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腺嘌呤核苷

产品编号 A108806 | CAS号 58-61-7 | Aladdin
Adenosine
用于细胞培养,>99.5%(HPLC)
组合的产品项目
货号 规格 库存 价格 数量
A108806-25g 用于细胞培养,>99.5%(HPLC) 上海(1)
北方(预计3-5个工作日)
 
A108806-5g 用于细胞培养,>99.5%(HPLC) 上海(>10)
北方(预计3-5个工作日)
 
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属性

旋光率 -70 ° (C=2, 5% NaOH)
密度 2.0800
熔点 234-236°C
存贮条件 储存温度2-8°C

描述

产品介绍 稍微可溶于水,实际上不溶于醇。
别名 腺嘌呤核苷 ;腺苷,阿糖腺苷;9-β-D-Ribofuranosyladenine; Adenine riboside; Adenine-9-β-D-ribofuranoside;
应用 内源性的神经递质。
医药工业上主要用于制造阿糖腺苷(Ara-AR);腺苷三磷酸(ATP);辅酶A(COASH)及其系列产品环磷酸腺苷(CAMP)等药物的主要原料。
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安全声明(欧洲) S24/25
个人防护设备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
WGK德国 2
Merck Index 153
参考文献
H F HF Galley, A E AE Le Cras, K K Yassen, I S IS Grant, N R NR Webster
Nitric oxide synthase requires tetrahydrobiopterin for its activity. In animal models of sepsis, changes in circulating tetrahydrobiopterin concentrations precede increases in nitrate. We measured pla...Read More
Kevin Guo, Liang Li
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ...Read More
S Ekins, A J Williams, J J Xu
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...Read More
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....Read More
Zadkiel Alvarez, Kyungae Lee, Ernesto Abel-Santos
Bacillus anthracis, the etiological agent of anthrax, has a dormant stage in its life cycle known as the endospore. When conditions become favorable, spores germinate and transform into vegetative bac...Read More
Nigel N Greene, Lilia L Fisk, Russell T RT Naven, Reine R RR Note, Mukesh L ML Patel, Dennis J DJ Pelletier
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...Read More
Eisuke Murakami, Haiying Bao, Ralph T Mosley, Jinfa Du, Michael J Sofia, Phillip A Furman
Human N(6)-methyl-AMP/dAMP aminohydrolase has been shown to be involved in metabolism of pharmacologically important N(6)-substituted purine nucleosides and 5'-monophosphate prodrugs thereof. Thi...Read More
Helene H Girouard, Gang G Wang, Eduardo F EF Gallo, Josef J Anrather, Ping P Zhou, Virginia M VM Pickel, Costantino C Iadecola
Reactive oxygen species (ROS) and nitric oxide (NO) participate in NMDA receptor signaling. However, the source(s) of the ROS and their role in the increase in cerebral blood flow (CBF) induced by NMD...Read More
Naomi L NL Kruhlak, Sydney S SS Choi, Joseph F JF Contrera, James L JL Weaver, James M JM Willard, Kenneth L KL Hastings, Lawrence F LF Sancilio
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifes...Read More
M P Sanchez-Canete, L Carvalho, F J Perez-Victoria, F Gamarro, S Castanys
Miltefosine (hexadecylphosphocholine, MLF) is the first oral drug with recognized efficacy against both visceral and cutaneous leishmaniasis. However, some clinical studies have suggested that MLF sho...Read More
Zhichao Liu, Qiang Shi, Don Ding, Reagan Kelly, Hong Fang, Weida Tong
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...Read More
Denis Fourches, Julie C Barnes, Nicola C Day, Paul Bradley, Jane Z Reed, Alexander Tropsha
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...Read More
Abdalla E A Hassan, Reham A I Abou-Elkhair, James M Riordan, Paula W Allan, William B Parker, Rashmi Khare, William R Waud, John A Montgomery, John A Secrist
A series of C-6 alkyl, cycloalkyl, and aryl-9-(β-d-ribofuranosyl)purines were synthesized and their substrate activities with Escherichia coli purine nucleoside phosphorylase (E.?coli PNP) were evalu...Read More
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Shari L Wiseman, Yoshio Shimizu, Clive Palfrey, Angus C Nairn
Protein translation and degradation are critical for proper protein homeostasis, yet it remains unclear how these processes are dynamically regulated, or how they may directly balance or synergize wit...Read More
N Duewelhenke, O Krut, P Eysel
Osteomyelitis, osteitis, spondylodiscitis, septic arthritis, and prosthetic joint infections still represent the worst complications of orthopedic surgery and traumatology. Successful treatment requir...Read More
S Sugimura, K Narita, H Yamashiro, A Sugawara, T Shoji, Y Terashita, K Nishimori, T Konno, M Yoshida, E Sato
Interspecies somatic cell nucleus transfer (iSCNT) could be a useful bioassay system for assessing the ability of mammalian somatic cells to develop into embryos. To examine this possibility, we perfo...Read More
Jiyoung A Hong, Devayani P Bhave, Kate S Carroll
Mycobacterium tuberculosis adenosine-5'-phosphosulfate (APS) reductase is an iron-sulfur protein and a validated target to develop new antitubercular agents, particularly for the treatment of lat...Read More
Liqiang Chen, Riccardo Petrelli, Magdalena Olesiak, Daniel J Wilson, Nicholas P Labello, Krzysztof W Pankiewicz
Synthesis of novel inhibitors of human IMP dehydrogenase is described. These inhibitors are isosteric methylenebis(sulfonamide) analogues 5-8 of earlier reported mycophenolic adenine methylenebis(phos...Read More
Yoichi Y Nakayama, Ayako A Kinoshita, Masaru M Tomita
Cell simulation, which aims to predict the complex and dynamic behavior of living cells, is becoming a valuable tool. In silico models of human red blood cell (RBC) metabolism have been developed by s...Read More
James A Birrell, Judy Hirst
NADH:ubiquinone oxidoreductase (complex I) is a complicated respiratory enzyme that conserves the energy from NADH oxidation, coupled to ubiquinone reduction, as a proton motive force across the mitoc...Read More
Xijun Liu, Jin-Ming Yang, Samuel S Zhang, Xin-Yuan Liu, David X Liu
Differentiation therapy has been shown effective in treatment of several types of cancer cells and may prove to be effective in treatment of glioblastoma multiforme, the most common and most aggressiv...Read More
Enoch P EP Wei, Robert J RJ Hamm, Anna I AI Baranova, John T JT Povlishock
Traumatic brain injury (TBI) has been demonstrated to induce cerebral vascular dysfunction that is reflected in altered responses to various vasodilators. While previous reports have focused primarily...Read More
Medardo Hernández, Gillian E Knight, Scott S P Wildman, Geoffrey Burnstock
As adenosine 5'-triphosphate (ATP) is one of the inhibitory mediators of the bladder outflow region, this study investigates the possible release of ATP or related purines in response to electric...Read More
D A Valério, F I Ferreira, T M Cunha, J C Alves-Filho, F O Lima, J R De Oliveira, S H Ferreira, F Q Cunha, R H Queiroz, W A Verri
D-Fructose-1,6-bisphosphate (FBP) is an intermediate in the glycolytic pathway, exerting pharmacological actions on inflammation by inhibiting cytokine production or interfering with adenosine product...Read More
The ability of short peptide nucleic acid (PNA) oligomers and oligonucleotides containing modified residues of 5-methylcitidine, 2-aminoadenosine and 5-propynyl-2'-deoxyuridine (strong binding ol...Read More
James E Ip, Jim W Cheung, Jeffrey H Chung, Christopher F Liu, George Thomas, Steven M Markowitz, Bruce B Lerman
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Antonella Fioravanti, Coralie Fumeaux, Saswat S Mohapatra, Coralie Bompard, Matteo Brilli, Antonio Frandi, Vincent Castric, Vincent Villeret, Patrick H Viollier, Emanuele G Biondi
Several regulators are involved in the control of cell cycle progression in the bacterial model system Caulobacter crescentus, which divides asymmetrically into a vegetative G1-phase (swarmer) cell an...Read More
T Rassaf, A Albert
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Stephen P Ray, Nathan Duval, Terry G Wilkinson, Sean E Shaheen, Kingshuk Ghosh, David Patterson
Adenylosuccinate lyase (ADSL) is a homotetrameric enzyme involved in the de novo purine biosynthesis pathway and purine nucleotide cycle. Missense mutations in the protein lead to ADSL deficiency, an ...Read More
Jing Xu, Dan Lan, Guangming Yang, Tao Li, Liangming Liu
Our previous study demonstrated that protein kinase C (PKC) has an important protective role on vascular reactivity and calcium sensitivity after shock. Here, we investigated if hemorrhagic preconditi...Read More
Rachid R Macwar, Brent A Williams, Jamshid Shirani
Adenosine cardiac magnetic resonance imaging (AS-CMR) has emerged as an alternative to other stress tests for identifying coronary artery disease. From January 1, 2002 to January 1, 2009, 564 consecut...Read More
Marek Grygier, Aleksander Araszkiewicz, Maciej Lesiak, Stefan Grajek
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Stefan K James, Karen S Pieper, Christopher P Cannon, Robert F Storey, Richard C Becker, Philippe Gabriel Steg, Lars Wallentin, Robert A Harrington, Robert A Harrington
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Jesús García-López, Juan de Dios Hourcade, Jesús Del Mazo
Adenosine deaminases-acting-on-RNA (ADAR) proteins induce adenosine-to-inosine editing in double-stranded RNA molecules. This editing generates RNA diversity at the post-transcriptional level, and it ...Read More
M Wengert, M C Ribeiro, T P Abreu, R Coutinho-Silva, L R Le?o-Ferreira, A A S Pinheiro, C Caruso-Neves
ATP-activated P2Y receptors play an important role in renal sodium excretion. The aim of this study was to evaluate the modulation of ATPase-driven sodium reabsorption in the proximal tubule by ATP or...Read More
M Cecati, M Emanuelli, S R Giannubilo, V Quarona, R Senetta, F Malavasi, A L Tranquilli, F Saccucci
The interactions taking place between mother and embryo have been the focus of detailed studies in recent years, where pregnancy is considered as an in vivo transplant. The immune systems of the mothe...Read More
Lars-?ke Levin, Lars Wallentin, Lars Bernfort, David Andersson, Robert F Storey, Gina Bergstr?m, Carl-Johan Lamm, Magnus Janzon, Padma Kaul
The purpose of this study was to compare the effects of ticagrelor versus clopidogrel on health-related quality of life in the PLATelet inhibition and patient Outcomes (PLATO) trial.The PLATO trial sh...Read More
Nehal M Elsherbiny, Saif Ahmad, Mohammad Naime, Ahmed M Elsherbini, Sadanand Fulzele, Mohammed M Al-Gayyar, Laila A Eissa, Mamdouh M El-Shishtawy, Gregory I Liou
This study was undertaken to determine the effect of an adenosine kinase inhibitor (AKI) in diabetic retinopathy (DR). We have shown previously that adenosine signaling via A2A receptors (A2AAR) is in...Read More
Jakob Vinten-Johansen, Geoffrey P Dobson
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Zenichiro Saze, Patrick J Schuler, Chang-Sook Hong, Dongmei Cheng, Edwin K Jackson, Theresa L Whiteside
Antibody-independent role of B cells in modulating T-cell responses is incompletely understood. Freshly isolated or cultured B cells isolated from the peripheral blood of 30 normal donors were evaluat...Read More
Ralf G?ddertz
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Elisabete Augusto, Marco Matos, Jean Sévigny, Ali El-Tayeb, Margaret S Bynoe, Christa E Müller, Rodrigo A Cunha, Jiang-Fan Chen
Adenosine is a neuromodulator acting through inhibitory A1 receptors (A1Rs) and facilitatory A2ARs, which have similar affinities for adenosine. It has been shown that the activity of intracellular ad...Read More
Paul W Armstrong, Cynthia M Westerhout, Yuling Fu, Robert A Harrington, Robert F Storey, Hugo Katus, Stefan James, Lars Wallentin
We evaluated whether electrocardiogram (ECG) characteristics were aligned with clinical outcomes and the effect of ticagrelor within the diverse spectrum of non-ST-elevation acute coronary syndrome pa...Read More
Shin-Ichi Yokobori, Aya Kitamura, Henri Grosjean, Yoshitaka Bessho
In most bacteria, two tRNAs decode the four arginine CGN codons. One tRNA harboring a wobble inosine (tRNA(Arg)ICG) reads the CGU, CGC and CGA codons, whereas a second tRNA harboring a wobble cytidine...Read More
Sang Hee SH Lee, Byung Hwa BH Jung, Sun Yeou SY Kim, Bong Chul BC Chung
Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases. However, during the last decade, the analytical methods for nucleosides by gas chromatography/mass spect...Read More
R W RW Jansen, J K JK Kruijt, T J TJ van Berkel, D K DK Meijer
We covalently coupled 9-beta-D-arabinofuranosyladenine 5'-monophosphate (ara-AMP) to the carrier molecule lactosaminated human serum albumin using a water-soluble carbodiimide with a two-step con...Read More
J J Ontyd, J J Schrader
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J T JT Eells, R R Spector
Purine and pyrimidine base and nucleoside levels were determined in adult human lumbar (CSF) and plasma by reversed-phase high performance liquid chromatography (HPLC). Guanine, thymine, cytosine and ...Read More
Ines I Kaufmann, Alwin A Hoelzl, Florian F Schliephake, Theresia T Hummel, Alexander A Chouker, Lidia L ?ysenko, Klaus K Peter, Manfred M Thiel
Inasmuch as polymorphonuclear leukocytes (PMNs) play a major role in antibacterial defense but can also cause substantial tissue injury, drugs are needed which are able to attenuate tissue-toxic PMN r...Read More
Mihai Gheorghiade, John R Teerlink, Alexandre Mebazaa
Current therapies for acute heart failure syndromes (AHFS) target hemodynamics by decreasing congestion or increasing myocardial contraction. Several new agents for AHFS use novel mechanisms of action...Read More
Melanie M Maytin, Wilson S WS Colucci
The management of acute heart failure syndromes (AHFS) focuses primarily on improving hemodynamic function and alleviating symptoms. Emerging evidence has raised the possibility that patients with AHF...Read More
Bj?rn Steen BS Sk?lhegg, Ane A Funderud, Heidi Hatledal HH Henanger, Tilahun Tolesa TT Hafte, Anja Camilla AC Larsen, Anne-Katrine AK Kvissel, Sissel S Eikvar, Sigurd S ?rstavik
In several cases of immunodeficiency and autoimmunity, the dysfunctional immune system is associated with either hypo- or hyperactive T and B cells. In autoimmune conditions such as systemic lupus ery...Read More
Kimberly L Dodge-Kafka, Joseph Soughayer, Genevieve C Pare, Jennifer J Carlisle Michel, Lorene K Langeberg, Michael S Kapiloff, John D Scott
Cyclic adenosine 3', 5'-monophosphate (cAMP) is a ubiquitous mediator of intracellular signalling events. It acts principally through stimulation of cAMP-dependent protein kinases (PKAs) but...Read More
Michael Koeris, Lars Funke, Jay Shrestha, Alexander Rich, Stefan Maas
RNA editing by A-to-I modification has been recognized as an important molecular mechanism for generating RNA and protein diversity. In mammals, it is mediated by a family of adenosine deaminases that...Read More
Victoria G VG Dunne, Shermina S Bhattachayya, Michael M Besser, Caroline C Rae, Julian L JL Griffin
Following subarachnoid haemorrhage the most significant complication is sustained cerebral vascular contraction (vasospasm), which may result in terminal brain damage from cerebral infarction. Despite...Read More
Peri J Ballantyne
Current incidence, prevalence and survival rates determine that breast cancer is primarily a disease of older women. This integrative essay provides an extensive review of the literature on (i). the s...Read More
Claudia C Vidotto, David D Fousert, Marteen M Akkermann, Andrea A Griesmacher, Mathias M MM Müller
Various enzyme defects in the metabolic pathways of purines and pyrimidines are known, which result in different diseases occurring in children. They mainly affect kidney function, central nervous sys...Read More
M C Capogrossi, M R Holdiness, Z H Israili
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Zhan-Guo Gao, Heng T Duong, Tatiana Sonina, Soo-Kyung Kim, Philippe Van Rompaey, Serge Van Calenbergh, Liaman Mamedova, Hea Ok Kim, Myong Jung Kim, Ae Yil Kim, Bruce T Liang, Lak Shin Jeong, Kenneth A Jacobson
An alternative approach to overcome the inherent lack of specificity of conventional agonist therapy can be the reengineering of the GPCRs and their agonists. A reengineered receptor (neoceptor) could...Read More
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Nai-Kuei NK Huang, Yijuang Y Chern, Jim-Min JM Fang, Chia-I CI Lin, Wan-Ping WP Chen, Yun-Lian YL Lin
Serum deprivation-induced neuronal-like PC12 cell apoptosis was used as an ischemic/hypoxic model to screen neuroprotective compounds from the rhizomes of Gastrodia elata, a traditional Chinese medici...Read More
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The design and synthesis of novel adenosine-derived inhibitors of HSP70, guided by modeling and X-ray crystallographic structures of these compounds in complex with HSC70/BAG-1, is described. Examples...Read More
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Two l-nucleosides, l-3'-amino-3'-deoxy-N^6-dimethyladenosine (l-3'-ADMdA) 1, previously synthesized in our laboratory, and the novel l-3'-amino-3'-deoxy-N^6-methyladenosine-5&...Read More
Prathan Luecha, Kaoru Umehara, Toshio Miyase, Hiroshi Noguchi
Antiestrogenic compounds were investigated from Thai indigenous plants for galactogogues since estrogen is reported to suppress lactation in breastfeeding women. The aerial parts of the Thai medicinal...Read More
Adrian Wai-Hing Cheung, John Brinkman, Fariborz Firooznia, Alexander Flohr, Joseph Grimsby, Mary Lou Gubler, Kevin Guertin, Rachid Hamid, Nicholas Marcopulos, Roger D Norcross, Lida Qi, Gwendolyn Ramsey, Jenny Tan, Yang Wen, Ramakanth Sarabu
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The highly potent but modestly selective N-(2-amino-4-methoxy-benzothiazol-7-yl)-N-ethyl-acetamide derivative 2 was selected as the starting point for the design of novel selective A"2"B ant...Read More
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Molecular modeling of agonist binding to the human A(2A) adenosine receptor (AR) was assessed and extended in light of crystallographic structures. Heterocyclic adenine nitrogens of cocrystallized ago...Read More
S A Hutchinson, P J Scammells
Adenosine receptors are widely distributed in the body and modulate numerous physiological processes. Four receptor subtypes (termed A(1), A(2A), A(2B) and A(3)) have been identified based on their ph...Read More
Bertil B BB Fredholm, Jiang-Fan JF Chen, Susan A SA Masino, Jean-Marie JM Vaugeois
Adenosine and its receptors have been the topic of many recent reviews. These reviews provide a good summary of much of the relevant literature--including the older literature. We have, therefore, cho...Read More
M M Livingston, L G LG Heaney, M M Ennis
Adenosine is a ubiquitous molecule present in every cell of the human body. It has a wide range of physiological functions mediated predominantly through specific cell surface adenosine receptors. Ade...Read More
Gail W GW Sullivan
Stressed or injured tissues release endogenous adenosine, which blocks potentially destructive inflammatory cascades by binding to A2A adenosine receptors (ARs) and decreasing activation of platelets,...Read More
Steuart S Rorke, Stephen T ST Holgate
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The early activation of microglia that induces retinal inflammation in DR may serve as a target for therapeutic intervention of DR. Our demonstration that retinal inflammation is attenuated via adenos...Read More
Oyvind Jakobsen, Tor Steensrud
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David Lu, Paul A Insel
The establishment of set points for cellular activities is essential in regulating homeostasis. Here, we demonstrate key determinants of the fibrogenic set point of cardiac fibroblasts (CFs) by focusi...Read More
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The present study examine the in vivo effects of Dorstenia Picta (D. picta) on urinary volume and sodium excretion in streptozotocin-induced diabetic rats, and determine a possible mechanism by which ...Read More
Leo C K Wan, Daniel Y L Mao, Dante Neculai, Jonathan Strecker, David Chiovitti, Igor Kurinov, Gennadiy Poda, Neroshan Thevakumaran, Fang Yuan, Rachel K Szilard, Elena Lissina, Corey Nislow, Amy A Caudy, Daniel Durocher, Frank Sicheri
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Hypertension is the most prevalent life-threatening disease worldwide and is frequently associated with chronic kidney disease (CKD). However, the molecular basis underlying hypertensive CKD is not fu...Read More
Paola P Gilli, Gastone G Gilli, Pier Andrea PA Borea, Katia K Varani, Angelo A Scatturin, Alessandro A Dalpiaz
Drug-receptor binding thermodynamics has proved to be a valid tool for pharmacological and pharmaceutical characterization of molecular mechanisms of receptor-recognition phenomena. The large number o...Read More
Alexander C Roy, Faylene A Lunn, Stephen L Bearne
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Yukiko Muroi, Fei Ru, Yang-Ling Chou, Michael J Carr, Bradley J Undem, Brendan J Canning
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