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4-雄烯-4-醇-3,17-二酮

¥ 280.00

产品编号 A109617 | CAS号 566-48-3 | Aladdin
4-Androsten-4-ol-3,17-dione
99%
组合的产品项目
货号 规格 库存 价格 数量
A109617-10g 99% 上海(6)
北方(预计3-5个工作日)
 
A109617-1g 99% 上海(>10)
北方(2)
 
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属性

密度 1.1900
存贮条件 储存温度 2-8°C

描述

别名 4-雄烯-4-醇-3,17-二酮 ;福美司坦,4-羟基雄甾烷-4-烯-3,17-二酮;4-Hydroxy-4-androstene-3,17-dione Formestane
应用 芳香酶抑制剂,用作抗肿瘤载体,抵抗雌激素类肿瘤。
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标识符号 GHS08 GHS08
信号词 Danger
风险声明 (欧洲) 60
安全声明(欧洲) 53,36/37/39,45
警示性声明 P201,P308+P313
危害码(欧洲) T
危害声明 H360
个人防护设备 Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS BV8152500
WGK德国 3
参考文献
P E PE L?nning, J J Geisler, D C DC Johannessen, H P HP Gschwind, F F Waldmeier, W W Schneider, B B Galli, T T Winkler, W W Blum, H P HP Kriemler, W R WR Miller, J W JW Faigle
Formestane (Lentaron(R), 4-hydroxyandrostenedione) is a steroidal aromatase inhibitor used for treatment of advanced breast cancer. Clinically, it is administered as a depot form once fortnightly by i...Read More
A M AM Brodie, V C VC Njar
Estrogens are known to be important in the growth of breast cancers in both pre- and postmenopausal women. The number of breast cancer patients with hormone-dependent disease increases with age, as do...Read More
J Thomas JT Sanderson
Steroid hormones are essential for maintenance of pregnancy and fetal development. The expression and catalytic activity of the key steroidogenic enzymes involved in the production of progesterone and...Read More
Michael J MJ Haas, Prafull P Raheja, Sarada S Jaimungal, Mae M Sheikh-Ali, Arshag D AD Mooradian
Increased oxidative stress and endoplasmic reticulum stress (ER stress) have been implicated in atherosclerosis. Estrogens have potent antioxidant activity but their effects on ER stress have not been...Read More
Jing Fu, Zhong-Hua Shen, Fei-Xiong Cheng, Gui-Xia Liu, Wei-Hua Li, Yun Tang
Aromatase is a key enzyme responsible for in vivo estrogen biosynthesis. Inhibition of the activity of the aromatase has become an alterative way for treatment of breast cancer. In this review, the st...Read More
Thomas Piper, Gregor Fussh?ller, Caroline Emery, Wilhelm Sch?nzer, Martial Saugy
The aromatase inhibitor formestane (4-hydroxy-androst-4-ene-3,17-dione, F) is prohibited in sports by the World Anti-Doping Agency (WADA). F possesses only weak androgenic properties and is presumed t...Read More
Yuan-Ping Lin, Lih-Ren Chen, Chih-Feng Chen, Jenn-Fa Liou, Yi-Ling Chen, Jenn-Rong Yang, Yow-Ling Shiue
Early transcripts related to male development in chicken embryos and their expression profiles were examined. A total of 89 and 127 candidate male development transcripts that represented 83 known and...Read More
Carla Cavaliere, Sara Corvigno, Mario Galgani, Gennaro Limite, Agostina Nardone, Bianca Maria Veneziani
In breast cancer, stromal cells surrounding cancer epithelial cells can influence phenotype by producing paracrine factors. Among many mediators of epithelial-stromal interactions, aromatase activity ...Read More
Aaron T Wright, Joongyu D Song, Benjamin F Cravatt
Cytochrome P450 (P450) enzymes regulate a variety of endogenous signaling molecules and play central roles in the metabolism of xenobiotics and drugs. We recently showed that an aryl alkyne serves as ...Read More
Ana G Guti??rrez-Garc?-a, Carlos M Contreras, Diana I V??squez-Hern??ndez, Tania Molina-Jim??nez, Emma Jacome-Jacome
Testosterone exerts anxiolytic effects, but the participation of its aromatase metabolic product estradiol is controversial. Therefore, we used the defensive burying paradigm in female Wistar rats to ...Read More
Adam T AT Cawley, Graham J GJ Trout, Rymantas R Kazlauskas, Adrian V AV George
Studies have shown that the administration of androstenedione (ADIONE) significantly increases the urinary ratio of testosterone glucuronide to epitestosterone glucuronide (T/E) - measured by gas chro...Read More
J L Nu?ez, M M McCarthy
The maturation of the hippocampus is impacted by a multitude of factors, including the regulation of intracellular calcium levels. Depolarizing actions of Gamma-Aminobutyric Acid (GABA) can profoundly...Read More
Sanjay K Sharma, Weizhong Zheng, Alummoottil V Joshua, Douglas N Abrams, Alexander J B McEwan
Synthesis of 4-amino-4,6-androstadiene-3,17-dione 7, an analog of formestane used in breast cancer therapy as an aromatase inhibitor, from 4-acetoxy-4-androstene-3,17-dione 2 is described. This is the...Read More
Bryan P Nelson, Russ P Henriet, Andrew W Holt, Katherine C Bopp, Alexander P Houser, Ottie E Allgood, James E Turner
The brain is a steroidogenic organ and is thus dependent on estrogen for many aspects of its development and maintenance in both males and females. The purpose of this study was to develop a model to ...Read More
Isabel R IR Barbosa, António J A AJ Nogueira, Amadeu M V M AM Soares
Steroid compounds have been globally detected in surface waters. The ecological impacts of these biologically active chemicals are largely unknown. Toxicity of testosterone and 4-hydroxyandrostenedion...Read More
Bianca Maria Veneziani, Vittoria Criniti, Carla Cavaliere, Sara Corvigno, Agostina Nardone, Silvia Picarelli, Giampaolo Tortora, Fortunato Ciardiello, Gennaro Limite, Sabino De Placido
Molecularly targeted, customized therapies are designed based on the molecular portraits of cancer tissue. The efficacy of targeted therapy in individual patients depends on the contribution of single...Read More
Alia A Hamad, Matthew M Kluk, Joshua J Fox, Matthew M Park, James E JE Turner
It has been shown that the steroid hormone estrogen plays an important role in the development of the central nervous system. The purpose of these studies was to determine the effect of estrogen on ze...Read More
Lucía L Martínez-Mota, José Juan JJ Cruz-Martínez, Sergio S Márquez-Baltazar, Alonso A Fernández-Guasti
In male rats, the antidepressant-like effect of fluoxetine (FLX) and desipramine (DMI) in the forced swimming test (FST) is reduced by orchidectomy and partially restored by testosterone (T). It is un...Read More
Thomas T Nisslein, Johannes J Freudenstein
Non-steroidal as well as steroidal aromatase inhibitors are currently being discussed as alternatives to tamoxifen in the first-line treatment of patients with hormone-dependent breast cancer. Many of...Read More
Maxie Kohler, Maria K Parr, Georg Opfermann, Mario Thevis, Nils Schl?rer, Franz-Josef Marner, Wilhelm Sch?nzer
4-Hydroxyandrost-4-ene-3,17-dione is a second generation, irreversible aromatase inhibitor and commonly used as anti breast cancer medication for postmenopausal women. 4-Hydroxytestosterone is adverti...Read More
Xin X Wang, Shiuan S Chen
Using Western blot as the major technique, we studied the effects of the three Food and Drug Administration (FDA)-approved aromatase inhibitors (AI) on aromatase protein stability in the aromatase-ove...Read More
Ichiro I Sakata, Toru T Tanaka, Mami M Yamazaki, Takashi T Tanizaki, Zhao Z Zheng, Takafumi T Sakai
Ghrelin, an endogenous ligand for the GH secretagogue receptor, is predominantly produced in the stomach. Little is known about the regulation mechanism of gastric ghrelin. Here, we report that estrog...Read More
Jenifer R JR Prosperi, Fredika M FM Robertson
The present studies evaluated the direct effects of the presence of human cyclooxygenase-2 (Cox-2) on gene expression of specific promoter regions of the P450 Cyp19 enzyme aromatase enzyme and its pro...Read More
Davide Mauri, Nicholas Pavlidis, Nikolaos P Polyzos, John P A Ioannidis
Aromatase inhibitors and inactivators have been extensively tested in patients with advanced breast cancer, but it is unclear whether they offer any survival benefits compared with standard hormonal t...Read More
Joseph J Cernich, Jill D JD Jacobson, Wayne V WV Moore, Jadranka J Popovic
Estrogen has been shown to have an important role in skeletal maturation in both males and females. The use of aromatase inhibitors may provide a means to delay skeletal maturation and increase final ...Read More
Bogus?aw B Czerny, Maria M Teister, Zygmunt Z Juzyszyn, Andrzej A Modrzejewski, Andrzej A Pawlik
4-Hydroxyandrost-4-ene-3,17-dione (formestane) is a selective aromatase inhibitor. It is indicated for postmenopausal patients with advanced breast cancer. The aim of the present study was to investig...Read More