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2-氨基嘧啶

¥ 54.00

产品编号 A109732 | CAS号 109-12-6 | 阿拉丁
2-Aminopyrimidine
98%
组合的产品项目
货号 规格 库存 价格 数量
A109732-100g 98% 上海(3)
北方(预计3-5个工作日)
 
A109732-250g 98% 上海(预计3-7周)
北方(预计3-7周)
 
A109732-25g 98% 上海(>10)
北方(预计3-5个工作日)
 
A109732-500g 98% 上海(1)
北方(预计3-5个工作日)
 
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属性

密度 1.2160
熔点 127°C
沸点 158°C

描述

产品介绍 易溶于水、醇、丙酮和氯仿,微溶于乙醚、苯。易升华。
别名 2-氨基嘧啶 ;2-嘧啶胺,2-嘧啶基胺;2-Pyrimidinamine 2-Amino-1,3-diazine
应用 用于有机合成,作医药中间体、生化试剂。
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标识符号 GHS07 GHS07
信号词 Warning
风险声明 (欧洲) R36/37/38
安全声明(欧洲) S26;S37/39
警示性声明 P261,P305+P351+P338
危害码(欧洲) Xi
危害声明 H315,H319,H335
个人防护设备 dust mask type N95 (US),Eyeshields,Gloves
RTECS UV6326000
WGK德国 3
闪点(摄氏) 103 °C
参考文献
Sabine Schultes, Harald Engelhardt, Luc Roumen, Obbe P Zuiderveld, Eric E J Haaksma, Iwan J P de Esch, Rob Leurs, Chris de Graaf
SAR beyond protein-ligand interactions: By combining structure-affinity relationships, protein-ligand modeling studies, and quantum mechanical calculations, we show that ligand conformational energies...Read More
Graham G Smith, Urs D UD Wermuth, Jonathan M JM White
The structures of the anhydrous 1:1 proton-transfer compounds of 4,5-dichlorophthalic acid (DCPA) with the monocyclic heteroaromatic Lewis bases 2-aminopyrimidine, 3-(aminocarbonyl)pyridine (nicotinam...Read More
N Prabavathi, A Nilufer, V Krishnakumar, L Akilandeswari
The FTIR and FT-Raman spectra of 2-aminopyrimidine (2-AP) and 4-aminopyrazolo[3,4-d]pyrimidine (4-APP) has been recorded in the region 4000-400 and 3500-100 cm(-1), respectively. The tautomeric stabil...Read More
Kamaljit K Singh, Hardeep H Kaur, Kelly K Chibale, Jan J Balzarini, Susan S Little, Prasad V PV Bharatam
2-Aminopyrimidine based 4-aminoquinolines were synthesized using an efficacious protocol. Some of the compounds showed in?vitro anti-plasmodial activity against drug-sensitive CQ(S) (3D7) and drug-res...Read More
Rajani R Giridhar, Riyaj S RS Tamboli, R R Ramajayam, Dhaval G DG Prajapati, M R MR Yadav
A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in?vitro assay. Compound 14k was found to be two times more potent than aspirin. These...Read More
Jinho Lee, Kyoung-Hee Kim, Shinwu Jeong
A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibi...Read More
Xusheng Wang, Hongdeng Qiu, Xia Liu, Shengxiang Jiang
N-methylimidazolium ionic liquid (IL) -modified silica was prepared with the reaction of 3-chloropropyl modified silica and N-methylimidazole using toluene as solvent. Based on the multiple interactio...Read More
D S DS Ermolat'ev, B B Savaliya, A A Shah, E E Van der Eycken
An efficient microwave-assisted one-pot two-step protocol was developed for the construction of disubstituted 2-amino-1H-imidazoles. This process involves the sequential formation of 2,3-dihydro-2-hyd...Read More
Rogier A Smits, Rob Leurs, Iwan JP de Esch
The search for new and potent histamine H"4 receptor ligands is leading to a steadily increasing number of scientific publications and patent applications. Several interesting and structurally di...Read More
Paul S Humphries, Jennifer A Lafontaine, Charles S Agree, David Alexander, Ping Chen, Quyen-Quyen T Do, Lilian Y Li, Elizabeth A Lunney, Ranjan J Rajapakse, Karen Siegel, Sergei L Timofeevski, Tianlun Wang, David M Wilhite
The development of a series of novel 4-substituted-2-aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, and the in vitro inhib...Read More
Manuel Tzouros, Axel Pa?hler
Covalent binding of reactive metabolites is generally accepted as one underlying mechanism of drug-induced toxicity. However, identification of protein targets by reactive metabolites still remains a ...Read More
Robert J RJ Altenbach, Ronald M RM Adair, Brian M BM Bettencourt, Lawrence A LA Black, Shannon R SR Fix-Stenzel, Sujatha M SM Gopalakrishnan, Gin C GC Hsieh, Huaqing H Liu, Kennan C KC Marsh, Michael J MJ McPherson, Ivan I Milicic, Thomas R TR Miller, Tim
A series of 2-aminopyrimidines was synthesized as ligands of the histamine H4 receptor (H4R). Working in part from a pyrimidine hit that was identified in an HTS campaign, SAR studies were carried out...Read More
Adel M AM Awadallah, Jalal A JA Zahra
The reaction of nitrilimine 6a with ethyl pyridine-2-acetate (7) gave the corresponding pyrrolo[1,2-a]pyridine 8, while the reaction of 6b containing an ester moiety afforded the acyclic adduct 9. The...Read More
Teodor Silviu TS Balaban, Richard R Goddard, Myriam M Linke-Schaetzel, Jean-Marie JM Lehn
The 2-aminopyrimidin-5-yl ligand is revealed to be a promising candidate for the construction of supramolecular porphyrin arrays with broad absorption bands for efficient light-harvesting. 10-Mono- an...Read More
Maya M Tutughamiarso, Guido G Wagner, Ernst E Egert
The antifungal drug 5-fluorocytosine (4-amino-5-fluoro-1,2-dihydropyrimidin-2-one) was cocrystallized with five complementary compounds in order to better understand its drug-receptor interaction. The...Read More
Erick A Lindsey, Roberta J Worthington, Cristina Alcaraz, Christian Melander
An efficient synthetic route to a series of substituted 2-aminopyrimidine (2-AP) derivatives has been developed. Subsequent biofilm screening has allowed comparison between the biological activity of ...Read More
Nimisha N Singh, Sarvesh Kumar SK Pandey, Namrata N Anand, Richa R Dwivedi, Shyam S Singh, Sudhir Kumar SK Sinha, Vinita V Chaturvedi, Natasa N Jaiswal, Arvind Kumar AK Srivastava, Priyanka P Shah, M Imran MI Siddiqui, Rama Pati RP Tripathi
An economical and efficient one step synthesis of a series of 8-(arylidene)-4-(aryl)-5,6,7,8-tetrahydro-quinazolin-2-ylamines and 9-(arylidene)-4-(aryl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-yla...Read More
Markus K Dahlgren, Christopher T Oberg, Erika A Wallin, P?r G Janson, Mikael Elofsson
Salicylidene acylhydrazides are inhibitors of type III secretion in several gram-negative pathogens. To further develop the salicylidene acylhydrazides, scaffold hopping was applied to replace the cor...Read More
Nicholas R NR Perl, Nathan D ND Ide, Sudeep S Prajapati, Hahdi H HH Perfect, Sergio G SG Durón, David Y DY Gin
A convergent synthesis of (-)-crambidine is reported. The sequence capitalizes on two novel key transformations, including a [4+2] annulation of thioimidates with vinyl carbodiimides and an alkyne hyd...Read More
Miguel Angel MA Vilchis-Reyes, Alejandro A Zentella, Miguel Angel MA Martínez-Urbina, Angel A Guzmán, Omar O Vargas, María Teresa MT Ramírez Apan, José Luis JL Ventura Gallegos, Eduardo E Díaz
A series of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidines derivatives were synthesized using a convenient synthetic route. We evaluate the isosteric replacement of methy...Read More
SA Abdel-Latif, HB Hassib, YM Issa
The formation constants of some transition metal ions Cr(III), Mn(II), Fe(III), Ni(II) and Cu(II) binary complexes containing Schiff bases resulting from condensation of salicylaldehyde with aniline (...Read More
Ye-Xiang YX Xie, Shao-Feng SF Pi, Jian J Wang, Du-Lin DL Yin, Jin-Heng JH Li
Efficient and solvent-free copper-catalyzed N-arylations of imidazoles with aryl and heteroaryl halides have been demonstrated. In the presence of CuBr, 2-aminopyrimidine-4,6-diol, and TBAF (n-Bu4NF),...Read More
Teruyoshi Kitamura, Atushi Hikita, Hironori Ishikawa, Akira Fujimoto
The electronic absorption and fluorescence spectra of 2-aminopyrimidine (2APM), 2-amino-4-methylpyrimidine (2A4MPM), and 2-amino-4,6-dimethylpyrimidine (2ADMPM) with acetic acid (AcOH) were measured i...Read More
A A A?tmambetov, Z Z Menlimuratova
The reaction of chalcones and flavones with guanidine in ethanol results in (2-aminopyrimidinyl-4)phenols....Read More