in areas with intense ultraviolet radiation....Read More
Nan N Li, Xiaohong X Wu, Weibu W Jia, Michelle C MC Zhang, Fengping F Tan, Jerry J Zhang
The aim of this study is to investigate the effect of ionization and vehicle of topical formulations on skin absorption and penetration of azelaic acid (AZA)....Read More
Vaneeta M VM Sheth, Amit G AG Pandya
Several methods of treatment are available to patients with melasma. First-line therapy usually consists of topical compounds that affect the pigment production pathway, broad-spectrum photoprotection...Read More
C C Schnopp, M M Mempel
Acne vulgaris is a very common inflammatory skin disease originating from the pilosebaceous unit. Peak incidence is at puberty, but acne can affect all age groups. Prepubertal acne is rare, but import...Read More
Ronald G RG Wheeland, Sunil S Dhawan
This study evaluated the efficacy and tolerability of treating mild-to-moderate facial acne using a new, hand-held, light-emitting diode blue light device in conjunction with a foam cleanser containin...Read More
Leon H LH Kircik
Although there are few differences in the incidence and pathophysiology of acne across various races and ethnicities, there is some evidence that black patients may have larger sebaceous glands and in...Read More
Chizuru Sato, Norikuni Oka, Kensuke Nabeta, Hideyuki Matsuura
Treating the leaves of sweet pepper (Capsicum annuum L. var. grossum) with an aqueous solution of cellulase resulted in a four-fold increase in the salicylic acid level compared to a control plant. Th...Read More
Nicola N Castellucci, Giuseppe G Falini, Gaetano G Angelici, Claudia C Tomasini
A small library of stereoisomeric pseudopeptides able to make gels in different solvents has been prepared and their attitude to make gels in the presence of several metal ions was evaluated. Four ben...Read More
Esther J van Zuuren, Sharon Kramer, Ben Carter, Mark A Graber, Zbys Fedorowicz
Rosacea is a common chronic skin condition affecting the face, characterised by flushing, redness, pimples, pustules, and dilated blood vessels. The eyes are often involved and thickening of the skin ...Read More
Nitin Chauhan, David A F Ellis
This article presents an overview of the pathophysiology, epidemiology, and clinical presentations of rosacea. It also presents the therapeutic spectrum for effective management of this challenging an...Read More
Hamidreza H Pazoki-Toroudi, Shahab S Babakoohi, Mohammad Ali MA Nilforoushzadeh, Mansour M Nassiri-Kashani, Mohammad M Shizarpour, Marjan M Ajami, Rouhollah R Habibey, Bardia B Sadr, Mehdi M Rashighi-Firoozabadi, Alireza A Firooz
We're sorry this abstract is currently not available....Read More
Tsutomu Matsubara, Naoki Tanaka, Kristopher W Krausz, Soumen K Manna, Dong Wook Kang, Erik R Anderson, Hans Luecke, Andrew D Patterson, Yatrik M Shah, Frank J Gonzalez
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is among the most potent environmentally toxic compounds. Serum metabolomics identified azelaic acid monoesters as significantly increased metabolites after ...Read More
James Q Del Rosso, Neal Bhatia
Azelaic acid (AzA) gel 15% is approved by the US Food and Drug Administration (FDA) for the treatment of papulopustular rosacea (PPR). Its efficacy and safety as monotherapy have been demonstrated. Re...Read More
Changgeng C Liu, Jie J Gan, Yang Y Zhang, Miao M Liang, Xi X Shu, Jinian J Shu, Bo B Yang
As an organophosphorous insecticide, phosmet is widely used for plant protection as well as against the ectoparasites on productive livestock. It emits into the atmosphere in both gas and particulate ...Read More
Hamidreza H Pazoki-Toroudi, Mohamad Ali MA Nilforoushzadeh, Marjan M Ajami, Fariba F Jaffary, Nahid N Aboutaleb, Mansour M Nassiri-Kashani, Alireza A Firooz
Acne vulgaris, an inflammatory skin disease with different clinical appearances, is a common problem in most adolescents. It seems that using combinations of topical agents can decrease resistance to ...Read More
J Mark Jackson, Leon H Kircik, Douglas J Lorenz
Rosacea is one of the most commonly occurring dermatoses treated by dermatologists. There are multiple therapeutic options available for the treatment of papulopustular rosacea. Rosacea is an inflamma...Read More
Shanmugam Muthulakshmi, Ramalingam Saravanan
Excess fat intake induces hyperinsulinaemia, increases nutrient uptake and lipid accumulation, amplifies ROS generation, establishes oxidative stress and morphological changes leading to tissue injury...Read More
P S Mackrides, A F Shaughnessy
Azelaic acid is another option for the topical treatment of mild to moderate inflammatory acne vulgaris. It offers effectiveness similar to that of other agents without the systemic side effects of or...Read More
James E JE Frampton, Antona J AJ Wagstaff
Azelaic acid is a naturally occurring, straight-chain dicarboxylic acid which is effective in the treatment of rosacea, presumably on account of its anti-inflammatory properties. In randomized, double...Read More
Zoe Diana Draelos
When first approved in December 2002, 15% azelaic acid (AzA) gel represented a significant advance over the available 20% AzA cream. Although a smaller amount of AzA was present in the new formulation...Read More
Alan B Fleischer
Azelaic acid (AzA) is a naturally occurring dicarboxylic acid that has a long and complex history in the treatment of skin disorders. We summarize research on AzA from the past 25 years and follow its...Read More
Heather L HL Roebuck
We're sorry this abstract is currently not available....Read More
Esther J van Zuuren, Mark A Graber
The Cochrane Collaboration is an international nonprofit organization that conducts systematic reviews of healthcare interventions. The organization has recently reviewed all studies meeting designate...Read More
John E Wolf
Despite its prevalence, rosacea has not received the same attention of researchers as other dermatologic disorders. Nevertheless, new pharmacologic and nonpharmacologic therapies for the condition con...Read More
Kimberly A KA Cayce, Amy J AJ McMichael, Steven R SR Feldman
Hyperpigmentation disorders of the skin are common. Three of the more common forms include melasma, lentigines, and post-inflammatory hyperpigmentation. Significant negative psychological consequences...Read More
Karol Burkhart KB Lindow
We're sorry this abstract is currently not available....Read More
Boni Elewski, Diane Thiboutot
Azelaic acid (AzA) initially was released in a 20% cream formulation, which has been shown to be effective in the treatment of mild to moderate rosacea. Recently, a 15% gel formulation was developed t...Read More
Rebat M Halder, Georgianna M Richards
Pigmentary disorders are one of the most common skin disorders among people of color. Dyspigmentation in the form of either hyperpigmentation or hypopigmentation is often psychologically devastating t...Read More
Valerie D Callender
Patients with ethnic skin are at an increased risk for developing postinflammatory hyperpigmentation (PIH) and keloid scarring subsequent to acne lesions. Treatment approaches for acne in darker skinn...Read More
John E Wolf
Many topical and oral pharmacologic agents have shown well-tolerated efficacy for the treatment of rosacea. Metronidazole was the first topical therapy approved for rosacea and is still considered the...Read More
James Q JQ Del Rosso
Due to the development and release of newer topical formulations, the diagnosis and treatment of rosacea has received renewed attention over the past 3-5 years both in the literature and at medical sy...Read More
David C Liao
Precise classification methods are used to define acne according to type (comedonal, papulopustular, or nodular) and severity. The relative effectiveness of several topical and systemic agents has bee...Read More
James Q Del Rosso
We're sorry this abstract is currently not available....Read More
J F JF Hermanns, L L Petit, O O Martalo, C C Piérard-Franchimont, G G Cauwenbergh, G E GE Piérard
During photoaging, the density of melanin chromatophores is heterogeneous in the epidermis....Read More
S H SH Korman, H H Mandel, A A Gutman
We're sorry this abstract is currently not available....Read More
V Rocamora, L Puig, J Romaní, J M de Moragas
Amelanotic lentigo maligna melanoma (ALMM) is an infrequent presentation of lentigo maligna melanoma, less than thirty cases having been reported to date. Hypopigmented or erythematous macules on the ...Read More
R M RM Halder, G M GM Richards
Disorders of hyperpigmentation are difficult to treat, particularly in dark-skinned individuals. The goal is to reduce the hyperpigmentation without causing undesirable hypopigmentation or irritation ...Read More
J J JJ Russell
Acne is a common problem in adolescents and young adults. The disorder is caused by abnormal desquamation of follicular epithelium that results in obstruction of the pilosebaceous canal. This obstruct...Read More
Sarah Purdy
We're sorry this abstract is currently not available....Read More
James Q Del Rosso
Topical azelaic acid (AzA) is approved for the treatment of acne vulgaris and inflammatory (papulopustular) rosacea. Because of diverse mechanisms of action that correlate with potential therapeutic b...Read More
A Mayer-da-Silva, H Gollnick, M Detmar, J Gassmüller, A Parry, R Müller, C E Orfanos
The effects of azelaic acid (AZA) on the epidermis of 47 individuals (12 with normal skin, 15 with seborrheic skin and 20 suffering from acne) and on in vitro cultured keratinocytes are reported. Topi...Read More
Arun Sreekumar, Laila M Poisson, Thekkelnaycke M Rajendiran, Amjad P Khan, Qi Cao, Jindan Yu, Bharathi Laxman, Rohit Mehra, Robert J Lonigro, Yong Li, Mukesh K Nyati, Aarif Ahsan, Shanker Kalyana-Sundaram, Bo Han, Xuhong Cao, Jaeman Byun, Gilbert S Omenn,
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...Read More
Aditya K AK Gupta, Melissa D MD Gover
In December of 2002, the FDA approved azelaic acid 15% gel for the topical treatment of inflammatory papules and pustules of mild to moderate rosacea. Azelaic acid is a saturated dicarboxylic acid, wh...Read More
Wolf-Ingo Worret, Joachim W Fluhr
We're sorry this abstract is currently not available....Read More
A A Fitton, K L KL Goa
Azelaic acid is a naturally occurring saturated dicarboxylic acid which, on topical application (usually as a 20% cream), has been shown to be effective in the treatment of comedonal acne and inflamma...Read More
Aditya K Gupta, Melissa D Gover, Keyvan Nouri, Susan Taylor
Melasma is an irregular brown or grayish-brown facial hypermelanosis, often affecting women, especially those living in areas of intense UV radiation. The precise cause of melasma remains unknown; how...Read More
Sarah Purdy
We're sorry this abstract is currently not available....Read More
Greg G Goodman
The management of acne is a gratifying experience. Available treatments are effective, relatively nontoxic and generally safe. However, there is no quick fix. Antibiotics, hormone therapies and topica...Read More
Rosemarie H Liu, Molly K Smith, Sameh A Basta, Evan R Farmer
OBJECTIVE: To evaluate the clinical efficacy of topical 20% azelaic acid cream and 15% azelaic acid gel compared with their respective vehicles and metronidazole gel in the treatment of papulopustular...Read More
Esther J van Zuuren, Aditya K Gupta, Melissa D Gover, Mark Graber, Sally Hollis
Background: Rosacea is a common chronic skin and ocular condition. It is unclear which treatments are most effective. We have conducted a Cochrane review of rosacea therapies.^1 This article is a dist...Read More
D D Stamatiadis, M C MC Bulteau-Portois, I I Mowszowicz
The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3...Read More
J J Brasch, E E Christophers
Azelaic acid is a therapeutic agent with well-known antibacterial properties, but its antimycotic effect has not yet been investigated systematically. In this study we have used an agar dilution techn...Read More
G F Hoffmann, W Meier-Augenstein, S St?ckler, R Surtees, D Rating, W L Nyhan
Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...Read More
Zhichao Liu, Qiang Shi, Don Ding, Reagan Kelly, Hong Fang, Weida Tong
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...Read More
F Guneral, C Bachmann
Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...Read More
Wolfram W Gronwald, Matthias S MS Klein, Raoul R Zeltner, Bernd-Detlef BD Schulze, Stephan W SW Reinhold, Markus M Deutschmann, Ann-Kathrin AK Immervoll, Carsten A CA B?ger, Bernhard B Banas, Kai-Uwe KU Eckardt, Peter J PJ Oefner
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used...Read More