产品编号 A109915 | CAS号 26093-31-2 | 阿拉丁
货号 规格 库存 价格 数量
A109915-1g 98% 上海(10)
A109915-250mg 98% 上海(预计3-7周)
A109915-25g 98% 上海(3)
A109915-5g 98% 上海(>10)


敏感性 对光敏感
密度 1.2750
熔点 223-226°C
溶解性 Soluble in acetone (10 mg/ml), DMSO (10 mg/ml), and DMF.
存贮条件 储存温度 2-8℃


产品介绍 7-Amino-4-methylcoumarin (AMC) is a well-known laboratory reagent employed in the preparation of fluorogenic AMC-based substrates for the detection of proteolytic enzyme activity. AMC has been utilized as a fluorescent probe to analyze glycoproteins' monosaccharides and N-linked oligosaccharides via chromatography and has been used as a laser dye. Recent research shows that AMC was extracted from an endophytic Xylaria fungal species and exhibited strong antibacterial and antifungal activities in vitro against Aspergillus, Candida, Escherichia, Staphylococcus, Salmonella and Vibrio species, among others. This product is also useful as a reference standard in enzymatic assays.
别名 7-氨基-4-甲基香豆素(AMC) ;香豆素120;Coumarin 120; 7-Amino-4-methyl-2H-chromen-2-one; AMC
应用 用作激光染料。荧光标记试剂,用于痕量检测酶。
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标识符号 GHS07 GHS07
信号词 Warning
风险声明 (欧洲) R36/37/38;
安全声明(欧洲) S26;S36;
警示性声明 P261,P305+P351+P338
危害码(欧洲) Xi
危害声明 H315,H319,H335
个人防护设备 dust mask type N95 (US),Eyeshields,Gloves
WGK德国 3
Changning Wang, Chunying Wu, Junqing Zhu, Robert H Miller, Yanming Wang
Myelination represents one of the most fundamental biological processes in the vertebrate nervous system. Abnormalities and changes in myelination in the central nervous system (CNS) are seen in many ...Read More
Andrew M Pickering, Kelvin J A Davies
Proteins are sensitive to oxidation, and oxidized proteins are excellent substrates for degradation by proteolytic enzymes such as the proteasome and the mitochondrial Lon protease. Protein labeling i...Read More
Salma M Al-Kindy, James N Miller
A high-performance liquid chromatography (HPLC) method for the analysis of nitrated polcyclic aromatic hydrocarbons (NPAHs) is reported. NPAH mixtures were pre-concentrated using solid-phase extractio...Read More
Y Dai, R M Whittal, C A Bridges, Y Isogai, O Hindsgaul, L Li
Sulfated oligosaccharides are an important class of compounds in the field of glycobiology. Mass spectrometric analysis of these molecules is challenging due to their readiness to dissociate in sample...Read More
Y Kanaoka, T Takahashi, H Nakayama, T Ueno, T Sekine
We're sorry this abstract is currently not available....Read More
M Zimmerman, B Ashe, E C Yurewicz, G Patel
We're sorry this abstract is currently not available....Read More
Letícia Christina Pires Gon?alves, Renata Rosito Tonelli, Piero Bagnaresi, Renato Arruda Mortara, Antonio Gilberto Ferreira, Erick Leite Bastos
A model betalainic dye was semisynthesized from betanin, the magenta pigment of the red beet, and was effective for live-cell imaging of Plasmodium-infected red blood cells. This water-soluble fluores...Read More
Donatella Trivigno, Frank Essmann, Stephan M Huber, Justine Rudner
Myeloid cell leukemia sequence 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family, is often overexpressed in tumor cells limiting the therapeutic success. Mcl-1 differs from other Bcl-2 members by...Read More
Hakan H Kalay, Martino M Ambrosini, Patrick H C PH van Berkel, Paul W H I PW Parren, Yvette Y van Kooyk, Juan J JJ García Vallejo
The characterization of the repertoire of glycans at the quantitative and qualitative levels on cells and glycoproteins is a necessary step to the understanding of glycan functions in biology. In addi...Read More
Sander S SS van Berkel, Bas B van der Lee, Floris L FL van Delft, Rob R Wagenvoord, H Coenraad HC Hemker, Floris P J T FP Rutjes
The synthesis of a series of peptides containing C-terminal 7-amino-4-methylcoumarin (AMC) for use in the thrombin generation test (TGT) is described. The lead structure in this project was H-Gly-Gly-...Read More
Rashmi R Tandon, Prija P Ponnan, Neha N Aggarwal, Rakesh R Pathak, Anil S AS Baghel, Garima G Gupta, Anu A Arya, Mahendra M Nath, Virinder S VS Parmar, Hanumantharao G HG Raj, Ashok K AK Prasad, Mridula M Bose
The objective of the present study was to evaluate the antitubercular activity of amino and acyl amino derivatives of coumarins when used alone and in combination with isoniazid, rifampicin, streptomy...Read More
Mal-Gi MG Choi, Eungyeong E Lee, Hye-Shin HS Chung, Sei-Heon SH Jang, ChangWoo C Lee
Enteropeptidase is a serine protease secreted by the pancreas and converts inactive trypsinogen to active trypsin. Enteropeptidase cleaves the C-terminal end of the substrate recognition sequence Asp-...Read More
Jens Müller, Tobias Becher, Jennifer Braunstein, Philipp Berdel, Sascha Gravius, Falk Rohrbach, Johannes Oldenburg, Günter Mayer, Bernd P?tzsch
We're sorry this abstract is currently not available....Read More
Darakhshan Qaiser, Mohd Shahid Khan, R D Singh, Zahid H Khan, Santa Chawla
The interaction between Coumarin C440 with Fullerene C"6"0 has been studied by fluorescence and time resolved spectroscopic techniques. The Coumarin C440-Fullerene C"6"0 pair shows...Read More
Qinghua Q Hou, Li L Ling, Fang F Wang, Shihui S Xing, Zhong Z Pei, Jinsheng J Zeng
Endostatin (ES) has been recognized as a potent anti-angiogenic factor. We here investigated the expression of ES in ischemic brain and the consequence of cells expressing ES after stroke in adult str...Read More
Yu Feng, Jiahui Wu, Lei Chen, Chen Luo, Xu Shen, Kaixian Chen, Hualiang Jiang, Dongxiang Liu
Sirtuins are nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases that catalyze the deacetylation of proteins such as histones and p53. A sensitive and convenient fluorometric assay for e...Read More
Bernadette S Creaven, Michael Devereux, Dariusz Karcz, Andrew Kellett, Malachy McCann, Andy Noble, Maureen Walsh
The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with coppe...Read More
Wenjing Chen, Ke Mou, Bo Xu, Xiaomei Ling, Jingrong Cui, Ping Xu
A method for studying 20S proteasome inhibitors by capillary electrophoresis (CE) has been developed. Proteasome plays a fundamental role in degrading key regulatory proteins. The 20S proteasome can d...Read More
Dirk Wildeboer, Fiona Jeganathan, Robert G Price, Ramadan A Abuknesha
Bacteria produce a range of proteolytic enzymes. In an attempt to detect and identify bacteria on the basis of their protease activity, a panel of protease substrates was investigated. Peptides conjug...Read More
Masayasu M Taki, Mika M Desaki, Akio A Ojida, Shohei S Iyoshi, Tasuku T Hirayama, Itaru I Hamachi, Yukio Y Yamamoto
We described here a coumarin-based dual-excitation ratiometric probe for cadmium, CadMQ. This fluorescence sensor has high quantum yields of 0.59 and 0.70 in the metal-free and Cd2+-bound forms, respe...Read More
Masahiro M Yodoshi, Akiko A Tani, Yumiko Y Ohta, Shigeo S Suzuki
Reductive amination reaction using 7-amino-4-methylcoumarin (AMC) as a fluorescent probe enabled analyses of glycoproteins' monosaccharides and N-linked oligosaccharides. Reductive amination of N...Read More
Zengchen Z Liu, Bo B Li, Baodui B Wang, Zhengyin Z Yang, Qin Q Wang, Tianrong T Li, Dongdong D Qin, Yong Y Li, Mingfang M Wang, Mihui M Yan
In the present study, we report new water-soluble cell fluorescence imaging and contrast agents that are based on DTPA-AMC(7-amino-4-methyl coumarin)-Eu(3+) and DTPA-AMC(7-amino-4-methyl coumarin)-Gd(...Read More
Byoung Joon Ko, Jennifer S Brodbelt
The fragmentation patterns of hydrazide-conjugated and reductively aminated oligosaccharides, including lacto-N-fucopentaoses and lacto-N-difucohexaoses, produced on collisionally induced dissociation...Read More
Tetsuya Sakata, Yukio Kawashima, Haruyuki Nakano
The solvent effect on the absorption spectra of coumarin 120 (C120) in water was studied utilizing the combined quantum mechanical∕molecular mechanical (QM∕MM) method. In molecular dynamics (MD) s...Read More
Qi Q Chen, Kristin G KG Rausch, Holger H Sch?nherr, G Julius GJ Vancso
Herein the reactivity of the enzyme α-chymotrypsin in the confinement of polystyrene-block-poly(acrylic acid) (PS-b-PAA) vesicles was investigated. Enzyme and substrate molecules were encapsulated in...Read More
Azza Eissa, Vanessa Amodeo, Christopher R Smith, Eleftherios P Diamandis
Kallikrein-related peptidase-8 (KLK8) is a relatively uncharacterized epidermal protease. Although proposed to regulate skin-barrier desquamation and recovery, the catalytic activity of KLK8 was never...Read More
Maru?ka Budi?, Marjetka Kidri?, Vladimir Megli?, Bla? Cigi?
A zymography technique based on native polyacrylamide gel electrophoresis (PAGE) has been devised, which enables the substrate specificities, content and pH profiles of proteolytic enzymes to be deter...Read More
Katrien Brak, Patricia S Doyle, James H McKerrow, Jonathan A Ellman
Cruzain is the major cysteine protease of Trypanosoma cruzi, which is the causative agent of Chagas disease and is a promising target for the development of new chemotherapy. With the goal of developi...Read More
Xiaoli X Liu, Mingsheng M Dong, Xiaohong X Chen, Mei M Jiang, Xin X Lv, Jianzhong J Zhou
An endophytic Xylaria sp., having broad antimicrobial activity, was isolated and characterized from Ginkgo biloba L. From the culture extracts of this fungus, a bioactive compound P3 was isolated by b...Read More
Maria E Riveiro, Albertina Moglioni, Ramiro Vazquez, Natalia Gomez, Graciela Facorro, Lidia Piehl, Emilio Rubin de Celis, Carina Shayo, Carlos Davio
The present work evaluates the structural requirements of related hydroxycoumarins to induce apoptosis in a leukemic cell line, suggesting that reactive oxygen species generation plays a critical role...Read More
Daniel Riester, Christian Hildmann, Patricia Haus, Antonia Galetovic, Andreas Schober, Andreas Schwienhorst, Franz-Josef Meyer-Almes
Histone deacetylases reside among the most important and novel target classes in oncology. Selective lead structures are intensively developed to improve efficacy and reduce adverse effects. The commo...Read More
Fabrizio F Carta, Alfonso A Maresca, Andrea A Scozzafava, Claudiu T CT Supuran
A series of coumarins incorporating tert-butyl-dimethylsilyloxy- or allyoxy- moieties in positions 4-, 6 or 7 of the heterocyclic ring have been synthesized and then converted to the corresponding 2-t...Read More