|别名||氯亚铂酸铵 ;四氯铂酸铵;Platinum(II)-ammonium chloride|
|标识符号||GHS05, GHS06, GHS08|
|个人防护设备||Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges|
Interleukin-1beta and surface marker expression changes induced by tetrachloroplatinate in human monocyte-derived dendritic cells.
Platinum salts, known occupational respiratory sensitizers, may also induce contact hypersensitivity in animal models. The aim of this study was to determine the effect of potassium tetrachloroplatina...Read More
Indian tasar silk is produced by a wild insect called Antheraea mylitta. Insects do not have any antigen-antibody mediated immune system like vertebrates but they produce a wide variety of effector pr...Read More
Preparation of a DNA aptamer-Pt complex and its use in the colorimetric sensing of thrombin and anti-thrombin antibodies.
DNA aptamers carrying Pt nanoparticles were prepared by the reaction of DNA aptamers (without functionalization with biotin, thiol, or other reactive groups) with K 2[PtCl 4] in solution at 60-90 degr...Read More
Noncovalent functionalization of DNA-wrapped single-walled carbon nanotubes with platinum-based DNA cross-linkers.
A method for noncovalent functionalization of DNA-wrapped single-walled carbon nanotubes (SWNTs) using platinum-based DNA cross-linkers is investigated. In particular, cisplatin and potassium tetrachl...Read More
Although contact allergy to some metals is common, patch testing for allergy to platinum is rarely performed.To determine the prevalence of positive patch-test reactions to platinum in an unselected c...Read More
Speciation of inorganic platinum-chloride complexes in spiked environmental samples by SPE and ICP-AES
A method for the separation of tetrachloroplatinate PtCl"4^2^-, and hexachloroplatinate PtCl"6^2^-, by solid-phase extraction, using a Dowex 1x10 anion exchange resin is proposed. The sequen...Read More
Dendrimer-tetrachloroplatinate precursor interactions. 2. Noncovalent binding in PAMAM outer pockets.
Density functional theory is used to investigate the complexation ability of dendrimer outer pockets--in both tertiary amine protonated and unprotonated scenarios--toward molecular guests, particularl...Read More
Dendrimer-tetrachloroplatinate precursor interactions. 1. Hydration of Pt(II) species and PAMAM outer pockets.
Density functional theory is used to investigate the structure and energetics of the tetrachloroplatinate anion and its hydrolysis products at several degrees of hydration, as well as those of outer d...Read More
The objective of this study was to synthesize and characterize particles as a drug-delivery platform for gliomas, a highly advanced and invasive stage of brain tumor with poor prognosis. Poly(aminoeth...Read More
Predictive testing of immunotoxicity associated with chemical compounds is complicated and cannot be accomplished with a single test. As most of the existing tests for immunotoxicity employ experiment...Read More
Preparation of platinum(II) complexes with L-serine using KI. X-ray crystal structure, HPLC and 195Pt NMR spectra.
The preparation of platinum(II) complexes containing L-serine using K(2)[PtCl(4)] and KI as raw materials was undertaken. The cis-trans isomer ratio of the complexes in the reaction mixture differed s...Read More
Deuteron NMR study of the diverse mobility of the ammonium ions in the ordered phase of (ND4)2PtCl4.
A detailed description of the diverse mobility of the ND4+ ions in the low-temperature ordered phase of (ND4)2PtCl4 is developed on the basis of single-crystal deuteron NMR spectra and site-selective ...Read More
The interaction of platinum complexes with bovine heart pyruvate kinase (PK) was studied by absorption, CD, fluorescence spectroscopy and enzymic activity test. Our results showed that activity of PK ...Read More
Monitoring Local Disposition Kinetics of Carboplatinin Vivoafter Subcutaneous Injection in Rats by Means of^1^9^5Pt NMR
The anticancer drug carboplatin has been monitored in rats during treatment by means ofin vivo^1^9^5Pt NMR spectroscopy at 2.0 T. The purpose of the study was to assess local disposition kinetics in i...Read More
Impact of K2PtCl4 on the structure of human serum albumin and its binding ability of heme and bilirubin.
Absorption, CD, gel-filtration chromatography, and immunological tests were used to evaluate the interactions of K2PtCl4 with human serum albumin. Multidentate coordination of Pt(II) to HSA causes dis...Read More
We describe a DNA-specific staining procedure, using a blue platinum organic dye, which allows DNA imaging of chromosomes by detection of back-scattered electrons in the scanning electron microscope. ...Read More
We have prepared phosphorothioate-containing cyclic oligodeoxynucleotides that fold into 'dumbbells' containing CRE and TRE sequences, the binding sequences for the CREB and JUN proteins, re...Read More
Occupational immediate-type allergic asthma due to potassium tetrachloroplatinate in production of cytotoxic drugs.
Allergic immediate-type reactions by halogenated compounds of platinum (Pt) (platinum salts) have been described in workers in precious metal refineries and catalyst productions. In both industries th...Read More
Expressions are derived for the initial relaxation rate 1/T1 of protons and deuterons of nontunnelling NH4 and ND4 groups reorienting about various symmetry axes in solids. The reorientation rates are...Read More
Immunostimulatory effects of platinum compounds: correlation between sensitizing properties in vivo and modulation of receptor-mediated endocytosis in vitro.
The sensitizing properties of different complex salts of platinum were defined in vivo by means of the popliteal lymph node (PLN) assay in mice. Hexa- and tetrachloroplatinates were confirmed to be hi...Read More
We report a patient with contact stomatitis due to combined sensitization to palladium and platinum. Patch testing showed strong and persistent allergic patch test reactions to palladium chloride (1% ...Read More
To investigate the greatest therapeutic efficacy, we investigated the effect of scheduling on the cytotoxic interaction between hyperthermia and seven different platinum complexes in vitro and in vivo...Read More
Optimization of the efficiency of cross-linking PtII oligonucleotide phosphorothioate complexes to complementary oligonucleotides.
We have investigated the efficiency with which PtII complexes cross-link phosphorothioates of oligonucleotides to complementary DNA targets. The A and G residues 2-5 bases downstream from the 5'-...Read More